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Fibrinolysis and Remote Ischemic Conditioning: Mechanisms and Treatment Perspectives in Stroke.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurology, Danish Stroke Center, Aarhus University Hospital, Aarhus, Denmark.

Stroke is a leading cause of death and disability. Intravenous thrombolysis and mechanical thrombectomy have greatly improved outcomes in acute ischemic stroke (AIS). However, only a minority of patients receive reperfusion therapies, highlighting the need for novel neuroprotective therapies. Read More

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Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults.

Chemosphere 2021 Apr 14;279:130573. Epub 2021 Apr 14.

Department of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, Qingdao, Shandong, 266071, China; Municipal Centre of Disease Control and Prevention of Qingdao, Qingdao Institute of Prevention Medicine, Qingdao, Shandong, 266034, China. Electronic address:

Background: Bisphenol S (BPS) and bisphenol F (BPF), as substitutes for bisphenol A (BPA), are synthetic compounds detected increasingly frequently in plastics and resins. BPA, BPS, and BPF are endocrine disruptors with unclear effects on depressive symptoms. This study aims to evaluate the effects of these compounds on depressive symptoms in adults. Read More

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Clopidogrel underactivity is a common in patients with acute symptomatic severe carotid stenosis.

J Neurol Sci 2021 Apr 14;425:117450. Epub 2021 Apr 14.

Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Clopidogrel is commonly used for secondary stroke prevention in patients with large vessel stenosis. Reduced Clopidogrel high on treatment platelet reactivity (CR) can lead to Clopidogrel underactivity (CU) causing acute thrombosis. However, the prevalence of CU among patients with acute symptomatic carotid disease remains unknown. Read More

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Adverse childhood experiences in New Zealand and subsequent victimization in adulthood: Findings from a population-based study.

Child Abuse Negl 2021 Apr 17;117:105067. Epub 2021 Apr 17.

School of Māori Studies and School of Pacific Studies, Faculty of Arts, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

Background: Adverse childhood experiences (ACEs) are widespread and are associated with adverse outcomes in later life, yet few studies have explored their prevalence and consequences in New Zealand.

Objectives: To provide prevalence estimates of ACEs in New Zealand using a large sample of adults, and to explore the associations between ACEs and experience of violence by intimate partners and non-partners in adulthood.

Participants And Setting: 2,887 participants (1464 female, 1423 male) from the 2019 New Zealand Family Violence Survey, a population based study conducted in New Zealand between March 2017-March 2019. Read More

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Dietary flavonoid intake and risk of esophageal squamous cell carcinoma: A population-based case-control study.

Nutrition 2021 Mar 7;89:111235. Epub 2021 Mar 7.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address:

Objectives: The aim of this population-based case-control study was to investigate the association between dietary consumption of the total flavonoids, subclasses, and specific flavonoids and the risk of esophageal squamous cell carcinoma (ESCC) among adults in a high-risk area of China.

Methods: We recruited 820 ESCC participants and 863 control participants from Yanting County. Dietary flavonoids were assessed using a validated 76-item food frequency questionnaire. Read More

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The contribution of dietary glycemic index and glycemic load to the development of microvascular complications of diabetes.

Nutrition 2021 Mar 6;89:111234. Epub 2021 Mar 6.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. Electronic address:

Lifestyle modification, including a healthy diet, is of paramount importance in the management of diabetes mellitus. To this end, diets have been proposed with low glycemic index (an index of carbohydrate food expressing how quickly this nutrient can increase blood glucose) and glycemic load (an index obtained by multiplying the glycemic index by the grams of carbohydrate, then dividing by 100). The aim of this review was to discuss the potential contribution of diets with low glycemic index and glycemic load in diabetic microvascular complications. Read More

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Independent and combined associations of urinary heavy metals exposure and serum sex hormones among adults in NHANES 2013-2016.

Environ Pollut 2021 Apr 8;281:117097. Epub 2021 Apr 8.

State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Accumulating evidences indicated that heavy metals may disrupt human sex hormones. However, the combined effects of heavy metals on sex hormones remain to be clarified. To explore the independent and combined associations between heavy metal exposure and serum sex hormones among adults, data of 2728 adults from the National Health and Nutrition Examination Survey (NHANES) was applied. Read More

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The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: Study of 276 cases.

J Stomatol Oral Maxillofac Surg 2021 Apr 17. Epub 2021 Apr 17.

Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey.

Purpose: Benign fibro-osseous lesions (BFOLs) are heterogeneous intraosseous dis- ease processes sharing overlapping histopathologic features and demonstrate a wide range of biological behavior. The aim of this study is to highlight the importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws.

Materials And Methods: This is a cross-sectional retrospective study evaluating the three main groups of BFOLs: Cemento-osseous dysplasia, ossifying fibroma, and fibrous dysplasia. Read More

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Should return to pivoting sport be avoided for the secondary prevention of osteoarthritis after anterior cruciate ligament reconstruction? A prospective cohort study with MRI, radiographic and symptomatic outcomes.

Osteoarthritis Cartilage 2021 Apr 17. Epub 2021 Apr 17.

La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Australia. Electronic address:

Objective: To evaluate if returning to pivoting sport following anterior cruciate ligament reconstruction (ACLR) is associated with longitudinal structural and symptomatic osteoarthritis outcomes.

Design: Eighty-one adults aged 18-50 years were followed prospectively 1- to 5-years post-ACLR. Return to pivoting sport was assessed at 1-, 3- and 5-years. Read More

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Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia.

Acta Biomater 2021 Apr 17. Epub 2021 Apr 17.

College of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education), State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China. Electronic address:

The therapeutic effectiveness of cell transplantation in treatment of diseases and injuries is often limited by low cell retention, survivability, and engraftment. Extracellular matrix (ECM)-derived scaffolds are capable of controlling cell responses, thereby offering potential solutions to current challenges associated with cell therapy. However, it remains a technical challenge to produce ECM scaffolds with highly interconnected porous structure specifically required for cell transplantation. Read More

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Comparative analysis of antigen and molecular tests for the detection of Sars-CoV-2 and related variants: a study on 4266 samples.

Int J Infect Dis 2021 Apr 17. Epub 2021 Apr 17.

Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. Electronic address:

Objectives: The present study compared the performance of Lumipulse G Sars-CoV-2 Ag kit with TaqPath COVID-19 RT-PCR CE IVD kit.

Methods: The study was conducted on 4266 naso-oropharyngeal swabs. Samples were subjected to antigen RT-PCR tests for detection of Sars-CoV-2 and related variants. Read More

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Guideline No. 417: Prevention of Venous Thromboembolic Disease in Gynaecological Surgery: (En français : Prévention de la maladie thromboembolique veineuse en chirurgie gynécologique).

J Obstet Gynaecol Can 2021 Apr 17. Epub 2021 Apr 17.

Hamilton, ON.

Objective: The primary objective of this clinical practice guideline is to provide gynaecologists with an algorithm and evidence to guide the use of thromboprophylaxis in gynaecological surgery.

Target Population: All patients undergoing gynaecological surgery for benign or malignant indications.

Benefits, Harms, And Costs: The implementation of this guideline will benefit patients undergoing gynaecological surgery and provide physicians with a standard algorithm for the use of perioperative thromboprophylaxis. Read More

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Atezolizumab and blockade of LncRNA PVT1 attenuate cisplatin resistant ovarian cancer cells progression synergistically via JAK2/STAT3/PD-L1 pathway.

Clin Immunol 2021 Apr 17:108728. Epub 2021 Apr 17.

Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China; National Clinical Research Centre of Cancer, Tianjin 300060, China. Electronic address:

Objective: To investigate the relationship between lncRNA PVT1(PVT1) level and PD-L1 expression and their functions in cisplatin resistant epithelial ovarian cancer (CREOC).

Methods: PVT1 and PD-L1 in ovarian cancer tissues were detected and analyzed. The cells proliferation, apoptosis, invasion abilities and potential mechanism were detected by cell functional experiments and western-blot assay, respectively. Read More

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Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study: Sedentary behavior, cancer and mortality.

J Sport Health Sci 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Background: Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality, but evidence from the Chinese population is scarce. This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity (MVPA) on these relationships.

Methods: We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire. Read More

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A moderate intensity exercise program improves physical function and oxidative damage in older women with and without sarcopenic obesity.

Exp Gerontol 2021 Apr 17:111360. Epub 2021 Apr 17.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address:

Background And Objectives: The excess of body fat and muscle mass loss in adulthood results in sarcopenic obesity, which is associated with disability and poor physical condition. A relationship among obesity, sarcopenia and oxidative stress also has been established. These aspects limit a good muscle function which is crucial in the independence of older women with and without sarcopenic obesity. Read More

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High-capacity syringe: A useful instrument in prevention of the backspray during intralesional injections.

J Am Acad Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology and Venerology, First Hospital, Jilin University, Changchun 130021, China. Electronic address:

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O-antigen serves as a two-faced host factor for bacteriophage NJS1 infecting nonmucoid Klebsiella pneumoniae.

Microb Pathog 2021 Apr 17:104897. Epub 2021 Apr 17.

Department of Microbiology, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Klebsiella pneumoniae is an opportunistic pathogen commonly associated with nosocomial infections. In our previous study, we have demonstrated that colistin-resistant K. pneumoniae is more susceptible to killing by lytic tailed phages than the colistin-sensitive parent strain, including T1-like ФNJS1. Read More

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PcALF5 inhibits the proliferation of microbiota by binding to RPS4 and MscL of E. coli.

Dev Comp Immunol 2021 Apr 17:104106. Epub 2021 Apr 17.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, 271018, China. Electronic address:

Antimicrobial peptides (AMPs), most of which are small proteins, are necessary for innate immunity against pathogens. Anti-lipopolysaccharide factor (ALF) with a conserved lipopolysaccharide binding domain (LBD) can bind to lipopolysaccharide (LPS) and neutralize LPS activity. The antibacterial mechanism of ALF, especially its role in bacteria, needs to be further investigated. Read More

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Development and validation of a risk prediction model for high-risk adenomas at the time of first screening colonoscopy among screening aged Canadians.

Prev Med 2021 Apr 17:106563. Epub 2021 Apr 17.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, United States of America; Department of Oncology, Cumming School of Medicine, University of Calgary, Canada. Electronic address:

The aim of this study was to develop a risk prediction model for HRAs detected at screening colonoscopy based on readily available participant information. The cohort consisted of 3035 participants aged 50 to 74 years with no history of cancer who underwent a primary screening colonoscopy at a centralized colon cancer screening centre between 2008 and 2016. A multivariable logistic regression model was created using CRC risk factors identified from prior research. Read More

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Self-reported sickness absence and presenteeism as predictors of future disability pension: Cohort study with 11-year register follow-up.

Prev Med 2021 Apr 17:106565. Epub 2021 Apr 17.

National Research Centre for the Working Environment, Copenhagen, Denmark.

Many healthcare workers in eldercare are pushed out of the labor market before the official retirement age due to poor health. Identification of early warnings signs is important to avoid complete loss of work ability. The aim of this study was to investigate to what degree sickness absence and presenteeism increase future risk for disability pension among eldercare workers. Read More

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A Mobile Health Intervention to Increase Physical Activity in Pulmonary Arterial Hypertension.

Chest 2021 Apr 17. Epub 2021 Apr 17.

Division of Cardiovascular Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN. Electronic address:

Background: Supervised exercise training improves outcomes in patients with pulmonary arterial hypertension (PAH). The effect of an unsupervised activity intervention has not been tested.

Research Question: Can a text-based mobile health intervention increase step counts in patients with PAH?

Study Design And Methods: We performed a randomized, parallel arm, single-blind clinical trial. Read More

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A pre-specified analysis of the DAPA-CKD trial indicates effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy.

Kidney Int 2021 Apr 17. Epub 2021 Apr 17.

Department Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Immunoglobulin A (IgA) nephropathy is a common form of glomerulonephritis, which despite use of renin-angiotensin-aldosterone-system blockers and immunosuppressants, often progresses to kidney failure. In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial, dapagliflozin reduced risk of kidney failure and prolonged survival in participants with chronic kidney disease with and without type 2 diabetes, including those with IgA nephropathy. Here we randomized participants with estimated glomerular filtration rate (eGFR) 25-75 mL/min/1. Read More

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