73 results match your criteria preventing cvi


A Narrative Review on the Epidemiology, Prevention, and Treatment of Venous Thromboembolic Events in the Context of Chronic Venous Disease.

J Vasc Surg Venous Lymphat Disord 2021 Apr 15. Epub 2021 Apr 15.

Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI. Electronic address:

Background: Chronic venous disease (CVD) describes a spectrum of conditions associated with venous hypertension. The association between various CVD etiologies and subsequent risk of venous thromboembolic (VTE) events, such as deep vein thrombosis or pulmonary embolism, is a topic of considerable clinical interest. The aims of this review are to characterize the risk of VTE according to CVD etiology and to determine the optimal anticoagulation strategy for treatment or prevention of VTE in patients with CVD. Read More

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Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses.

Sci Rep 2021 Mar 2;11(1):4554. Epub 2021 Mar 2.

Center for Vaccines and Immunology, University of Georgia, 501 D.W. Brooks Drive, CVI Room 1504, Athens, GA, 30602, USA.

While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in their ability to elicit protective immune responses against co-circulating influenza virus variant strains. Improved influenza virus vaccines need to elicit protective immune responses against multiple influenza virus drift variants within each season. Read More

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Design and validation of brucellosis prevention questionnaire focused on animal vaccination.

BMC Public Health 2021 Jan 2;21(1). Epub 2021 Jan 2.

Department of Health Sciences, Unit for Public Health Sciences, Mid Sweden University, Sundsvall, Sweden.

Background: The inadequate awareness of livestock breeders on brucellosis transmission, as well as their improper knowledge about preventing brucellosis is considered as one of the important barriers to animal vaccination against brucellosis. The present study aimed to design and validate a brucellosis prevention questionnaire focused on animal vaccination. The valid questionnaire was used to design, implement, and evaluate an interventional training program. Read More

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January 2021

Construction and validation of educational technology to prevent complications in intestinal ostomies / periestomy skin.

Rev Bras Enferm 2020 21;73(suppl 5):e20190825. Epub 2020 Dec 21.

Universidade Regional do Cariri. Crato, Ceará, Brazil.

Objective: To build and validate an educational booklet for preventing complications in intestinal ostomy and peristomy skin.

Methods: Methodological study developed in: 1. Survey of the clinical profile of patients; 2. Read More

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December 2020

Pine bark (Pinus spp.) extract for treating chronic disorders.

Cochrane Database Syst Rev 2020 09 29;9:CD008294. Epub 2020 Sep 29.

Division of Human Nutrition, Stellenbosch University, Cape Town, South Africa.

Background: Pine bark (Pinus spp.) extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Commercially-available extract supplements are marketed for preventing or treating various chronic conditions associated with oxidative stress. Read More

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September 2020

[Validity and Reliability of a Korean Version of Yale Food Addiction Scale for Children (YFAS-C)].

J Korean Acad Nurs 2019 Feb;49(1):59-68

College of Nursing Science · East-West Nursing Research Institute, Kyung Hee University, Seoul, Korea.

Purpose: This study evaluated the psychometric properties of the Korean version of Yale Food Addiction Scale for Children (YFAS-C).

Methods: Participants were 419 young adolescent students (11~15 years old). The content validity of the expert group was calculated as the content validity index (CVI) after the translation and reverse translation process of the 25 items of the YFAS-C. Read More

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February 2019

Long-term outcome of open surgery in CVI patients concerning postoperative complications, perioperative hemodynamics and clinical efficacy, Part II1.

Clin Hemorheol Microcirc 2019 ;71(2):117-127

Dermatological Clinic of the University of Greifswald, Germany.

Background: Chronic venous disease (CVD) is extremely common worldwide with prevalence increasing with age. It is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its' endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. Read More

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[The application of combined low-intensity laser therapy for the treatment of the patients presenting with trophic ulcers associated with chronic venous insufficiency of the lower extremities].

Vopr Kurortol Fizioter Lech Fiz Kult 2018;95(6):27-33

O.K. Skobelkin State Scientific Centre of Laser Medicine, Russian Federal Medico-Biological Agency, Moscow, Russia.

Aim: The objective of the present study was the evaluation of the effectiveness of the combined treatment of the patients presenting with trophic ulcers associated with chronic venous insufficiency of the lower extremities of venous etiology with the application of low-intensity laser therapy (LILT) at different wavelengths.

Material And Methods: The study included the patients presenting with chronic venous insufficiency (CVI) (class C6 in accordance with the CEAP clinical classification). The ultrasonic Doppler examination (USDG) of the lower extremities revealed valvular insufficiency in the saphenous veins in 98. Read More

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Long-term outcome of open surgery in CVI patients concerning postoperative complications, perioperative hemodynamics and clinical efficacy, Part I.

Clin Hemorheol Microcirc 2018 ;70(4):399-411

Dermatological Clinic of the University of Greifswald, Germany.

Background: Chronic venous disease (CVD) is extremely common worldwide. The prevalence is increasing with age and is associated with a reduced quality of life, particularly in relation to pain, physical function and mobility. Symptomatic chronic venous insufficiency (CVI) with venous ulcer at its' endpoint, indicates interventional surgery to cure venous reflux therewith promoting wound healing and preventing recurrence. Read More

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Validation of primer for promoting maternal self-efficacy in preventing childhood diarrhea.

Rev Bras Enferm 2018 ;71(suppl 3):1412-1419

Universidade Federal do Ceará. Fortaleza, Ceará, Brasil.

Objective: to validate an educational primer, regarding content and design, for promoting maternal self-efficacy in preventing childhood diarrhea.

Method: methodological study composed of 31 mothers of children under five years of age, in which the validation of the primer You can prevent diarrhea in your child! was carried out from the Content Validity Index (CVI), being evaluated as to the domains understanding, attractiveness, self-efficacy, cultural acceptance, and persuasion.

Results: the primer was considered relevant and clear, with average concordance of 99. Read More

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January 2019

Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection.

Clin Vaccine Immunol 2017 Dec 5;24(12). Epub 2017 Dec 5.

University of Pennsylvania, Vaxconsult, Philadelphia, Pennsylvania, USA.

A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity, particularly sensorineural hearing loss (SNHL), in newborns, and the public health impact of this infection on maternal and child health is underrecognized. Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing transplacental transmission is accumulating. Read More

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December 2017

Development of a High-Throughput Respiratory Syncytial Virus Fluorescent Focus-Based Microneutralization Assay.

Clin Vaccine Immunol 2017 Dec 5;24(12). Epub 2017 Dec 5.

Translational Medicine, MedImmune, Gaithersburg, Maryland, USA.

Neutralizing antibodies specific for respiratory syncytial virus (RSV) represent a major protective mechanism against RSV infection, as demonstrated by the efficacy of the immune-prophylactic monoclonal antibody palivizumab in preventing RSV-associated lower respiratory tract infections in premature infants. Accordingly, the RSV neutralization assay has become a key functional method to assess the neutralizing activity of serum antibodies in preclinical animal models, epidemiology studies, and clinical trials. In this study, we qualified a 24-h, fluorescent focus-based microneutralization (RSVA FFA-MN) method that requires no medium exchange or pre- or postinfection processing to detect green fluorescent protein-expressing RSV strain A2 (RSVA-GFP)-infected cells, using a high-content imaging system for automated image acquisition and focus enumeration. Read More

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December 2017

Development and Qualification of an Opsonophagocytic Killing Assay To Assess Immunogenicity of a Bioconjugated Escherichia coli Vaccine.

Clin Vaccine Immunol 2017 Dec 5;24(12). Epub 2017 Dec 5.

Janssen Vaccines & Prevention B.V., Bacterial Vaccines Discovery & Early Development, Leiden, The Netherlands.

The global burden of disease caused by extraintestinal pathogenic (ExPEC) is increasing as the prevalence of multidrug-resistant strains rises. A multivalent ExPEC O-antigen bioconjugate vaccine could have a substantial impact in preventing bacteremia and urinary tract infections. Development of an ExPEC vaccine requires a readout to assess the functionality of antibodies. Read More

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December 2017

Equine Arteritis Virus Elicits a Mucosal Antibody Response in the Reproductive Tract of Persistently Infected Stallions.

Clin Vaccine Immunol 2017 Oct 5;24(10). Epub 2017 Oct 5.

Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky, USA

Equine arteritis virus (EAV) has the ability to establish persistent infection in the reproductive tract of the stallion (carrier) and is continuously shed in its semen. We have recently demonstrated that EAV persists within stromal cells and a subset of lymphocytes in the stallion accessory sex glands in the presence of a significant local inflammatory response. In the present study, we demonstrated that EAV elicits a mucosal antibody response in the reproductive tract during persistent infection with homing of plasma cells into accessory sex glands. Read More

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October 2017

Randomized controlled Phase III study comparing hepatic arterial infusion with systemic chemotherapy after curative resection for liver metastasis of colorectal carcinoma: JFMC 29-0003.

J Cancer Res Ther 2017 Jan-Mar;13(1):84-90

Japanese Foundation for Multidisciplinary Treatment of Cancer, Tokyo, Japan.

Background: The feasibility and efficacy of adjuvant hepatic arterial infusion (HAI) in preventing the development of liver metastases in patients with advanced colon carcinoma have not been validated. The aim of this randomized controlled study was to compare the feasibility of HAI and the protective effect against liver metastasis after curative resection to those of systemic chemotherapy.

Methods: Between July 2000 and June 2003, 91 patients were enrolled. Read More

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February 2018

Cytomegalovirus Virions Shed in Urine Have a Reversible Block to Epithelial Cell Entry and Are Highly Resistant to Antibody Neutralization.

Clin Vaccine Immunol 2017 Jun 5;24(6). Epub 2017 Jun 5.

Virginia Commonwealth University, Richmond, Virginia, USA

Cytomegalovirus (CMV) causes sensorineural hearing loss and developmental disabilities in newborns when infections are acquired Pregnant women may acquire CMV from oral exposure to CMV in urine or saliva from young children. Neutralizing antibodies in maternal saliva have the potential to prevent maternal infection and, in turn, fetal infection. As CMV uses different viral glycoprotein complexes to enter different cell types, the first cells to be infected in the oral cavity could determine the type of antibodies needed to disrupt oral transmission. Read More

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Dormant and after-Ripened Arabidopsis thaliana Seeds are Distinguished by Early Transcriptional Differences in the Imbibed State.

Front Plant Sci 2016 30;7:1323. Epub 2016 Aug 30.

Wageningen Seed Laboratory, Laboratory of Plant Physiology, Wageningen University Wageningen, Netherlands.

Seed dormancy is a genetically controlled block preventing the germination of imbibed seeds in favorable conditions. It requires a period of dry storage (after-ripening) or certain environmental conditions to be overcome. Dormancy is an important seed trait, which is under selective pressure, to control the seasonal timing of seed germination. Read More

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September 2016

Validation and psychometric evaluation of physical activity belief scale among patients with type 2 diabetes mellitus: an application of health action process approach.

Health Promot Perspect 2016 11;6(2):71-9. Epub 2016 Jun 11.

Department of Basic Sciences, Qom University of Medical Sciences, Qom, Iran.

Background: Moderate increase in physical activity (PA) may be helpful in preventing or postponing the complications of type 2 diabetes mellitus (T2DM). The aim of this study was to assess the psychometric properties of a health action process approach (HAPA)-based PA inventory among T2DM patients.

Methods: In 2015, this cross-sectional study was carried out on 203 participants recruited by convenience sampling in Isfahan, Iran. Read More

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Validity and Reliability of Health Promoting Lifestyle Profile II in the Iranian Elderly.

Int J Prev Med 2016 19;7:74. Epub 2016 May 19.

Department of Health Promotion and Education, School of Public Health, Arak University of Medical Sciences, Arak, Iran.

Background: With increasing age, the prevalence of chronic diseases increases. Since health-promoting behaviors (HPB) are considered a basic way of preventing diseases, especially chronic diseases, it is important to assess HPB. This study examines the validity and reliability of the Health Promoting Lifestyle Profile II (HPLP-II). Read More

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Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate.

Clin Vaccine Immunol 2016 02 9;23(2):137-47. Epub 2015 Dec 9.

Infectious Disease Research Institute, Seattle, Washington, USA Department of Global Health, University of Washington, Seattle, Washington, USA PAI Life Sciences, Inc., Seattle, Washington, USA.

Mycobacterium tuberculosis HN878 represents a virulent clinical strain from the W-Beijing family, which has been tested in small animal models in order to study its virulence and its induction of host immune responses following infection. This isolate causes death and extensive lung pathology in infected C57BL/6 mice, whereas lab-adapted strains, such as M. tuberculosis H37Rv, do not. Read More

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February 2016

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice.

Clin Vaccine Immunol 2015 Sep 1;22(9):1004-12. Epub 2015 Jul 1.

The Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom

The continued discovery and development of adjuvants for vaccine formulation are important to safely increase potency and/or reduce the antigen doses of existing vaccines and tailor the adaptive immune response to newly developed vaccines. Adjuplex is a novel adjuvant platform based on a purified lecithin and carbomer homopolymer. Here, we analyzed the adjuvant activity of Adjuplex in mice for the soluble hemagglutinin (HA) glycoprotein of influenza A virus. Read More

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September 2015

Protective Immunity and Reduced Renal Colonization Induced by Vaccines Containing Recombinant Leptospira interrogans Outer Membrane Proteins and Flagellin Adjuvant.

Clin Vaccine Immunol 2015 Aug 24;22(8):965-73. Epub 2015 Jun 24.

Laboratório de Bacteriologia, Instituto Butantan, São Paulo, SP, Brazil

Leptospirosis is a global zoonotic disease caused by different Leptospira species, such as Leptospira interrogans, that colonize the renal tubules of wild and domestic animals. Thus far, attempts to develop effective leptospirosis vaccines, both for humans and animals, have failed to induce immune responses capable of conferring protection and simultaneously preventing renal colonization. In this study, we evaluated the protective immunity induced by subunit vaccines containing seven different recombinant Leptospira interrogans outer membrane proteins, including the carboxy-terminal portion of the immunoglobulinlike protein A (LigA(C)) and six novel antigens, combined with aluminum hydroxide (alum) or Salmonella flagellin (FliC) as adjuvants. Read More

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A Review of Knowledge Gaps and Tools for Orbivirus Research.

Vector Borne Zoonotic Dis 2015 Jun;15(6):339-47

5 Vector-Borne Diseases Programme, The Pirbright Institute , Pirbright, Woking, United Kingdom .

Although recognized as causing emerging and re-emerging disease outbreaks worldwide since the late 1800 s, there has been growing interest in the United States and Europe in recent years in orbiviruses, their insect vectors, and the diseases they cause in domestic livestock and wildlife. This is due, in part, to the emergence of bluetongue (BT) in northern Europe in 2006-2007 resulting in a devastating outbreak, as well as severe BT outbreaks in sheep and epizootic hemorrhagic disease (EHD) outbreaks in deer and cattle in the United States. Of notable concern is the isolation of as many as 10 new BT virus (BTV) serotypes in the United States since 1999 and their associated unknowns, such as route of introduction, virulence to mammals, and indigenous competent vectors. Read More

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Generation and Characterization of Human Monoclonal Antibodies Targeting Anthrax Protective Antigen following Vaccination with a Recombinant Protective Antigen Vaccine.

Clin Vaccine Immunol 2015 May 18;22(5):553-60. Epub 2015 Mar 18.

Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Beijing, China

The anthrax protective antigen (PA) is the central component of the three-part anthrax toxin, and it is the primary immunogenic component in the approved AVA anthrax vaccine and the "next-generation" recombinant PA (rPA) anthrax vaccines. Animal models have indicated that PA-specific antibodies (AB) are sufficient to protect against infection with Bacillus anthracis. In this study, we investigated the PA domain specificity, affinity, mechanisms of neutralization, and synergistic effects of PA-specific antibodies from a single donor following vaccination with the rPA vaccine. Read More

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Prospective cohort study on the effectiveness of influenza and pneumococcal vaccines in preventing pneumonia development and hospitalization.

Clin Vaccine Immunol 2015 Feb 24;22(2):229-34. Epub 2014 Dec 24.

Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea Transgovernmental Enterprise for Pandemic Influenza in Korea (TEPIK), Seoul, Republic of Korea

Pneumonia and acute exacerbation of chronic illness are leading causes of influenza-related hospitalization. Therefore, influenza and pneumococcal vaccinations are strongly recommended for adults with comorbidities. Using a hospital-based influenza surveillance system, we performed a multicenter, prospective cohort study of patients visiting emergency rooms with influenza-like illness (ILI) during the influenza epidemic period in 2013 to 2014. Read More

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February 2015

Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections.

Am J Reprod Immunol 2015 Feb 28;73(2):162-74. Epub 2014 Aug 28.

Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Problem: Gestational genitourinary infections are associated with lifelong disabilities, but it is unknown if neonatal inflammation is involved.

Method: Mothers of 914 infants born before 28th gestation week reported cervical/vaginal infection (CVI), and/or urine/bladder/kidney infection (UTI), or neither. Inflammation proteins measured in baby's blood on postnatal days 1, 7, and 14 were considered elevated if in the top quartile for gestational age. Read More

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February 2015

Sensitive and specific enzyme-linked immunosorbent assay for detecting serum antibodies against Mycobacterium avium subsp. paratuberculosis in fallow deer.

Clin Vaccine Immunol 2014 Aug 28;21(8):1077-85. Epub 2014 May 28.

Department of Animal Health, Basque Institute for Agricultural Research and Development, NEIKER-Tecnalia, Technological Park of Bizkaia, Derio, Bizkaia, Spain

The enzyme-linked immunosorbent assay (ELISA) is the diagnostic test most commonly used in efforts to control paratuberculosis in domestic ruminants. However, commercial ELISAs have not been validated for detecting antibodies against Mycobacterium avium subsp. paratuberculosis in wild animals. Read More

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Comparison of the immunogenicity and safety of the conventional subunit, MF59-adjuvanted, and intradermal influenza vaccines in the elderly.

Clin Vaccine Immunol 2014 Jul 14;21(7):989-96. Epub 2014 May 14.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea Transgovernmental Enterprise for Pandemic Influenza in Korea, Seoul, Republic of Korea.

The influenza vaccination is known as the most effective method for preventing influenza infection and its complications in the elderly. Conventional subunit (Agrippal S1; Novartis), MF59-adjuvanted (Fluad; Novartis), and intradermal (IDflu15; Sanofi Pasteur) influenza vaccines are widely used throughout South Korea. However, few comparative studies evaluating the safety and immunogenicity of these vaccines are available. Read More

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Human antibody responses to the polyclonal Dryvax vaccine for smallpox prevention can be distinguished from responses to the monoclonal replacement vaccine ACAM2000.

Clin Vaccine Immunol 2014 Jun 23;21(6):877-85. Epub 2014 Apr 23.

United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA

Dryvax (Wyeth Laboratories, Inc., Marietta, PA) is representative of the vaccinia virus preparations that were previously used for preventing smallpox. While Dryvax was highly effective, the national supply stocks were depleted, and there were manufacturing concerns regarding sterility and the clonal heterogeneity of the vaccine. Read More

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