Clin Vaccine Immunol 2016 02 9;23(2):137-47. Epub 2015 Dec 9.
Infectious Disease Research Institute, Seattle, Washington, USA Department of Global Health, University of Washington, Seattle, Washington, USA PAI Life Sciences, Inc., Seattle, Washington, USA.
Mycobacterium tuberculosis HN878 represents a virulent clinical strain from the W-Beijing family, which has been tested in small animal models in order to study its virulence and its induction of host immune responses following infection. This isolate causes death and extensive lung pathology in infected C57BL/6 mice, whereas lab-adapted strains, such as M. tuberculosis H37Rv, do not. Read More