10,266 results match your criteria prevented severe

Comparison of two pandemics: H1N1 and SARS-CoV-2.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):115-119

Karadeniz Technical University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology - Trabzon, Turkey.

Objective: We aimed to compare the clinical, epidemiological, and prognostic features of the H1N1 pandemic in 2009 and the severe acute respiratory syndrome coronavirus 2 pandemic in 2020.

Methods: This retrospective study involved subjects from seven centers that were admitted and found to be positive for H1N1 or COVID-19 real-time polymerase chain reaction test.

Results: A total of 143 patients with H1N1 and 309 patients with COVID-19 were involved in the study. Read More

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January 2021

Rhinovirus Reduces the Severity of Subsequent Respiratory Viral Infections by Interferon-Dependent and -Independent Mechanisms.

mSphere 2021 Jun 23:e0047921. Epub 2021 Jun 23.

Institute for Modeling Collaboration and Innovation, University of Idahogrid.266456.5, Moscow, Idaho, USA.

Coinfection by heterologous viruses in the respiratory tract is common and can alter disease severity compared to infection by individual virus strains. We previously found that inoculation of mice with rhinovirus (RV) 2 days before inoculation with a lethal dose of influenza A virus [A/Puerto Rico/8/34 (H1N1) (PR8)] provides complete protection against mortality. Here, we extended that finding to a second lethal respiratory virus, pneumonia virus of mice (PVM), and analyzed potential mechanisms of RV-induced protection. Read More

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A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice.

bioRxiv 2021 Jun 17. Epub 2021 Jun 17.

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 14 (SLR14), in viral control, disease prevention, post-infection therapy, and cross-variant protection in mouse models of SARS-CoV-2 infection. A single dose of SLR14 prevented viral replication in the lower respiratory tract and development of severe disease in a type I interferon (IFN-I) dependent manner. Read More

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Delayed stillbirth by hysterectomy following early-term uterine rupture with fetal demise in secundigravida.

Radiol Case Rep 2021 Aug 8;16(8):2081-2085. Epub 2021 Jun 8.

Department of Obstetrics in hospital of Xinjiang Uygur Autonomous Region.

Uterine rupture and postterm pregnancy pose a number of life-threatening complications to both mother and child, including severe intra-abdominal bleeding and peritonitis, birth injury, hypoxia, and fetal loss. This report presents a rare case of a 20-year-old female experiencing fetal demise at 60 weeks of pregnancy, with uterine rupture and bone tissue discharge from her vagina without severe intra-abdominal bleeding and peritonitis. The mild clinical course despite complete uterine rupture was due to the firm adhesion of the amniotic sac to the uterus caused by inflammation. Read More

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Optical control of adenosine A receptor function in psoriasis.

Pharmacol Res 2021 Jun 19:105731. Epub 2021 Jun 19.

Pharmacology Unit, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Spain; Neuropharmacology and Pain Group, Neuroscience Program, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Spain. Electronic address:

Psoriasis is a chronic and relapsing inflammatory skin disease lacking a cure that affects approximately 2% of the population. Defective keratinocyte proliferation and differentiation, and aberrant immune responses are major factors in its pathogenesis. Available treatments for moderate to severe psoriasis are directed to immune system causing systemic immunosuppression over time, and thus concomitant serious side effects (i. Read More

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Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis.

Nucleic Acids Res 2021 Jun 22. Epub 2021 Jun 22.

Department of General Microbiology, GZMB, Georg-August-University Göttingen, Göttingen, Germany.

RNA turnover is essential in all domains of life. The endonuclease RNase Y (rny) is one of the key components involved in RNA metabolism of the model organism Bacillus subtilis. Essentiality of RNase Y has been a matter of discussion, since deletion of the rny gene is possible, but leads to severe phenotypic effects. Read More

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Extracorporeal membrane oxygenation (ECMO) for acute exacerbations of chronic obstructive pulmonary disease: care modalities, experience, and precautions.

Am J Transl Res 2021 15;13(5):4922-4927. Epub 2021 May 15.

The First Department of Respiratory Medicine, The First People's Hospital of Wenling Wenling 317000, Zhejiang Province, China.

Purpose: The aim of this study was to summarize the care modalities, experiences, and corresponding precautions of ECMO for acute exacerbations of chronic obstructive pulmonary disease (COPD).

Methods: Seventy-three patients with acute exacerbations of COPD were enrolled, of whom 38 were treated with ECMO (experimental group) and 35 received conventional low-flow oxygen therapy, management of metabolic acidosis, infection control, bronchodilators for quick relief from severe spasms, and glucocorticoid-mediated suppression of inflammation (control group). The improvement in the patient's pulmonary ventilation and the incidence of complications were recorded. Read More

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Denosumab in active Charcot neuro-osteorthropathy of the foot.

Joint Bone Spine 2021 Jun 16:105241. Epub 2021 Jun 16.

Department of Rheumatology, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Saclay (HUPS), Hôpital Bicêtre, Le Kremlin-Bicêtre, France. Electronic address:

Objective: Active Charcot Neuro-osteoarthropathy (CN) is a rare and severe complication of peripheral neuropathy that leads to deformity and disability. No pharmacological treatment is available. Increased osteoclastic activity plays a central role in active CN, particularly via receptor activator of nuclear factor ligand (RANK-L). Read More

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Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trial.

CMAJ Open 2021 Apr-Jun;9(2):E693-E702. Epub 2021 Jun 18.

Division of Infectious Diseases (Schwartz, Mponponsuo), Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Alberta Strategy for Patient Oriented Research SUPPORT Unit (Boesen); Cumming School of Medicine (Boesen, Cerchiaro, Greenfield, Kenney, Ryckborst), University of Calgary; Section of Infectious Diseases (Edwards), Department of Medicine, and Department of Clinical Neurosciences (Doram, Ganesh, Karnik), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Quality Management in Clinical Research Office (Jamieson, Stewart), University of Alberta, Edmonton, Alta.; Division of Respirology (Lim), Department of Medicine, Cumming School of Medicine, and Departments of Clinical Neurosciences and Community Health Sciences (Menon, Metz), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.; Women and Children's Research Institute (Rathwell, Yaskina), and Department of Pediatrics (Richer), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Departments of Clinical Neurosciences, Community Health Sciences, and Medicine (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.

Background: Identification of therapies to prevent severe COVID-19 remains a priority. We sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 infection could prevent hospitalization, mechanical ventilation or death.

Methods: This randomized controlled trial was conducted in Alberta during the first wave of the COVID-19 pandemic without direct contact with participants. Read More

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The enigma of acute worsening after a latent interval in post-operative patients of craniovertebral junction instability.

Clin Neurol Neurosurg 2021 Jun 8;207:106741. Epub 2021 Jun 8.

Department of Neurosurgery, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India. Electronic address:

Objective: For reasons that are poorly understood and still undocumented, few patients of craniovertebral junction (CVJ) anomalies with instability/atlantoaxial dislocation (AAD) in our practice have been seen to suffer unprecedented acute neurological deterioration with respiratory compromise about 48-72 h post-surgery. This has been specifically observed after an uneventful, stable clinical condition in the immediate postoperative period. This study attempts to elucidate the factors and outcomes related to such latent worsening. Read More

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Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.

Chem Res Toxicol 2021 Jun 18. Epub 2021 Jun 18.

Department of Cardiovascular Pharmacotherapy and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka 569-1094, Japan.

Amiodarone is a benzofuran derivative used to treat arrhythmias, but its use is limited by adverse reactions. There is evidence that some of the severe adverse reactions such as liver injury and interstitial lung disease are immune-mediated; however, details of the mechanism have not been elucidated. We tested the ability of amiodarone to induce the release of danger-associated molecular patterns (DAMPs) that activate inflammasomes. Read More

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[Complex treatment of severe mental illnesses in old age].

Nervenarzt 2021 Jun 17. Epub 2021 Jun 17.

Professur Sozial- und Präventivmedizin, Universität Potsdam, Potsdam, Deutschland.

Background: The needs for assistance, support and treatment of older people with severe mental illnesses (SMI) are very high and linked to additional age-associated somatic diseases and impairments. Old people prefer to live independently in their own homes and to receive necessary treatment and support there; however, a resettlement in a residential nursing home is often necessary due to a lack of alternatives.

Objective: What is the current treatment reality in Germany for old people with SMI in their own homes and in residential nursing homes? How can coercive measures in this context be prevented?

Methods: Selected results from the scientific literature on psychogeriatric care models in older people with SMI are summarized and discussed. Read More

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Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity Effects on Th17 Responses.

Front Immunol 2021 1;12:701626. Epub 2021 Jun 1.

Department of Neurology, University Hospital Regensburg, Regensburg, Germany.

High-fat diets (HFD) are linked to obesity and associated comorbidities and induce pathogenic T helper (Th) 17 cells while decreasing regulatory T cells (Treg). This pro-inflammatory environment also aggravates immunopathology in experimental autoimmune encephalomyelitis (EAE) as a prototype model of T cell mediated autoimmunity. The strong association of HFD to obesity as well as the increasing risk of autoimmunity in the Western world stresses the importance to identify compounds that counteract this metabolically induced pro-inflammatory state in humans. Read More

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Characterization of a new SARS-CoV-2 variant that emerged in Brazil.

Proc Natl Acad Sci U S A 2021 07;118(27)

Department of Pulmonary Medicine, Keiyu Hospital, Kanagawa 220-8521, Japan.

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a key role in viral infectivity. It is also the major antigen stimulating the host's protective immune response, specifically, the production of neutralizing antibodies. Recently, a new variant of SARS-CoV-2 possessing multiple mutations in the S protein, designated P. Read More

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Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.

Clin Nutr 2021 May 11. Epub 2021 May 11.

Department of Clinical Nutrition, CHU Clermont-Ferrand, University of Clermont Auvergne, Human Nutrition Unit, CRNH Auvergne, F-63000, Clermont-Ferrand, France.

The COVID-19 pandemics has created unprecedented challenges and threats to patients and healthcare systems worldwide. Acute respiratory complications that require intensive care unit (ICU) management are a major cause of morbidity and mortality in COVID-19 patients. Among other important risk factors for severe COVID-19 outcomes, obesity has emerged along with undernutrition-malnutrition as a strong predictor of disease risk and severity. Read More

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Public healthcare system capacity during COVID-19: A computational case study of SARS-CoV-2.

Health Sci Rep 2021 Jun 4;4(2):e305. Epub 2021 Jun 4.

Department of Mathematics & SRM Research Institute SRM Institute of Science and Technology Kattankulathur India.

Aim: Coronavirus Disease (COVID-19) is spreading typically to the human population all over the world and the report suggests that scientists have been trying to map the pattern of the early transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) since it has been reported as an epidemic. Our main aim is to show if the rise-in-cases proceeds in a gradual and staggered manner instead of soaring quickly then we can suppress the burden of the health system. In this new case study, we are attempting to show how to control the outbreak of the infectious disease COVID-19 via mathematical modeling. Read More

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Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.

Biochem Biophys Res Commun 2021 Jun 12;566:177-183. Epub 2021 Jun 12.

Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, 606-8501, Japan. Electronic address:

Streptococcus pyogenes (Group A Streptococcus, GAS) causes a range of human diseases, including life-threatening and severe invasive GAS infections, such as streptococcal toxic shock syndrome (STSS). Several antibiotics, including penicillin, are effective against GAS. Still, invasive GAS diseases have a high mortality rate (>30%). Read More

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Review: SARS-CoV-2 infection in farmed minks - an overview of current knowledge on occurrence, disease and epidemiology.

Animal 2021 Jun 11;15(7):100272. Epub 2021 Jun 11.

Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznan University of Life Sciences, Wolynska 35, 60-637 Poznan, Poland.

Coronaviruses (CoVs), which are enveloped, positive-sense RNA viruses, may cause infections in mammals and birds. Apart from the respiratory manifestations, CoVs are also responsible for infections of the gastrointestinal tract and nervous systems. Their propensity to recombine allows them to easily transmit and adapt to new hosts. Read More

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Combination of AZD3463 and DZNep Prevents Bone Metastasis of Breast Cancer by Suppressing Akt Signaling.

Front Pharmacol 2021 28;12:652071. Epub 2021 May 28.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Osteolysis resulting from osteoclast overactivation is one of the severe complications of breast cancer metastasis to the bone. Previous studies reported that the anti-cancer agent DZNep induces cancer cell apoptosis by activating Akt signaling. However, the effect of DZNep on breast cancer bone metastasis is unknown. Read More

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Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Ecotoxicol Environ Saf 2021 Sep 9;220:112401. Epub 2021 Jun 9.

Department of Botany, S.P. College, Srinagar, Jammu and Kashmir, India. Electronic address:

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0. Read More

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September 2021

Late morbidity and mortality following revascularization surgery for moyamoya disease in the pediatric population.

J Neurosurg Pediatr 2021 Jun 11:1-6. Epub 2021 Jun 11.

Objective: There are limited reports on long-term morbidity in pediatric patients who have undergone surgical revascularization for moyamoya disease (MMD). Here, the authors report long-term morbidity and mortality in a population of pediatric patients who underwent pial synangiosis for MMD from 1988 through 2016.

Methods: A single-center retrospective review of the hospital and personal operative databases of the senior authors was carried out to identify all patients who were treated for MMD at Boston Children's Hospital between 1988 and 2016, and who experienced any episode of late morbidity or mortality, which the authors defined as an event resulting in significant neurological deficit or death occurring more than 1 year after revascularization surgery. Read More

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COVID-19 in the Context of Inborn Errors of Immunity: a Case Series of 31 Patients from Mexico.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Immune Deficiencies Lab., National Institute of Pediatrics, Av Iman 1, Torre de Investigacion Piso 9, Insurgentes Cuicuilco, Coyoacan, 04530, Mexico City, Mexico.

Introduction: Patients with inborn errors of immunity (IEI) have a compromised or inappropriate immune response. Although they might be considered a high-risk group for severe SARS-CoV-2 infection, the reported impact of COVID-19 in these patients has been reassuring, while the differential susceptibility of distinct types of IEI remains unclear.

Objective: We aimed to describe the findings and outcomes of our known patients with IEI who were diagnosed with COVID-19. Read More

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A versatile nanoagent for multimodal imaging-guided photothermal and anti-inflammatory combination cancer therapy.

Biomater Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Ultrasonography, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics, Guangzhou 510515, Guangdong Province, P. R. China.

Photothermal therapy (PTT) has drawn great attention in cancer treatment because of its minimal invasiveness and high spatiotemporal selectivity, but it still encounters severe obstacles like heat-resistance, metastasis and recurrence. A key reason for the treatment failure is the highly inflammatory tumor microenvironment caused by hyperthermia. A simultaneous anti-inflammatory therapy alongside the PTT has great potential for overcoming the drawbacks of PTT; however, it has been less reported and further study is urgently needed. Read More

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Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria.

Sci Rep 2021 Jun 8;11(1):12077. Epub 2021 Jun 8.

Laboratory of Malaria Research, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Pathological features observed in both human and experimental cerebral malaria (ECM) are endothelial dysfunction and changes in blood components. Blood transfusion has been routinely used in patients with severe malarial anemia and can also benefit comatose and acidotic malaria patients. In the present study Plasmodium berghei-infected mice were transfused intraperitoneally with 200 μL of whole blood along with 20 mg/kg of artemether. Read More

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Maternal iron deficiency perturbs embryonic cardiovascular development in mice.

Nat Commun 2021 06 8;12(1):3447. Epub 2021 Jun 8.

Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.

Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Read More

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Inadvertent injection of medetomidine in the cerebromedullaris cisterna of a dog during myelographic exam.

S Nannarone C Adami

Schweiz Arch Tierheilkd 2021 Jun;163(6):431-436

Department of Veterinary Medicine, University of Cambridge, UK.

Introduction: A mixed breed dog was anesthetized for diagnostic myelography to investigate acute onset neck pain. Instead of contrast medium, 444 μg/kg medetomidine were inadvertently injected into the cerebromedullaris cisterna owing to a human error. Severe bradycardia, undetectable peripheral pulse, respiratory arrest and loss of pupillary, palpebral and corneal reflexes were observed immediately after injection. Read More

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Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.

Mol Metab 2021 Jun 3:101265. Epub 2021 Jun 3.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Objective: Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims to prevent hypoglycemia, patients still experience hypoglycemic events. Read More

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Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.

Clin Immunol 2021 Jun 2;229:108764. Epub 2021 Jun 2.

Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610, United States of America.

C57BL/6 mice with pristane-induced lupus develop macrophage-dependent diffuse alveolar hemorrhage (DAH), which is blocked by treatment with liver X receptor (LXR) agonists and is exacerbated by low IL-10 levels. Serp-1, a myxomavirus-encoded serpin that impairs macrophage activation and plasminogen activation, blocks DAH caused by MHV68 infection. We investigated whether Serp-1 also could block DAH in pristane-induced lupus. Read More

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The therapeutic effects of Prunella vulgaris against fluoride-induced oxidative damage by using the metabolomics method.

Environ Toxicol 2021 Jun 5. Epub 2021 Jun 5.

Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, China.

Fluoride is considered as one of the most ubiquitous environmental pollutants. Numerous studies have linked reactive oxygen species (ROS)-dependent oxidative damage with fluoride intoxication, which could be prevented by antioxidants. However, the metabolomic changes induced by ROS disruptions in fluoride intoxication are yet unknown. Read More

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Coping with stress during the first wave of the COVID-19 pandemic by Turkish people with Multiple Sclerosis: The relationship between perceived stress and quality of life.

Mult Scler Relat Disord 2021 May 24;53:103039. Epub 2021 May 24.

Tekirdag Namık Kemal University, Health Center for Medical Research and Practice, Department of Neurology, Tekirdag, Turkey. Electronic address:

Background: Multiple sclerosis (MS) is a chronic inflammatory disease and acute exacerbations are also a part of the clinical course. The presence of the disease and relapses cause stress in people with MS (pwMS). For this reason, stress coping strategies of the patients are important in reducing perceived stress. Read More

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