11,428 results match your criteria prevent moderate

A new method for broad-scale modeling and projection of plant assemblages under climatic, biotic, and environmental cofiltering.

Conserv Biol 2021 Jun 15. Epub 2021 Jun 15.

Environmental Science Center, Qatar University, Doha, P.O. Box 2713, Qatar.

There is increasing interest in broad-scale analysis, modeling, and prediction of the distribution and composition of plant species assemblages under climatic, environmental, and biotic filtering, particularly for conservation purposes. We devised a method (broad-scale analysis & modeling of plant assemblages under climatic-biotic-environmental co-filtering, BAM-PACC) for reliably predicting the impact of climate change on arbitrarily large assemblages of plant communities, while also considering competing biotic and abiotic factors. When applied to a large set of plant communities in the Swiss Alps, BAM-PACC explained presences/absences of 175 plant species in 608 plots with >87% cross-validated accuracy, predicted decreases in α, β, and γ diversity by 2040 under both moderate and extreme climate scenarios, and identified plant species likely to be favored/disfavored by climate change. Read More

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Dark side of laundry pods: Analysis of exposure to laundry detergent capsules in children.

J Paediatr Child Health 2021 Jun 15. Epub 2021 Jun 15.

Department of Paediatrics and Gastroenterology, Medical University of Lublin, Lublin, Poland.

Aim: We aimed to evaluate the epidemiological characteristic and clinical features of laundry detergent capsule (LDC) exposure in children.

Methods: Retrospective review of medical records of patients hospitalised due to the exposure to LDC at the Department of Paediatrics and Gastroenterology, Medical University of Lublin, Poland, from 2014 to 2019 was conducted.

Results: During the study period, 38 children including 19 (50%) boys and 19 (50%) girls were admitted to our department due to exposure to LDC. Read More

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Alcohol abuse associated with poor response to systemic therapies for psoriasis: findings from a prospective multicentre cohort study.

Br J Dermatol 2021 Jun 14. Epub 2021 Jun 14.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK.

Background: Factors that might influence response to systemic treatment for moderate-to-severe psoriasis are varied, and generally, are poorly understood, aside from high body weight, suggesting that other unidentified factors may be relevant in determining response to treatment. The impact of alcohol abuse on treatment response has not been previously investigated.

Objective: To investigate whether alcohol abuse is associated with poor response to treatment for psoriasis. Read More

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Prevalence of malocclusion and assessment of orthodontic treatment needs among Syrian refugee children and adolescents: a cross-sectional study.

BMC Oral Health 2021 Jun 14;21(1):305. Epub 2021 Jun 14.

Restorative Dentistry, Division of Dentistry, School of Medical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: There is a scarcity of data concerning the prevalence and pattern of malocclusion and orthodontic treatment needs in Syrian refugee. In this study, extra and intra-oral features of malocclusion and the dental health component of the Index of Orthodontic Treatment Need (IOTN) were reported.

Methods: Examination of 606 Syrian children/adolescents refugees attending Zaatari clinic was carried out (males = 280, females = 326, mean age = 11. Read More

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Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy.

Front Neurol 2021 28;12:654606. Epub 2021 May 28.

Division of Neurology and Translational Epilepsy Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States.

Epilepsy is characterized by recurrent, spontaneous seizures and is a major contributor to the global burden of neurological disease. Although epilepsy can result from a variety of brain insults, in many cases the cause is unknown and, in a significant proportion of cases, seizures cannot be controlled by available treatments. Understanding the molecular alterations that underlie or are triggered by epileptogenesis would help to identify therapeutics to prevent or control progression to epilepsy. Read More

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Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial.

Front Pharmacol 2021 28;12:669362. Epub 2021 May 28.

Freelance Statistician, Nagpur, India.

Coronavirus disease-2019 (COVID-19) has a wide range of pathophysiological effects. Curcumin, an active constituent of Curcuma longa (turmeric), has several properties, including anti-inflammatory, antioxidant, antiviral, anti-thrombotic, and anti-proliferative effects, which make it a promising candidate for the symptomatic treatment of COVID-19. We aimed to determine the effects of curcumin administered with piperine (to optimize absorption) on symptoms in patients with COVID-19 in a double-blind, randomized, controlled trial at a 30-bed dedicated COVID Health Center (DCHC) in Maharashtra, India. Read More

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Association between mesenteric panniculitis and non-neoplastic disorders.

Clin Imaging 2021 May 18;79:219-224. Epub 2021 May 18.

Department of Radiology, University of Health Sciences, Dıskapı Yıldırım Beyazıt Training and Research Hospital, Dıskapı, 06130 Ankara, Turkey.

Purpose: To assess the relationship between MP and coexisting non-neoplastic disorders.

Methods: Consecutive abdominal computed tomography (CT) scans of 4674 patients were evaluated retrospectively for CT features of MP between January 2017 and January 2018. Clinical findings of patients were analyzed. Read More

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Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.

Eur J Med Chem 2021 May 25;222:113541. Epub 2021 May 25.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), Shanghai, China; SJTU-Agilent Technologies Joint Laboratory for Pharmaceutical Analysis, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China; Academy of Pharmacy, Xi'an Jiaotong - Liverpool University, Suzhou, 215123, China. Electronic address:

A series of benzofuran piperidine derivatives were designed, synthesized and evaluated as multifunctional Aβ antiaggregant to treat Alzheimer's disease (AD). In vitro results revealed that all of them are very good Aβ antiaggregants and some of the compounds are potent acetylcholinesterase (AChE) inhibitors with moderate antioxidant property. Selected compounds were also tested for neuroprotection activity, LDH release, ATP production and inhibitory activity to prevent Aβ peptides binding to the cell membrane. Read More

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Coping with stress in a warming Gulf: the postlarval American lobster's cellular stress response under future warming scenarios.

Cell Stress Chaperones 2021 Jun 11. Epub 2021 Jun 11.

School of Marine Sciences, University of Maine, Orono, ME, 04469, USA.

The Gulf of the Maine (GoM) is one of the fastest warming bodies of water in the world, posing serious physiological challenges to its marine inhabitants. Marine organisms can cope with the cellular and molecular stresses created by climate change through changes in gene expression. We used transcriptomics to examine how exposure to current summer temperatures (16 °C) or temperature regimes reflective of projected moderate and severe warming conditions (18 °C and 22 °C, respectively) during larval development alters expression of transcripts affiliated with the cellular stress response (CSR) in postlarval American lobsters (Homarus americanus). Read More

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Safety Profile of the Adjuvanted Recombinant Zoster Vaccine in Immunocompromised Populations: An Overview of Six Trials.

Drug Saf 2021 Jul 11;44(7):811-823. Epub 2021 Jun 11.

GSK, Avenue Fleming 20, 1300, Wavre, Belgium.

Introduction: The adjuvanted recombinant zoster vaccine (RZV) has demonstrated high efficacy against herpes zoster in older adults and immunocompromised populations. We present comprehensive safety data from six clinical trials in immunocompromised populations (autologous hematopoietic stem cell transplant and renal transplant recipients, patients with hematologic malignancies, patients with solid tumors, and human immunodeficiency virus-infected adults) who are at an increased risk of herpes zoster.

Methods: In all trials, immunocompromised adults ≥ 18 years of age were administered RZV or placebo. Read More

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International survey of strategies to mitigate transfusion-transmitted Trypanosoma cruzi in non-endemic countries, 2016-2018.

Vox Sang 2021 Jun 10. Epub 2021 Jun 10.

US Food and Drug Administration, CBER/OBRR, Silver Spring, Maryland, USA.

Background And Objectives: Chagas disease, caused by Trypanosoma cruzi, is endemic to Mexico, Central and South America. While initially limited to the Americas, emigration of infected persons triggered geographically broader blood safety challenges. To mitigate transfusion-transmitted Chagas (TTC), transfusion services implemented approaches including risk factor questions and serologic testing. Read More

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Cause Clarification of Cysteine Oxidation by Active Species Generated during the Oxidation Process of Cinnamaldehyde and Impact on an In Chemico Alternative Method for Skin Sensitization Using a Nucleophilic Reagent Containing Cysteine.

Chem Res Toxicol 2021 Jun 10. Epub 2021 Jun 10.

Safety Evaluation Centre, Ecology & Quality Management Division, ESG Division, Fujifilm Corporation, 210 Nakanuma, Minamiashigara-shi, Kanagawa, Japan.

Aldehydes comprise a major portion of skin sensitizers because they can react with both cysteine and lysine. Moreover, cinnamaldehyde (CA) is a typical moderate sensitizer and is often used in an alternative test method for skin sensitization. The amino acid derivative reactivity assay (ADRA) is an in chemico test method that evaluates the reactivity of cysteine derivatives (-(2-(1-naphthyl)acetyl)-l-cysteine, NAC) and lysine derivatives with the test chemicals and uses CA as a proficiency substance. Read More

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Critical Appraisal of Amyloid Lowering Agents in AD.

Curr Neurol Neurosci Rep 2021 Jun 10;21(8):39. Epub 2021 Jun 10.

Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W. Bonneville Ave, Las Vegas, NV, 89106, USA.

Purpose Of Review: According to the amyloid cascade hypothesis, removing amyloid beta (Aβ) should cure Alzheimer's disease (AD). In the past three decades, many agents have been tested to try to lower Aβ production, prevent Aβ aggregation, and dissolve Aβ deposits. However, the paucity in definitive preventative or curative properties of these agents in clinical trials has resulted in more avant-garde approaches to therapeutic investigations. Read More

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Can probiotic supplements prevent early childhood caries? A systematic review and meta-analysis.

Benef Microbes 2021 Jun 10;12(3):231-238. Epub 2021 Jun 10.

Novozymes A/S, Krogshøjvej 36, 2820 Bagsværd, Denmark.

The aim of this study was to explore the preventive effect of probiotic supplements on the development of early childhood caries (ECC). We searched the PubMed, Google Scholar and Cochrane databases up to January 15, 2021. The authors screened the hits independently for relevance, extracted outcome data and assessed the risk of bias. Read More

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Physical exercise consequences on memory in obesity: A systematic review.

Obes Rev 2021 Jun 8. Epub 2021 Jun 8.

Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Diamantina, Brazil.

Obesity is associated with changes in memory. Thus, the aim of this systematic review was to investigate the physical exercise consequences on memory in obesity. A search was carried out in the PubMed, Lilacs, and Scielo databases with the following descriptors: "physical exercise," "memory," and "obesity. Read More

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Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?: intersection between inflammation, mTOR pathway, autophagy and calorie restriction.

Virusdisease 2021 Jun 4:1-10. Epub 2021 Jun 4.

University of Tennessee Medical Center, Knoxville, TN USA.

The coronavirus disease 2019 (COVID-19) pandemic is provoking a global public health crisis. Even though the academic world is intensively pursuing new therapies, there is still no "game changer" in the management of COVID 19. The Mammalian Target of Rapamycin (mTOR) is an ancient signaling system that has been proposed as a molecular tool used by coronaviruses and other RNA and DNA viruses in order to replicate and persist in the host cell. Read More

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Effect of a lay counselor-delivered integrated maternal mental health and early childhood development group-based intervention in Northern Ghana: a cluster-randomized controlled trial.

Glob Ment Health (Camb) 2021 26;8:e18. Epub 2021 May 26.

Catholic Relief Services Head Quarters, Baltimore, MD, USA.

Background: Caregiver mental health is linked to early childhood development, yet more robust evidence of community-based interventions to prevent maternal depression and optimize socio-emotional development of young children is needed. Objectives of this cluster-randomized controlled trial (cRCT), based in Northern Ghana, are to assess the impact of the lay counselor-delivered, group-based Integrated Mothers and Babies Course and Early Childhood Development (iMBC/ECD) program on (1) the mental health of mothers of children under age 2; and (2) the socio-emotional development of their children.

Methods: This cRCT randomized 32 women's groups - 16 received iMBC/ECD content (intervention) and 16 received general health education content (control). Read More

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Brain injury in preterm infants with surgical necrotizing enterocolitis: clinical and bowel pathological correlates.

Pediatr Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.

Background: The objective of this study was to determine the risk factors and outcomes of white matter brain injury (WMBI) on magnetic resonance imaging (MRI) at term-equivalent age in infants with surgical necrotizing enterocolitis (NEC).

Methods: This retrospective study compared clinical/pathological information between infants with and those without WMBI.

Results: Out of 69 infants with surgical NEC, 17 (24. Read More

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Variability in waxy (Wx) allele, in-vitro starch digestibility, glycemic response and textural behaviour of popular Northern Himalayan rice varieties.

Sci Rep 2021 Jun 8;11(1):12047. Epub 2021 Jun 8.

Department of Food Technology, Islamic University of Science and Technology, Awantipora, 192122, India.

Eight commonly cultivated and consumed rice varieties of Northern Himalayan regions and a popular high amylose rice variety were characterized at Wx locus and evaluated for resistant starch (RS), in-vitro starch digestibility, predicted glycemic index (pGI), glycemic load (GL) and textural parameters. Cytosine and thymine repeats (CT)n at waxy locus (Wx) showed high association with apparent amylose content (AAC). Both pGI and GL varied substantially within the selected varieties. Read More

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High frequency ultrasound-guided pericardiocentesis performed in the sitting position: A novel apical approach.

Clin Cardiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.

Background: So far, few approaches have been described to reduce inadvertent injury to structure of the heart and nearby organs in percutaneous pericardiocentesis.

Hypothesis: We hypothesized that an in-plane high frequency ultrasound-guided apical approach, performed in the sitting position, would provide additional benefits in terms of feasibility and safety for draining malignant pericardial effusion (MPE).

Methods: The authors selected 53 consecutive patients with moderate or large symptomatic MPE who underwent high frequency ultrasound-guided pericardiocentesis. Read More

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General Health Checks in Adult Primary Care: A Review.

JAMA 2021 06;325(22):2294-2306

Division of General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Importance: General health checks, also known as general medical examinations, periodic health evaluations, checkups, routine visits, or wellness visits, are commonly performed in adult primary care to identify and prevent disease. Although general health checks are often expected and advocated by patients, clinicians, insurers, and health systems, others question their value.

Observations: Randomized trials and observational studies with control groups reported in prior systematic reviews and an updated literature review through March 2021 were included. Read More

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Effects of olives and their constituents on the expression of ulcerative colitis: a systematic review of randomized controlled trials.

Br J Nutr 2021 Jun 8:1-53. Epub 2021 Jun 8.

Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Lidcombe, NSW 2141, Australia.

Extra virgin olive oil (EVOO) is often associated with anti-inflammatory and antioxidant properties. Its effects on inflammatory conditions such as Ulcerative Colitis (UC) however has yet to be defined. As such, we aimed to conduct a systematic review and meta-analysis of studies investigating olive-based interventions in UC. Read More

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Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis.

Sci Rep 2021 Jun 7;11(1):11922. Epub 2021 Jun 7.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Many pharmacologic agents were investigated for the effect to prevent delirium. We aimed to comprehensively compare the effect of the pharmacological interventions to prevent postoperative delirium. A Bayesian network meta-analysis of randomized trials was performed using random effects model. Read More

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Interventions to Prevent Drugged Driving: A Systematic Review.

Am J Prev Med 2021 Jun 4. Epub 2021 Jun 4.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada; Department of Epidemiology, Faculty of Medicine and Health Sciences, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Context: Literature suggests that cannabis legalization may increase fatal motor vehicle collisions. However, evidence on the effectiveness of interventions to prevent drugged driving is limited.

Evidence Acquisition: MEDLINE, PsycINFO, Web of Science, Embase, SafetyLit, Criminal Justice Database, Transport Research International Documentation, bibliographies, and relevant gray literature were searched systematically through May 2020. Read More

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Prevalence of tuberculosis infection and its relationship to stunting in children (under five years) household contact with new tuberculosis cases.

Indian J Tuberc 2021 Jul 4;68(3):350-355. Epub 2020 Nov 4.

Pediatric Department, RSCM Hospital, Faculty of Medicine, University of Indonesia, Indonesia.

Background: Children who inhabit the same house with tuberculosis (TB) patients are at high risk for infection and illness with TB. Nutritional status (stunting) in children is related to the child's ability to withstand MTB (Mycobacterium Tuberculosis). This study aims to estimated the prevalence of tuberculosis infection and its relationship to stunting in children (under five years) with household contact (HHC) with new TB cases. Read More

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Locoregional Flap Reconstruction Following Oromaxillofacial Oncologic Surgery in Dogs and Cats: A Review and Decisional Algorithm.

Front Vet Sci 2021 21;8:685036. Epub 2021 May 21.

Dentistry and Oromaxillofacial Surgery Unit, Department of Surgery, ADVETIA Centre Hospitalier Vétérinaire, Vélizy-Villacoublay, France.

Primary treatment of most oromaxillofacial tumors in dogs and cats is resective surgery. Management of malignant tumors may be very challenging as wide/radical free-margin surgical removal must be achieved while preserving vital functions. Removal of orofacial tumors may result in large defects exposing the oral cavity or creating a communication with the nasal, pharyngeal, or orbital cavities. Read More

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Maintaining Bone Health in the Lumbar Spine: Routine Activities Alone Are Not Enough.

Front Bioeng Biotechnol 2021 19;9:661837. Epub 2021 May 19.

Structural Biomechanics, Department of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.

Public health organisations typically recommend a minimum amount of moderate intensity activities such as walking or cycling for two and a half hours a week, combined with some more demanding physical activity on at least 2 days a week to maintain a healthy musculoskeletal condition. For populations at risk of bone loss in the lumbar spine, these guidelines are particularly relevant. However, an understanding of how these different activities are influential in maintaining vertebral bone health is lacking. Read More

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Food Insecurity: A Constant Factor in the Lives of Low-Income Families in Scotland and England.

Front Public Health 2021 19;9:588254. Epub 2021 May 19.

Healthy Living Laboratory, Northumbria University, Newcastle upon Tyne, United Kingdom.

During the school summer holidays, pressures on the already tight budgets of low-income families are compounded, particularly when the safety net of free school meals is removed. The main aim of the current study was to investigate how low-income parents and carers feed their families during term time when children receive free school meals and if, and how, strategies differ during the school summer holidays. A secondary aim was to investigate the role of holiday activity and food programmes in supporting parents and carers to feed their children during the school summer holidays. Read More

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Revealing the Neural Mechanism Underlying the Effects of Acupuncture on Migraine: A Systematic Review.

Front Neurosci 2021 20;15:674852. Epub 2021 May 20.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Migraine is a chronic neurological disorder characterized by attacks of moderate or severe headache and various neurological symptoms. Migraine is typically treated by pharmacological or non-pharmacological therapies to relieve pain or prevent migraine attacks. Pharmacological therapies show limited efficacy in relieving headache and are often accompanied by adverse effects, while the benefits of acupuncture, a non-pharmacological therapy, have been well-documented in both the treatment and prevention of acute migraine attacks. Read More

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Social media use in China before and during COVID-19: Preliminary results from an online retrospective survey.

J Psychiatr Res 2021 May 26;140:35-38. Epub 2021 May 26.

Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Medical Neurobiology of Zhejiang Province, Hangzhou, China; Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address:

Background: More people reported symptoms of stress, anxiety and depression during the outbreak of the coronavirus (COVID-19). They might have increased their social media use during the outbreak of COVID-19 compared to before COVID-19.

Methods: An online retrospective survey was conducted on a total sample of 10,963 participants. Read More

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