7,616 results match your criteria prevent excessive


Switching from conventional therapy to burosumab injection has the potential to prevent nephrocalcinosis in patients with X-linked hypophosphatemic rickets.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatrics, Osaka Hospital, Japan Community Healthcare Organization (JCHO), Osaka, Japan.

Objectives: X-linked hypophosphatemic rickets (XLH) is a congenital fibroblast growth factor (FGF)23-related metabolic bone disease that is treated with active vitamin D and phosphate as conventional therapies. Complications of these therapies include nephrocalcinosis (NC) caused by excessive urine calcium and phosphate concentrations. Recently, an anti-FGF23 antibody, burosumab, was developed and reported to be effective in poorly-controlled or severe XLH patients. Read More

View Article and Full-Text PDF

Dietary intake and growth in children with Prader-Willi syndrome.

J Hum Nutr Diet 2021 Apr 9. Epub 2021 Apr 9.

Discipline of Paediatrics, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Background: The management of Prader-Willi Syndrome (PWS) requires strict dietary supervision to prevent obesity, avoid micronutrient deficiencies and ensure optimal growth. The present study aimed to examine the growth and dietary intake of children with PWS.

Methods: All children with genetically confirmed PWS attending Children's Health Ireland (CHI) at Tallaght (n = 44) were invited to participate. Read More

View Article and Full-Text PDF

Ulnar Collateral Ligament Laxity After Repetitive Pitching: Associated Factors in High School Baseball Pitchers.

Am J Sports Med 2021 Apr 8:3635465211002507. Epub 2021 Apr 8.

Division of Sports Medicine, Department of Orthopaedic Surgery, Saitama Medical University, Moroyama, Japan.

Background: Medial elbow injury is common in baseball pitchers, with evidence of elbow valgus instability after only 60 consecutive pitches. However, the tissue-specific effects of repetitive pitching on medial elbow stabilizers are largely unknown.

Purpose/hypothesis: This study aimed to investigate changes in the ulnar collateral ligament (UCL) and forearm flexor-pronator muscles (FPMs) during repetitive pitching and factors that relate to identified change. Read More

View Article and Full-Text PDF

Persistent bone resorption lacunae on necrotic bone distinguish bisphosphonate-related osteonecrosis of jaw from denosumab-related osteonecrosis.

J Bone Miner Metab 2021 Apr 8. Epub 2021 Apr 8.

Tokyo Dental College Research Branding Project, 2-9-18 Kanda-Misaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.

Background: Bisphosphonate and denosumab are widely used for the treatment of osteoporosis and bone metastasis of cancer to prevent excessive bone resorption. Osteonecrosis of the jaw is a serious adverse effect of bisphosphonate or denosumab referred to as bisphosphonate-related osteonecrosis of the jaw (BRONJ) or denosumab-related osteonecrosis of the jaw (DRONJ), respectively. Since bisphosphonate and denosumab inhibit bone resorption by different mechanism, we evaluated whether these drug types result in different histopathological characteristics related to bone resorption. Read More

View Article and Full-Text PDF

Live births after in vitro maturation of oocytes in women who had suffered adnexal torsion and unilateral oophorectomy following conventional ovarian stimulation.

J Assist Reprod Genet 2021 Apr 7. Epub 2021 Apr 7.

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 109, Brussels, Belgium.

Purpose: To report the first successful application of in vitro maturation (IVM) of oocytes resulting in live births in two anovulatory women who had suffered oophorectomy following ovarian torsion after stimulation with gonadotropins.

Methods: Data abstraction was performed from medical records of two subfertile women with excessive functional ovarian reserve. Both women had previously received gonadotropins for ovulation induction or ovarian stimulation, resulting in ovarian torsion. Read More

View Article and Full-Text PDF

Chemical Composition and Ultraviolet Absorption Activity of an Aqueous Alkali Extract from the Fruiting Bodies of the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes).

Int J Med Mushrooms 2021 ;23(4):23-37

Competence Center for Applied Mycology and Environmental Studies, Department of Food Science and Nutrition, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.

White rot mushroom Fomes fomentarius is a medicinal fungus with great potential to be explored. This work focused on the chemical composition of a basic aqueous extract from F. fomentarius fruiting bodies. Read More

View Article and Full-Text PDF
January 2021

Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review).

Authors:
Hui-Chen Lo

Int J Med Mushrooms 2021 ;23(3):29-41

Department of Nutritional Science, Fu Jen Catholic University, 510 Zhongzheng Road, Xinzhuang District, New Taipei City 24205, Taiwan.

Nonalcoholic fatty liver disease (NAFLD) is a global disease that is closely associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Excessive fat accumulation, fatty degeneration, and chronic inflammation of the liver activate the progression of NAFLD from simple steatosis to nonalcoholic steatohepatitis and further to liver fibrosis, cirrhosis, and hepatocellular carcinoma. The underlying mechanism for the development and progression of NAFLD is complex and a multiple-hit hypothesis including dietary, environmental, genetic, and epigenetic factors has been raised. Read More

View Article and Full-Text PDF
January 2021

Hypovolemic shock induced by a large chest wall hematoma caused by a single rib fracture in an elderly patient.

Trauma Case Rep 2021 Apr 17;32:100459. Epub 2021 Mar 17.

Department of Emergency and Disaster Medicine, Showa University.

Displaced rib fractures can injure intercostal vessels leading to chest wall hematomas. As the bleeding occurs within the vessel, compression of the vessel wall helps in preventing further bleeding. Therefore, chest wall hematomas rarely result in shock. Read More

View Article and Full-Text PDF

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis.

Front Immunol 2021 19;12:645717. Epub 2021 Mar 19.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function. Th2 T cell-derived cytokines including IL-4 and IL-13 have been shown to contribute to inflammation and fibrotic remodeling in multiple tissues. Interleukin-31 (IL-31) is a newly identified cytokine that is predominantly produced by CD4 Th2 T cells, but its signaling receptor IL-31RA is primarily expressed by non-hematopoietic cells. Read More

View Article and Full-Text PDF

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.

J Biol Chem 2021 Apr 1:100623. Epub 2021 Apr 1.

Division of Endocrinology and Metabolism, Duke University Medical Center, Durham, North Carolina, USA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA. Electronic address:

Excessive sugar consumption is a contributor to the worldwide epidemic of cardiometabolic disease. Understanding mechanisms by which sugar is sensed and regulates metabolic processes may provide new opportunities to prevent and treat these epidemics. Carbohydrate Responsive-Element Binding Protein (ChREBP) is a sugar sensing transcription factor that mediates genomic responses to changes in carbohydrate abundance in key metabolic tissues. Read More

View Article and Full-Text PDF

The Influence of Parental Dietary Behaviors and Practices on Children's Eating Habits.

Nutrients 2021 Mar 30;13(4). Epub 2021 Mar 30.

Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), University of Zaragoza, 50009 Zaragoza, Spain.

Poor dietary habits established during childhood might persist into adulthood, increasing the risk of developing obesity and obesity-related complications such as Type 2 Diabetes Mellitus. It has been found that early modifications in eating habits, especially during childhood, might promote health and decrease the risk of developing diseases during later life. Various studies found a great influence of parental dietary habits on dietary behaviors of their children regardless of demographic characteristics such as gender, age, socioeconomic status and country; however, the exact mechanism is still not clear. Read More

View Article and Full-Text PDF

Potential of Nutraceutical Supplementation in the Modulation of White and Brown Fat Tissues in Obesity-Associated Disorders: Role of Inflammatory Signalling.

Int J Mol Sci 2021 Mar 25;22(7). Epub 2021 Mar 25.

Department of Health Sciences, Institute of Research for Food Safety & Health IRC-FSH, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.

The high incidence of obesity is associated with an increasing risk of several chronic diseases such as cardiovascular disease, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Sustained obesity is characterized by a chronic and unsolved inflammation of adipose tissue, which leads to a greater expression of proinflammatory adipokines, excessive lipid storage and adipogenesis. The purpose of this review is to clarify how inflammatory mediators act during adipose tissue dysfunction in the development of insulin resistance and all obesity-associated diseases. Read More

View Article and Full-Text PDF

Lifestyle Changes and Determinants of Children's and Adolescents' Body Weight Increase during the First COVID-19 Lockdown in Greece: The COV-EAT Study.

Nutrients 2021 Mar 13;13(3). Epub 2021 Mar 13.

Second Department of Paediatrics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Previous studies showed that the coronavirus disease 2019 (COVID-19) lockdown imposed changes in adults' lifestyle behaviors; however, there is limited information regarding the effects on youth. The COV-EAT study aimed to report changes in children's and adolescents' lifestyle habits during the first COVID-19 lockdown and explore potential associations between changes of participants' lifestyle behaviors and body weight. An online survey among 397 children/adolescents and their parents across 63 municipalities in Greece was conducted in April-May 2020. Read More

View Article and Full-Text PDF

A Longitudinal Study of Subjective Daytime Sleepiness Changes in Elementary School Children Following a Temporary School Closure Due to COVID-19.

Children (Basel) 2021 Mar 1;8(3). Epub 2021 Mar 1.

Department of Psychiatry, Tokyo Medical University, 6-7-1 Nishi-Shinkuku, Shinjuku, Tokyo 160-0023, Japan.

Excessive daytime sleepiness is increasingly being recognized as a major global health concern. However, there have been few studies related to sleepiness and its associated factors in elementary school children. In Japan, all schools were closed from February to May 2020 to prevent coronavirus disease 2019 (COVID-19) outbreaks. Read More

View Article and Full-Text PDF

Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-β1-Induced Intestinal Fibrosis on CCD-18Co Cells.

Nutrients 2021 Mar 9;13(3). Epub 2021 Mar 9.

Department of Life, Health & Environmental Sciences, University of L'Aquila, Via Pompeo Spennati, Building Rita Levi Montalcini, Coppito, 67100 L'Aquila, Italy.

Fibrosis is a severe complication of chronic inflammatory disorders, such as inflammatory bowel disease (IBD). Current strategies are not fully effective in treating fibrosis; therefore, innovative anti-fibrotic approaches are urgently needed. TGF-β1 plays a central role in the fibrotic process by inducing myofibroblast differentiation and excessive extracellular matrix (ECM) protein deposition. Read More

View Article and Full-Text PDF

Transparent Polyaniline Thin Film Synthesized Using a Low-Voltage-Driven Atmospheric Pressure Plasma Reactor.

Materials (Basel) 2021 Mar 8;14(5). Epub 2021 Mar 8.

School of Electronic and Electrical Engineering, College of IT Engineering, Kyungpook National University, Daegu 41566, Korea.

The use of low-voltage-driven plasma in atmospheric pressure (AP) plasma polymerization is considered as a simple approach to reducing the reactivity of the monomer fragments in order to prevent excessive cross-linking, which would have a negative effect on the structural properties of the polymerized thin films. In this study, AP-plasma polymerization can be processed at low voltage by an AP-plasma reactor with a wire electrode configuration. A bare tungsten wire is used as a powered electrode to initiate discharge in the plasma area (defined as the area between the wide glass tube and the substrate stand), thus allowing plasma polymerization to proceed at a lower voltage compared to other AP-plasma reactors with dielectric barriers. Read More

View Article and Full-Text PDF

Load Transference with the Gain of Excessive Body Mass: A Two-Year Longitudinal Study.

Int J Environ Res Public Health 2021 Mar 11;18(6). Epub 2021 Mar 11.

Key Laboratory of Leather Chemistry and Engineering, Sichuan University, Chengdu 610065, China.

Previous studies investigating the effect of excessive weight on the foot have commonly been cross-sectional; therefore, it is still unclear how the foot function gradually changes with the increased body mass that is physiologically gained over time. This study aimed to use a load transfer method to identify the mechanism of how the foot function changed with the increased excessive body mass over two years. Taking normal weight as the baseline, fifteen children became overweight or obese (group 1), and fifteen counterparts maintained normal weight (group 0) over the two years. Read More

View Article and Full-Text PDF

Loneliness and Its Associated Factors Nine Months after the COVID-19 Outbreak: A Cross-National Study.

Int J Environ Res Public Health 2021 03 11;18(6). Epub 2021 Mar 11.

Department of Social Work, Faculty of Social Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.

COVID-19 has been a global healthcare concern impacting multiple aspects of individual and community wellness. As one moves forward with different methods to reduce the infection and mortality rates, it is critical to continue to study the impact that national and local "social distancing" policies have on the daily lives of individuals. The aim of this study was to examine loneliness in relation to risk assessment, measures taken against risks, concerns, and social media use, while adjusting for sociodemographic variables. Read More

View Article and Full-Text PDF

Avoiding Radical Removal of Posterior Elements in Posterior Vertebral Column Resections: A Modified Schwab Grade 6 Osteotomy for Severe Post-tuberculous Kyphotic Deformity.

World Neurosurg 2021 Mar 30. Epub 2021 Mar 30.

Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Beijing, China.

Objective: Posterior vertebral column resections (PVCRs) is a versatile technique for the correction of severe and rigid spinal deformities, but the high rate of neurological complications is a major disadvantage of this procedure. The purpose of this study was to describe a modified PVCRs technique for the safe treatment of severe post-tuberculous kyphotic deformity.

Methods: Four consecutive patients with severe post-tuberculous kyphosis underwent modified PVCRs. Read More

View Article and Full-Text PDF

[Compartment syndrome of the forearm in a child].

Ned Tijdschr Geneeskd 2021 03 18;165. Epub 2021 Mar 18.

UMC Utrecht, afd. Traumachirurgie, Utrecht.

Background: Compartment syndrome is a rare but serious entity with various causes. Timely diagnosis and treatment are essential.

Case Description: We present a case of a 14-year-old boy with a crush injury of the forearm including a fracture of the radius and ulna. Read More

View Article and Full-Text PDF

Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity.

J Appl Physiol (1985) 2021 Apr 1. Epub 2021 Apr 1.

Department of Bioengineering, Northeastern University, United States.

The current therapeutic approach to asthma focuses exclusively on targeting inflammation and reducing airway smooth muscle force to prevent the recurrence of symptoms. However, even when inflammation is brought under control, airways in an asthmatic can still hyper-constrict when exposed to a low dose of agonist. This suggests that there are mechanisms at play that are likely triggered by inflammation and eventually become self-sustaining so that even when airway inflammation is brought back under control, these alternative mechanisms continue to drive airway hyperreactivity in asthmatics. Read More

View Article and Full-Text PDF

New Mechanical Fat Separation Technique: Adjustable Regenerative Adipose-tissue Transfer (ARAT) and Mechanical Stromal Cell Transfer (MEST).

Aesthet Surg J Open Forum 2020 Dec 22;2(4):ojaa035. Epub 2020 Jul 22.

Department of Plastic and Reconstructive Surgery, MEST Medical Services, Izmir, Turkey.

Background: Adipose tissue is not only a very important source of filler but also the body's greatest source of regenerative cells.

Objectives: In this study, adipose tissue was cut to the desired dimensions using ultra-sharp blade systems to avoid excessive blunt pressure and applied to various anatomical areas-a procedure known as adjustable regenerative adipose-tissue transfer (ARAT). Mechanical stromal cell transfer (MEST) of regenerative cells from fat tissue was also examined. Read More

View Article and Full-Text PDF
December 2020

Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders.

Sci Adv 2021 Mar 31;7(14). Epub 2021 Mar 31.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Excessive carbohydrate intake is linked to the growing prevalence of diabetes, nonalcoholic fatty liver disease (NAFLD), and obesity. α-Glucosidases inhibitor, the only Food and Drug Administration-approved drug for limiting the absorption of polysaccharides and disaccharides, is ineffective for monosaccharides. Here, we develop a boronic acid-containing polymer nanocomplex (Nano-Poly-BA), absorbing all saccharides into nanocomplex with the diol/boronic acid molar ratio far above 1, to prevent saccharides' absorption in the gut. Read More

View Article and Full-Text PDF

A novel combined bioactivity / chemoactivity holistic approach for the evaluation of dietary supplements.

Food Chem Toxicol 2021 Mar 28;152:112159. Epub 2021 Mar 28.

Department of Biochemistry-Biotechnology, University of Thessaly, 41500 Larissa, Greece. Electronic address:

There is increasing evidence that the excessive generation of free radicals in the human body plays a major role in the pathophysiology and development of various diseases, closely associated with oxidative damage. In this frame, the consumption of antioxidant nutrients through food or dietary supplements may prevent from the harmful effects of free radicals on human cells. This work proposes a holistic approach consisting of distinct methodologies, suitable to evaluate the antioxidant and chemoprotective activity of three novel dietary supplements, each one containing active substances with complementary properties. Read More

View Article and Full-Text PDF

A new technique of seawater intrusion control: development of geochemical cutoff wall.

Environ Sci Pollut Res Int 2021 Mar 31. Epub 2021 Mar 31.

Laboratory of Modeling in Hydraulics and Environment (LMHE), National Engineering School of Tunis (ENIT), University of Tunis El Manar (UTM), Bp 37, Le Belvédère, 1002, Tunis, Tunisia.

The construction of a subsurface dam and/or physical cutoff barriers is one of the most known techniques used to prevent seawater intrusion during excessive exploitation of freshwater from a coastal aquifer. This method is widely used in many sites around the world (Japan, Brazil, India, Burkina Faso…). In this study, we present an innovative technique for constructing subsurface barriers based on geochemical reactions. Read More

View Article and Full-Text PDF

Diabetes Insipidus: Pathogenesis, Diagnosis, and Clinical Management.

Cureus 2021 Feb 23;13(2):e13523. Epub 2021 Feb 23.

Basic Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

Diabetes insipidus (DI) is an endocrine condition involving the posterior pituitary peptide hormone, antidiuretic hormone (ADH). ADH exerts its effects on the distal convoluted tubule and collecting duct of the nephron by upregulating aquaporin-2 channels (AQP2) on the cellular apical membrane surface. DI is marked by expelling excessive quantities of highly dilute urine, extreme thirst, and craving for cold water. Read More

View Article and Full-Text PDF
February 2021

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction.

Exp Mol Med 2021 Mar 30;53(3):468-482. Epub 2021 Mar 30.

Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea.

The AHNAK nucleoprotein has been determined to exert an anti-obesity effect in adipose tissue and further inhibit adipogenic differentiation. In this study, we examined the role of AHNAK in regulating hepatic lipid metabolism to prevent diet-induced fatty liver. Ahnak KO mice have reportedly exhibited reduced fat accumulation in the liver and decreased serum triglyceride (TG) levels when provided with either a normal chow diet or a high-fat diet (HFD). Read More

View Article and Full-Text PDF

Caught Between External Pressures and Internal Battles: Psychosocial Factors Affecting Gestational Weight Gain - A Scoping Review.

Cureus 2021 Feb 22;13(2):e13487. Epub 2021 Feb 22.

Internal Medicine, King Edward Medical University, Lahore, PAK.

Many physical factors (including maternal comorbidities) affecting gestational weight gain (GWG) have been widely studied; however, the psychosocial aspects pertaining to this need to be put under the microscope, especially in countries characterized by low indicators of socioeconomic development. Gaining and maintaining an adequate amount of weight during pregnancy is important to prevent premature deliveries, fetal demise, fetal macrosomia, shoulder dystocia during delivery, emergency cesarean sections, postpartum weight retention, childhood obesity, etc. A scoping review of the articles published in the last five years has revealed that perinatal outcomes like gestational weight are influenced by certain psychosocial factors, including, but not limited to, intimate partner violence, lack of social support and recognition, financial distress, household food insecurity, chronic stress and depression related to pregnancy, eating pathologies, and low self-esteem. Read More

View Article and Full-Text PDF
February 2021

The use of probiotics in animal feeding for safe production and as potential alternatives to antibiotics.

Vet World 2021 Feb 3;14(2):319-328. Epub 2021 Feb 3.

Department of microbiology and virology, Institute of Medicine, RUDN University, Moscow, Russia.

Although the production of safe food for human consumption is the primary purpose for animal rearing, the environment and well-being of the animals must also be taken into consideration. Based on microbiological point of view, the production of healthy food from animals involves considering foodborne pathogens, on the one hand and on the other hand, the methods used to fight against germs during breeding. The conventional method to control or prevent bacterial infections in farming is the use antibiotics. Read More

View Article and Full-Text PDF
February 2021

Protective potential of cerium oxide nanoparticles in diabetes mellitus.

J Trace Elem Med Biol 2021 Mar 10;66:126742. Epub 2021 Mar 10.

School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia. Electronic address:

Background: Diabetes mellitus (DM) is a non-communicable metabolic disease which is closely related to excessive oxidative stress after constant exposure to high plasma glucose. Although the current antidiabetic medications are effective in lowering blood glucose, these medications do not prevent or reverse the disease progression. Thus, there is a crucial need to explore new therapeutic interventions that could address this shortcoming. Read More

View Article and Full-Text PDF