3,337 results match your criteria prevalence hpv-dna

The Association of Human Papillomavirus in Benign and Malignant Laryngeal Lesions-a Pilot Study.

Indian J Surg Oncol 2021 Jun 13;12(2):306-310. Epub 2020 Jun 13.

Department of Head and Neck surgery, Christian Medical College Hospital, Vellore, 632004 India.

Various etiological factors have been described in laryngeal carcinogenesis. Tobacco and alcohol play a major role in the development of laryngeal cancers. However, recently there has been an overshadowing of association of human papillomavirus infection in laryngeal cancers. Read More

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Anogenital HPV Infection, Seroprevalence, and Risk Factors for HPV Seropositivity Among Sexually Active Men Enrolled in a Global HPV Vaccine Trial.

Clin Infect Dis 2021 Jul 15. Epub 2021 Jul 15.

Department of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA.

Background: In men, human papillomavirus (HPV)-related cancer incidence is rising, but data regarding male HPV infection and seroprevalence are available from only a few countries.

Methods: This analysis of a global HPV vaccine trial evaluated baseline data from 1399 HIV-negative heterosexual men (HM) and men who have sex with men (MSM). Key objectives included assessment of HPV prevalence and risk factors for seropositivity to 9-valent HPV (9vHPV) vaccine types (6/11/16/18/31/33/45/52/58), and concordance between seropositivity and prevalent HPV type. Read More

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Prevalence of oral human papillomavirus infection among Indian HIV-positive men who have sex with men: a cross-sectional study.

BMC Infect Dis 2021 Jul 12;21(1):675. Epub 2021 Jul 12.

Division of Infectious Diseases, Department of Medicine, University of California, Box 0654, 513 Parnassus Ave, Room S420, San Francisco, CA, 94143, USA.

Background: Oral human papillomavirus (HPV) infection has been causally linked to a subset of oropharyngeal cancers in Western populations, and both oropharyngeal cancer and oral HPV infection are increased among HIV-positive individuals. India has high incidences of oral and oropharyngeal cancers, and Indian HIV-positive men who have sex with men (MSM) may be at increased risk of developing oropharyngeal cancers. However, there is little information available on the prevalence of oral HPV in this population. Read More

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Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients.

J Int Med Res 2021 Jul;49(7):3000605211022534

Centre National de Référence Papillomavirus, CHU Besançon, Besançon, France.

Objectives: Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age <45 years compared with patients aged ≥45 years.

Methods: Thirty-nine patients aged <45 years who presented at Besançon University Hospital with HNSCC since 2005 were included in this retrospective study. Read More

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Oral secretory leukocyte protease inhibitor (SLPI): Associations with oropharyngeal cancer and treatment outcome.

PLoS One 2021 2;16(7):e0254161. Epub 2021 Jul 2.

Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.

Background: Rates of oropharyngeal cancer (OPC) associated with alcohol & tobacco use have decreased, while human papillomavirus (HPV) associated OPC has increased among men in the US. Secretory leukocyte protease inhibitor (SLPI), detectable in a variety of secretions, has been implicated in cancers of the head and neck, associated with tumor progression and anti-viral activity. Using the recently verified oral gargle specimen, this study aimed to assess the association of salivary SLPI expression with risk of OPC and response to treatment. Read More

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Sensitivity and Specificity of Human Papillomavirus (HPV) 16 Early Antigen Serology for HPV-Driven Oropharyngeal Cancer: A Systematic Literature Review and Meta-Analysis.

Cancers (Basel) 2021 Jun 16;13(12). Epub 2021 Jun 16.

Infections and Cancer Epidemiology Division, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Antibodies against HPV16 early proteins have been shown to be promising biomarkers for the identification of HPV-driven oropharyngeal cancer (HPV-OPC) among OPC cases in multiple studies. A systematic literature search was performed to identify original research articles comparing HPV early antigen serology with established reference methods to determine molecular HPV tumor status. Random-effects models were used to calculate summary estimates for sensitivity and specificity of HPV16 E2, E6 and E7 serology for HPV-OPC. Read More

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Wide Spectrum Analysis of Human Papillomavirus Genotypes in External Anogenital Warts.

Vaccines (Basel) 2021 Jun 5;9(6). Epub 2021 Jun 5.

Department of Pathology, Medical School and Clinical Center, University of Pécs, 7624 Pécs, Hungary.

External anogenital warts (EGW) are primarily associated with the low-risk human papillomavirus (HPV) genotypes 6 and 11, though coinfection with other low-risk and oncogenic high-risk HPV genotypes also occurs. Although there have been many studies on HPV-associated disease, the prevalence of HPV genotypes associated with EGW is not well characterized. The objective of our retrospective study was to determine the prevalence of HPV genotypes among patients diagnosed with EGW in the south-west of Hungary. Read More

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Rationale and design of the Prevent Anal Cancer Self-Swab Study: a protocol for a randomised clinical trial of home-based self-collection of cells for anal cancer screening.

BMJ Open 2021 Jun 29;11(6):e051118. Epub 2021 Jun 29.

Department Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Squamous cell carcinoma of the anus is a common cancer among sexual minority men, especially HIV-positive sexual minority men; however, there is no evidenced-based national screening protocol for detection of anal precancers. Our objective is to determine compliance with annual anal canal self-sampling or clinician-sampling for human papillomavirus (HPV) DNA.

Methods And Analysis: This is a prospective, randomised, two-arm clinical study to evaluate compliance with annual home-based versus clinic-based HPV DNA screening of anal canal exfoliated cells. Read More

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Reduction of HPV16/18 prevalence in young women after eight years of three- and two-dose vaccination schemes.

Vaccine 2021 Jul 25;39(32):4419-4422. Epub 2021 Jun 25.

Escuela de Salud Pública de México, Instituto Nacional de Salud Pública, Av. Universidad 655, Cuernavaca, Morelos 62100, México. Electronic address:

Background: Recommendations for human papillomavirus vaccination have relied on immunogenicity studies and efficacy results derived from adult women. Insufficient information exists regarding HPV effectiveness in vaccinated girls as they become sexually active, regardless of dose scheme. We aimed to compare the prevalence of high-risk HPV between unvaccinated and vaccinated young women eight years after immunization. Read More

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Concordance in HPV Detection Between Self-Collected and Health Provider-Collected Cervicovaginal Samples Using careHPV in Tanzanian Women.

JCO Glob Oncol 2021 Jun;7:985-991

Danish Cancer Society Research Center, Unit of Virus, Lifestyle and Genes, Copenhagen, Denmark.

Purpose: Cervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. Read More

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Absence of human papillomavirus in nasopharyngeal swabs from infants in a population at high risk of human papillomavirus infection.

Pediatr Investig 2021 Jun 18;5(2):136-139. Epub 2021 Jun 18.

Menzies School of Health Research Charles Darwin University Darwin Australia.

Maternal urogenital human papillomavirus (HPV) infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity. The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants, who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high. These data are necessary to inform HPV vaccination regimens. Read More

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Prevalent HPV infection increases the risk of HIV acquisition in African women: advancing the argument for HPV immunization.

AIDS 2021 Jun 24. Epub 2021 Jun 24.

Department of Epidemiology, University of Washington, Seattle, USA Department of Global Health, University of Washington, Seattle, USA Kenya Medical Research Institute, Nairobi, Kenya Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, USA Department of Biostatistics, University of Washington, Seattle, USA Clinical Trials Research Centre, University of Zimbabwe, Harare, Zimbabwe College of Health Sciences, University of Zimbabwe Department of Medicine/Division of Infectious Diseases, University of Alabama at Birmingham, Alabama, USA Kaiser Permanente Washington Health Research Institute, Seattle, USA Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa Wits Reproductive Health and HIV Institute in Johannesburg, South Africa Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa South Africa Medical Research Council, Durban, South Africa Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa The Aurum Institute, Klerksdorp, South Africa Makerere University-John Hopkins University Research Collaboration Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Soweto, South Africa Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA Department of Obstetrics and Gynecology, University of Washington, Seattle, USA.

Objective: Vaccine-preventable human papillomavirus (HPV) infection is common, especially in sub-Saharan Africa where HIV risk is also high. However, unlike other sexually transmitted infections (STIs), HPV's role in HIV acquisition is unclear. We evaluated this relationship using data from MTN-003, a clinical trial of HIV chemoprophylaxis among cisgender women in sub-Saharan Africa. Read More

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Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients.

Access Microbiol 2021 Mar 23;3(3):000216. Epub 2021 Mar 23.

Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.

Background: Since the work of Band . in 1990 ( 87:463-467), several studies have suggested a possible link between the pathogenesis of breast cancer and viral infection. Infection with oncogenic HPV has been one of the viruses implicated in breast cancer cases worldwide. Read More

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A NGS-based Blood Test for the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization.

Clin Cancer Res 2021 Jun 9. Epub 2021 Jun 9.

Institut de Cancérologie de Lorraine

Purpose: Use of circulating tumor DNA for diagnosis is limited regarding the low number of target molecules in early stage tumors. HPV-associated carcinomas represent a privileged model using circulating viral DNA (ctHPV DNA) as a tumor marker. However, the plurality of HPV genotypes represents a challenge. Read More

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Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus test result.

Am J Obstet Gynecol 2021 Jun 1. Epub 2021 Jun 1.

Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada; Lower Mainland Laboratories, Vancouver, British Columbia, Canada. Electronic address:

Background: Cervical cancer, a preventable disease associated with the human papillomavirus, is responsible for significant morbidity and mortality globally. Primary human papillomavirus testing is more sensitive in detecting precancerous cervical lesions than cytologic screening and can be conducted using either DNA- or RNA-based assays. Screening programs must select the most appropriate assay from several available assays for their population. Read More

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HPV-Negative Cervical Cancer: A Narrative Review.

Diagnostics (Basel) 2021 May 26;11(6). Epub 2021 May 26.

Obstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.

Cervical cancer (CC) is the fourth most frequent cancer in women worldwide. HPV infection is associated with the majority of CC cases, but a small proportion of CCs actually test negative for HPV. The prevalence of HPV among CC histotypes is very different. Read More

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Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas.

Viruses 2021 May 27;13(6). Epub 2021 May 27.

Institute of Microbiology and Virology, Riga Stradiņš University, Rātsupītes 5, LV-1067 Riga, Latvia.

Human papillomavirus (HPV) was proven to play a significant role in cancer development in the oropharynx. However, its role in the development of laryngeal (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) remains to be clarified. High-risk HPV (HR-HPV) viral proteins E6 and E7 are considered to be pertinent to HPV-related carcinogenesis. Read More

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Self-collected versus clinician-collected cervical samples for the detection of HPV infections by 14-type DNA and 7-type mRNA tests.

BMC Infect Dis 2021 May 31;21(1):504. Epub 2021 May 31.

Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway.

Background: HPV self-sampling has been widely supported by the scientific community following a strong body of literature on the subject. Self-sampling is important in cervical cancer screening as it has been shown to improve participation. It is well documented that HPV-testing has proven superior to cytology with regards to sensitivity in detection of CIN and cancer. Read More

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Prevalence of Human Papillomavirus (HPV) DNA among Men with Oropharyngeal and Anogenital Cancers: A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2021 May 1;22(5):1351-1364. Epub 2021 May 1.

Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective: The term ''Human Papillomavirus'' or ''HPV'' has become synonymous with uterine cervical cancer leading to feminisation of all the preventive measures, especially immunisation. Taking into consideration the rising number of HPV associated cancers among men in many developed countries and the risk of transmission to women, male HPV infection is a serious concern. A systematic review and meta-analysis of literature was performed to determine the global prevalence of HPV among men with oropharyngeal and anogenital cancers. Read More

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Development and evaluation of a new non-competitive Luminex immunoassay detecting antibodies against human papillomavirus types 6, 11, 16 and 18.

J Gen Virol 2021 May;102(5)

Laboratoire de santé publique du Québec, Institut national de santé publique Québec, 20045 Sainte-Marie Road, Sainte-Anne-de-Bellevue, Quebec, Canada.

Serum antibody levels can be used to measure the humoral immune response against human papillomaviruses (HPV). We developed and validated a rapid, technically simple and relatively inexpensive multiplex non-competitive Luminex-based immunoassay (ncLIA) to measure total IgG antibody levels against four HPV types. For the assay's solid phase, virus-like particles (VLPs) of HPV6, 11, 16 and 18 were bound to heparin-coated beads. Read More

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Comparison of two sample collection devices for anal cytology in HIV-positive men who have sex with men: Cytology brush and Dacron swab.

Cytopathology 2021 May 25. Epub 2021 May 25.

HIV and STD Unit (Infectious Disease Service), Bellvitge University Hospital/Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Objective: HIV-positive men who have sex with men (MSM) are a vulnerable group for anal cancer (AC), a cancer with a well-described precursor lesion, which can be detected early in screening programs using anal liquid-based cytology (aLBC). We aim to compare two aLBC sample collection devices: cytology brush (CB) and Dacron swab (DS).

Methods: Retrospective analysis of two consecutive study periods, the first using CB and the second DS. Read More

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Self-sampling in Human Papillomavirus screening during and post-COVID-19 pandemic.

Med J Malaysia 2021 05;76(3):298-303

Universiti Malaysia Sarawak, Faculty of Medicine and Health Sciences, Department of Obstetrics and Gynaecology, Kota Samarahan, Sarawak, Malaysia.

Introduction: Cervical cancer is the third most common cancer among Malaysian women. Sarawak, the largest state in Malaysia has consistently recorded the highest cervical cancer rate in the country where nearly half of its population still live in the rural areas and is at increased risk of the disease due to inequitable access to healthcare. The countrywide lockdown due to the COVID-19 pandemic had halted the accessibility to cervical cancer screening programme. Read More

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Non-invasive saliva-based screening of high-risk Human Papilloma Virus 16 and 18 in healthy young adults and creating awareness about its vaccination.

J Family Med Prim Care 2021 Jan 30;10(1):387-391. Epub 2021 Jan 30.

Department of Biochemistry All India Institute of Medical Sciences, Patna, Bihar, India.

Context: Human Papilloma Virus (HPV) has not only been linked with cervical cancer but also a key player in other types including oral cancer. Vaccine against HPV has shown promising outcomes in protection against cervical cancer. It is suggested that the same vaccine may be a safeguard against oral cancer as well. Read More

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January 2021

HPV self-sampling for cervical cancer screening: a systematic review of values and preferences.

BMJ Glob Health 2021 05;6(5)

Department of Sexual and Reproductive Health and Research, UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Geneva, Switzerland.

Introduction: The WHO recommends human papillomavirus (HPV) cervical self-sampling as an additional screening method and HPV DNA testing as an effective approach for the early detection of cervical cancer for women aged ≥30 years. This systematic review assesses end user's values and preferences related to HPV self-sampling.

Methods: We searched four electronic databases (PubMed, Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature and Embase) using search terms for HPV and self-sampling to identify articles meeting inclusion criteria. Read More

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The role of circumcision, tobacco, and alcohol use in genital human papillomavirus infection among men from Denmark.

Int J STD AIDS 2021 May 12:9564624211014727. Epub 2021 May 12.

Unit of Virus, Lifestyle and Genes, 165143Danish Cancer Society Research Center, Copenhagen, Denmark.

It is crucial to understand the natural history of genital human papillomavirus (HPV) infection in men to prevent the increasing male HPV-related disease burden. We evaluated the associations between HPV infection and circumcision, smoking, and alcohol use after accounting for sexual behavior. The study included 2331 male personnel from Danish barracks. Read More

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Male Circumcision Reduces Penile HPV Incidence and Persistence: A Randomized Controlled Trial in Kenya.

Cancer Epidemiol Biomarkers Prev 2021 Jun 10;30(6):1139-1148. Epub 2021 May 10.

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Illinois.

Background: Male circumcision reduces the risk of human immunodeficiency virus infection in men. We assessed the effect of male circumcision on the incidence and natural history of human papillomavirus (HPV) in a randomized clinical trial in Kisumu, Kenya.

Methods: Sexually active, 18- to 24-year-old men provided penile exfoliated cells for HPV DNA testing every 6 months for 2 years. Read More

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Discrepancy in p16 expression in patients with HPV-associated head and neck squamous cell carcinoma in Thailand: clinical characteristics and survival outcomes.

BMC Cancer 2021 May 6;21(1):504. Epub 2021 May 6.

Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but not non-OPSCC. We therefore evaluated the characteristic and association of p16 and HPV in Thai patients with HNSCC. Read More

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Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology.

BMC Infect Dis 2021 May 5;21(1):422. Epub 2021 May 5.

Facultad de Ciencias Médicas, Instituto de Virología "Dr. J. M. Vanella", Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n- Ciudad Universitaria, ZP: 5016, Córdoba, Argentina.

Background: HPV and C.trachomatis are the most prevalent, viral and bacterial STI worldwide. Both commonly have an asymptomatic development and can evolve into a persistent infection which, added to coinfections, may be important cofactors for the oncogenic transformation. Read More

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Incidence and clearance of penile high-risk HPV infection and their determinants among HIV-negative men who have sex with men.

Sex Transm Dis 2021 May 1. Epub 2021 May 1.

Department of Infectious Diseases, Public Health Service Amsterdam, the Netherlands Department of Internal Medicine, Amsterdam University Medical Centers, location AMC, University of Amsterdam, the Netherlands Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Background: Men who have sex with men (MSM) are at increased risk of anogenital HPV infections. We aimed to assess the incidence and clearance of penile high-risk HPV (hrHPV) infections and their determinants among HIV-negative MSM living in the Netherlands.

Methods: Between 2010 and 2015, HIV-negative MSM were semi-annually tested for penile HPV and completed detailed questionnaires on health and sexual behaviour. Read More

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Evaluation of Human Papillomavirus Genotype Distribution in Cervical Samples.

J Cytol 2021 Jan-Mar;38(1):44-49. Epub 2021 Feb 16.

Istanbul University, Istanbul Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul, Turkey.

Background: The most common sexually transmitted infection in the world is human papillomavirus (HPV). HPV types 16 and 18 are responsible for 60-80% of cervical cancers and precancerous cervical lesions worldwide.

Aim: In this study, it was aimed to evaluate the correlation of HPV genotype distribution with cervical cytology results in cervical smear samples and to contribute to HPV epidemiology. Read More

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February 2021