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25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Nuclear transfer and the development of genetically modified/gene edited livestock.

Reproduction 2021 Jun 11;162(1):F59-F68. Epub 2021 Jun 11.

Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking experiment challenged a long-standing dogma of irreversible cellular differentiation that prevailed for over a century and enabled the development of methodologies for reversal of differentiation of somatic cells, also known as nuclear reprogramming. Thanks to this new paradigm, novel alternatives for regenerative medicine in humans, improved animal breeding in domestic animals and approaches to species conservation through reproductive methodologies have emerged. Read More

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Microbial Safety of Smoothie Drinks from Fresh Bars Collected in Slovakia.

Foods 2021 Mar 7;10(3). Epub 2021 Mar 7.

Faculty of Chemical and Food Technology, Department of Nutrition and Food Quality Assessment, Slovak University of Technology, Radlinského 9, 81237 Bratislava, Slovakia.

Among the many consumers in Slovakia, smoothies are nowadays gaining popularity. Smoothie drinks are prepared from raw fruits and vegetables. Therefore, their microbiological safety depends on hygiene standards. Read More

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The evolution in the surgical management of Peyronie's disease.

Urologia 2021 May 30;88(2):79-89. Epub 2021 Mar 30.

Department of Urology, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

Peyronie's disease (PD) is due to a fibrotic alteration of the tunica albuginea of the penis. It is responsible of penile pain, angulation, and possible erectile dysfunction (ED). Despite almost three centuries have passed since the first description of the disease, etiology still remains uncertain. Read More

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Comparison Between Dunking (Invagination) Pancreaticojejunoanastomosis and Double Layer Duct to Mucosa Anastomosis After Cephalic Duodenopancreatectomy-Whipple Procedure for Pancreatic Cephalic Carcinoma.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Dec 8;41(3):39-47. Epub 2020 Dec 8.

Clinic of Digestive Surgery, Medical Faculty, Skopje, Republic of North Macedonia.

Introduction: Pancreatic cancer is malignancy with poor prognosis for quality of life and overall survival. The incidence is variant, 7.7/100,000 in Europe, 7. Read More

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December 2020

Microbial Community Structure in Arctic Lake Sediments Reflect Variations in Holocene Climate Conditions.

Front Microbiol 2020 24;11:1520. Epub 2020 Jul 24.

Department of Earth Science, University of Bergen, Bergen, Norway.

The reconstruction of past climate variability using physical and geochemical parameters from lake sedimentary records is a well-established and widely used approach. These geological records are also known to contain large and active microbial communities, believed to be responsive to their surroundings at the time of deposition, and proceed to interact intimately with their physical and chemical environment for millennia after deposition. However, less is known about the potential legacy of past climate conditions on the contemporary microbial community structure. Read More

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Evaluating the phytoplankton, nitrate, and ammonium interactions during summer bloom in tributary of a subtropical reservoir.

J Environ Manage 2020 Oct 23;271:110971. Epub 2020 Jun 23.

Division of Hydrologic Sciences, Desert Research Institute, Las Vegas, NV, USA.

The rational eutrophication management largely depends on the knowledge of the dynamics in the dissolved inorganic nutrients especially nitrogen forms which trigger exponential primary productivity in eutrophic systems. The present study investigated the phytoplankton interactions with the dissolved N forms, nitrate (NO) and ammonium (NH) in a sub-tropical Yangtze River tributary, China vulnerable to multiple anthropogenic stressors following the impoundment of the largest hydraulic structure, the Three Gorges Dam. Results indicated strong NO inhibition by the low NH pool exerting toxic effects on the major phytoplankton groups, particularly the Bacilliariophyta (relative abundance < 1%) while significant Cyanophyta proliferation prevailed (relative abundance ≥ 90%). Read More

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October 2020

Substantiation of diagnosis and treatment of chronic recurrent aphthous stomatitis in crohn's disease.

Wiad Lek 2020 ;73(3):512-516

Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.

Objective: The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn's disease.

Patients And Methods: Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn's disease (main group), mean age 31.8 + 2. Read More

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Heart reaction of male and female with streptozotocin induced diabetes on cholinergic impacts.

Wiad Lek 2020 ;73(2):224-228

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Objective: The aim: Find out the nature of the changes sensitivity of the heart to the cholinergic influences the development of diabetes depending on gender.

Patients And Methods: Materials and methods: In experiments on adult male and female rats, type 1 diabetes by momentary introduction of streptozotocin at a dose of 60 mg/ kg into the peritoneal cavity was modeled. Animals were examined after 15, 30, 60 and 90 days after introduction of streptozotocin. Read More

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[Morphological features of IgG4-related lesions at various sites].

Arkh Patol 2019 ;81(5):22-29

A.I. Burnazyan Federal Medical and Biophysical Center, Federal Biomedical Agency of Russia, Moscow, Russia.

Objective: To determine the morphological features of IgG4-related lesions and to improve pathomorphological criteria for diagnosing various clinical variants of IgG4-related disease.

Material And Methods: Biopsy and surgical materials from 100 patients with tumor-like lesions at various sites (63 cases of IgG4-related lesion and 37 cases of non-IgG4-related inflammatory processes) were studied. Histological and immunohistochemical studies were conducted to determine the absolute counts of CD138+ cells, IgG+ and IgG4+ in the inflammatory infiltrates, as well as IgG4/IgG and IgG4/CD138 cell ratios. Read More

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December 2019

Diversity of yeasts in the soil adjacent to fruit trees of the Rosaceae family.

Yeast 2019 10 5;36(10):617-631. Epub 2019 Aug 5.

Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Bratislava, Slovakia.

Yeasts are common constituents of different types of soil. Their diversity depends on the season, the type and depth of the soil, the plant species, and the locality. In this study, diversity of yeasts isolated from the soil adjacent to five fruit trees (apple, appricot, peach, pear, and plum) in two localities (in Slovakia) in four sampling periods was examined. Read More

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October 2019

[Functionality of mammary-coronary bypass grafts according to the data of intraoperative flowmetry].

Angiol Sosud Khir 2019 ;25(1):159-162

Department of Cardiovascular Surgery, Research Institute of Cardiology, Tomsk, Russia; Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russia.

Improvement of surgical treatment for ischaemic heart disease is one of the main trends in modern medicine. After the operation of coronary bypass grafting, further functioning of blood flow in the grafts largely depends upon its domination over the native blood flow in the target coronary arteries. Therefore, intraoperative diagnosis of functional competence of coronary bypass grafts by means of flowmetry is currently of special importance. Read More

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Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.

Clin Nutr 2020 02 25;39(2):585-591. Epub 2019 Mar 25.

Auckland City Hospital, Auckland, New Zealand.

Background & Aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).

Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90. Read More

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February 2020

Molecular characteristics of sedimentary organic matter in controlling mercury (Hg) and elemental mercury (Hg) distribution in tropical estuarine sediments.

Sci Total Environ 2019 Jun 23;668:592-601. Epub 2019 Feb 23.

Chemical Oceanography Division, CSIR-National Institute of Oceanography, Dona Paula, Goa 403004, India.

Sedimentary organic matter (SOM) plays an important role in hosting and reducing Hg in marine/estuarine sediment. This study provides a better understanding on the influence of nature of SOM, in regulating sedimentary mercury (Hg) and elemental mercury (Hg) distribution, and speciation in the Zuari and Mandovi Estuaries that are representative of monsoon fed tropical estuaries, located in the central west coast of India. Salinity of the overlying water column controlled the physical and chemical characteristics of SOM in the estuarine systems. Read More

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[Immediate outcomes of microsurgical treatment of cerebral arteriovenous malformations in non-hemorrhagic patients].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(6):30-37

Burdenko Neurosurgical Institute, Moscow, Russia.

Arteriovenous malformations (AVMs) are some of the most frequent congenital abnormalities of the cerebral vascular system and usually occur at a young age. Given the fact that AVMs can manifest, in addition to hemorrhages, as symptomatic epilepsy (17-40%) that occurs more often at a young age and may lead to significant disability, investigation of this pathology remains topical. Particular attention has recently been paid to the management of AVM patients without clinical signs of hemorrhage at the time of pathology diagnosis. Read More

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Tuberous sclerosis-associated neuropsychiatric disorders: a paediatric cohort study.

Dev Med Child Neurol 2019 02 9;61(2):168-173. Epub 2018 Oct 9.

Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy.

Aim: We aimed to study tuberous sclerosis-associated neuropsychiatric disorders (TAND) in children and adolescents with tuberous sclerosis complex (TSC).

Method: Retrospective and prospective cohort study conducted at a Paediatric Neurology Unit of an Italian Tertiary Care Hospital. Clinical and neuroimaging data were reviewed. Read More

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February 2019

Effects of technology assumptions on US power sector capacity, generation and emissions projections: Results from the EMF 32 Model Intercomparison Project.

Energy Econ 2018 ;73:290-306

Southern Company, 600 N. 18th Street, Birmingham, AL 35203, USA.

This paper is one of two syntheses in this special issue of the results of the EMF 32 power sector study. This paper focuses on the effects of technology and market assumptions with projections out to 2050. A total of 15 models contributed projections based on a set of standardized scenarios. Read More

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January 2018

Left-Biased Clavicle Length Asymmetry in Children and Young Adults 12 to 25 Years Old.

Orthopedics 2018 Jan 19;41(1):e104-e109. Epub 2017 Dec 19.

Management of clavicle fractures depends in part on the magnitude of shortening compared with the contralateral, intact clavicle. However, estimating prefracture length may be complicated by side-to-side asymmetry. The authors retrospectively reviewed chest radiographs using a ruler tool to measure clavicle length in 696 patients 12 to 25 years old. Read More

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January 2018

The ribosomal DNA metaphase loop of Saccharomyces cerevisiae gets condensed upon heat stress in a Cdc14-independent TORC1-dependent manner.

Cell Cycle 2018 21;17(2):200-215. Epub 2018 Jan 21.

a Unidad de Investigación , Hospital Universitario Ntra Sra de Candelaria , Ctra del Rosario 145, 38010 , Santa Cruz de Tenerife , Spain.

Chromosome morphology in Saccharomyces cerevisiae is only visible at the microscopic level in the ribosomal DNA array (rDNA). The rDNA has been thus used as a model to characterize condensation and segregation of sister chromatids in mitosis. It has been established that the metaphase structure ("loop") depends, among others, on the condensin complex; whereas its segregation also depends on that complex, the Polo-like kinase Cdc5 and the cell cycle master phosphatase Cdc14. Read More

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Resveratrol has a positive effect on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease.

Wiad Lek 2017;70(2 pt 2):286-291

Department of Propaedeutics of Internal Medicine With Care for Patients, General Practice (Family Medicine), Higher State Educational Establishment Of Ukraine "Ukrainian Medical Stomatological Academy", Poltava, Ukraine.

Introduction: Cardiovascular diseases, and primarily coronary heart disease (CHD), are the leading cause of mortality in the developing countries, including Ukraine. Prognosis for patients with CHD depends mainly on progression of coronary atherosclerosis (ASVD). Molecular mechanisms of atherogenesis are studied in detail in order to find new targets of pharmacological intervention. Read More

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Genome-Wide Spectra of Transcription Insertions and Deletions Reveal That Slippage Depends on RNA:DNA Hybrid Complementarity.

mBio 2017 08 29;8(4). Epub 2017 Aug 29.

Department of Integrative Biology, University of Texas, Austin, Texas, USA

Advances in sequencing technologies have enabled direct quantification of genome-wide errors that occur during RNA transcription. These errors occur at rates that are orders of magnitude higher than rates during DNA replication, but due to technical difficulties such measurements have been limited to single-base substitutions and have not yet quantified the scope of transcription insertions and deletions. Previous reporter gene assay findings suggested that transcription indels are produced exclusively by elongation complex slippage at homopolymeric runs, so we enumerated indels across the protein-coding transcriptomes of and , which differ widely in their genomic base compositions and incidence of repeat regions. Read More

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The effect of monocular deprivation on unihemispheric sleep in light and dark incubated/reared domestic chicks.

Laterality 2018 Mar 2;23(2):166-183. Epub 2017 Jul 2.

a Department of General Psychology , University of Padova , Padova , Italy.

Unihemispheric sleep is an aspect of the cerebral lateralization of certain species of birds. During sleep, domestic chicks (Gallus gallus) show brief periods of monocular-unihemispheric sleep (Mo-Un sleep): one eye is open and the connected hemisphere is awaken while the other eye remains shut and the connected hemisphere sleeps. The time spent in Mo-Un sleep was investigated following a brief monocular deprivation (MD) in chicks hatched from eggs incubated in darkness and reared in light (D-L), incubated in light and reared in light (L-L) and incubated in darkness and reared in darkness (D-D). Read More

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Therapeutic benefit of Salmonella attributed to LPS and TNF-α is exhaustible and dictated by tumor susceptibility.

Oncotarget 2017 May;8(22):36492-36508

Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

The potential of bacteria-mediated tumor therapy (BMTT) is highlighted by more than a century of investigation. Attenuated Salmonella has prevailed as promising therapeutic agents. For BMTT - categorized as an immune therapy - the exact contribution of particular immune reactions to the therapeutic effect remains ambiguous. Read More

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Trait assembly in grasslands depends on habitat history and spatial scale.

Oecologia 2017 05 19;184(1):1-12. Epub 2017 Jan 19.

Institute of Ecology and Earth Sciences, University of Tartu, Lai 40, 51005, Tartu, Estonia.

During the past century, grasslands in Europe have undergone marked changes in land-use, leading to a decline in plant diversity both at local and regional scales, thus possibly also affecting the mechanisms of species sorting into local communities. We studied plant species assembly in grasslands with differing habitat history and hypothesised that trait divergence prevails in historical grasslands due to niche differentiation and trait convergence prevails in more dynamic grasslands due to competitive exclusion and dispersal limitation. We tested these hypotheses in 35 grassland complexes in Estonia, containing neighbouring grassland habitats with different land-use histories: continuously managed open historical grassland, currently overgrown former grassland and young developing grassland. Read More

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[SECOND MESSENGERS IN PRESYNAPTIC REGULATION OF GLYCINERGIC SYNAPSE ON THE FROG MOTONEURON].

Ross Fiziol Zh Im I M Sechenova 2016 Sep;102(9):1099-1110

The possible pathways of inhibitory influences mediated by two kinds of metabotropic receptors, group III metabotropic glutamate receptors (mGluRs III) and GABAB receptors (GABABRs) to the miniature glycinergic events were investigated in the isolated spinal cord of the frog Rana ridibunda. The glycinergic events prevailed within the miniature inhibitory activity of motoneurons [3]. Selective agonists of GABABRs (baclofen) and group III mGluR (LAP4) reduce the frequency of miniature events to 48. Read More

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September 2016

Metal(loid)s behaviour in soils amended with nano zero-valent iron as a function of pH and time.

J Environ Manage 2017 Jan 10;186(Pt 2):268-276. Epub 2016 Jun 10.

Department of Environmental Geosciences, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Prague 6, Czech Republic. Electronic address:

Nano zero-valent iron (nZVI) is currently investigated as a stabilising amendment for contaminated soils. The effect of pH (4-8) and time (48 and 192 h) on the behaviour of nZVI-treated Pb-Zn and As-contaminated soil samples was assessed. Additionally, soil leachates were subsequently used to study the direct interaction between soil solution components and nZVI particles in terms of mineralogical changes and contaminant retention. Read More

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January 2017

[Centrally acting cholinomimetics in the complex therapy of progressive glaucomatous optic neuropathy].

Vestn Oftalmol 2016 Mar-Apr;132(2):33-37

Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.

Unlabelled: Many factors exist that are associated with higher risk of glaucoma progression. Arterial hypotension, low perfusion pressure, vasospastic syndrome, diabetes mellitus, myopia, etc. increase the need for neuroprotective therapy, which is aimed at stabilizing the pathological process and creating favorable conditions for maintaining visual functions. Read More

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HLA-A, -B, and -DRB1 allele and haplotype diversity in a cohort of Brazilian renal transplant candidates.

Hum Immunol 2016 Jun 22;77(6):464-9. Epub 2016 Apr 22.

Laboratory of Immunology and Experimental Transplantation-LITEX, Medical School of São José do Rio Preto - FAMERP, SP, Brazil; Laboratory of Immunology of Transplantation, Institute of Urology and Nephrology, São José do Rio Preto, SP, Brazil. Electronic address:

The distribution of organs for renal transplant depends on HLA matching between donor and recipient. This study aimed to characterize the allele and haplotype frequencies of HLA-A, -B, and -DRB1 in a cohort of renal transplant candidates populations in the region of Sao José do Rio Preto (State of São Paulo), to compare the allele frequencies between Caucasian and Black in that region, as well as to compare these frequencies with different Brazilian populations reported. The HLA-A, -B, and -DRB1 allele and haplotypes frequencies were analyzed in a sample of 2. Read More

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Mechanical Properties of Abutments: Resin-Bonded Glass Fiber-Reinforced Versus Titanium.

Int J Prosthodont 2016 Jan-Feb;29(1):77-9

Purpose: The clinical success and longevity of endosseous implants, after their prosthetic finalization, mainly depends on mechanical factors. Excessive mechanical stress has been shown to cause initial bone loss around implants in the presence of a rigid implant-prosthetic connection. The implant abutments are manufactured with high elastic modulus materials such as titanium, steel, precious alloys, or esthetic ceramics. Read More

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Efficacy of Ultrasonography at the Ankle Level for Estimation of Pedal Microcirculation.

Ann Vasc Dis 2015 20;8(3):198-202. Epub 2015 Aug 20.

Department of Plastic and Reconstructive Surgery, Saitama Medical University, Saitama, Japan.

Chronic wounds due to diabetes mellitus (DM) and/or peripheral arterial disease (PAD) often occur in the pedal region peripheral to the ankle. To predict wound healing potential of limb ulcers, skin perfusion pressure (SPP) and transcutaneous oxygen tension (TcPO2) have recently become popular as the parameters that reflect skin microcirculation. On the other hand, ultrasonography for the macrocirculatory vessels has already prevailed widely as the standard vascular investigation. Read More

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September 2015

Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2175-80. Epub 2015 Feb 2.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan

A unique feature of hepatitis B virus (HBV) infection in humans is that viral clearance heavily depends on the age of exposure. However, the reason for this remains unclear. Here we show that gut microbiota contribute to the age dependence of HBV immunity in a hydrodynamic transfection mouse model. Read More

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February 2015