13,284 results match your criteria pressure systole

Function of arteries and veins in conditions of simulated cardiac arrest.

Bioimpacts 2021 7;11(2):157-164. Epub 2021 Mar 7.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, USA.

The study examined the behavior of vasculature in conditions of eliminated cardiac function using mathematical modeling. In addition, we addressed the question of whether the stretch-recoil capability of veins, at least in part accounts for the slower response to simulated cardiac arrest. In the first set of computational experiments, blood flow and pressure patterns in veins and arteries during the first few seconds after cardiac arrest were assessed via a validated multi-scale mathematical model of the whole cardiovascular system, comprising cardiac dynamics, arterial and venous blood flow dynamics, and microcirculation. Read More

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Correlation Between Longitudinal Strain in the Apical Segments of the Left Ventricle at End-Systole Obtained by 2-Dimensional Speckle-Tracking Echocardiography and Left Ventricular Relaxation.

Circ J 2021 Apr 10. Epub 2021 Apr 10.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.

Background: It is well acknowledged that left ventricular (LV) contractile performance affects LV relaxation via LV elastic recoil. Accordingly, we aimed to investigate whether global longitudinal strain (GLS), particularly longitudinal strain at LV apical segments at end-systole (ALS), obtained by 2-dimensional speckle-tracking echocardiography could be used to assess LV relaxation.Methods and Results:We enrolled 121 patients with suspected or definite coronary artery disease in whom echocardiography and diagnostic cardiac catheterization were performed on the same day. Read More

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Prediction of extubation readiness using lung ultrasound in preterm infants.

Pediatr Pulmonol 2021 Apr 5. Epub 2021 Apr 5.

Department of Neonatology, Cleveland Clinic Children's, Cleveland, Ohio, USA.

We aimed to test the hypothesis that a lung ultrasound severity score (LUS) and assessment of left ventricular eccentricity index of the interventricular septum (LVEI) by focused heart ultrasound can predict extubation success in mechanically ventilated infants. We conducted a prospective study on premature infants less than 34 weeks' of gestation. LUS was performed on postnatal Days 3 and 7 by an investigator who was masked to infants' ventilator parameters. Read More

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Cardiovascular magnetic resonance-assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions.

J Cardiovasc Magn Reson 2021 Apr 1;23(1):38. Epub 2021 Apr 1.

National Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore, Singapore.

Background: Parameters of myocardial deformation may provide improved insights into right ventricular (RV) dysfunction. We quantified RV longitudinal myocardial function using a fast, semi-automated method and investigated its diagnostic and prognostic values in patients with repaired tetralogy of Fallot (rTOF) and pulmonary arterial hypertension (PAH), who respectively exemplify patients with RV volume and pressure overload conditions.

Methods: The study enrolled 150 patients (rTOF, n = 75; PAH, n = 75) and 75 healthy controls. Read More

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Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats.

Mol Med Rep 2021 Jun 31;23(6). Epub 2021 Mar 31.

Emergency Department, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

The purpose of the present study was to evaluate whether tanshinone IIA (TIIA) could treat cardiac dysfunction and fibrosis in heart failure (HF) by inhibiting oxidative stress. An HF model was induced by ligation of the left anterior descending artery to cause ischemia myocardial infarction (MI) in Sprague‑Dawley rats. Cardiac fibrosis was evaluated using Masson's staining, and the levels of collagen I, collagen III, TGF‑β, α‑smooth muscle actin (α‑SMA), matrix metalloproteinase (MMP) 2 and MMP9 were determined using PCR or western blotting. Read More

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Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model.

Biomech Model Mechanobiol 2021 Mar 26. Epub 2021 Mar 26.

School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 8SQ, UK.

This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). Read More

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Impact of type 2 diabetes mellitus on left ventricular diastolic function in patients with essential hypertension: evaluation by volume-time curve of cardiac magnetic resonance.

Cardiovasc Diabetol 2021 Mar 25;20(1):73. Epub 2021 Mar 25.

Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Background: Essential hypertension and type 2 diabetes mellitus (T2DM) are two common chronic diseases that often coexist, and both of these diseases can cause heart damage. However, the additive effects of essential hypertension complicated with T2DM on left ventricle (LV) diastolic function have not been fully illustrated. This study aims to investigate whether T2DM affects the diastolic function of the LV in patients with essential hypertension using the volume-time curve from cardiac magnetic resonance (CMR). Read More

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Repeatability, reproducibility, and reference intervals for indices of right atrial longitudinal strain derived from speckle-tracking echocardiography in healthy dogs.

Am J Vet Res 2021 Apr;82(4):274-279

Objective: To determine repeatability, reproducibility, and reference intervals of indices of right atrial longitudinal strain (RALS) derived from speckle-tracking echocardiography (STE) in dogs without heart disease.

Animals: 110 client-owned dogs and 10 laboratory Beagles.

Procedures: To determine intraobserver within-day (repeatability) and interobserver (reproducibility) coefficients of variation, RALS during ventricular systole (ϵS), ventricular early diastole (ϵE), and atrial systole (ϵA), as derived with STE, were obtained by 2 investigators for 5 randomly selected client-owned dogs and analyzed by linear regression. Read More

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Quantification of Cardiac Kinetic Energy and Its Changes During Transmural Myocardial Infarction Assessed by Multi-Dimensional Seismocardiography.

Front Cardiovasc Med 2021 8;8:603319. Epub 2021 Mar 8.

Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Seismocardiography (SCG) records cardiac and blood-induced motions transmitted to the chest surface as vibratory phenomena. Evidences demonstrate that acute myocardial ischemia (AMI) profoundly affects the SCG signals. Multidimensional SCG records cardiac vibrations in linear and rotational dimensions, and scalar parameters of kinetic energy can be computed. Read More

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Feasibility of a Dielectric Elastomer Augmented Aorta.

Adv Sci (Weinh) 2021 Mar 25;8(6):2001974. Epub 2021 Jan 25.

Integrated Actuators Laboratory École Polytechnique fédérale de Lausanne (EPFL) Neuchâtel 2000 Switzerland.

Although heart transplantation is a gold standard for severe heart failure, there is a need for alternative effective therapies. A dielectric-elastomer aorta is used to augment the physiological role of the aorta in the human circulatory system. To this end, the authors developed a tubular dielectric elastomer actuator (DEA) able to assist the heart by easing the deformation of the aorta in the systole and by increasing its recoil force in the diastole. Read More

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Estimating Central Pulse Pressure From Blood Flow by Identifying the Main Physical Determinants of Pulse Pressure Amplification.

Front Physiol 2021 23;12:608098. Epub 2021 Feb 23.

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Several studies suggest that central (aortic) blood pressure (cBP) is a better marker of cardiovascular disease risk than peripheral blood pressure (pBP). The morphology of the pBP wave, usually assessed non-invasively in the arm, differs significantly from the cBP wave, whose direct measurement is highly invasive. In particular, pulse pressure, PP (the amplitude of the pressure wave), increases from central to peripheral arteries, leading to the so-called pulse pressure amplification (ΔPP). Read More

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February 2021

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats.

Int J Nanomedicine 2021 24;16:1377-1390. Epub 2021 Feb 24.

Jagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET), Krakow, 30-348, Poland.

Background: Vascular drug delivery becomes a promising direction in the development of novel therapeutic strategies in the treatment of cardiovascular pathologies, such as hypertension. However, targeted delivery of hydrophobic substances, with poor bioavailability, remains a challenge. Here, we described the hypotensive effects of a low dose of curcumin delivered to the vascular wall using hyaluronic acid-based nanocapsules. Read More

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Transcatheter Heart Valve Downstream Fluid Dynamics in an Accelerated Evaluation Environment.

Ann Biomed Eng 2021 Feb 26. Epub 2021 Feb 26.

Department of Biomedical Engineering, The Pennsylvania State University, Chemical and Biomedical Engineering Building, 122, University Park, PA, 16802, USA.

Transcatheter aortic valve replacements (TAVRs) provide minimally invasive delivery of bioprosthetic heart valves (BHVs) for the treatment of aortic valve disease. While surgical BHVs show efficacy for 8-10 years, long-term TAVR durability remains unknown. Pre-clinical testing evaluates BHV durability in an ISO:5840 compliant accelerated wear tester (AWT), yet, the design and development of AWTs and their accuracy in predicting in vivo performance, is unclear. Read More

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February 2021

Walking for hypertension.

Cochrane Database Syst Rev 2021 02 24;2:CD008823. Epub 2021 Feb 24.

Medical Affairs Division, Hualien Armed Forces General Hospital, Hualien, Taiwan.

Background: Increased physical activity has been recommended as an important lifestyle modification for the prevention and control of hypertension. Walking is a low-cost form of physical activity and one which most people can do. Studies testing the effect of walking on blood pressure have revealed inconsistent findings. Read More

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February 2021

Evaluation of Optimal Diastolic Blood Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg.

JAMA Netw Open 2021 02 1;4(2):e2037554. Epub 2021 Feb 1.

Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Importance: Extremely low diastolic blood pressure has been reported to be associated with increased adverse cardiovascular events (ie, the diastolic J-shape phenomenon); however, current US guidelines recommend an intensive blood pressure target of less than 130/80 mm Hg without mentioning the lower limits of diastolic blood pressure.

Objectives: To evaluate whether there is a diastolic J-shape phenomenon for patients with an treated systolic blood pressure of less than 130 mm Hg and to explore the safe and optimal diastolic blood pressure ranges for this patient population.

Design, Setting, And Participants: This cohort study analyzed outcome data of patients at high cardiovascular risk who were randomized to intensive or standard blood pressure control and achieved treated systolic blood pressure of less than 130 mm Hg in the Systolic Blood Pressure Intervention Trial (SPRINT) and Action to Control Cardiovascular Risk in Diabetes-Blood Pressure (ACCORD-BP) trial. Read More

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February 2021

Body Mass Index and Arterial Stiffness Are Associated With Greater Beat-to-Beat Blood Pressure Variability After Transient Ischemic Attack or Minor Stroke.

Stroke 2021 Apr 16;52(4):1330-1338. Epub 2021 Feb 16.

Wolfson Centre for Prevention of Stroke and Dementia, Department of Clinical Neurosciences, University of Oxford, United Kingdom.

[Figure: see text]. Read More

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The Estimate of Relative Increase in Stroke Volume of a Heart under Influence of Low Frequency Mechanical Vibrations.

J Biomed Phys Eng 2021 Feb 1;11(1):85-92. Epub 2021 Feb 1.

PhD Candidate, Department of Histology, Cytology and Embryology, Bukovinian State Medical University, Chernivtsi, Ukraine.

Background: An automatic massage produces health improving effects. After a single automatic massage, patients admit a feeling of invigoration, and a sense of relaxation. Some quantitative characteristics of physical effects produced by the automatic massage on the body, including the work of a heart were unavailable at that moment. Read More

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February 2021

Influence of different physiological hemodynamics on fractional flow reserve values in the left coronary artery and right coronary artery.

Heart Vessels 2021 Feb 6. Epub 2021 Feb 6.

Division of Cardiology, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, 5731010, Japan.

Background: Although the left coronary artery (LCA) has a flow profile in that most blood flow occurs during diastole rather than systole, the right coronary artery (RCA) has a flow pattern that is less diastolic dominant. This study assessed whether coronary pressure waveforms distal to stenoses with the same fractional flow reserve (FFR) was the same between the LCA and RCA.

Methods: A total of 347 vessels from 318 patients who underwent FFR measurements were included. Read More

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February 2021

4D flow MRI left atrial kinetic energy in hypertrophic cardiomyopathy is associated with mitral regurgitation and left ventricular outflow tract obstruction.

Int J Cardiovasc Imaging 2021 Feb 1. Epub 2021 Feb 1.

Department of Radiology, Northwestern University, Feinberg School of Medicine, 737 N Michigan, Suite 1600, Chicago, IL, 60611, USA.

To noninvasively assess left atrial (LA) kinetic energy (KE) in hypertrophic cardiomyopathy (HCM) patients using 4D flow MRI and evaluate coupling associations with mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction. Twenty-nine retrospectively identified patients with HCM underwent 4D flow MRI. MRI-estimated peak LVOT pressure gradient (∆P) was used to classify patients into non-obstructive and obstructive HCM. Read More

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February 2021

Resting Blood Pressure in Collegiate Swimmers During a Competitive Season: A Prospective Observational Study.

Cureus 2020 Dec 28;12(12):e12340. Epub 2020 Dec 28.

Exercise and Sport Science, College of Education, Wayne State University, Detroit, USA.

Introduction The purpose of this study was to describe and examine differences in resting blood pressure (BP) during an eight-week time frame in the course of the competitive season among collegiate swimmers of varied sexes. Methods A prospective observational study using a sample of convenience of National Collegiate Athletic Association (NCAA) Division 1 female and male swimmers from one university were invited to participate. Blood pressure was measured using standardized methodology at six encounters spaced over eight weeks. Read More

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December 2020

Leptin administration during lactation leads to different nutritional, biometric, hemodynamic, and cardiac outcomes in prepubertal and adult female Wistar rats.

J Dev Orig Health Dis 2021 Feb 1:1-6. Epub 2021 Feb 1.

Laboratory of Experimental Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

Literature reports that insults, such as hormonal disturbances, during critical periods of development may modulate organism physiology and metabolism favoring cardiovascular diseases (CVDs) later in life. Studies show that leptin administration during lactation leads to cardiovascular dysfunction in young and adult male Wistar rats. However, there are sex differences regarding CVD. Read More

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February 2021

The 2020 "WHO Technical Specifications for Automated Non-Invasive Blood Pressure Measuring Devices With Cuff".

Hypertension 2021 Mar 1;77(3):806-812. Epub 2021 Feb 1.

Biomedical Engineer, Independent Senior Consultant, Veracrus, México (L.P.L.M.).

High systolic blood pressure (BP) is the single leading modifiable risk factor for death worldwide. Accurate BP measurement is the cornerstone for screening, diagnosis, and management of hypertension. Inaccurate BP measurement is a leading patient safety challenge. Read More

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Analysis of the passive biomechanical behavior of a sheep-specific aortic artery in pulsatile flow conditions.

Comput Methods Biomech Biomed Engin 2021 Jan 21:1-14. Epub 2021 Jan 21.

Radiology department and biomedical imaging center, school of medicine, Pontificia Universidad Católica de Chile.

In this work, a novel numerical-experimental procedure is proposed, through the use of the Cardiac Simulation Test (CST), device that allows the exposure of the arterial tissue to in-vitro conditions, mimicking cardiac cycles generated by the heart. The main goal is to describe mechanical response of the arterial wall under physiological conditions, when it is subjected to a variable pressure wave over time, which causes a stress state affecting the biomechanical behavior of the artery wall. In order to get information related to stress and strain states, numerical simulation via finite element method, is performed under a condition of systolic and diastolic pressure. Read More

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January 2021

Relationship Between Mitral Leaflet Size and Coaptation and Their Associated Factors in Patients with Normal Left Ventricular Size and Systolic Function.

Int Heart J 2021 Jan 16;62(1):95-103. Epub 2021 Jan 16.

Department of Clinical Laboratory, The University of Tokyo Hospital.

Enlargement of the mitral valve (MV) has gained attention as a compensatory mechanism for functional mitral regurgitation (FMR). We aimed to determine if MV leaflet area is associated with MV coaptation-zone area and identify the clinical factors associated with MV leaflet size and coaptation-zone area in patients with normal left ventricle (LV) systolic function and size using real-time 3D echocardiography (RT3DE).We performed RT3DE in 135 patients with normal LV size and ejection fraction. Read More

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January 2021

Echocardiographic evaluation of pulmonary hypertension, right ventricular function, and right ventricular-pulmonary arterial coupling in patients with rheumatoid arthritis.

Clin Rheumatol 2021 Jan 14. Epub 2021 Jan 14.

Division of Rheumatology, Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico.

Introduction: Rheumatoid arthritis (RA) patients are at increased risk for developing cardiovascular disease, including right heart failure. The evaluation of right ventricle (RV) using the relationship between tricuspid annular plane systolic excursion (TAPSE) and right ventricular systolic pressure (RVSP) is of clinical prognostic relevance. Mild echocardiographic pulmonary hypertension (ePH) has been associated with worse RV function. Read More

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January 2021

Reference Values of Carotid Ultrafast Pulse-Wave Velocity: A Prospective, Multicenter, Population-Based Study.

J Am Soc Echocardiogr 2021 Jan 7. Epub 2021 Jan 7.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Background: Ultrafast ultrasound imaging has been demonstrated to be an effective method to evaluate carotid stiffness through carotid pulse-wave velocity (PWV) with high reproducibility, but a lack of reference values has precluded its widespread use in clinical practice. The aims of this study were to establish reference values of PWV for ultrafast ultrasound imaging in a prospective, multicenter, population-based cohort study and to investigate the main determinants of carotid PWV.

Methods: A total of 1,544 healthy Han Chinese volunteers (581 men [38%]; age range, 18-95 years) were enrolled from 32 collaborating laboratories in China. Read More

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January 2021

Cine MRI detects elevated left heart pressure in pulmonary hypertension.

J Magn Reson Imaging 2021 Jan 9. Epub 2021 Jan 9.

Department of Radiology, Northwestern University, Chicago, Illinois, USA.

Cine magnetic resonance imaging (MRI) is an emerging modality for evaluating left ventricular (LV) motion/deformation patterns, which may have potential to identify LV dysfunctions underlying postcapillary pulmonary hypertension (PH). The aim of this study was to test the hypothesis that cine MRI-derived LV motion/deformation indices can be used to identify an elevated left heart pressure in PH. This was a retrospective study, which included 26 precapillary and 28 postcapillary PH patients (23 males, 58. Read More

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January 2021

Left atrial strain rate during atrial contraction predicts raised pulmonary capillary wedge pressure: evidence for left atrio-ventricular interaction.

Int J Cardiovasc Imaging 2021 Jan 3. Epub 2021 Jan 3.

Institute of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

This study aimed to assess the relationship between different LA strain components and PCWP as well as to the relationship with other established methods. We studied 144 symptomatic patients, age 63 ± 14 years, 54 males, using conventional transthoracic echocardiography protocols, including LA and LV myocardial deformation from speckle tracking technique investigations along with simultaneous right heart catheterization (RHC) using established techniques. From RHC, pulmonary artery pressure (PAP), and pulmonary capillary wedge pressure (PCWP) were measured and pulmonary vascular resistance (PVR) calculated. Read More

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January 2021