718 results match your criteria preserving surrounding


Transient Receptor Potential Vanilloid in the Brain Gliovascular Unit: Prospective Targets in Therapy.

Pharmaceutics 2021 Mar 4;13(3). Epub 2021 Mar 4.

INSERM, U1144, F-75006 Paris, France.

The gliovascular unit (GVU) is composed of the brain microvascular endothelial cells forming blood-brain barrier and the neighboring surrounding "mural" cells (e.g., pericytes) and astrocytes. Read More

View Article and Full-Text PDF

A Comprehensive Review on Plant-Derived Mucilage: Characterization, Functional Properties, Applications, and Its Utilization for Nanocarrier Fabrication.

Polymers (Basel) 2021 Mar 28;13(7). Epub 2021 Mar 28.

Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 20-280 Lublin, Poland.

Easily sourced mucus from various plant parts is an odorless, colorless and tasteless substance with emerging commercial potential in agriculture, food, cosmetics and pharmaceuticals due to its non-toxic and biodegradable properties. It has been found that plant-derived mucilage can be used as a natural thickener or emulsifier and an alternative to synthetic polymers and additives. Because it is an invisible barrier that separates the surface from the surrounding atmosphere, it is used as edible coatings to extend the shelf life of fresh vegetables and fruits as well as many food products. Read More

View Article and Full-Text PDF

Anatomy-guided PET reconstruction usingbowsher prior.

Phys Med Biol 2021 Mar 29. Epub 2021 Mar 29.

Nuclear Medicine, Seoul National University, Seoul 03080, Korea, Seoul, 03080, Korea (the Republic of).

Advances in simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) technology have led to an active investigation of the anatomy-guided regularized PET image reconstruction algorithm based on MR images. Among the various priors proposed for anatomy-guided regularized PET image reconstruction, Bowsher's method based on second-order smoothing priors sometimes suffers from over-smoothing of detailed structures. Therefore, in this study, we propose a Bowsher prior based on thenorm and an iteratively reweighting scheme to overcome the limitation of the original Bowsher method. Read More

View Article and Full-Text PDF

The internal pedal amputation as a salvage procedure in diabetic and ischemic foot infection. A meta-analysis.

Foot Ankle Surg 2021 Mar 16. Epub 2021 Mar 16.

Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital, Lebanese American University, School of Medicine, Lebanon; Center for Evidence-Based Anatomy, Sport & Orthopedics Research, Lebanon.

Background: Osteomyelitis of the diabetic foot is a very challenging condition and amputation is often indicated. In some cases where the infection is localized and the surrounding soft tissue is mildly involved, an internal pedal amputation (IPA) based on resection and limited excision of the infected bone have been suggested as a viable option. This systematic review aims to look for the effectiveness of this technique in treating selected cases of diabetic foot osteomyelitis. Read More

View Article and Full-Text PDF

Outside-In Capsulotomy of the Hip for Arthroscopic Pincer Resection.

Arthrosc Tech 2021 Mar 2;10(3):e615-e620. Epub 2021 Feb 2.

Cedar-Sinai Kerlan-Jobe Orthopedic Clinic, Los Angeles, California, U.S.A.

Hip surgical techniques have evolved significantly, transitioning from open techniques to arthroscopic techniques. Hip arthroscopy has many advantages over open techniques, including reduced trauma to surrounding tissues, reduced risk of infection, and improved patient-reported outcome measures. Hip arthroscopic techniques are now commonly used for pathologies such as femoroacetabular impingement (FAI). Read More

View Article and Full-Text PDF

Comparison of alternate preparative techniques on wall thickness in coronary artery bypass grafts: The HArVeST randomized controlled trial.

J Card Surg 2021 Mar 12. Epub 2021 Mar 12.

Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, Bristol, UK.

Background: The success of coronary artery bypass grafting surgery (CABG) is dependent on long-term graft patency, which is negatively related to early wall thickening. Avoiding high-pressure distension testing for leaks and preserving the surrounding pedicle of fat and adventitia during vein harvesting may reduce wall thickening.

Methods: A single-centre, factorial randomized controlled trial was carried out to compare the impact of testing for leaks under high versus low pressure and harvesting the vein with versus without the pedicle in patients undergoing CABG. Read More

View Article and Full-Text PDF

A Novel Experimental Approach for Analyses of the Salivary Gland Microvasculature.

Front Immunol 2020 17;11:604470. Epub 2021 Feb 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Ludwig-Maximilians-Universität München, Munich, Germany.

Microvascular dysfunction plays a fundamental role in the pathogenesis of salivary gland disorders. Restoring and preserving microvascular integrity might therefore represent a promising strategy for the treatment of these pathologies. The mechanisms underlying microvascular dysfunction in salivary glands, however, are still obscure, partly due to the unavailability of adequate models. Read More

View Article and Full-Text PDF
February 2021

Development of Multifunctional Materials Based on Poly(ether ether ketone) with Improved Biological Performances for Dental Applications.

Materials (Basel) 2021 Feb 23;14(4). Epub 2021 Feb 23.

Laboratory for Biomaterials and Bioengineering (CRC-I), Department of Min-Met-Materials Engineering & CHU de Quebec Research Center, Laval University, Quebec City, QC G1V0A6, Canada.

The main target for the future of materials in dentistry aims to develop dental implants that will have optimal integration with the surrounding tissues, while preventing or avoiding bacterial infections. In this project, poly(ether ether ketone) (PEEK), known for its suitable biocompa-tibility and mechanical properties for dental applications, was loaded with 1, 3, and 5 wt.% ZnO nanoparticles to provide antibacterial properties and improve interaction with cells. Read More

View Article and Full-Text PDF
February 2021

Enhancing CT imaging: A safe protocol to stain and de-stain rare fetal museum specimens using diffusible iodine-based staining (diceCT).

J Anat 2021 Mar 4. Epub 2021 Mar 4.

Department of Biology, San Diego State University, San Diego, CA, USA.

Computed tomography (CT) scanning is being increasingly employed in the study of natural history, particularly to investigate the internal anatomy of unique specimens in museum collections. Different techniques to enhance the contrast between tissues have been developed to improve the quality of the scans while preserving the integrity of these rare specimens. Diffusible iodine-based contrast enhanced computed tomography (diceCT) was found to be particularly effective and reversible for staining tissues in formalin preserved specimens. Read More

View Article and Full-Text PDF

A Method to Preserve Wetland Roots and Rhizospheres for Elemental Imaging.

J Vis Exp 2021 02 15(168). Epub 2021 Feb 15.

National Synchrotron Radiation Lightsource-II, Brookhaven National Laboratory.

Roots extensively interact with their soil environment but visualizing such interactions between roots and the surrounding rhizosphere is challenging. The rhizosphere chemistry of wetland plants is particularly challenging to capture because of steep oxygen gradients from the roots to the bulk soil. Here a protocol is described that effectively preserves root structure and rhizosphere chemistry of wetland plants through slam-freezing and freeze drying. Read More

View Article and Full-Text PDF
February 2021

Perilesional neurodegenerative injury in multiple sclerosis: Relation to focal lesions and impact on disability.

Mult Scler Relat Disord 2021 Jan 5;49:102738. Epub 2021 Jan 5.

Neuroimaging Unit, Neuro-immunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Hospital, TN Valley Healthcare System, Nashville, TN, USA. Electronic address:

Background: Axonal injury is the primary source of irreversible neurological decline in persons with multiple sclerosis (pwMS). Identifying and quantifying myelin and axonal loss in lesional and perilesional tissue in vivo is fundamental for a better understanding of multiple sclerosis (MS) outcomes and patient impairment. Using advanced magnetic resonance imaging (MRI) methods, consisting of selective inversion recovery quantitative magnetization transfer imaging (SIR-qMT) and multi-compartment diffusion MRI with the spherical mean technique (SMT), we conducted a cross-sectional pilot study to assess myelin and axonal damage in the normal appearing white matter (NAWM) surrounding chronic black holes (cBHs) and how this pathology correlates with disability in vivo. Read More

View Article and Full-Text PDF
January 2021

[The Italian National Center for Oncological Adrotherapy (CNAO): status and perspectives].

Authors:
Sandro Rossi

G Ital Med Lav Ergon 2020 Dec;42(4):247-251

Fondazione CNAO (Centro Nazionale di Adroterapia Oncologica), Pavia.

Summary: A complex particle accelerator has been built at the Italian National Centre for Oncological Adrotherapy in Pavia, called synchrotron, which is able to decompose atoms and create beams of particles to be directed to tumour cells in order to destroy them. It is the hadrontherapy, a very advanced radiation therapy for the treatment of X-ray resistant or inoperable tumours. In particular, the CNAO synchrotron in Pavia is the only one in Italy capable of extracting carbon ions from the atom, which are the most powerful particles capable of destroying the DNA of cancer cells while preserving the surrounding healthy tissues. Read More

View Article and Full-Text PDF
December 2020

Preserving pulp vitality: part two - vital pulp therapies.

Br Dent J 2021 Feb 12;230(3):148-155. Epub 2021 Feb 12.

School of Dentistry, University of Birmingham, UK.

Vital pulp therapies (VPTs) aim to preserve the vitality of the pulp. The European Society of Endodontology have begun a campaign to raise awareness on the efficacy of VPTs following on from the publication of their 2019 position statement, aimed at both specialists and general dental practitioners. This review examines the current evidence surrounding VPTs and provides a rational approach to the management of the exposed pulp with the aid of case studies. Read More

View Article and Full-Text PDF
February 2021

Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments.

Cells 2021 Jan 22;10(2). Epub 2021 Jan 22.

Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, Italy.

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as "addicted to the host"; indeed, the crosstalk between leukemic cells and the tumor microenvironment is essential for leukemic clone maintenance supporting CLL cells' survival, proliferation, and protection from drug-induced apoptosis. CLL cells are not innocent bystanders but actively model and manipulate the surrounding microenvironment to their own advantage. Read More

View Article and Full-Text PDF
January 2021

Preserving pulp vitality: part one - strategies for managing deep caries in permanent teeth.

Br Dent J 2021 Jan 22;230(2):77-82. Epub 2021 Jan 22.

School of Dentistry, University of Birmingham, UK.

This is the first article in a series reviewing the current literature surrounding the management of deep caries in permanent teeth. Approaches to caries management are continuing to evolve, with more conservative management increasingly favoured. This philosophy has never been more important than in managing the deep carious lesion. Read More

View Article and Full-Text PDF
January 2021

[A Successful Case of Pancreaticoduodenectomy after Neoadjuvant Therapy for Pancreatic Head Cancer with Acute Pancreatitis Due to Iatrogenic Injury of the Pancreatic Duct].

Gan To Kagaku Ryoho 2021 Jan;48(1):118-120

Dept. of Surgery, Tohoku University Graduate School of Medicine.

A 64-year-old woman was referred to our hospital for treatment of pancreatic head cancer with acute pancreatitis due to iatrogenic injury of the pancreatic duct during endoscopic retrograde cholangiopancreatography. In addition to a 28 mm pancreatic head tumor, soft tissue shadow and fluid collection surrounding the superior mesenteric artery(SMA)due to pancreatitis were observed in the abdominal CT scan. The tumor was histologically diagnosed as adenocarcinoma by endoscopic ultrasound-guided fine needle aspiration. Read More

View Article and Full-Text PDF
January 2021

Mesh patch and anchors can improve clinical results of prosthetic replacement after resection of primary proximal humerus malignant tumor.

Sci Rep 2021 Jan 12;11(1):734. Epub 2021 Jan 12.

Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, Beijing, People's Republic of China.

The purpose of this study was to evaluate the functional results, complications and related factors of prosthesis reconstruction after malignant tumor resection of primary proximal humeral, and also evaluate whether soft tissue reconstruction with mesh patch and anchors can improve clinical results. From 2002 to 2016, forty-one patients were enrolled in this study. The pathological diagnosis contained 27 cases of osteosarcoma, 7 cases of chondrosarcoma and other primary malignant bone tumors. Read More

View Article and Full-Text PDF
January 2021

A Case of Duodenal Neuroendocrine Tumor Accompanied by Gastrointestinal Stromal Tumors in Type 1 Neurofibromatosis Complicated by Life-Threatening Vascular Lesions.

Am J Case Rep 2021 Jan 11;22:e927562. Epub 2021 Jan 11.

Department of Medical Laboratory, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.

BACKGROUND Type 1 neurofibromatosis (NF1) is known to be associated with not only neurogenic tumors but also gastrointestinal (GI) neoplasms. However, there are few reports on vascular lesions and the incidence is unknown. CASE REPORT We report here the case of a 45-year-old woman with a history of NF1 referred to our hospital for the purpose of detailed examination for positive fecal occult blood test. Read More

View Article and Full-Text PDF
January 2021

Biomaterial-supported MSC transplantation enhances cell-cell communication for spinal cord injury.

Stem Cell Res Ther 2021 Jan 7;12(1):36. Epub 2021 Jan 7.

Department of Orthopedics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215000, Jiangsu Province, China.

The spinal cord is part of the central nervous system (CNS) and serves to connect the brain to the peripheral nervous system and peripheral tissues. The cell types that primarily comprise the spinal cord are neurons and several categories of glia, including astrocytes, oligodendrocytes, and microglia. Ependymal cells and small populations of endogenous stem cells, such as oligodendrocyte progenitor cells, also reside in the spinal cord. Read More

View Article and Full-Text PDF
January 2021

Laparoscopic middle colic artery-preserved right hemicolectomy with true D3 lymph node dissection for right-sided colon cancer: modified complete mesocolic excision.

Surg Endosc 2021 Jan 6. Epub 2021 Jan 6.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: Complete mesocolic excision (CME) has been demonstrated to be a useful surgical procedure for advanced colon cancer. We previously reported on laparoscopic (Lap) CME with true central vascular ligation (CVL) for advanced right-sided colon cancer. Lap CME with true CVL is highly plausible from the perspective of surgical oncology. Read More

View Article and Full-Text PDF
January 2021

Reply to: Beyond Money: Conscientious Objection in Medicine as a Conflict of Interests.

Authors:
Michal Pruski

J Bioeth Inq 2021 Mar 6;18(1):177-180. Epub 2021 Jan 6.

Manchester University NHS Foundation Trust, Manchester, UK.

Giubilini and Savulescu in their recent Journal of Bioethical Inquiry symposium article presented an account of conscientious objection that argues for its recognition as a non-financial conflict of interest. In this short commentary, I highlight some problems with their account. First, I discuss their solicitor analogy. Read More

View Article and Full-Text PDF

Finite Element Simulations of the ID Venous System to Treat Venous Compression Disorders: From Model Validation to Realistic Implant Prediction.

Ann Biomed Eng 2021 Jan 4. Epub 2021 Jan 4.

Department of Civil and Environmental Engineering, Politecnico di Milano, Milano, Italy.

The ID Venous System is an innovative device proposed by ID NEST MEDICAL to treat venous compression disorders that involve bifurcations, such as the May-Thurner syndrome. The system consists of two components, ID Cav and ID Branch, combined through a specific connection that prevents the migration acting locally on the pathological region, thereby preserving the surrounding healthy tissues. Preliminary trials are required to ensure the safety and efficacy of the device, including numerical simulations. Read More

View Article and Full-Text PDF
January 2021

Stress distribution patterns in mini-implant and bone in the infra-zygomatic crest region at different angulations: A finite element study.

J World Fed Orthod 2021 03 23;10(1):29-34. Epub 2020 Dec 23.

Professor and Head, Department of Orthodontics and Dentofacial Orthopaedics, Army College of Dental Sciences, Secunderabad, India. Electronic address:

Purpose: To evaluate, using the finite element method (FEM), von Mises stress patterns produced both in a mini-implant (MI) and the infra-zygomatic crest region (IZC) at different placement angles and force magnitudes.

Material And Methods: FEM modeling of an infra-zygomatic crest MI, of dimensions 2 mm × 12 mm, was designed and placed in the IZC bone. The MI was inserted at 50°, 60°, 70°, 80°, and 90° angulations to the IZC surface. Read More

View Article and Full-Text PDF

Voice banking for people living with motor neurone disease: Views and expectations.

Int J Lang Commun Disord 2021 Jan 22;56(1):116-129. Epub 2020 Dec 22.

Language and Cognition, University College London, London, UK.

Background: More than 80% of people living with MND (plwMND) develop difficulties with their speech, affecting communication, self-identity and quality of life. Most plwMND eventually use an augmentative and alternative communication device (AAC) to communicate. Some AAC devices provide a synthesized voice for speech, however these voices are often viewed as impersonal and a factor in AAC acceptance. Read More

View Article and Full-Text PDF
January 2021

Unveiling the controversy on egg freezing in The Netherlands: A Q-methodology study on women's viewpoints.

Reprod Biomed Soc Online 2021 Mar 9;12:32-43. Epub 2020 Nov 9.

Erasmus University Rotterdam, Erasmus School of Health Policy and Management, Rotterdam, the Netherlands.

Preserving the option to conceive through egg freezing (oocyte cryopreservation) is surrounded by value conflicts and diverse viewpoints, particularly when non-medical or so-called 'social' reasons are involved. The debate is controversial and shaped by normative perceptions of the life course, including concepts regarding reproductive ageing, gender, motherhood and biomedicalization. To unravel the controversy and systematically identify the variety of viewpoints on egg freezing, a Q-methodology study was conducted in The Netherlands between December 2018 and October 2019. Read More

View Article and Full-Text PDF

Marine reserve benefits and recreational fishing yields: The winners and the losers.

PLoS One 2020 10;15(12):e0237685. Epub 2020 Dec 10.

UPVD-CNRS, Centre de Formation et de Recherche sur les Environnements Méditerranéens, UMR 5110, Université de Perpignan Via Domitia, Perpignan, France.

Marine reserves constitute effective tools for preserving fish stocks and associated human benefits. However, not all reserves perform equally, and predicting the response of marine communities to management actions in the long run is challenging. Our decadal-scale survey of recreational fishing yields at France's 45-year old Cerbère-Banyuls marine reserve indicated significant protection benefits, with 40-50% higher fishing yields per unit effort in the partial-protection zone of the reserve (where fishing is permitted but at a lower level) than in surrounding non-reserve areas. Read More

View Article and Full-Text PDF
January 2021

Robotic Surgery for Rectal Cancer: Hype or Hope? (Indian Experience).

Indian J Surg Oncol 2020 Dec 8;11(4):604-612. Epub 2020 Jun 8.

Manipal Comprehensive Cancer Center, Manipal Hospital, Bangalore, 560017 India.

The primary goal to achieve cure in oncology is to reduce recurrence, maximize disease-free survival, maintain function, and optimize quality of life. Surgery remains the mainstay treatment modality in rectal cancer. The current trend is to perform least invasive method of doing complex surgeries while not compromising in the oncological of functional outcomes of patients. Read More

View Article and Full-Text PDF
December 2020

Extracellular Vesicles as Drug Delivery Systems in Cancer.

Pharmaceutics 2020 Nov 26;12(12). Epub 2020 Nov 26.

Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.

Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Differentiated Cancer Cells (DCCs) may reverse their phenotype and gain CSC-like features to preserve tumor progression and ensure tumor survival. This strongly suggests the existence of paracrine communication within tumor cells. Read More

View Article and Full-Text PDF
November 2020

An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration.

J Neuroinflammation 2020 Nov 27;17(1):359. Epub 2020 Nov 27.

Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.

Background: Inflammation and particularly interleukin-1β (IL-1β), a pro-inflammatory cytokine highly secreted by activated immune cells during early AMD pathological events, contribute significantly to retinal neurodegeneration. Here, we identify specific cell types that generate IL-1β and harbor the IL-1 receptor (IL-1R) and pharmacologically validate IL-1β's contribution to neuro-retinal degeneration using the IL-1R allosteric modulator composed of the amino acid sequence rytvela (as well as the orthosteric antagonist, Kineret) in a model of blue light-induced retinal degeneration.

Methods: Mice were exposed to blue light for 6 h and sacrificed 3 days later. Read More

View Article and Full-Text PDF
November 2020

Stromal vapors for real-time molecular guidance of breast-conserving surgery.

Sci Rep 2020 11 18;10(1):20109. Epub 2020 Nov 18.

Division of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute (M4I), University of Maastricht, Maastricht, The Netherlands.

Achieving radical tumor resection while preserving disease-free tissue during breast-conserving surgery (BCS) remains a challenge. Here, mass spectrometry technologies were used to discriminate stromal tissues reported to be altered surrounding breast tumors, and build tissue classifiers ex vivo. Additionally, we employed the approach for in vivo and real-time classification of breast pathology based on electrosurgical vapors. Read More

View Article and Full-Text PDF
November 2020