1,380 results match your criteria preserving fertility

A Stereological Study of Mouse Ovary Tissues for 3D Bioprinting Application.

Cell Mol Bioeng 2021 Jun 15;14(3):259-265. Epub 2021 Mar 15.

Department of Gynecology, Second Hospital, Hebei Medical University, No.215, He Ping Road (West), Xin Hua District, Shijiazhuang, Hebei Province China.

Introduction: The use of 3D-bioprinted ovaries has been proven to be a promising technique for preserving fertility. Stereology is an accurate method to obtain quantitative 3D information and the stereological data is the basis for 3D bioprinting ovaries.

Methods: In this study, six female mice were used to acquire the ovarian tissues. Read More

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Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression.

Cell Biosci 2021 Jun 7;11(1):107. Epub 2021 Jun 7.

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, China.

Background: Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline stem cells (FGSCs) in response to aging caused by oxidative stress.

Results: We found that Spermidine (SPD) significantly increased protein expression of autophagy markers microtubule-associated protein 1 light chain 3 beta-II (MAP1LC3B-II/LC3B-II) and sequestosome-1/p62 (SQSTM1/p62), and evoked autophagic flux in FGSCs. Read More

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Characteristics of progestin-insensitive early stage endometrial cancer and atypical hyperplasia patients receiving second-line fertility-sparing treatment.

J Gynecol Oncol 2021 Jul;32(4):e57

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: This study investigated the characteristics of progestin-insensitive endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH) patients receiving fertility-sparing treatments and assessed the therapeutic effects of second-line fertility-preserving treatments.

Methods: Three hundred and thirty-eight patients with EEC (n=75) or AEH (n=263) receiving fertility-preserving treatment were retrospectively analyzed. 'Progestin-insensitive' was defined as meeting one of the following criteria: 1) presented with progressed disease at any time during conservative treatment, 2) remained with stable disease after 7 months of treatment, and/or 3) did not achieve complete response (CR) after 10 months of treatment. Read More

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A novel low uterine segment sandwich technique (Caliskan's technique) for the management of post-cesarean hemorrhage due to placenta previa accreta

Turk J Obstet Gynecol 2021 06;18(2):79-84

Okan University School of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey

Objective: Placenta previa (PP) and placenta accreta spectrum (PAS) disorders are major causes of postpartum hemorrhage (PPH). There is a variety of surgical management options with inexplicit reported success rates. Uterine sandwich is a combination of uterine compression sutures and intrauterine balloon placement to achieve hemostasis. Read More

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Successful pregnancy following transmyometrial embryo transfer after robot-assisted radical trachelectomy.

Clin Exp Reprod Med 2021 Jun 25;48(2):184-187. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Radical trachelectomy is a fertility-preserving alternative to radical hysterectomy in carefully selected young women with early-stage cervical cancer. However, in cases with subsequent severe cervical stenosis, assisted reproductive techniques can be difficult. This is a case report of a 34-year-old patient who underwent robot-assisted radical trachelectomy and cerclage for early-stage (IB2) adenosquamous carcinoma. Read More

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Pediatric and Adolescent Oncofertility in Male Patients-From Alpha to Omega.

Genes (Basel) 2021 May 8;12(5). Epub 2021 May 8.

2nd Department of Surgery-Pediatric Surgery and Orthopedics, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.

This article reviews the latest information about preserving reproductive potential that can offer enhanced prospects for future conception in the pediatric male population with cancer, whose fertility is threatened because of the gonadotoxic effects of chemotherapy and radiation. An estimated 400,000 children and adolescents aged 0-19 years will be diagnosed with cancer each year. Fertility is compromised in one-third of adult male survivors of childhood cancer. Read More

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Overview of fertility sparing treatments for cervical cancer.

Thomas Ind

Best Pract Res Clin Obstet Gynaecol 2021 May 6. Epub 2021 May 6.

Royal Marsden Hospital, London, SW3 6JA, UK; St George's University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK. Electronic address:

Until the late 1980s, the mainstay of treatment for cervical cancer has been either hysterectomy or radiotherapy. From the mid to late 1990s, surgical treatments have been focussed more on sparing fertility by preserving the corpus of the womb with trachelectomy or even conserving part of the cervical stroma with a cone biopsy. In carefully selected cases, less radical treatment that preserves the uterus has been considered safe. Read More

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Fertistat: a potential tool for adolescent sexual health.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Geneva University Hospitals, Department of Woman, Child and Adolescent, Catherine McCarey, Department of Woman, Child and Adolescent, Geneva University Hospitals, 30, boulevard de la Cluse, 1205 Geneva, Switzerland.

The FertiStat (fertility status awareness) tool provides personalized advice on reducing risk factors for infertility and seeking medical advice based on lifestyle and reproductive profile.

Study Objective: The aim of our research was to test the FertiStat tool in younger patients (14-24 years). A secondary objective was to screen for and evaluate knowledge of risk factors impacting fertility. Read More

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Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats.

Life Sci 2021 Aug 11;278:119605. Epub 2021 May 11.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult male rats by high-fat diet consumption for 12 weeks, accompanied by a single dose streptozotocin injection. Read More

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Abdominal radical trachelectomy as fertility-sparing management for early stages of cervical cancer: Our experience in 18 cases.

Exp Ther Med 2021 Jul 23;22(1):674. Epub 2021 Apr 23.

First Obstetrics and Gynecology Clinic, 'George Emil Palade' University of Medicine, Pharmacy, Science and Technology, 540136 Târgu Mures, Romania.

The aim of this study was to present our experience of 18 cases of abdominal radical trachelectomy (ART), including 5 performed during pregnancy, analyzing patient selection, surgical complications, and oncological and obstetrical outcomes. This reproductive study included all early stage cervical cancer patients referred for ART at the 1st Obstetrics and Gynecology Clinic of the Emergency Clinical County Hospital Targu Mures, between 2010 and 2020. A total of 19 women were considered for ART, and only 1 case required conversion to radical hysterectomy. Read More

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The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):506-519. Epub 2021 Mar 22.

Center for Innovative Medical Technologies "European Clinic", Moscow, Russian Federation.

Cervical cancer is an important problem in women's health and a worldwide oncological disease. In 2018, the WHO registered 569,847 new cases in the world, and 3.4% were in the Russian Federation. Read More

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Cryopreservation of Orchid Pollinia Using the V Cryo-Plate Method.

Cryo Letters 2021 Jan-Feb;42(1):25-32

Department of Plant Science, Faculty of Science, Mahidol University, Bangkok, Thailand.

Background: Preserving pollinia viability and fertility for pollination at specific times of the year is very important in orchid breeding. One possible method is cryopreservation using aluminium cryo-plate which is increasingly used for the long-term storage of plant genetic resources.

Objective: To determine a V cryo-plate method for the cryopreservation of orchid pollinia and apply it to some Thai orchid species for breeding. Read More

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Experience of the "Prof. Dr. Panait Sarbu" Hospital in Oncofertility among Breast Cancer Patients.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):105-109

Oncofertility represents a new field, dedicated to patients at childbearing age who are diagnosed with a neoplasic disease and who want to have a biologic child after they complete the oncological and surgical treatment. Because of new screening and treatment methods, most patients survive the disease, but the main long-term complication remains infertility. Young women with breast cancer are candidates for preserving their fertility mostly because of the risk of chemotherapy-related infertility due to the alkylating agent, causing dose-dependent destruction of oocytes and follicular depletion and thus bringing cortical fibrosis and ovarian blood-vessel damage (1). Read More

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Management and Recommendations for Future Pregnancy in Patients with Early-Stage Endometrial Cancer: A Survey of Gynecologic Oncologists and Reproductive Endocrinology and Infertility Specialists.

J Adolesc Young Adult Oncol 2021 May 6. Epub 2021 May 6.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

To determine how young patients with early-stage endometrial cancer are counseled regarding fertility preserving therapy and pregnancy options by gynecologic oncology and reproductive endocrinology and infertility (REI) providers. Anonymous online survey of Society of Gynecology Oncology (SGO) and the Society for Reproductive Endocrinology and Infertility (SREI) members; data were analyzed using chi-square and -tests. Twelve percent (169/1433) of SGO and 6. Read More

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Artificial testis: a testicular tissue extracellular matrix as a potential bio-ink for 3D printing.

Biomater Sci 2021 May;9(9):3465-3484

Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran. and Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Testicular scaffolds may be an option for fertility preservation. The aim was to develop various procedures for the decellularization of testicular tissue and to design a bio-ink to construct a bioartificial testis. Ram testicular tissue fragments were decellularized using NaCl buffer, NaCl buffer-Triton, SDS and SDS-Triton. Read More

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Cardiovascular disease among pregnant women after anticancer therapy.

J Obstet Gynaecol Res 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Osaka, Japan.

Recent advances in cancer therapies have enabled many women diagnosed with malignancies during childhood and adolescence to survive longer and therefore to reach an age where they wish to conceive. When providing cancer treatment such as anticancer drugs and radiotherapy, attention is often paid to preserving future fertility, but little is known about maternal pregnancy risks, and in particular cardiovascular complications. Recent studies have shown that cardiovascular diseases such as cardiomyopathy, heart failure, and arrhythmias often occur during and soon after anticancer therapy. Read More

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Retrospective Analysis of Factors Affecting Recurrence in Borderline Ovarian Tumors.

South Asian J Cancer 2020 Jul 19;9(3):168-173. Epub 2021 Mar 19.

Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.

 Borderline ovarian tumors (BOTs) are an intermediate form of neoplasia, between benign and malignant. The aim of this retrospective analysis is to evaluate the clinicopathological characteristic profile of BOTs and to determine the predictors of recurrence in BOTs.  A retrospective review of all patients diagnosed, treated, and followed up for BOTs between 2010 and 2017 at Amrita Institute of Medical Sciences, Kerala, India, was conducted. Read More

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A Duplicated Copy of the Meiotic Gene Preserves up to 50% Pollen Viability and Grain Number in Polyploid Wheat.

Biology (Basel) 2021 Apr 2;10(4). Epub 2021 Apr 2.

Crop Genetics Department, John Innes Centre, Colney, Norwich NR4 7UH, UK.

Although most flowering plants are polyploid, little is known of how the meiotic process evolves after polyploidisation to stabilise and preserve fertility. On wheat polyploidisation, the major meiotic gene on chromosome 3B duplicated onto 5B and diverged (). was recently shown to promote homologous pairing, synapsis and crossover, and suppress homoeologous crossover. Read More

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Cesarean Scar Ectopic Pregnancy-Case Series: Treatment Decision Algorithm and Success with Medical Treatment.

Medicina (Kaunas) 2021 Apr 8;57(4). Epub 2021 Apr 8.

FEA Obstetric and Gynecology Hospital Regional Materno Infantil, C.P.29011 Málaga, Spain.

: Cesarean scar ectopic pregnancies are a rare form of extrauterine pregnancies, yet their incidence has increased along with the rise in the number of cesarean deliveries. As with other ectopic pregnancies, cesarean scar ectopic pregnancies pose a greater risk for maternal hemorrhage and ultimately maternal mortality. : We present a series of clinical cases of cesarean scar ectopic pregnancy diagnosed by transvaginal ultrasonography. Read More

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Vascular Dysfunction after Modeled Traumatic Brain Injury Is Preserved with Administration of Umbilical Cord Derived Mesenchymal Stromal Cells and Is Associated with Modulation of the Angiogenic Response.

J Neurotrauma 2021 Jun 9. Epub 2021 Jun 9.

Keenan Research Centre, St. Michaels's Hospital, Toronto, Ontario, Canada.

Vascular dysfunction arising from blood-brain barrier (BBB) breakdown after traumatic brain injury (TBI) can adversely affect neuronal health and behavioral outcome. Pericytes and endothelial cells of the neurovascular unit (NVU) function collectively to maintain strict regulation of the BBB through tight junctions. Secondary injury mechanisms, such as pro-angiogenic signals that contribute to pericyte loss, can prolong and exacerbate primary vascular injury. Read More

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Long-term follow-up of endometriosis surgery in Ontario: a population-based cohort study.

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynaecology, Queen's University, Kingston Health Sciences Centre, Kingston, Ontario, Canada; Institute for Clinical Evaluative Sciences, Queen's University, Kingston, Ontario, Canada.

Background: Endometriosis is a chronic gynecological disease affecting approximately 10% of reproductive aged females and leads to decreased quality of life and productivity. Despite effective medical options, many women do require surgery for endometriosis. There is limited literature examining long term outcomes of endometriosis surgery. Read More

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Updates on conservative management of endometrial cancer in patients younger than 45 years.

Gynecol Oncol 2021 Jun 20;161(3):802-809. Epub 2021 Apr 20.

Department of Gynecology and Obstetrics, Sanatorio Allende, Córdoba, Argentina.

Endometrial cancer is the most common gynecologic malignancy in developed country. Women under the age of 40 represent 5% of all endometrial cancer and the majority are nulliparous at the time of diagnosis. The aim of this review was to compare oncologic and fertility outcomes among different fertility-preserving therapies in patients under 45 years of age with grade 1 or 2 endometrial cancer. Read More

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An appraisal of current service delivery and future models of care for young people with gender dysphoria.

Eur J Pediatr 2021 Apr 14. Epub 2021 Apr 14.

Department of Paediatric Endocrinology, Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF, UK.

The clinical needs of young people with gender dysphoria (GD) have outpaced the capacity of health services to provide appropriate care. The study aimed to explore the interface of Paediatric Endocrinology and young people with GD, detailing the clinical characteristics and the clinical care provided, in order to inform future service development. Medical records of all young people with GD (n=91, 59 (65%) birth-assigned females and 32 (35%) birth-assigned males) referred to Paediatric Endocrinology during 2011-2019 for puberty suppression were reviewed. Read More

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Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol.

Adv Ther 2021 05 8;38(5):2717-2731. Epub 2021 Apr 8.

Gynecology Department, Hospital El Pilar, Barcelona, Spain.

Introduction: Endometrial cancer is the fifth most common cancer in women and atypical endometrial hyperplasia is a precancerous lesion. Obesity is an important risk factor for endometrioid endometrial adenocarcinoma and endometrial hyperplasia. Progesterone is recommended as first-line treatment in endometrial cancer or atypical endometrial hyperplasia in women who wish to preserve fertility, but optimal treatment schedules have not been defined. Read More

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Clinical features of congenital complete vaginal atresia combined with cervical aplasia: A retrospective study of 19 patients and literature review.

Congenit Anom (Kyoto) 2021 Apr 8. Epub 2021 Apr 8.

Gynecologic Department, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.

Congenital vaginal atresia is a rare congenital reproductive tract abnormality. To assess the clinical manifestations and feasibility of preserving uterus for congenital complete vaginal atresia with cervical aplasia, nineteen cases who underwent surgical treatment in West China Second Hospital of Sichuan University were retrospectively studied. The cervical status, clinical manifestations, the rate of vaginal re-stenosis and pelvic inflammation after surgery were assessed. Read More

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Preservation of female fertility: The current therapeutic strategy.

Int J Gynaecol Obstet 2021 Apr 8. Epub 2021 Apr 8.

Center for Assisted Medical Procreation-University of Liège, CHR Liège Hospital, Liège, Belgium.

Background: Preservation of female fertility is a relatively new field in medicine that has grown very rapidly in recent decades. At the beginning, embryo freezing remained the most effective technique. Thereafter, cryopreservation of oocytes and ovarian tissue was considered a secure tool in human fertility preservation. Read More

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The Effectiveness of Anti-Apoptotic Agents to Preserve Primordial Follicles and Prevent Tissue Damage during Ovarian Tissue Cryopreservation and Xenotransplantation.

Int J Mol Sci 2021 Mar 3;22(5). Epub 2021 Mar 3.

Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.

The purpose of this study is to investigate the effectiveness of sphingosine-1-phosphate (S1P) and Z-VAD-FMK (Z-VAD) as anti-apoptotic agents to preserve ovarian function and prevent tissue damage during ovarian tissue cryopreservation and transplantation. This study consisted of two steps, in vitro and in vivo. In the first step, human ovarian tissues were cryopreserved using slow-freezing media alone, S1P, or Z-VAD (control, S1P, Z-VAD group); based on the outcomes in these groups, Z-VAD was selected for subsequent xenotransplantation. Read More

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A new and feasible uterine compression suture technique in uterine atony to save mothers from postpartum hemorrhage.

Niger J Clin Pract 2021 Mar;24(3):335-340

Department of Obstetrics and Gynecology, Zonguldak Bülent Ecevit University Hospital, Zonguldak, Turkey.

Background: Postpartum hemorrhage (PPH) is one of the emergency situations of obstetrics practice that constitutes of 1 to 5% of vaginal and cesarean deliveries. Uterine atony is the number one cause of PPH and is responsible for at least 75% of PPH cases. Uterine compression sutures have been regarded as an effective method in PPH cases, as well as preserving fertility by preserving the uterus. Read More

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In Vitro Activation and Development of Goat Preantral Follicles Enclosed in Ovarian Tissue Co-cultured with Mesenchymal Stem Cells.

Reprod Sci 2021 Jun 15;28(6):1709-1717. Epub 2021 Mar 15.

Integrated Nucleus of Morphology and Research with Stem Cells (NUPCelt), Federal University of Piauí, Teresina, PI, Brazil.

The development of culture systems capable of maintaining follicular growth since the preantral stage has been the target of investigations. Mesenchymal stem cells (MSC) present potential for use in a wide range of applications, including research aimed at preserving fertility. Therefore, this study investigated the use of caprine Wharton's Jelly Mesenchymal Stem Cells (WJMSC) on the survival and in vitro development of goat preantral follicles enclosed in ovarian fragments cultured for 1 or 7 days. Read More

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A call to action: unified clinical practice guidelines for oncofertility care.

J Assist Reprod Genet 2021 Mar 11. Epub 2021 Mar 11.

Vios Fertility Institute, 1455 N Milwaukee Ave, Chicago, IL, 60622, USA.

By 2030, WHO estimates that 1.4 million reproductive-aged women will be diagnosed with cancer annually. Fortunately, cancer is no longer considered an incurable disease in many cases. Read More

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