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Ethics, Integrity and Retributions of Digital Detection Surveillance Systems on Infectious Diseases: Systematic literature review.

J Med Internet Res 2021 Sep 14. Epub 2021 Sep 14.

Department of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 3/F, Ap Lei Chau Clinic161 Main Street, Ap Lei Chau, Hong Kong, HK.

Background: The COVID-19 pandemic has raised the importance of the deployment of digital detection surveillance systems to support early warning and monitoring of infectious diseases (ID). These opportunities create a "double-edge sword" as the ethical governance of such approaches often lag behind technological achievements.

Objective: The aim was to investigate ethical issues identified from utilizing AI-augmented surveillance or early warning systems to monitor and detect common or novel ID outbreaks. Read More

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September 2021

Galcanezumab in Patients with Multiple Previous Migraine Preventive Medication Category Failures: Results from the Open-Label Period of the CONQUER Trial.

Adv Ther 2021 Sep 20. Epub 2021 Sep 20.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.

Introduction: Results from the open-label extension of the phase 3b CONQUER trial are presented to evaluate the effectiveness and safety of galcanezumab, a monoclonal antibody targeting calcitonin gene-related peptide, for up to 6 months in patients with multiple prior migraine preventive treatment failures.

Methods: Patients were 18-75 years old with episodic or chronic migraine and 2-4 standard-of-care migraine preventive medication category failures. After 3 months of randomized treatment with galcanezumab (120 mg/month with 240 mg loading dose; n = 232) or placebo (n = 230), patients entered a 3-month open-label extension (120 mg/month galcanezumab with a blinded 240 mg loading dose for previous-placebo patients). Read More

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September 2021

Fetal and perinatal expression profiles of proinflammatory cytokines in the neuroplacodes of rats with myelomeningoceles: A contribution to the understanding of secondary spinal cord injury in open spinal dysraphism.

J Neurotrauma 2021 Sep 19. Epub 2021 Sep 19.

Universitätsklinikum Schleswig-Holstein, 54186, Neurosurgery, Kiel, Schleswig-Holstein, Germany.

The cellular and molecular mechanisms that presumably underlie the progressive functional decline of the myelomeningocele (MMC) placode are not well understood. We previously identified key players in posttraumatic spinal cord injury cascades in human MMC tissues obtained during postnatal repair. In this study we conducted experiments to further investigate these mediators in the prenatal time course under standardized conditions in a retinoic-acid-induced MMC rat model. Read More

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September 2021

Neutral Comet Assay to Detect and Quantitate DNA Double-Strand Breaksin Hematopoietic Stem Cells.

Bio Protoc 2021 Aug 20;11(16):e4130. Epub 2021 Aug 20.

School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Kerala, 695 551, India.

In vertebrates, hematopoietic stem cells (HSCs) regulate the supply of blood cells throughout the lifetime and help to maintain homeostasis. Due to their long lifespan, genetic integrity is paramount for these cells, and accordingly, a number of stem cell-specific mechanisms are employed. However, HSCs tend to show more DNA damage with increasing age due to an imbalance between proliferation rates and DNA damage responses. Read More

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Correlation of plasma galectin-3 and plasma lipoprotein-associated phospholipase A2 with the severity and prognosis of coronary artery disease.

Am J Transl Res 2021 15;13(8):8997-9004. Epub 2021 Aug 15.

Cardiovascular Department, The First Affiliated Hospital of Hebei North University Hebei, China.

Objective: To evaluate the correlation of galectin-3 (Gal-3) and lipoprotein-associated phospholipase A2 (Lp-PLA2) with the severity of coronary artery disease and major adverse cardiovascular events (MACE).

Methods: 130 patients diagnosed with coronary heart disease (CHD) by coronary angiography from October 2018 to August 2019 in the Department of Cardiology, the First Affiliated Hospital of Hebei North University, were matched into the CHD group, with 68 cases in the mild stenosis (MS) group (degree of stenosis 50%~75%), and 62 cases in the severe stenosis (SS) group (degree of stenosis ≥75%). For comparison, patients with negative results of angiography during the same period (stenosis degree <50%) were assigned to the normal group. Read More

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Template-directed synthesis of zeolitic imidazolate framework-8 derived Zn-Al layered double oxides decorated on the electrochemically anodized nanoporous aluminum substrate for thin film microextraction of chlorophenols followed by determination with high-performance liquid chromatography.

J Chromatogr A 2021 Sep 10;1656:462550. Epub 2021 Sep 10.

Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.

In this work, hierarchical ZIF-8 coated anodized aluminum foil was prepared through in situ template-directed method without addition of any zinc salt. The hierarchical sorbent was synthesized by the formation of the final HZIF-8 on the previously created layered double oxide (LDO) template. The LDO template was created by calcining the firstly in situ prepared desired layered double hydroxide (LDH) precursor coated on the electrochemically anodized porous Al foil in an air atmosphere. Read More

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September 2021

Efficacy of Vibegron and Mirabegron for Overactive Bladder: A Systematic Literature Review and Indirect Treatment Comparison.

Adv Ther 2021 Sep 18. Epub 2021 Sep 18.

Urovant Sciences, Irvine, CA, USA.

Background: In the absence of head-to-head trials, we performed an indirect treatment comparison of the β-adrenergic agonists vibegron and mirabegron in the treatment of overactive bladder (OAB).

Methods: PubMed, Embase, and Cochrane Library were searched for articles related to phase 3, double-blind, controlled trials of vibegron 75 mg and mirabegron 25/50 mg in patients with OAB. Efficacy outcomes included change from baseline at weeks 4, 12, and 52 in mean daily number of total urinary incontinence episodes and micturitions and mean volume voided/micturition. Read More

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September 2021

Safety of Eslicarbazepine Acetate in Elderly Versus Non-Elderly Patients with Focal Seizures: From Pooled Data of Clinical Studies to 8 Years of Post-Marketing Experience.

Drug Saf 2021 Sep 18. Epub 2021 Sep 18.

Division of Research and Development, Bial-Portela & Cª, S.A., À Avenida da Siderurgia Nacional, 4745‑457, Coronado (S. Romão e S. Mamede), Portugal.

Introduction: The prevalence of epilepsy increases in elderly patients aged > 65 years, and treatment is challenging because clinical data are limited.

Objective: Our objective was to evaluate the safety of eslicarbazepine acetate (ESL) in patients aged ≥ 65 years versus non-elderly patients with focal seizures.

Methods: The safety data of seven phase II and III, double-blind, open-label, randomized clinical studies of ESL in adults were pooled. Read More

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September 2021

A Forgotten Ureteral Stent: Potential Risks for the Urinary Function.

Urol Int 2021 Sep 14:1-4. Epub 2021 Sep 14.

Department of Urology, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.

A 32-year-old man presented with painless macrohaematuria. An endoscopic stone removal of the upper moiety of a left double kidney with ureter duplex was performed 4 years ago. The inserted ureteral catheter (DJ) was not removed although it was communicated to the patient and written in the discharge report. Read More

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September 2021

Forgotten DJ stent presenting with emphysematous pyelonephritis: A life threatening complication.

Int J Surg Case Rep 2021 Sep 15;87:106405. Epub 2021 Sep 15.

Department of Surgery, Patan Hospital, Patan Academy of Health Sciences, Lalitpur, Nepal.

Introduction: Emphysematous pyelonephritis (EPN) is an uncommon suppurative infection of renal parenchyma and perirenal tissue characterized by production of gas within renal parenchyma, collecting system or perinephric tissue.

Case Presentation: We report a case of young non diabetic female with past history of extracorporeal shock wave lithotripsy (ESWL) who presented with intermittent lower abdominal pain, dysuria and left lower limb swelling. Abdomen examination was notable for tenderness at left iliac fossa and fullness at left renal angle. Read More

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September 2021

Successful retrograde intrarenal surgery (RIRS) for a 2-centimeter stone in a chronic renal failure (CRF) patient.

Int J Surg Case Rep 2021 Sep 14;87:106375. Epub 2021 Sep 14.

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Importance: Retrograde intrarenal surgery (RIRS) is the best complementary method to Flexible Ureterorenoscopy (URF). In the case of renal insufficiency in patients with urolithiasis, the stone treatment strategy can be different because it should have the least injury to the kidney and be minimally invasive. There was no previous evidence of RIRS in stone-breaking in a chronic renal failure (CRF) patient. Read More

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September 2021

Double whammy: anticoagulant-related nephropathy with leukocytoclastic vasculitis due to warfarin.

CEN Case Rep 2021 Sep 17. Epub 2021 Sep 17.

Department of Nephrology, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi, 110060, India.

Anticoagulation-related nephropathy (ARN) is a rare form of acute kidney injury where the use of anticoagulation causes hemorrhage in various compartments of nephron including glomerulus, renal tubules, and interstitial compartment. Also, warfarin-induced vasculitis is an extremely rare condition characterized by the appearance of purpuric lesions on the skin which on biopsy are suggestive of leukocytoclastic vasculitis (LV). We hereby report a case presenting with coexistent warfarin-induced nephropathy and cutaneous vasculitis. Read More

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September 2021

Hydrogen peroxide as auxiliary treatment for COVID-19: A randomized double-blind clinical trial.

Epidemiol Health 2021 Aug 3:e2021051. Epub 2021 Aug 3.

University of Passo Fundo, Passo Fundo, Brazil.

Objectives: Evaluate the effectiveness of hydrogen peroxide (H2O2) as mouthwash and nasal spray on the relief of symptoms for COVID-19 patients.

Methods: Patients positive for SARS-CoV-2, treated in hospital or at home, and patients' family members (not positive for SARS-CoV-2), were randomized into two groups: experimental (1% H2O2 for gargling, 0.5% H2O2 for nasal wash), and control. Read More

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The effects of anaerobic reactor post-treatments by rapid filtration systems and conventional techniques.

Environ Sci Pollut Res Int 2021 Sep 16. Epub 2021 Sep 16.

Research Group on Environmental and Sanitary Analytical Chemistry, State University of Ponta Grossa, Av. General Carlos Cavalcanti, 4748, Ponta Grossa, PR, 84030-900, Brazil.

Although anaerobic reactors are an excellent alternative in the treatment of domestic effluents, they have the disadvantage of requiring post-treatment. Many technologies have been studied and, recently, rapid filtration systems have been presented as a viable alternative for post-treatment. This work compared post-treatment techniques for anaerobic upflow sludge blanket (UASB) reactors by rapid filtration systems (double filtration (DF); triple filtration with clinoptilolite (TFc); and triple filtration with activated carbon (TFac)) to conventional systems (facultative pond (FP); biological filter (BF); biological filter with recirculation and decantation (BFD)), verifying their potential for improvement of the final effluent quality. Read More

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September 2021

Supernumerary lacrimal puncta: Case series.

Saudi J Ophthalmol 2020 Oct-Dec;34(4):328-330. Epub 2021 Jul 29.

King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Supernumerary lacrimal punctum is rare, and very few cases have been reported. Most patients are asymptomatic, but in some excessive tearing could be a symptom. In addition, obstruction of the canaliculi causing canaliculitis has been reported. Read More

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Maintenance Therapy with Pembrolizumab after Platinum-Doublet Chemotherapy Leading to Hyperprogression in a Patient with Metastatic Bladder Cancer.

Asia Pac J Oncol Nurs 2021 Sep-Oct;8(5):586-590. Epub 2021 Aug 27.

Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China.

The anti-programmed cell death receptor 1 (anti-PD-1) immunotherapy has been recommended in several treatment scenarios of metastatic urothelial cancer (UC), including as a maintenance therapy after first-line chemotherapy. However, the PD-1 inhibitor accelerates tumor growth occasionally, causing hyperprogressive disease (HPD). We presented here a case of HPD in a 43-year-old male Chinese patient with bladder UC, metastasizing to liver and bone, and harboring amplification of , and 2. Read More

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Intoxication by Hand-Sanitizers and other Toxic Alcohols in a Low-Resource Setting: Two Case Reports.

Eur J Case Rep Intern Med 2021 3;8(8):002751. Epub 2021 Aug 3.

Department of Internal Medicine, Curaçao Medical Center, Curaçao.

Toxic alcohol poisoning can be lethal if not identified early and treated appropriately. Toxic alcohol assays are often unavailable in low-resource setting, so clinicians have to infer a diagnosis based on suspicion, repeated evaluation and biochemical course. We report a case of toxic alcohol poisoning concealed by auto-intoxication with in-hospital hand sanitizer. Read More

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Dynamic capacity allocation in a radiology service considering different types of patients, individual no-show probabilities, and overbooking.

BMC Health Serv Res 2021 Sep 14;21(1):968. Epub 2021 Sep 14.

Mathematics Department, Universidade Federal de Mato Grosso, Cuiabá, Brazil.

Background: We propose a mathematical model formulated as a finite-horizon Markov Decision Process (MDP) to allocate capacity in a radiology department that serves different types of patients. To the best of our knowledge, this is the first attempt at considering radiology resources with different capacities and individual no-show probabilities of ambulatory patients in an MDP model. To mitigate the negative impacts of no-show, overbooking rules are also investigated. Read More

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September 2021

Outbreak of oral ulcers (glossitis) among the students of three central schools under Tsirang district Bhutan, 2018.

BMC Oral Health 2021 Sep 14;21(1):444. Epub 2021 Sep 14.

Yebilaptsa Hospital, Zhemgang District, Bhutan.

Background: Nutritional deficiencies are common worldwide and is most notable in low and middle income countries. In the early weeks of September 2018, oral sores mostly affecting the tongue were reported in three central schools under Tsirang district, Bhutan. A total of 204 students were affected in the three central schools. Read More

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September 2021

Improved SARS-CoV-2 PCR detection and genotyping with double-bubble primers.

Biotechniques 2021 Sep 14. Epub 2021 Sep 14.

Keenan Research Centre for Biomedical Science of St Michael's Hospital, Unity Health Toronto & The Departments of Surgery, St Michael's Hospital & The University of Toronto, Toronto, Canada.

A new approach for improved RT-PCR is described. It is based on primers designed to form controlled stem-loop and homodimer configurations, hence the name 'double-bubble' primers. The primers contain three main regions for efficient RT-PCR: a 3' short overhang to allow reverse transcription, a stem region for hot start and a template-specific region for PCR amplification. Read More

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September 2021

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy.

Am J Case Rep 2021 Sep 14;22:e932959. Epub 2021 Sep 14.

Department of Rheumatology, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

BACKGROUND Patients with late-onset systemic lupus erythematosus (SLE) do not present with typical SLE symptoms or serology, and this can lead to a major delay in diagnosis. We report a complex case of an older woman who developed autoimmune hemolytic anemia and sixth cranial nerve palsy that posed considerable challenges in diagnosing late-onset SLE. CASE REPORT A 78-year-old Japanese woman presented with polyarthritis associated with generalized fatigue for 2 months, who later developed diplopia. Read More

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September 2021

Zinc Pthalocyanine loaded poly (lactic acid) nanoparticles by double emulsion methodology for photodynamic therapy against 9 L/LacZ gliosarcoma cells.

J Biomater Sci Polym Ed 2021 Sep 13:1-13. Epub 2021 Sep 13.

Organic Synthesis Laboratory, Institute of Research and Development, University of Vale do Paraíba, São José dos Campos, Brazil.

Development delivery systems, such as nanoparticles, represent a growing area in biomedical research. Nanoparticles (NP) were prepared using a double-emulsion method to load zinc(II) phthalocyanine (ZnPc). NP were obtained using poly (lactic acid) (PLA). Read More

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September 2021

A microchip device based liquid-liquid-solid microextraction for the determination of permethrin and cypermethrin in water samples.

Talanta 2021 Dec 23;235:122731. Epub 2021 Jul 23.

Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran. Electronic address:

In this work, for the first time, a microchip device integrating liquid-liquid-solid phase microextraction is presented. As a novel approach to microchip systems, liquid-liquid-solid microextraction was performed in a sandwiched microchip device. The microchip device consisted of three poly(methyl methacrylate) layers along with a double "Y"-shaped microchannel. Read More

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December 2021

Fuzzy integral inequalities on coordinates of convex fuzzy interval-valued functions.

Math Biosci Eng 2021 Jul;18(5):6552-6580

Department of Mathematics and Statistics, College of Science, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia.

In this study, we introduce and study new fuzzy-interval integral is known as fuzzy-interval double integral, where the integrand is fuzzy-interval-valued functions (FIVFs). Also, some fundamental properties are also investigated. Moreover, we present a new class of convex fuzzy-interval-valued functions is known as coordinated convex fuzzy-interval-valued functions (coordinated convex FIVFs) through fuzzy order relation (FOR). Read More

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Child prodigies in Paris in the belle époque: Between child stars and psychological subjects.

Andrea Graus

Hist Psychol 2021 08;24(3):255-274

Centre Alexandre Koyre, Centre National de la Recherche Scientifique.

This article considers the double role of child prodigies as child stars and psychological subjects in Paris in the Belle Époque. I argue that the celebrity status of child prodigies during this time contributed to their transformation into objects of scientific curiosity. The notions of innate talent and natural-born genius contributed heavily to stories of child prodigies within the public sphere; these stories also circulated in psychological accounts of such children. Read More

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Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.

J Mol Histol 2021 Sep 12. Epub 2021 Sep 12.

Department of Endodontics, College of Stomatology, Tianjin Medical University, Num22, Road Qixiangtai, Heping District, Tianjin, 300070, China.

TRPA1 and TRPV1 channels respond to external stimulation as pain mediators and form a complex with a transmembrane protein TMEM100 in some tissues. However, their expression and interaction in dental pulp is unclear. To investigate the functional co-expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts (HODs), immunohistochemistry, immunofluorescence staining and Western blot were used to study their co-localization and expression in both native HODs and cultured HOD-like cells. Read More

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September 2021

Computational and NMR Conformational Analysis of Galactofuranoside Cycles Presented in Bacterial and Fungal Polysaccharide Antigens.

Front Mol Biosci 2021 25;8:719396. Epub 2021 Aug 25.

Laboratory of Glycoconjugate Chemistry, N.D. Zelinsky Institute of Organic Chemistry RAS, Moscow, Russia.

Unlike pyranoside cycles which are generally characterized by strictly defined conformational preferences, furanosides are flexible and may adopt a wide range of available conformations. During our previous studies, conformational changes of galactofuranoside cycles upon total sulfation were described computationally, using a simple Hartree-Fock (HF) method, and principal conformers of the 5-membered galactose ring were revealed. However, in the case of more complex disaccharide structures, it was found that this method and the widely applied DFT-B3LYP produced results that deviated from experimental evidence. Read More

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Clinical features and laboratory findings first case of B. 1.617.2 (delta) variant concern (VOC) in Iraq.

Ann Med Surg (Lond) 2021 Sep 4;69:102814. Epub 2021 Sep 4.

Department of Critical Care Nursing, College of Nursing, Urmia University of Medical Science, Iran.

Since the initial report of the severe acute respiratory syndrome (SARS CoV-2) in Wuhan, China, in 2019, the virus has constantly mutated, resulting in the appearance of novel variants. In December 2020, the B.1. Read More

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September 2021

Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.

Front Cell Neurosci 2021 26;15:699736. Epub 2021 Aug 26.

Department of Anatomy, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

Disruption of the blood-brain barrier (BBB) and the subsequent formation of brain edema is the most severe consequence of intracerebral hemorrhage (ICH), leading to drastic neuroinflammatory responses and neuronal cell death. A better understanding of ICH pathophysiology to develop effective therapy relies on selecting appropriate animal models. The collagenase injection ICH model and the autologous arterial whole blood infusion ICH model have been developed to investigate the pathophysiology of ICH. Read More

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Using capillary electrophoresis to characterize the hydrodynamic and electrostatic properties of DNA in solutions containing various monovalent cations.

Electrophoresis 2021 Sep 12. Epub 2021 Sep 12.

Department of Biochemistry, University of Iowa, Iowa City, IA, USA.

This review describes the results obtained by using free solution capillary electrophoresis to probe the electrostatic and hydrodynamic properties of DNA in solutions containing various monovalent cations. In brief, we found that the mobilities of double-stranded DNAs (dsDNAs) increase with increasing molecular weight before leveling off and becoming constant at molecular weights ≥ 400 bp. The mobilities of single stranded DNAs (ssDNAs) go through a maximum at ∼10-20 nucleotides before decreasing and becoming constant for oligomers larger than ∼30-50 bases. Read More

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September 2021