103,691 results match your criteria presented developed


A simplified model for simulating anaerobic digesters: Application to valorisation of bagasse and distillery spent wash.

Bioresour Technol 2021 Jun 9;337:125395. Epub 2021 Jun 9.

Multiphase Flows, Reactors and Intensification Group, School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast BT9 5AG, United Kingdom; Bernal Institute, University of Limerick, Limerick V94T9PX, Ireland. Electronic address:

Current anaerobic digestion (AD) design methods rely on crude empirical models or sophisticated anaerobic digestion models (like ADM1) requiring a large number of parameters which are difficult to obtain experimentally. A simplified model for simulating AD was developed in this work. The model requires knowledge of CH/CO ratio in biogas or indigestible fraction in substrate and batch biomethane potential (BMP) data for estimating three kinetic parameters (maximum specific growth rate, half velocity constant and cell death rate). Read More

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COVID-19 in Argentine teriflunomide-treated multiple sclerosis patients: First national case series.

Mult Scler Relat Disord 2021 May 30;53:103049. Epub 2021 May 30.

Centro de Esclerosis Múltiple de Buenos Aires, CABA; Argentina; Servicio de Neurología, Hospital Universitario CEMIC, Buenos Aires, Argentina.

We report COVID-19 presentation, course and outcomes in teriflunomide-treated MS patients in Argentina.

Methods: descriptive, retrospective, multicentre, study that included MS patients receiving teriflunomide who developed COVID-19, with clinical follow-up at reference MS centres, also listed in a nationwide registry.

Results: Eighteen MS patients on teriflunomide treatment, from eight MS centres developed COVID-19. Read More

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Clarithromycin As an Alternative and Prophylactic Agent in a Hematopoietic Stem Cell Transplantation Patient.

Am J Case Rep 2021 Jun 15;22:e931731. Epub 2021 Jun 15.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

BACKGROUND Nocardia infections have rarely been reported in hematopoietic stem cell transplantation (HSCT) patients, who usually receive the prophylactic use of sulfamethoxazole/trimethoprim (ST) against Pneumocystis jiroveci. However, the ST prophylaxis, sensitive to Nocardia species, sometimes induces renal toxicities. Therefore, alternative prophylactic or therapeutic drugs are required for nocardiosis in HSCT patients. Read More

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Reinforcement Learning Based Optimal Tracking Control Under Unmeasurable Disturbances With Application to HVAC Systems.

IEEE Trans Neural Netw Learn Syst 2021 Jun 15;PP. Epub 2021 Jun 15.

This paper presents the design of an optimal controller for solving tracking problems subject to unmeasurable disturbances and unknown system dynamics using reinforcement learning (RL). Many existing RL control methods take disturbance into account by directly measuring it and manipulating it for exploration during the learning process, thereby preventing any disturbance induced bias in the control estimates. However, in most practical scenarios, disturbance is neither measurable nor manipulable. Read More

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A Resident-Led Intervention to Increase Initiation of Buprenorphine Maintenance for Hospitalized Patients With Opioid Use Disorder.

J Hosp Med 2021 Jun;16(6):339-344

Department of Pediatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Hospitalized patients with opioid use disorder (OUD) are rarely started on buprenorphine or methadone maintenance despite evidence that these medications reduce all-cause mortality, overdoses, and hospital readmissions.

Objective: To assess whether clinician education and a team of residents and hospitalist attendings waivered to prescribe buprenorphine increased the rate of starting patients with OUD on buprenorphine maintenance.

Design, Setting, And Participants: Quality improvement study conducted at a large, urban, academic hospital in Maryland involving hospitalized patients with OUD on internal medicine resident services. Read More

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Atezolizumab and bevacizumab-induced encephalitis in advanced hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2021 06;100(24):e26377

Department of Hepatology and Gastroenterology.

Introduction: On the basis of the results of the IMBRAVE-150 trial, the combination of atezolizumab, a programmed cell death ligand 1 (PD-L1) antibody, as well as bevacizumab, a vascular endothelial growth factor (VEGF) antibody, represents a promising novel first-line therapy in patients with advanced hepatocellular carcinoma (HCC). Despite favorable safety data, serious adverse events have been described. However, central nervous system complications such as encephalitis have rarely been reported. Read More

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A Caregiver Digital Intervention to Support Shared Decision Making in Child and Adolescent Mental Health Services: Development Process and Stakeholder Involvement Analysis.

JMIR Form Res 2021 Jun 15;5(6):e24896. Epub 2021 Jun 15.

Anna Freud National Centre for Children & Families, London, United Kingdom.

Background: Parents and caregivers are generally recognized by literature and the law as key to child and adolescent mental health decisions. Digital interventions are increasingly being used to support care and treatment in child and adolescent mental health services (CAMHS). However, evidence of the design and development process is generally not made available. Read More

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Pop-out illusion as the initial presentation of posterior cortical atrophy.

Neurocase 2021 Jun 15:1-4. Epub 2021 Jun 15.

Department of Neurological Sciences, Christian Medical College, Vellore, India.

Posterior cortical atrophy is a rare neurodegenerative disease that presents with progressive higher-order visual impairment. We describe a case of posterior cortical atrophy in a 62-year-old, right-handed man, who initially presented with difficulty in viewing the television screen, followed by reading difficulty a few months later, and then developed features of Balint's syndrome over the course of 3 years. We report an illusion, which we noticed at the time of the initial presentation, where the characters in the television appeared to be popping out of the screen. Read More

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Do standards of care and early outcomes of periprosthetic fractures change during the COVID-19 pandemic? A multicentre study.

J Orthop Traumatol 2021 Jun 14;22(1):22. Epub 2021 Jun 14.

Department of Orthopaedic Surgery, ASST Papa Giovanni XXIII, Piazza OMS 1, 24127, Bergamo, Italy.

Background: Periprosthetic fractures (PPFs) are a growing matter for orthopaedic surgeons, and patients with PPFs may represent a frail target in the case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of this study is to investigate whether hospital reorganisations during the most severe phase of the SARS-CoV-2 pandemic affected standards of care and early outcomes of patients treated for PPFs in Northern Italy.

Materials And Methods: Data were retrieved from a multicentre retrospective orthopaedics and traumatology database, including 14 hospitals. Read More

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Topical delivery of chemotherapeutic drugs using nano-hybrid hydrogels to inhibit post-surgical tumour recurrence.

Biomater Sci 2021 Jun;9(12):4356-4363

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.

Residual microtumours after surgical resection leading to tumour relapse is one of the major challenges for cancer therapy. Herein, we developed a nano-hybrid oligopeptide hydrogel for topical delivery of a chemotherapeutic drug, docetaxel (DTX), to inhibit the post-surgical tumour recurrence. This nano-hybrid hydrogel (DTX-CTs/Gel) was prepared by encapsulating DTX in cell-penetrating peptide-modified transfersomes followed by embedment in an oligopeptide hydrogel. Read More

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Mathematical modeling of COVID-19 in India and its states with optimal control.

Model Earth Syst Environ 2021 Jun 10:1-16. Epub 2021 Jun 10.

Division of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Chennai, India.

A pandemic is an epidemic spread over a huge geographical area. COVID-19 is such pandemic documented after 1918 flu pandemic. In this work, we frame a mathematical epidemic model taking inspiration from the classic SIR model and develop a compartmental model with ten compartments to study the coronavirus dynamics in India and three of its most affected states, namely, Maharashtra, Karnataka, and Tamil Nadu, with inclusion of factors related to face mask efficacy, contact tracing, and testing along with quarantine and isolation. Read More

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Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics.

Sci Rep 2021 Jun 14;11(1):12456. Epub 2021 Jun 14.

Chair of Medical Informatics, Friedrich-Alexander University (FAU) of Erlangen-Nürnberg, Erlangen, Germany.

The family of RNA-binding proteins (RBP) functions as a crucial regulator of multiple biological processes and diseases. However, RBP function in the clinical setting of idiopathic pulmonary fibrosis (IPF) is still unknown. We developed a practical in silico screening approach for the characterization of RBPs using multi-sources data information and comparative molecular network bioinformatics followed by wet-lab validation studies. Read More

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Can PIMS-TS lead to a facial nerve palsy?

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Department of Infectious Diseases and Tropical Medicine, Guys and St Thomas Hospital, London, UK.

Paediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) is a recently described syndrome. We describe the case of a 17-year-old man presenting with a recent illness consistent with COVID-19 who presented with fever, chest pain and anterior uveitis. He was treated with aspirin, pulsed methylprednisolone and tocilizumab followed by oral steroids. Read More

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Upper-Extremity Phlegmasia Cerulea Dolens with Compartment Syndrome in Coronavirus Disease 2019 Sepsis.

J Hand Surg Am 2021 May 4. Epub 2021 May 4.

Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX.

A 54-year-old woman with leukemia presented with coronavirus disease 2019 and a right upper-extremity indwelling peripherally inserted central catheter line for chemotherapy administration. On hospital admission day 9, she developed acute right upper-extremity edema and pain. Ultrasound demonstrated complete superficial and deep venous thrombosis up to the proximal subclavian vein. Read More

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Application of substitution box of present cipher for automated detection of snoring sounds.

Artif Intell Med 2021 Jul 6;117:102085. Epub 2021 May 6.

Ngee Ann Polytechnic, Department of Electronics and Computer Engineering, 599489, Singapore; Department of Biomedical Engineering, School of Science and Technology, SUSS University, Singapore; Department of Biomedical Informatics and Medical Engineering, Asia University, Taichung, Taiwan.

Background And Purpose: Snoring is one of the sleep disorders, and snoring sounds have been used to diagnose many sleep-related diseases. However, the snoring sound classification is done manually which is time-consuming and prone to human errors. An automated snoring sound classification model is proposed to overcome these problems. Read More

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A new approach for interpretability and reliability in clinical risk prediction: Acute coronary syndrome scenario.

Artif Intell Med 2021 Jul 13;117:102113. Epub 2021 May 13.

Cardiology Department, Leiria Hospital Centre, Leiria, Portugal. Electronic address:

Introduction: The risk prediction of the occurrence of a clinical event is often based on conventional statistical procedures, through the implementation of risk score models. Recently, approaches based on more complex machine learning (ML) methods have been developed. Despite the latter usually have a better predictive performance, they obtain little approval from the physicians, as they lack interpretability and, therefore, clinical confidence. Read More

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Challenges in Treating Tardive Dyskinesia: Assessing the Impact of Virtual Medical Education.

CNS Spectr 2021 Apr;26(2):165

Global Medical Education, New York, NY, USA.

Introduction: Tardive Dyskinesia (TD) refers to abnormal, involuntary, choreoathetoid movements of the tongue, lips, face, trunk, and extremities and is associated with long-term exposure to dopamine-blocking agents, such as antipsychotic medications. Once established, these movements usually persist. The movements are disfiguring and can bring unwanted attention to affected individuals. Read More

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Othello Syndrome: Delusional Disorder - Jealous Type ≠ Violence.

CNS Spectr 2021 Apr;26(2):160-161

University of Florida College of Medicine, Department of Psychiatry, Gainesville, FL, USA.

Background: Othello syndrome, also known as morbid jealousy, pathological jealousy, and conjugal paranoia, is a rare delusional disorder related to partner's infidelity. There are no large scale or comprehensive studies on delusional jealousy, and only few case reports and cases series leave delusional disorder jealous type (DDJT) largely unknown. Herein, we report a case of DDJT, its possible etiology and describe its characteristics, comorbidities, and interventions. Read More

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Can Low Dose Sertraline Cause Serotonin Syndrome in Pediatric Patients? 2 Case Reports.

Authors:
Sultana Jahan

CNS Spectr 2021 Apr;26(2):155

University of Missouri, Department of Psychiatry, Columbia, MO, USA.

Background: Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. Serotonin syndrome is underreported complication of pharmacotherapy. The Hunter Criteria for serotonin syndrome (SS) are fulfilled if the patient has taken a serotonergic agent and has one of the following symptoms: 1) spontaneous clonus, 2) inducible clonus and agitation or diaphoresis, 3) ocular clonus and agitation or diaphoresis, 4) tremor and hyperreflexia, 5) hypertonia, or 6) temperature above 38 C and ocular clonus or inducible clonus. Read More

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Predictive factors for survival following stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumour thrombosis and construction of a nomogram.

BMC Cancer 2021 Jun 15;21(1):701. Epub 2021 Jun 15.

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.

Background: We evaluated the treatment response and predictive factors for overall survival (OS) in patients with hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT), who underwent stereotactic body radiotherapy (SBRT). Additionally, we developed and validated a personalised prediction model for patient survival.

Methods: Clinical information was retrospectively collected for 80 patients with HCC and PVTT, who were treated with SBRT at the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) between December 2015 and June 2019. Read More

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Green Synthesis of Silver Nanoparticles using Datura metel Flower Extract Assisted by Ultrasound Method and Its Antibacterial Activity.

Recent Pat Nanotechnol 2021 Jun 14. Epub 2021 Jun 14.

Laboratory of Materials for Energy and Environment, Chemistry Department, Universitas Islam Indonesia, Yogyakarta, Indonesia.

Background: Green synthesis method of nanoparticles has been developed for several years. Besides providing an environmental-friendly process, the green synthesis of nanoparticles using plant extract provides a synergistic effect of the secondary metabolite. In recent times, the study involving the intensification process in nanoparticle formation also attracts great attention. Read More

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Studying the ophthalmic toxicity potential of developed Ketoconazole loaded nanoemulsion formulation for ophthalmic administration.

Toxicol Mech Methods 2021 Jun 14:1-27. Epub 2021 Jun 14.

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Ocular fungal infections are one of the essential reasons of vision loss especially in developing countries for tropical regions. Ketoconazole (KZ), a broad-spectrum anti-fungal drug, is a lipophilic compound and practically insoluble in water. Since topical ophthalmic drug delivery confronts low bioavailability, an in situ gel formulation designed to improve the residence time and consequently the bioavailability. Read More

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Gross motor dysfunction and balance impairments in children and adolescents with Down syndrome: a systematic review.

Clin Exp Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Department of Physiotherapy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular co-contraction, inadequate postural control, and disturbed proprioception. These factors are responsible for the developmental challenges faced by children with Down syndrome. These individuals also present with balance dysfunctions. Read More

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Asymmetric pyrone Diels-Alder reactions enabled by dienamine catalysis.

Chem Sci 2019 Dec 26;11(8):2175-2180. Epub 2019 Dec 26.

Department of Chemistry, University of Chicago 5735 S. Ellis Avenue Chicago IL 60637 USA

Despite the proven value in utilizing pyrone dienes to create molecular complexity Diels-Alder reactions with varied dienophiles, few examples of effective catalytic, asymmetric variants of this process have been developed. Herein, we show that the use of Jørgensen-Hayashi-type catalysts can convert an array of α,β-unsaturated aldehydes into chiral dienamines that can formally add in a Diels-Alder fashion to a number of electron-deficient pyrones of the coumalate-type to generate optically active [2.2. Read More

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December 2019

Diastereoselective synthesis of chiral 3-substituted isoindolinones rhodium(III)-catalyzed oxidative C-H olefination/annulation.

Org Biomol Chem 2021 Jun 14. Epub 2021 Jun 14.

College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. Read More

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Significant difference in response of malignant tumor cells of individual patients to photodynamic treatment as revealed by digital holographic microscopy.

J Photochem Photobiol B 2021 Jun 3;221:112235. Epub 2021 Jun 3.

Ioffe Institute, Russian Academy of Sciences, St. Petersburg, Russia.

The investigation of in-vitro response of cell cultures derived from tumor material of individual patients with similar tumor localizations to photodynamic treatment is presented. Tumor types included in the research were renal cell carcinoma, melanoma and alveolar, synovial, lypo- and osteo- sarcomas. Long-term observations of treatment-induced morphological changes in cells were performed by means of digital holographic microscopy. Read More

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Symptoms in patients with asthma infected by SARS-CoV-2.

Respir Med 2021 Jun 8;185:106495. Epub 2021 Jun 8.

Section of Respiratory Medicine, Hospital General Universitario de Elche, Elche, Alicante, Spain.

Introduction: Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who became infected with SARS-CoV-2. Read More

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Sediment contamination and toxicity of Marine Protected Areas in southeastern Brazilian coast: A baseline for management planning.

Mar Pollut Bull 2021 Jun 11;170:112613. Epub 2021 Jun 11.

São Paulo State University (UNESP), Praça Infante Dom Henrique, s/n, 11330-900 São Vicente, SP, Brazil.

Recent studies have shown that the effectiveness of establishing Marine Protected Areas (MPAs) is threatened by toxic effects of contaminants. São Paulo is the most economically developed state of Brazil, and its coast is protected by a system of MPAs, including the North Shore Marine Protected Area (NSMPA). The present study provides a first assessment of sediment quality in NSMPA and two reference sites. Read More

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Simultaneous characterization of insulin HMWP and protamine sulphate in complex formulations through SEC-coupled mass spectrometry.

J Pharm Biomed Anal 2021 Jun 3;203:114188. Epub 2021 Jun 3.

Biocon Biologics Limited, Molecular Characterization Lab, Biocon Research Limited - SEZ Unit, Plot No. 2&3, Phase IV- B.I.A, Bommasandra-Jigani Link Road, Bangalore 560099, Karnataka, India. Electronic address:

High molecular weight protein aggregates present in a recombinant human insulin and analogs are conventionally quantified by SEC-HPLC and identified by SEC-MALS as oligomeric population which lacks precise identification of species. The limitation of these two techniques is vanquished though simultaneous separation and identification by SEC coupled with MS. The identification was established with organic solvent based isocratic elution followed by MS for parallel separation and identification of HMWP species. Read More

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Adaptive lymphocyte profile analysis discriminates mild and severe forms of COVID-19 after solid organ transplantation.

Kidney Int 2021 Jun 11. Epub 2021 Jun 11.

Institut National de la Santé et de la Recherche Médicale- Centre de Physiopathologie Toulouse Purpan, Inserm UMR 1043- CNRS 5282, F-31000 Toulouse, France; Université Paul Sabatier Toulouse III, Toulouse, France; Laboratory of Immunology, Biology Department, CHU Toulouse, Toulouse, France.

Solid organ transplant recipients are at high risk for the development of severe forms of COVID-19. However, the role of immunosuppression in the morbidity and mortality of the immune phenotype during COVID-19 in transplant recipients remains unknown. In this retrospective study, we compared peripheral blood T and B cell functional and surface markers, as well as serum antibody development during 29 cases of mild (World Health Organization 9-point Ordinal Scale (WOS) of 3-4) and 22 cases of severe COVID-19 (WOS 5-8) in solid organ transplant (72% kidney transplant) recipients hospitalized in our center. Read More

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