196,652 results match your criteria presentation treatment

Atraumatic Anterior Hip Dislocation as High Grade of Hip Instability: A Case Report.

JBJS Case Connect 2021 Apr 14;11(2). Epub 2021 Apr 14.

Shoulder and Elbow, Orthopaedics, Macquarie University Hospital, Sydney, Australia.

Case: Fifty-year-old woman who presented an atraumatic anterior hip dislocation during a local traditional dance exhibition. The dislocation occurred during a dance step in which extreme hip position in extension and external rotation was held. After urgent closed reduction under general anesthesia, the patient underwent conservative management with a follow-up of 24 months. Read More

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Cancer cells relax and resist cytotoxic attack.

Immunity 2021 May;54(5):853-855

Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

When it comes to cancer evading the immune response, antigen presentation usually gets all the attention. In this issue of Immunity, Tello-Lafoz et al. reveal that cancer cells have another card up their sleeve: by regulating gene expression to "soften" their actin cytoskeleton, cancer cells limit susceptibility to lymphocyte-mediated cytotoxic attack. Read More

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Evolution of Disparities in Prostate Cancer Treatment: Is This a New Normal?

Am Soc Clin Oncol Educ Book 2021 Mar;41:1-12

Winship Cancer Institute, Emory University, Atlanta, GA.

Despite notable screening, diagnostic, and therapeutic advances, disparities in prostate cancer incidence and outcomes remain prevalent. Although commonly discussed in the context of men of African descent, disparities also exist based on socioeconomic level, education level, and geographic location. The factors in these disparities span systemic access issues affecting availability of care, provider awareness, and personal patient views and mistrust. Read More

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Acute death caused by invasive aspergillosis after living-donor liver transplantation despite good graft function: a case report.

Surg Case Rep 2021 May 12;7(1):118. Epub 2021 May 12.

Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University Hospital, Kyushu University, 3 Chome-1-1 Maidashi, Higashiku, Fukuoka, Fukuoka, 812-8582, Japan.

Background: Invasive aspergillosis (IA) is one of the most serious causes of death after liver transplantation (LT). IA is the second most common fungal infection, and its mortality rate exceeds 80%.

Case Presentation: A 67-year-old man presented to our hospital because of fulminant hepatitis caused by hepatitis B virus. Read More

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Avoiding anticoagulation drugs for postoperative atrial fibrillation enabled successful conservative treatment of left atrial dissection: a case report.

Surg Case Rep 2021 May 12;7(1):120. Epub 2021 May 12.

Department of Cardiovascular Surgery, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, 010-8543, Japan.

Background: Left atrial dissection is a rare complication of cardiac surgery, most commonly associated with mitral valve surgery. Herein, we report on the successful conservative treatment of left atrial dissection while avoiding anticoagulation therapy.

Case Presentation: A 64-year-old man developed left atrial dissection during operation for acute type A aortic dissection, most likely due to retrograde cardioplegia cannulation. Read More

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Variable presentation of diabetic papillopathy and treatment dilemma- A case series.

Nepal J Ophthalmol 2020 Jul;12(24):382-332

Biratnagar Eye Hospital, Biratnagar, Nepal.

Introduction: Diabetic papillopathy (DP) is a diagnosis of exclusion in type 1 and type 2 diabetics with transient disc edema. It was initially described in young patients with type1 diabetes mellitus (DM) as a bilateral disease with minimal visual symptoms which resolved spontaneously. Lately, DP has been a focus of controversy because of its wide clinical spectrum. Read More

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Characteristics and surgical outcomes of pediatric intracranial aneurysms in Romania.

Turk Neurosurg 2021 Feb 5. Epub 2021 Feb 5.

University of Medicine and Pharmacy Carol Davila, Department of Neurosurgery, Bucharest, Romania.

Aim: Pediatric aneurysms are rare, occurring in under 5% of cases, and their clinical presentation, rupture probability, location, and outcome differ from those in adults. The present study aimed to analyze the demographic characteristics and surgical outcomes of the largest series of patients with pediatric aneurysms reported in Romania, in consideration of the primary factors that lead to good long-term outcomes. Given that all cases involved ruptured aneurysms, we also investigated the ability of microsurgical clipping to prevent massive hemorrhage and aggravation of neurological deficits. Read More

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February 2021

Efficacy and safety of dupilumab in two adolescents with severe atopic dermatitis.

Einstein (Sao Paulo) 2021 10;19:eRC6064. Epub 2021 May 10.

Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

We report the cases of two adolescent siblings with severe atopic dermatitis, who, despite weighing approximately 40kg, presented a good response to dupilumab with the off-label dose for individuals aged 12 years and weighing 60kg. Both had already used cyclosporine, azathioprine, methotrexate and oral corticosteroids for long periods, plus topical treatments with no adequate disease control. Skin lesions were constant and widespread, with frequent skin infections and very poor quality of life, with numerous physical and psychosocial consequences, such as dropping out of school activities due to severe itching, appearance and bullying. Read More

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Recent developments in the diagnosis and treatment of extrapulmonary non-tuberculous mycobacterial diseases.

Int J Tuberc Lung Dis 2021 May;25(5):340-349

Department of Clinical Research, ICMR, NIRT, Chennai, India.

Diseases due to pathogenic mycobacteria cause significant health and economic impact on humans worldwide. Although mycobacterial diseases primarily affect the lungs, the involvement of extrapulmonary organs has also gained ground, particularly among individuals with co-existing medical conditions. Besides complex organisms, non-tuberculous mycobacteria (NTM) are also known to cause pulmonary and extrapulmonary diseases. Read More

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Critical diagnostic delay associated with unusual presentation of hepatocellular carcinoma (HCC) with orbital metastases: a case report.

Ann Palliat Med 2021 May 11. Epub 2021 May 11.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

Orbital metastases are an extremely rare finding in patients with hepatocarcinoma (HCC), especially as its first presentation. Therefore, the risk of misdiagnosis is high, as well as that of drastic delays of the therapeutic algorithm. Here we report a 71-year-old man presenting with orbital metastases as the initial sign of HCC, whose initial misdiagnosis led to the impossibility to start life-saving cancer treatment. Read More

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Acute gastric mucosal lesions caused by acute infection of non-Helicobacter pylori Helicobacter: a case report.

Helicobacter 2021 May 11:e12814. Epub 2021 May 11.

Department of Internal Medicine, Showa Inan General Hospital, Komagane, Japan.

Background: Non-Helicobacter pylori Helicobacter (NHPH) is not widely recognized as a cause of acute gastric mucosal lesions (AGML), as only a few cases of AGML caused by NHPH have been reported. We present here one case and examine the species and eradication of NHPH together with the three previously reported cases.

Case Presentation: A 52-year-old woman presented with a two-day history of severe epigastric pain, nausea, and vomiting. Read More

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GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation.

Neurol Sci 2021 May 11. Epub 2021 May 11.

Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico GB Rossi, P.le LA Scuro 10, 37134, Verona, Italy.

Introduction: Neurological disorders are considered rare complications of immune-checkpoint inhibitor.

Case Description: We report a 63-year-old man with recurrence of melanoma who presented epilepsy, limbic encephalitis, cerebellar ataxia, and stiff person syndrome soon after treatment with nivolumab, an immune-checkpoint inhibitor. On autoimmune screening, serum and CSF GAD65 were detected. Read More

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Rare case of immunoglobulin G4-related disease arising in gonadal glands with long-term remission without steroid treatment: Discussion and literature review.

IJU Case Rep 2021 May 15;4(3):188-191. Epub 2021 Mar 15.

Department of Nephro-Urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan.

Introduction: Immunoglobulin G4-related disease embraces a wide range of extra-pancreatic manifestations. However, localized pathogenesis in gonadal glands, including testes or seminal vesicles, is rare. The clinical course and therapeutic strategy for this disease have not been clearly characterized. Read More

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Laparoendoscopic single-site simple nephrectomy and reduced port procedure for inflammatory nonfunctioning kidney.

IJU Case Rep 2021 May 17;4(3):184-187. Epub 2021 Mar 17.

Department of Uro-Oncology Saitama Medical University International Medical Center Hidaka Saitama Japan.

Introduction: To describe laparoendoscopic single-site simple nephrectomy and reduced port simple nephrectomy for inflammatory nonfunctioning kidney.

Case Presentation: Case 1: a 58-year-old female with fever was referred to our hospital. Computed tomography demonstrated a markedly atrophic right kidney and mild hydronephrosis. Read More

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First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion.

IJU Case Rep 2021 May 17;4(3):176-179. Epub 2021 Mar 17.

Department of Urology Keio University School of Medicine Tokyo Japan.

Introduction: Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known.

Case Presentation: A 67-year-old man presented with ductal adenocarcinoma of the prostate accompanied by multiple lung metastases and advanced bone metastases. Read More

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Transcription factor 4 expression in circulating tumor cells from castration-resistant prostate cancer.

IJU Case Rep 2021 May 22;4(3):159-162. Epub 2021 Mar 22.

Department of Urology Juntendo University Graduate School of Medicine Tokyo Japan.

Introduction: Neuroendocrine differentiation is partly caused by antiandrogen therapy and exhibits an androgen receptor-independent growth mechanism. We hypothesized that the expression of transcription factor 4, an inducer of neuroendocrine differentiation, in circulating tumor cells is related to drug resistance in castration-resistant prostate cancer.

Case Presentation: We evaluate the messenger ribonucleic acid expression of transcription factor 4 in circulating tumor cells from 17 patients with castration-resistant prostate cancer and compared these levels between patients receiving antiandrogen therapies and those who were resistant to antiandrogen therapies and receiving chemotherapies. Read More

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Only three cycles of nivolumab showed remarkable durable response and reversible myeloradiculoneuropathy in a patient with metastatic papillary renal cell carcinoma type 2.

IJU Case Rep 2021 May 17;4(3):139-142. Epub 2021 Feb 17.

Department of Urology Oita University Faculty of Medicine Yufu Oita Japan.

Introduction: The efficacy of nivolumab for non-clear cell renal cell carcinoma is still unclear. We present a rare case of metastatic papillary renal cell carcinoma remarkably responded to nivolumab but developed myeloradiculoneuropathy as immune-related adverse event.

Case Presentation: The patient had previously undergone radical nephrectomy for right renal mass and was diagnosed as papillary renal cell carcinoma type 2, pT3bN0M0. Read More

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Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy.

IJU Case Rep 2021 May 10;4(3):136-138. Epub 2021 Mar 10.

Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan.

Introduction: Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow-up periods are growing longer, the rate of unusual visceral metastases may increase.

Case Presentation: A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Read More

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Laparoscopic ileal ureteral replacement to preserve the natural anti-reflux system: An initial case report.

IJU Case Rep 2021 May 16;4(3):132-135. Epub 2021 Feb 16.

Department of Urology Oita University Faculty of Medicine Yufu Oita Japan.

Introduction: Ileal ureteral replacement is one of the treatment options for long ureteral strictures. Most ileal ureteral replacements anastomose the distal side of the ileal segment directly to the bladder. We have reported here an initial case of laparoscopic ileal ureteral replacement for preserving the natural anti-reflux system. Read More

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Chronic Nonbacterial Osteomyelitis of the Sternocostoclavicular Region in Adults: A Single-Center Dutch Cohort Study.

JBMR Plus 2021 May 10;5(5):e10490. Epub 2021 Apr 10.

Centre for Bone Quality, Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden The Netherlands.

Sternocostoclavicular hyperostosis (SCCH) is a rare autoinflammatory bone disorder caused by chronic nonbacterial osteomyelitis (CNO), which is associated with sclerosis and hyperostosis primarily affecting the sternum, the medial end of the clavicles, and the first ribs. Other areas of the axial skeleton may also be affected. The more severe synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is additionally associated with dermatoses and joint manifestations. Read More

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Co-infection with Coronavirus Disease 2019, previously undiagnosed Human Immunodeficiency Virus, pneumonia and Cytomegalovirus pneumonitis, with possible Immune Reconstitution Inflammatory Syndrome.

IDCases 2021 May 7:e01153. Epub 2021 May 7.

Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Suite GB, Boston, MA, 02215, USA.

Background: Case reports, case series and cohort studies have been published describing the clinical course and outcomes of people living with human immunodeficiency virus (PLWH) who contract coronavirus disease 2019 (COVID-19) pneumonia. However, the majority of the published work focuses on patients with well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy (ART).

Case Presentation: We present a case of a new diagnosis of HIV with Acquired Immune Deficiency Syndrome (AIDS) made simultaneously to diagnosis of COVID-19, with co-infection with pneumonia (PJP) and possible cytomegalovirus (CMV) pneumonitis. Read More

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Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case Rep Infect Dis 2021 21;2021:5555613. Epub 2021 Apr 21.

National Hospital-Kandy, Kandy, Sri Lanka.

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Read More

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Auto-brewery syndrome caused by oral fungi and periodontal disease bacteria.

Acute Med Surg 2021 Jan-Dec;8(1):e652. Epub 2021 May 3.

Department of Central Clinical Laboratory Iwate Medical University Hospital Morioka Japan.

Background: Auto-brewery syndrome (ABS) is often caused by fungi in the intestinal tract. We describe a rare case of alcohol production by and periodontal disease bacteria in the oral cavity.

Case Presentation: A man aged in his 60s had a car accident, and alcohol was detected on his breath. Read More

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Recalcitrant Keratitis with Hyphaema.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):214-218. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore, Singapore.

Purpose: To report a case of recalcitrant pseudomonas keratitis with a rare presentation of hyphaema.

Observation: A 45-year-old female was noted to have contact lens-related pseudomonas keratitis with hyphaema. The organism was refractory to multiple antibiotics and only responded to Tazocin eye drops. Read More

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Metastasis of Osteosarcoma to the Abdomen: A Report of Two Cases and a Review of the Literature.

Case Rep Oncol 2021 Jan-Apr;14(1):647-658. Epub 2021 Mar 31.

Department of Orthopedics, Sarcoma Service, University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Two cases of primary distal femur osteosarcoma with subsequent metastasis to the abdomen are presented. In both cases, the development of abdominal metastasis was quickly followed by patient decline and death. A review of the literature was performed, assessing the presentation and survival of patients with osteosarcoma metastasized to the abdomen. Read More

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Relative Adrenocortical Insufficiency Following Radioactive Iodine Therapy for Graves' Disease: A Report of Two Cases.

Hanxin Zhao Yu Ruan

Int J Gen Med 2021 3;14:1641-1646. Epub 2021 May 3.

Department of Endocrinology and Metabolism, Zhejiang University Affiliated Sir Run Run Shaw Hospital, School of Medicine, Hangzhou, People's Republic of China.

Introduction: In recent years, radioactive iodine (RAI) therapy has become a main choice for Graves' disease. The rapid release of thyroid hormones following RAI may on occasion trigger severe events, such as thyroid storm or heart block. This study presents two cases of possible acute adrenocortical insufficiency precipitated by radioiodine therapy. Read More

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Presentation and outcome of COVID-19 in HIV patients with high viral loads and opportunistic infections: a case series.

Ghana Med J 2020 Dec;54(4 Suppl):121-124

Ashanti Regional Health Directorate, Ghana Health Service, Kumasi, Ghana.

Coronavirus disease 2019 (COVID-19) is especially severe in patients with underlying chronic conditions, with increased risk of mortality. There is concern that people living with HIV (PLWH), especially those with severe immunosuppression, and COVID-19 may have severe disease and a negative clinical outcome. Most studies on COVID-19 in PLWH are from Asia, Europe and America where population dynamics, antiretroviral treatment coverage and coexisting opportunistic infections may differ from that in sub-Saharan Africa. Read More

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December 2020

Atypical presentation of COVID-19 in a patient with type 2 diabetes at an urban primary care facility in Accra, Ghana.

Ghana Med J 2020 Dec;54(4 Suppl):117-120

Department of Community Health, University of Ghana Medical School, University of Ghana, Accra, Ghana.

This is a case report of a 55-year-old man with Type 2 Diabetes Mellitus who presented with progressive breathlessness, chest pain and hyperglycaemia. An initial impression of a chest infection was made. Management was initiated with antibiotics, but this was unsuccessful, and he continued to desaturate. Read More

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December 2020

Profile and outcomes of hospitalized patients with COVID-19 at a tertiary institution hospital in Ghana.

Ghana Med J 2020 Dec;54(4 Suppl):39-45

Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: In high-income countries, mortality related to hospitalized patients with the Coronavirus disease 2019 (COVID-19) is approximately 4-5%. However, data on COVID-19 admissions from sub-Saharan Africa are scanty.

Objective: To describe the clinical profile and determinants of outcomes of patients with confirmed COVID-19 admitted at a hospital in Ghana. Read More

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December 2020

Combined Liposuction and Physiologic Treatment Achieves Durable Limb Volume Normalization in Class II-III Lymphedema: A Treatment Algorithm to Optimize Outcomes.

Ann Plast Surg 2021 May;86(5S Suppl 3):S384-S389

From the Division of Plastic and Reconstructive Surgery, Stanford University, Palo Alto, CA.

Introduction: Outcomes of surgical lymphedema treatment are currently suboptimal. Physiologic procedures including lymphovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT) reestablish lymphatic flow but cannot correct fibroadipose deposition, whereas liposuction alone cannot prevent disease progression. We propose a treatment algorithm combining liposuction with LVA or VLNT that can achieve normal limb volumes and prevent disease progression in stage II-III lymphedema. Read More

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