93,225 results match your criteria presentation pathology

Cytomorphological spectrum of cysticercosis: a study of 26 cases.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Department Of Pathology, Atal Bihari Vajpayi Institute Of Medical Sciences & Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Background: Cysticercosis is a systemic parasitic disease caused by the larval stage of Taenia solium. It is the most common parasitic disease worldwide. Fine needle aspiration cytology plays an important role in prompt recognition of this disease. Read More

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Perforated Meckel's diverticulum in omphalocele in a newborn: A case report of an uncommon presentation from northern Tanzania.

Int J Surg Case Rep 2021 Jul 27;85:106246. Epub 2021 Jul 27.

Kilimanjaro Christian Medical University College, Faculty of Medicine, P O Box 2240, Moshi, Tanzania; Department of Pediatrics, Kilimanjaro Christian Medical Centre, P O Box 3010, Moshi, Tanzania.

Introduction And Importance: The concurrent existence of Omphalocele and Meckel's diverticulum is not unheard of but is relatively uncommon. A few cases of their coexistence have been reported. Due to the uncommon dual presentation, it is easy to delay or even miss the diagnosis, delaying management. Read More

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Sialendoscopy: A 4-Year Single Center Experience.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

OMFS IMPATH research group, Faculty of Medicine, Clinical intern, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium; Professor and Chairperson, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Purpose: Sialendoscopy is a relatively new technique designed to diagnose and treat benign obstructive salivary gland disease using a minimally invasive approach. The purpose of this study is to present our experiences regarding the use of sialendoscopy in the form of a 4-year, single center experience and to demonstrate its usefulness in oral and maxillofacial practice.

Methods: We collected data on patients who underwent sialendoscopy at the Oral-Maxillofacial Surgery Department of UZ Leuven between November 2015 and August 2019, including age, gender, sex, initial clinical presentation and symptoms, gland involvement, type of diagnostic investigations, diagnosis, localization of the obstruction, therapeutic intervention, surgeon, type of anesthesia, materials used, complications, secondary treatment, duration of follow-up, and outcome. Read More

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Eosinophilic Gastritis/Gastroenteritis.

Curr Gastroenterol Rep 2021 Jul 30;23(8):13. Epub 2021 Jul 30.

David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, suite 345, Los Angeles, CA, 90095, USA.

Purpose Of Review: Eosinophilic gastritis/gastroenteritis (EG/EGE) are rare eosinophilic infiltrative disorders in children and adults that fall under the umbrella term eosinophilic gastrointestinal disorders (EGIDs). EGIDs also include eosinophilic esophagitis (EoE) and eosinophilic colitis. In this article, we present the current literature regarding the clinical presentation, diagnostic criteria, and management of EG/EGE. Read More

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Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient.

BMJ Case Rep 2021 Jul 30;14(7). Epub 2021 Jul 30.

Pathology and Laboratory Medicine, University of Puerto Rico School of Medicine, Río Piedras, Puerto Rico.

Primary lymphoma of the visual pathway is rare, especially at the chiasm. Very few cases have been reported. The lesion is frequently confused with an optic-hypothalamic glioma. Read More

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Primary synovial sarcoma of thyroid gland: A case report and review of literature.

Int J Surg Case Rep 2021 Jul 26;85:106245. Epub 2021 Jul 26.

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Introduction And Importance: Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Read More

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Diffuse intrathyroidal dissemination of papillary thyroid carcinoma with no stromal fibrosis at presentation: A pattern of aggressive differentiated thyroid carcinoma.

Pathol Res Pract 2021 Jun 23;224:153510. Epub 2021 Jun 23.

Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Electronic address:

Background: Multifocal Papillary thyroid carcinoma (PTC) is a very common condition. In certain cases, it is possible to find tens to hundreds of foci with a diffuse intrathyroidal spread in the whole thyroid with no stromal fibrosis. Herein, PTC with such features was nominated as diffuse disseminate variant (DDV) PTC. Read More

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Zonation in NASH-a key paradigm for understanding pathophysiology and clinical outcomes.

Liver Int 2021 Jul 30. Epub 2021 Jul 30.

Department of Medicine, Columbia University, New York, NY, USA.

Non-alcoholic fatty liver disease (NAFLD) exists as a spectrum ranging from simple steatosis to histologically defined hepatocyte injury and inflammatory changes that define steatohepatitis (NASH), and increase risk for fibrosis. Although zonal differences in NASH have not been systematically studied, periportal involvement has been associated with worse metabolic outcomes and more hepatic fibrosis as compared to pericentral disease. These data suggest that hepatic zonation of disease may influence the diversity of clinical presentations. Read More

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Long-term survival in thymic carcinoma with postoperative pleural dissemination.

Surg Case Rep 2021 Jul 30;7(1):171. Epub 2021 Jul 30.

Department of General Thoracic Surgery, Osaka International Cancer Institute, 1,3,4: 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: We report a patient with thymic squamous cell carcinoma who underwent multiple rounds of surgical resection and definitive radiotherapy for both primary tumor and postoperative recurrence. However, the patient remains well and healthy 18 years after initial diagnosis. Since long-term survival after postoperative recurrence of thymic carcinoma is extremely rare, we also present her immunohistochemical staining results, which suggested indolent disease. Read More

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Presentation, patterns of care, and outcomes of patients with prostate cancer in sub-Saharan Africa: A population-based registry study.

Cancer 2021 Jul 30. Epub 2021 Jul 30.

Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Although prostate cancer (PCa) is the most commonly diagnosed cancer in men of sub-Saharan Africa (SSA), little is known about its management and survival. The objective of the current study was to describe the presentation, patterns of diagnosis, treatment, and survival of patients with PCa in 10 countries of SSA.

Methods: In this observational registry study with data collection from 2010 to 2018, the authors drew a random sample of 738 patients with PCa who were registered in 11 population-based cancer registries. Read More

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Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis with Kidney Involvement in a Patient with AL Amyloidosis.

Case Rep Nephrol Dial 2021 May-Aug;11(2):183-189. Epub 2021 Jul 8.

Division of Nephrology, University of Vermont Medical Center, Burlington, Vermont, USA.

Antineutrophil cytoplasmic autoantibody (ANCA) vasculitis has occasionally been associated with other systemic glomerulonephritis, such as anti-glomerular basement membrane disease. Here, we report the first clinical case of ANCA-associated crescentic glomerulonephritis with AL amyloidosis. An 81-years-old gentleman presented to the hospital with acute kidney injury (serum creatinine 4. Read More

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CD5+ Diffuse Large B-Cell Lymphoma With Leukemic Transformation: A Rare Case With Central Nervous System Involvement, Treated With R-CHOP and Intrathecal Methotrexate/Cytarabine.

Cureus 2021 Jun 22;13(6):e15838. Epub 2021 Jun 22.

Department of Oncology, University of Texas MD Anderson Cancer Center, Galveston, USA.

Diffuse large B-cell lymphoma (DLBCL) is one of several subtypes of non-Hodgkin's lymphoma, and one that can present in a myriad of ways. One unique and particularly aggressive presentation is leukemic transformation with CD5 positivity, which leads to systemic symptoms, a relatively high peripheral tumor load, and higher rates of CNS involvement. The prevalence of leukemic transformation has not been determined, as published literature is limited to case reports and small case series. Read More

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Medullary Carcinoma of the Colon: A Histopathologic Challenge.

Cureus 2021 Jun 22;13(6):e15831. Epub 2021 Jun 22.

Medical Oncology, East Tennessee State University, Johnson City, USA.

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Read More

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Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria.

Case Rep Obstet Gynecol 2021 15;2021:5578686. Epub 2021 Jul 15.

Department of Pathology, Cancer Research Centre, Tishreen University, Lattakia, Syria.

Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42-58 years of age. ESS is usually misdiagnosed as leiomyoma. Read More

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Huge Intraosseous Tibial Haemangioma Managed with Embolisation, Excision and Fibular Ilizarov Reconstruction: A Case Report.

Strategies Trauma Limb Reconstr 2021 Jan-Apr;16(1):60-63

Department of Orthopedics, Tumor Section, University of the Philippines - Philippine General Hospital, Manila, Philippines.

Aim: Our aim is to report the successful treatment of an intraosseous haemangioma of tibia with an atypical presentation through a multidisciplinary approach of preoperative embolisation, a subtotal resection of the tibia and subsequent reconstruction with the Ilizarov medial fibular translation technique.

Background: En bloc excision is the treatment of choice for large tumours of the tibia. However, there is no single recommended method for the reconstruction of the resulting bony defect. Read More

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Clinical Features and Overall Survival of Females with Hepatocellular Carcinoma: A Retrospective Study and Review of the Literature in the Association of Southeast Asian Nations.

Int J Womens Health 2021 22;13:717-725. Epub 2021 Jul 22.

Department of Medicine, Chulabhorn International College of Medicine (CICM) at Thammasat University, Pathumthani, Thailand.

Introduction: Hepatocellular carcinoma (HCC) causes more than 200,000 women deaths annually. This study aimed to investigate the clinical features, provide prognostic factors for female patients with HCC, and performed a literature review on them in the Association of Southeast Asian Nations (ASEAN).

Materials And Methods: We conducted a retrospective cohort study of female patients with HCC at Thammasat University Hospital, Thailand between January 2009 and January 2019. Read More

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A novel MT-CO2 variant causing cerebellar ataxia and neuropathy: The role of muscle biopsy in diagnosis and defining pathogenicity.

Neuromuscul Disord 2021 Jun 4. Epub 2021 Jun 4.

Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; NHS Highly Specialised Services for Rare Mitochondrial Disorders, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK; Directorate of Neurosciences, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK. Electronic address:

Pathogenic variants in mitochondrial DNA (mtDNA) are associated with significant clinical heterogeneity with neuromuscular involvement commonly reported. Non-syndromic presentations of mtDNA disease continue to pose a diagnostic challenge and with genomic testing still necessitating a muscle biopsy in many cases. Here we describe an adult patient who presented with progressive ataxia, neuropathy and exercise intolerance in whom the application of numerous Mendelian gene panels had failed to make a genetic diagnosis. Read More

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Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report.

World J Surg Oncol 2021 Jul 29;19(1):225. Epub 2021 Jul 29.

Department of Endocrinology and Metabolism, Kocaeli University Faculty of Medicine, İzmit, Kocaeli, Turkey.

Background: Extramedullary leukemia, also known as myeloid sarcoma, is a rare form of acute myeloid leukemia and often accompanies bone marrow involvement. Myeloid infiltration of the thyroid gland is extremely rare. Here, a unique case in which thyroid cancer tissue was infiltrated with myeloid cells is presented. Read More

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Vedolizumab combined with surgical resection successfully treated perforating Crohn's disease with peritoneal space to rectal and vaginal fistulas: a case report.

BMC Gastroenterol 2021 Jul 29;21(1):299. Epub 2021 Jul 29.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Chang Gung University College of Medicine, 5, Fu-Hsin Street, Guei-Shan District, Taoyuan City, 33305, Taiwan.

Background: Intestinal perforations and fistulas are common complications of Crohn's disease. However, chronic perforation with peritoneal space to rectal and vaginal fistulas have not been previously reported.

Case Presentation: A 38-year-old female suffered from progressive lower abdominal pain, diarrhea and weight loss. Read More

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Factors That Drive Annual Variation in Pediatric Elbow Fracture Occurrence, Severity, and Resource Utilization.

J Pediatr Orthop 2021 Jul 29. Epub 2021 Jul 29.

Vanderbilt University School of Medicine Division of Pediatric Orthopaedics, Monroe Carell Jr. Children's Hospital at Vanderbilt Department of Orthopaedics, Vanderbilt University Medical Center Departments of Pharmacology Pediatrics Pathology, Microbiology, and Immunology Center for Bone Biology, Nashville, TN The Wharton School at the University of Pennsylvania, Philadelphia, PA.

Background: Elbow fractures are the most common pediatric fractures requiring operative treatment. To date, few studies have examined what annual factors drive pediatric elbow fracture incidence and no studies have examined which annual factors drive elbow fracture severity or resource utilization. The goal of this study was to not only document the annual patterns of pediatric elbow fracture incidence and severity but also the impact of these patterns on resource utilization in the emergency department, emergency medical service transportation, and the operating room (OR). Read More

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Light Chain Deposition Disease presenting as an Atrial Mass: A Case Report and Review of Literature.

Cardiovasc Pathol 2021 Jul 26:107368. Epub 2021 Jul 26.

Department of Pathology, Fairfield Medical Center, Lancaster, Ohio. Electronic address:

Light chain deposition disease (LCDD) also known as Non-Amyloidotic Immunoglobulin Deposition Disease (NIDD) is a rare systemic disorder due to the abnormal deposition of immunoglobulin in multiple organs caused by the clonal proliferation of B lymphocytes and plasma cells. Renal involvement is the most common with cardiac manifestations being the most common extra renal presentation of the disease. Renal involvement is not always associated with LCDD. Read More

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Measuring the Efficacy of Pathology Career Recruitment Strategies in US Medical Students.

Arch Pathol Lab Med 2021 Jul 29. Epub 2021 Jul 29.

The Department of Pathology, Microbiology, and Immunology, New York Medical College at Westchester Medical Center, Valhalla, New York (Islam, Pattarkine, Mares, Lento).

Context.—: Multiple articles and surveys in the literature suggest that medical students find a career in pathology undesirable and believe it is disproportionately focused primarily on the autopsy.

Objective. Read More

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Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review - a case report.

J Egypt Natl Canc Inst 2021 Jul 29;33(1):18. Epub 2021 Jul 29.

Department of Pediatrics, ABVIMS & Dr. RML Hospital, New Delhi, India.

Background: Gastrointestinal complications are not uncommon in patients of Acute Leukemia. Intussusception as a complication in leukemia, although described, is exceedingly rare. Also, it is usually seen after chemotherapy and not as a part of the native disease process. Read More

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Ewing family tumors of the appendicular skeleton: a retrospective analysis of prognostic factors.

Eur J Orthop Surg Traumatol 2021 Jul 29. Epub 2021 Jul 29.

Department of Orthopaedic Oncology, Azienda Ospedaliera Universitaria Careggi, Largo Palagi 1, Firenze, Italy.

Purpose: Authors retrospectively analyzed possible prognostic factors in a series of patients affected by Ewing sarcoma of extremities (eEWS) and treated over a 20-year period at a single institution.

Methods: Between 1997 and 2017, 88 bone eEWS were treated at our institution. Staging, age, gender, tumoral volume, local treatment, surgical margins, post-ChT necrosis were investigated for prognostic correlation with overall survival (OS) and event-free survival (EFS). Read More

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The human melanoma proteome atlas-Defining the molecular pathology.

Clin Transl Med 2021 Jul;11(7):e473

Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. Read More

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A multi-ethnic analysis of immune-related gene expression signatures in patients with ovarian clear cell carcinoma.

J Pathol 2021 Jul 28. Epub 2021 Jul 28.

School of Medicine, , College of Medicine, National Taiwan University.

Little is known about the immune environment of ovarian clear cell carcinoma (OCCC) and its impact on various ethnic backgrounds. The aim of this OCCC immune-related gene expression signatures (irGES) study was to address the interaction between tumour and immune environment of ethnically-diverse Asian and Caucasian populations and to identify relevant molecular subsets of biological and clinical importance. Our study included 264 women from three different countries (Singapore, Japan, and UK) and identified four novel immune subtypes (PD1-high, CTLA4-high, antigen-presentation and pro-angiogenic subtype) with differentially expressed pathways, and gene ontologies using the NanoString nCounter PanCancer Immune Profiling Panel. Read More

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Acute on chronic severe aortic insufficiency due to rheumatoid arthritis-associated valvulitis.

Am J Cardiovasc Dis 2021 15;11(3):404-409. Epub 2021 Jun 15.

Division of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA, USA.

Rheumatoid Arthritis associated valvular heart disease (RA-VHD) may occur in patients in varying degrees of severity. Aortic valve involvement leading to severe symptomatic aortic insufficiency is a rare complication of rheumatoid arthritis. This entity has not been well characterized and its clinical predictors are undefined. Read More

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Therapeutic lessons from transfusion in pregnancy-effect on hematological parameters and coagulation profile.

Am J Blood Res 2021 15;11(3):303-316. Epub 2021 Jun 15.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus Ansari Nagar, New Delhi, India.

Introduction: Transfusion is commonly done in clinical indications and complications arising due to Anemia, shock, blood loss, thrombocytopenia due to any cause, ineffective erythropoiesis. Pregnancy is a physiological condition characterized by Anemia, fluid overload, hypercoagulable state, and antifibrinolytic condition, which can cause various reactions that could be anticipated during a blood transfusion. With an aim to understand the effects of transfusions on hematological parameters in pregnancy. Read More

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Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.

Front Mol Neurosci 2021 12;14:686034. Epub 2021 Jul 12.

Department of Pathology, University of California, San Diego, La Jolla, CA, United States.

Cerebral cortex projection neurons (PNs) are generated from intermediate progenitors (IPs), which are in turn derived from radial glial progenitors (RGPs). To investigate developmental processes in IPs, we profiled IP transcriptomes in embryonic mouse neocortex, using transgenic -GFP mice, cell sorting, and microarrays. These data were used in combination with hybridization to ascertain gene sets specific for IPs, RGPs, PNs, interneurons, and other neural and non-neural cell types. Read More

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Treatment with Theresienöl - a new option in the management of vulvar leukoplakia.

Prz Menopauzalny 2021 Jun 24;20(2):72-75. Epub 2021 May 24.

Department of Obstetrics and Gynaecology, Medical University Pleven, Pleven, Bulgaria.

Introduction: The term vulvar leukoplakia encompasses a variety of non-inflammatory diseases that lead to skin discoloration of the external genitalia and white colouration. Most commonly, these are vulvar lichen sclerosus (VLS) and squamous cell hyperplasia of the vulva (SCHV). They have similar aetiology, clinical presentation, and treatment but different anatomical pathology. Read More

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