Lung Cancer 2021 Jun 8;158:55-59. Epub 2021 Jun 8.
CHU Grenoble-Alpes, Department of Pathology, 38043, Grenoble, France; Univ Grenoble Alpes, CNRS UMR5309, Inserm U1209, Institute for Advanced Biosciences, F-38000, Grenoble, France. Electronic address:
NUT carcinoma (NC), formerly known as NUT midline carcinoma, is a rare and very aggressive cancer. It is genetically defined by the presence of acquired chromosomal rearrangement of the NUTM1 (NUclear protein in Testis Midline carcinoma family member 1) gene at chromosome 15q14 with a member of the bromodomain-containing protein (BRD) family gene, usually BRD4. Although primarily reported in the head and neck, and mediastinum locations of younger individuals, it is now established that NC arises in multiple sites in patients of all ages, with no gender predilection. Read More