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COVID-19 in Argentine teriflunomide-treated multiple sclerosis patients: First national case series.

Mult Scler Relat Disord 2021 May 30;53:103049. Epub 2021 May 30.

Centro de Esclerosis Múltiple de Buenos Aires, CABA; Argentina; Servicio de Neurología, Hospital Universitario CEMIC, Buenos Aires, Argentina.

We report COVID-19 presentation, course and outcomes in teriflunomide-treated MS patients in Argentina.

Methods: descriptive, retrospective, multicentre, study that included MS patients receiving teriflunomide who developed COVID-19, with clinical follow-up at reference MS centres, also listed in a nationwide registry.

Results: Eighteen MS patients on teriflunomide treatment, from eight MS centres developed COVID-19. Read More

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Sensitive and quantitative detection of MHC-I displayed neoepitopes using a semi-automated workflow and TOMAHAQ mass spectrometry.

Mol Cell Proteomics 2021 Jun 12:100108. Epub 2021 Jun 12.

Genentech, South San Francisco, 94080, California, USA. Electronic address:

Advances in several key technologies, including MHC peptidomics, have helped fuel our understanding of basic immune regulatory mechanisms and the identification of T cell receptor targets for the development of immunotherapeutics. Isolating and accurately quantifying MHC-bound peptides from cells and tissues enables characterization of dynamic changes in the ligandome due to cellular perturbations. However, the current multi-step analytical process is challenging, and improvements in throughput and reproducibility would enable rapid characterization of multiple conditions in parallel. Read More

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Aberrant expression of multiple T cell markers on diffuse large B cell lymphoma: a case report.

J Egypt Natl Canc Inst 2021 Jun 15;33(1):14. Epub 2021 Jun 15.

Department of Laboratory and Transfusion Services, Rajiv Gandhi Cancer Institute & Research Centre, Sector 5, Rohini, Delhi, 110085, India.

Background: Aberrant T cell antigen expression has been well documented in diffuse large B cell lymphomas. However, co-expression of multiple T cell antigens including CD3, which has been considered a specific marker for T cells is extremely rare. Awareness about such aberrant expression is important so as not to misdiagnose or wrongly classify a lymphoma. Read More

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The Rapid Mood Screener: A Novel and Pragmatic Screener Tool for Bipolar I Disorder.

CNS Spectr 2021 Apr;26(2):167-168

University Health Network, Toronto, Ontario, Canada.

Introduction: Approximately 70% of patients with bipolar disorder (BPD) are initially misdiagnosed, resulting in significantly delayed diagnosis of 7-10 years on average. Misdiagnosis and diagnostic delay adversely affect health outcomes and lead to the use of inappropriate treatments. As depressive episodes and symptoms are the predominant symptom presentation in BPD, misdiagnosis as major depressive disorder (MDD) is common. Read More

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Discordant structural chromosomal aberrations in chorionic villi and amniotic fluid leading to a formation of an isochromosome 21: a case report.

Mol Cytogenet 2021 Jun 14;14(1):30. Epub 2021 Jun 14.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Background: Fetoplacental discrepancies occur in approximately 1-2% of analyzed prenatal cases. They are typically due to confined placental mosaicism, where an aberration is observed in the placental cells but not found in the fetal cells. Confined placental mosaicism usually involves aneuploidies and more sparsely structural chromosomal aberrations. Read More

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Socioeconomic Status and Rurality Among Patients With Head and Neck Cancer.

Otolaryngol Head Neck Surg 2021 Jun 15:1945998211019278. Epub 2021 Jun 15.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: Describe the relationship among rurality, socioeconomic status (SES), and patient/tumor characteristics in patients presenting with head and neck cancer.

Study Design: Retrospective single-institution study.

Setting: Academic tertiary-level medical center. Read More

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A case of Philadelphia chromosome-positive acute lymphocytic leukaemia with type I CD36 deficiency.

Vox Sang 2021 Jun 14. Epub 2021 Jun 14.

Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Background: CD36 is a glycoprotein expressed on platelets and monocytes of the blood. There are two types of CD36 deficiency, type I and type II. Individuals with type I-deficiency do not express CD36 in any cell type and can produce the CD36 antibody, which causes pathological conditions, such as fetal/neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractory (PTR), through antigenic exposure via transfusion or pregnancy. Read More

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Clinical features of patients with Rocky Mountain spotted fever, dengue and chikungunya infection.

Gac Med Mex 2021 ;157(1):58-63

Department of Medicine and Health Sciences, Universidad de Sonora, Sonora. Mexico.

Introduction: Clinical distinction between arbovirus infections and those caused by rickettsia is crucial to initiate appropriate medical treatment.

Objective: To compare the differences between Rocky Mountain spotted fever (RMSF) and other vector-borne diseases (dengue and chikungunya) with similar clinical presentation, and to identify data that could aid rapid diagnosis of these diseases.

Methods: We evaluated sociodemographic, clinical and laboratory data of 399 patients from five hospitals and clinics of Sonora, Mexico, between 2004 and 2016, with laboratory-confirmed diagnosis of RMSF, dengue, or chikungunya. Read More

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January 2021

An atypical presentation of small bowel adenocarcinoma; a case report.

J Pak Med Assoc 2021 Apr;71(4):1255-1257

Department of General Surgery Unit-1, Lahore General Hospital, Lahore, Pakistan.

Small bowel malignancy (SBM) is a rare malignancy in the gastrointestinal tract. Duodenum is the most commonly involved segment and the most common histological subtype is adenocarcinoma (40%). Due to a lack of screening tools and vague symptoms, its clinical detection is very challenging. Read More

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SARS-CoV-2 RNA DETECTION IN CEREBROSPINAL FLUID: PRESENTATION OF TWO CASES AND REVIEW OF LITERATURE.

Brain Behav Immun Health 2021 Jun 8:100282. Epub 2021 Jun 8.

Department of Neurology, Sanatorio Güemes - University Hospital, Buenos Aires, Argentina.

Neurological manifestations of SARS-CoV-2 infection are multiple and heterogeneous. However, confirmation of nervous system impairment by viral RNA detection in cerebrospinal fluid (CSF) is uncommon. We report two cases of central nervous system (CNS) involvement with positive real-time reverse-transcriptase polymerase chain reaction (RT-PCR) test in CSF. Read More

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Interventricular septum mass presenting as a late acute coronary syndrome with ST-segment elevation: a case report.

Eur Heart J Case Rep 2021 May 12;5(5):ytab164. Epub 2021 May 12.

Radiology Department, Hopital Saint-Joseph, 185 Rue Raymond Losserand, 75014 Paris, France.

Background: Intracardiac masses are relatively rare but the diagnosis can be challenging for the cardiologist and the clinical presentation can be misleading. While most of the cardiac masses are benign, malignant masses are mostly metastatic tumours.

Case Summary: An 81-year-old man was admitted to the cardiology department for congestive heart failure with the complaint of recent dyspnoea. Read More

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Importance of duration of acute kidney injury after severe trauma: a cohort study.

Trauma Surg Acute Care Open 2021 27;6(1):e000689. Epub 2021 May 27.

Surgery, University of Texas McGovern Medical School, Houston, Texas, USA.

Background: Acute kidney injury (AKI) is common after severe trauma. AKI incidence and AKI stage have previously been shown to be associated with poor outcomes after trauma. However, AKI duration may also be important for outcomes after trauma, given that it is associated with long-term morbidity and mortality in general intensive care unit (ICU) and hospitalized patients. Read More

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Cardiac Arrest and Inverted Takotsubo Cardiomyopathy Following Intramyometrial Vasopressin Injection During Myomectomy.

Eur J Case Rep Intern Med 2021 21;8(5):002504. Epub 2021 May 21.

Department for Intensive Internal Medicine, University Medical Center Ljubljana, Slovenia.

Vasopressin is involved in cardiovascular homeostasis that can influence coronary perfusion. It is commonly used as a local vasoconstricting agent during gynaecological procedures. We present a case of cardiac arrest and inverse Takotsubo features following intramyometrial vasopressin administration during myomectomy. Read More

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Trying to stomach multiple myeloma: A case report.

J Family Med Prim Care 2021 Apr 29;10(4):1785-1788. Epub 2021 Apr 29.

College of Medicine Chattanooga, The University of Tennessee Health Science Center, Chattanooga, TN 37403, USA.

We report a case of a 51-year-old male with minimal past medical history who presented to his primary care provider with nausea, vomiting and constipation in the outpatient setting. Concomitantly, he was found to have a renal injury, anemia and lytic lesions which were confirmed to be due to multiple myeloma. After further investigation of the gastrointestinal symptoms, he was diagnosed with gastroparesis. Read More

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Pembrolizumab in FIGO IVB Verrucous Carcinoma of the Vulva: A Case Report.

Front Oncol 2021 28;11:598594. Epub 2021 May 28.

Department of Gynecological Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Vulvar cancer is the fourth most common gynecologic cancer, and prognosis is poor in advanced vulvar cancer patients. Treatment for advanced vulvar cancer has not been satisfactory. In this report, we firstly report a FIGO IVB vulva verrucous carcinoma patient who obtained good prognosis after systemic treatment. Read More

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Spontaneous Intracranial Hemorrhage: A Sign of Cavernous Angioma Diagnosis in Pediatric Age Group.

Cureus 2021 May 9;13(5):e14917. Epub 2021 May 9.

Department of Neuroscience, Salmaniya Medical Complex, Manama, BHR.

Cerebral cavernous malformation (CCM) is a developmental abnormality of blood vessels that supply the brain. It is composed of large, adjacent capillaries which contain little or no neural tissue. They mostly occur in the supratentorial region. Read More

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Upper Extremity Superficial Vein Thromboses Presenting as Acute Neck Pain in a Young and Healthy Male: A Case Report.

Int J Sports Phys Ther 2021 Jun 1;16(3):854-861. Epub 2021 Jun 1.

U.S. Army Research Institute of Environmental Medicine.

Background And Purpose: Neck pain in the United States is pervasive and contributes to disability. While the majority of neck pain in young and healthy individuals is neuromusculoskeletal in nature, screening for red flags is necessary for ruling-out serious medical pathologies. The purpose of this case report is to describe a young and healthy male subject with a primary complaint of acute neck pain with multiple underlying upper extremity superficial vein thromboses (UESVTs). Read More

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Management of Hematologic Adverse Events Associated With Immune Checkpoint Inhibitors.

J Adv Pract Oncol 2021 May 1;12(4):392-404. Epub 2021 May 1.

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Immune checkpoint inhibitors target suppressor receptors, including cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), and programmed cell death ligand 1 (PD-L1). The activated T cells are not antigen specific; therefore, the blockade of the immune checkpoint may result in the development of autoimmune adverse events. The most common immune-related adverse events (irAEs) are rash, colitis, and endocrinopathies. Read More

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Survival Benefit of Intervention Treatment in Advanced Anaplastic Thyroid Cancer.

Int J Surg Oncol 2021 3;2021:5545127. Epub 2021 Jun 3.

Department of Otorhinolaryngology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: The management of anaplastic thyroid cancer (ATC) is controversial; thus, proper treatment and prognostic factors should be investigated.

Objectives: To compare the survival outcomes of the intervention and palliative treatment in ATC patients.

Methods: A hospital-based retrospective study was conducted at a single tertiary university hospital. Read More

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Undifferentiated Embryonal Sarcoma of the Liver With Rhabdoid Morphology Mimicking Carcinoma: Expanding the Morphologic Spectrum or a Distinct Variant?

Pediatr Dev Pathol 2021 Jun 14:10935266211018930. Epub 2021 Jun 14.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare aggressive neoplasm that occurs predominantly in children. Like mesenchymal hamartoma of the liver (MHL), UESL harbors recurrent rearrangements involving 19q13.3 and 19q13. Read More

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An Analysis of Traumatic Ankle Fracture Patients: Does Income Status Influence Access to Acute Orthopaedic Surgical Care?

J Health Care Poor Underserved 2021 ;32(2):1059-1068

Purpose: To evaluate if income status affects the timing of presentation to orthopaedic care, surgical treatment, or continuity of care following a closed ankle fracture.

Methods: Th is retrospective study identified 434 patients with closed ankle fractures treated with operative fixation from 2014 to 2016. Median income data were extracted using the patients' ZIP codes and data from the U. Read More

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January 2021

Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report.

Allergy Asthma Clin Immunol 2021 Jun 13;17(1):58. Epub 2021 Jun 13.

Division of Internal Medicine, Northern Ontario School of Medicine, Sudbury, ON, Canada.

Background: Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathophysiological mechanisms including a Type I and Type IV hypersensitivity reaction. Here we present the case of a patient with APD whose episodic flares were controlled by the addition of omalizumab, after a bilateral oophorectomy failed to resolve her symptoms. Read More

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A case of peritoneal dialysis-associated peritonitis caused by Rhodococcus kroppenstedtii.

BMC Infect Dis 2021 Jun 13;21(1):565. Epub 2021 Jun 13.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, 321# Zhongshan Road, Gulou District, Nanjing City, Jiangsu Province, 210008, P. R. China.

Background: Rhodococcus kroppenstedtii is an aerobic, gram-positive bacterium firstly identified in the environment, which has not been reported in human-related infection. Herein, we reported the first case of peritoneal dialysis (PD)-associated peritonitis caused by R. kroppenstedtii which was identified by whole genome sequencing. Read More

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Unilateral Optic Neuritis Associated with SARS-CoV-2 Infection: A Rare Complication.

Am J Case Rep 2021 Jun 13;22:e931665. Epub 2021 Jun 13.

Department of Medicine, St. George's University School of Medicine, St. Georges, Grenada.

BACKGROUND Since the outbreak of the SARS-CoV-2 infection, extensive research has been conducted on the pulmonary implications of this novel disease. However, there has been limited data on the extrapulmonary manifestations. There have been few documented causes of optic involvement and little is understood about the pathophysiology around its presentation and the possible treatments to prevent long-term complications. Read More

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Whole jejunoileal diverticulosis with recurrent inflammation and perforation: A case report.

Int J Surg Case Rep 2021 May 27;84:106020. Epub 2021 May 27.

Department of Surgery, Hoshigaoka Medical Center, 4-8-1 Hoshigaoka, Hirakata, Osaka, Japan. Electronic address:

Introduction: Jejunoileal diverticulitis is uncommon and poorly understood. We report a case of whole jejunoileal diverticulosis with recurrent inflammation and perforation.

Case Presentation: A 72-year-old man with hemodialysis presented with fever and abdominal pain. Read More

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Iliac-femoral stent-graft infection after hybrid procedure redo: Case report.

Int J Surg Case Rep 2021 Jun 8;84:106096. Epub 2021 Jun 8.

Vascular Surgery Unit, AOUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Stent-graft infection in peripheral arteries is rare and potentially dangerous. The use of hybrid procedures, in complicated patients previously treated, involves an increase of infective risk especially in no collaborative patients.

Presentation Of Case: We report a case of rare stent-graft infection in a patient treated for a Rutherford IV Multiple Peripheral Arterial Disease (MPAD) involving the right iliac-femoral axis with stenosis on deep femoral artery due to a previously stenting procedure for Superficial Femoral artery (SFA) stenosis. Read More

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Thoracic NUT carcinoma: Common pathological features despite diversity of clinical presentations.

Lung Cancer 2021 Jun 8;158:55-59. Epub 2021 Jun 8.

CHU Grenoble-Alpes, Department of Pathology, 38043, Grenoble, France; Univ Grenoble Alpes, CNRS UMR5309, Inserm U1209, Institute for Advanced Biosciences, F-38000, Grenoble, France. Electronic address:

NUT carcinoma (NC), formerly known as NUT midline carcinoma, is a rare and very aggressive cancer. It is genetically defined by the presence of acquired chromosomal rearrangement of the NUTM1 (NUclear protein in Testis Midline carcinoma family member 1) gene at chromosome 15q14 with a member of the bromodomain-containing protein (BRD) family gene, usually BRD4. Although primarily reported in the head and neck, and mediastinum locations of younger individuals, it is now established that NC arises in multiple sites in patients of all ages, with no gender predilection. Read More

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Influence of loneliness and social isolation on the diagnosis and treatment of Japanese patients with advanced lung cancer: a prospective cohort study.

Ann Palliat Med 2021 Jun 2. Epub 2021 Jun 2.

Center for Innovative Research for Communities and Clinical Excellence, Fukushima Medical University, Fukushima, Fukushima, Japan; Department of General Internal Medicine, Fukushima Medical University, Fukushima, Fukushima, Japan.

Background: Social determinants of health (SDHs) are social factors that affect human health; loneliness and social isolation are core SDH factors. There is a possibility that SDHs are related to passive decisionmaking. However, few studies have evaluated SDHs, especially social isolation and loneliness, among lung cancer patients. Read More

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Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.

Int J Surg Case Rep 2021 May 23;83:106008. Epub 2021 May 23.

Department of Surgery, Division of Surgical Oncology, University of California San Francisco, San Francisco, CA, USA. Electronic address:

Introduction And Importance: Functioning pancreatic neuroendocrine tumors (pNETs) that express pancreatic polypeptide-PPomas-do not yet have a pathognomonic clinical syndrome associated with them due to their overall rarity and diverse symptoms. Moreover, in patients with MEN1, the often multifocal nature of pNETs presents a unique clinical issue.

Case Presentation: We report a case of a 22-year-old man with a known MEN1 gene mutation who was suffering from severe diarrhea (7-8 bowel movements per day) and was found to have only elevated PP levels on biochemical work-up. Read More

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Implementation of a Palliative Oncology Tumor Board.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Penn Medicine Lancaster General Health Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania, USA.

Context: The integration of palliative care into standard oncologic care has been shown to improve multiple outcomes in patients with advanced cancer. Ideal methods for integrating these disciplines is an ongoing area of discussion. One method of integration is a palliative oncology tumor board (POTB). Read More

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