365,081 results match your criteria presentation congenital


Psychogenic pseudo-myasthenic ptosis - management with ayurvedic medicines and meditation.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Department of Manasaroga, VPSV Ayurveda College, Kottakkal, Kerala, India.

Objectives: Patients presenting with functional neurological symptoms like non-epileptic seizures and weakness have an underlying psychological component and tend to persist for a prolonged time, despite repeated evaluations and interventions. Ayurveda, with its holistic approach to health and disease, can provide better management for such disorders, in the form of customized treatment protocols and unique methods of psychotherapy.

Case Presentation: The patient presented with drooping of both eyelids, initially diagnosed as ocular myasthenia, and later found to have psychogenic pseudo-myasthenic ptosis. Read More

View Article and Full-Text PDF

Herbal supplement (Combi-5) in the management of COVID 19 individual with mild to moderate symptoms: a case report.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Plateau State Specialist Hospital, Jos, Plateau State, Nigeria.

Objective: To explore repurposing known natural products for managing patients with mild to moderate symptoms of COVID-19.

Case Presentation: We present a case report of a middle aged woman, who was positive to COVID 19, with mild to moderate symptoms; who self -managed at home using well formulated herbal supplement (Combi-5) taken along with vitamin C and Zinc supplements. She recovered within a short time. Read More

View Article and Full-Text PDF

COVID-19 and atrial fibrillation in older patients. Does oral anticoagulant therapy provide a survival benefit? An insight from the GeroCovid Registry.

Thromb Haemost 2021 May 7. Epub 2021 May 7.

Department of Medicine, Campus Bio-Medico University, Roma, Italy.

Introduction: Atrial fibrillation (AF), the most frequent arrhythmia of older patients, associates with serious thrombo-embolic complications and high mortality. COVID-19 severely affects aged subjects, determining an important prothrombotic status. Aim of this study was to evaluate mortality-related factors in older AF patients with COVID-19. Read More

View Article and Full-Text PDF

Identifying patients at risk for nonroutine discharge after surgery for cervical myelopathy: an analysis from the Quality Outcomes Database.

J Neurosurg Spine 2021 May 7:1-9. Epub 2021 May 7.

15Department of Neurological Surgery, University of Utah, Salt Lake City, Utah.

Objective: Optimizing patient discharge after surgery has been shown to impact patient recovery and hospital/physician workflow and to reduce healthcare costs. In the current study, the authors sought to identify risk factors for nonroutine discharge after surgery for cervical myelopathy by using a national spine registry.

Methods: The Quality Outcomes Database cervical module was queried for patients who had undergone surgery for cervical myelopathy between 2016 and 2018. Read More

View Article and Full-Text PDF

Pediatric mild head trauma: is outpatient follow-up imaging necessary or beneficial?

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

3Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.

Objective: Pediatric traumatic brain injury (TBI) is the leading cause of death among children and is a significant cause of morbidity. However, the majority of injuries are mild (Glasgow Coma Scale score 13-15) without any need for neurosurgical intervention, and clinically significant neurological decline rarely occurs. Although the question of repeat imaging within the first 24 hours has been discussed in the past, the yield of short-term follow-up imaging has never been thoroughly described. Read More

View Article and Full-Text PDF

Cost-effectiveness of endovascular thrombectomy in patients with low Alberta Stroke Program Early CT Scores (< 6) at presentation.

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

Departments of1Radiology and Biomedical Imaging and.

Objective: The utility of endovascular thrombectomy (EVT) in patients with acute ischemic stroke, large vessel occlusion (LVO), and low Alberta Stroke Program Early CT Scores (ASPECTS) remains uncertain. The objective of this study was to determine the health outcomes and cost-effectiveness of EVT versus medical management in patients with ASPECTS < 6.

Methods: A decision-analytical study was performed with Markov modeling to estimate the lifetime quality-adjusted life-years (QALYs) and associated costs of EVT-treated patients compared to medical management. Read More

View Article and Full-Text PDF

Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence.

J Neurosurg 2021 May 7:1-8. Epub 2021 May 7.

Departments of1Neurological Surgery.

Objective: Silent corticotroph adenomas (SCAs) are a distinct subtype of nonfunctioning pituitary adenomas (NFAs) that demonstrate positive immunohistochemistry for adrenocorticotropic hormone (ACTH) without causing Cushing's disease. SCAs are hypothesized to exhibit more aggressive behavior than standard NFAs. The authors analyzed their institution's surgical experience with SCAs in an effort to characterize rates of invasion, postoperative clinical outcomes, and patterns of disease recurrence and progression. Read More

View Article and Full-Text PDF

Distinct Clinical and Radiographic Phenotypes in Pediatric Patients With Moyamoya.

Pediatr Neurol 2021 Apr 2;120:18-26. Epub 2021 Apr 2.

Division of Neurology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Given the expanding evidence of clinico-radiological differences between moyamoya disease (MMD) and moyamoya syndrome (MMS), we compared the clinical and radiographic features of childhood MMD and MMS to identify predictors of ischemic event recurrence.

Methods: We reviewed a pediatric moyamoya cohort followed between 2003 and 2019. Clinical and radiographic characteristics at diagnosis and follow-up were abstracted. Read More

View Article and Full-Text PDF

Acute abdomen: Unusual presentation of Herlyn-Werner Wunderlich syndrome.

Int J Surg Case Rep 2021 Apr 27;82:105911. Epub 2021 Apr 27.

Department of Surgery, Samlaniya Medical Complex, P.O. Box 12, Manama, Bahrain.

Introduction And Importance: The presentation of an acute abdomen has a wide range of differentials. Developmental anomalies are rarely considered as part of the clinical reasoning process due to it being a mimicker of other commoner diseases. The importance of considering such anomalies and recognizing them early is essential in order to prevent complications, such as infertility. Read More

View Article and Full-Text PDF

Surgical debridement, maggot therapy, negative pressure wound therapy, and silver foam dressing revive hope for patients with diabetic foot ulcer: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105931. Epub 2021 Apr 29.

Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Introduction And Importance: Diabetic foot ulcers (DFUs), as one of the most debilitating complications of diabetes, can lead to amputation. Treatment and management of d DFUs are among the most critical challenges for the patients and their families.

Case Presentation: The present case report is of a 63-year-old man with a 5-year history of uncontrolled type 2 diabetes who has had DFU for the past three years on three sites of the left external ankle in the form of two deep circular ulcers with sizes of 6 × 4 cm and 6 × 8 cm, the sole as a superficial ulcer with a size of 6 × 3 cm, and the left heel as a deep skin groove. Read More

View Article and Full-Text PDF

A complex fracture of the hyoid bone and the larynx after a bicycle accident - Case report and review of literature.

Int J Surg Case Rep 2021 Apr 27;82:105922. Epub 2021 Apr 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

Introduction And Importance: Reports about laryngeal trauma and fractures of the hyoid bone are rare in the literature. Most cases are forensic cases and the results of postmortem analysis. Traumatic larynx and hyoid bone fractures represent a rare but important differential diagnosis of the common symptom hoarseness. Read More

View Article and Full-Text PDF

A case report and literature review of heterotopic mesenteric ossification.

Int J Surg Case Rep 2021 Apr 27;82:105905. Epub 2021 Apr 27.

Department of General Surgery, Al-Hada Armed Forces Hospital, Taif, Saudi Arabia.

Introduction And Importance: Heterotopic mesenteric ossification is a benign bony tissue growth in the mesentery that mostly follows repetitive or severe abdominal injuries leading to reactive bone formation in the mesentery. There are only 73 cases (51 publications) identified in the literature up to the beginning of 2020.

Case Presentation: 45-year-old Saudi male underwent multiple laparotomies to manage complicated appendicitis which ended with a diverting ileostomy and a colostomy as a mucus fistula. Read More

View Article and Full-Text PDF

The advantage of laparoscopic surgery in the treatment of Spigelian hernia: A report of two cases.

Int J Surg Case Rep 2021 Apr 27;82:105903. Epub 2021 Apr 27.

Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan. Electronic address:

Introduction And Importance: The usefulness of laparoscopic surgery in the treatment of Spigelian hernias and the appropriate insufflation pressure remains unclear.

Case Presentation: Case 1 involved an 81-year-old woman presented with a right abdominal protrusion. CT scan demonstrated a defect in the abdominal wall at the lateral edge of the right rectus abdominis muscle. Read More

View Article and Full-Text PDF

Horseshoe kidney leading to ERCP failure; innovative use of guide wire during laparoscopic CBD exploration: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105927. Epub 2021 Apr 29.

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

Introduction: Horseshoe kidneys are the most common fusion defect of the kidneys, which amounts to about 0.25% of the population. They are usually asymptomatic and are often identified incidentally. Read More

View Article and Full-Text PDF

Breast cancer metastasizing to the contralateral axilla several years after treatment: A case report with literature review.

Int J Surg Case Rep 2021 Apr 27;82:105900. Epub 2021 Apr 27.

Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan, Iraq; Department of Medical Analysis, Tishk International University, Erbil, Kurdistan Region, Iraq.

Introduction And Importance: Lymph node metastasis is the most prominent prognostic factor in breast cancer. The aim of this paper is to report a case of contralateral axillary lymph node metastasis (CAM) which look like metachronous initially, but histopathologicaly confirmed as synchronous CAM.

Case Presentation: A-44-year old female was a known case of left breast cancer five years prior to this presentation (T2,N2,M0, grade III, Triple negative, multifocal invasive ductal carcinoma). Read More

View Article and Full-Text PDF

Treatment of liver failure post one anastomosis gastric bypass by revising to normal anatomy: A case report.

Int J Surg Case Rep 2021 Apr 27;82:105914. Epub 2021 Apr 27.

College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Eastern Province, Saudi Arabia.

Introduction: Obesity and the associated metabolic syndrome are global health problems. Significant weight loss after bariatric surgery can cause a substantial difference in those comorbidities in obese patients. In this case, we described a rare complication of a patient who developed acute liver failure after an uneventful one anastomosis gastric bypass treated conservatively and revision of the one anastomosis gastric bypass to normal anatomy. Read More

View Article and Full-Text PDF

A case report of necrotizing soft tissue infection of the chest wall: Effective management with serial debridement.

Int J Surg Case Rep 2021 Apr 27;82:105908. Epub 2021 Apr 27.

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Sapporo, Hokkaido, Japan.

Introduction: Necrotizing soft tissue infection (NSTI) of the chest wall is a rare, rapidly spreading, highly lethal surgical disease. Radical debridement interferes with the important anatomical function of the chest wall. We report a case of chest wall NSTI that was successfully managed with early diagnosis and serial debridement. Read More

View Article and Full-Text PDF

Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8 T cells.

Biomaterials 2021 Apr 27;274:120844. Epub 2021 Apr 27.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Identification of tumor-specific mutations, called neoantigens, offers new exciting opportunities for personalized cancer immunotherapy. However, it remains challenging to achieve robust induction of neoantigen-specific T cells and drive their infiltration into the tumor microenvironment (TME). Here, we have developed a novel polyethyleneimine (PEI)-based personalized vaccine platform carrying neoantigen peptides and CpG adjuvants in a compact nanoparticle (NP) for their spatio-temporally concerted delivery. Read More

View Article and Full-Text PDF

Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3.

Eur J Med Chem 2021 Apr 27;220:113500. Epub 2021 Apr 27.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Prague 4, Czech Republic. Electronic address:

Galectin-3 plays a crucial role in cancerogenesis; its targeting is a prospective pathway in cancer diagnostics and therapy. Multivalent presentation of glycans was shown to strongly increase the affinity of glycoconjugates to galectin-3. Further strengthening of interaction with galectin-3 may be accomplished using artificial glycomimetics with apt aryl substitutions. Read More

View Article and Full-Text PDF

Long term outcomes of idiopathic intracranial hypertension: Observational study and literature review.

Clin Neurol Neurosurg 2021 Jan 5;205:106463. Epub 2021 Jan 5.

Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address:

Background: Idiopathic intracranial hypertension (IIH) is an unexplained increase in intracranial pressure often associated with obesity. The aim of this study was to conduct a retrospective observational study of the long term clinical, visual, and treatment outcomes in IIH patients.

Methods: A retrospective observational study of patients diagnosed with IIH over a 12-year period at a single centre was completed via database review. Read More

View Article and Full-Text PDF
January 2021

Calcaneal osteomyelitis caused by Acremonium sp in an immunocompetent adult - A case report.

Foot (Edinb) 2021 Jan 22;47:101781. Epub 2021 Jan 22.

Department of Internal Medicine, PGIMER Dr RML Hospital, New Delhi, India.

Fungal osteomyelitis of calcaneus is rare in immunocompetent adults. A case of fungal osteomyelitis of calcaneus in a 19 year old immunocompetent female without any history of trauma caused by Acremonium sp is presented. The patient was treated with surgical debridement, autogenous iliac crest bone grafting and antifungal chemotherapy for 6 months. Read More

View Article and Full-Text PDF
January 2021

Association of Neighborhood Socioeconomic Disadvantage With Complicated Appendicitis in Children.

J Surg Res 2021 May 4;265:245-251. Epub 2021 May 4.

Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: Lower socioeconomic status (SES) is linked to poorer outcomes for a variety of health conditions in children, potentially through delay in accessing care. The objective of this study was to measure the association between SES and delay in surgical care as marked by presentation with complicated appendicitis (CA).

Methods: Children treated for acute appendicitis between 2015-2019 at a large academic children's hospital were reviewed. Read More

View Article and Full-Text PDF

Cross-talk between next generation sequencing methodologies to identify genomic signatures of esophageal cancer.

Crit Rev Oncol Hematol 2021 May 4:103348. Epub 2021 May 4.

Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India; Department of GI Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India. Electronic address:

The asymptomatic behaviour of esophageal cancerous cells at early stages develops advanced clinical presentation of the disease, resulting in poor prognosis and curbed intervention of therapeutic modalities. The endeavours to detect diagnostic and prognostic markers have been proven futile at the clinical platform. While several biomarkers have been investigated, including CYFRA 21-1, carcinoembryonic antigen and squamous cell carcinoma antigen, their sensitivity has not proved consistently satisfactory across the various stages of esophageal cancer. Read More

View Article and Full-Text PDF

Thymic Carcinoma with Multiple Paraneoplastic Disorders.

Am J Med Sci 2021 May 4. Epub 2021 May 4.

2(nd) Academic Department of Internal Medicine, Medical School, National & Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece. Electronic address:

Thymic neoplasms are rare and may run an indolent course. Among them, thymic epithelial carcinoma is exceptional as it may be presented with extensive local invasion and distant metastases. There is a wide spectrum of autoimmune/paraneoplastic syndromes associated with thymic tumors including autoimmune diseases, some of which may precede the diagnosis of thymoma. Read More

View Article and Full-Text PDF

SEX AND RACIAL DIFFERENCES IN HIGH-DENSITY LIPOPROTEIN LEVELS IN ACUTE CORONARY SYNDROMES.

Am J Med Sci 2021 May 4. Epub 2021 May 4.

Division of Cardiology, University of Florida College of Medicine, Jacksonville, FL. Electronic address:

Background: This study aimed to assess sex and racial differences related to high-density lipoprotein cholesterol (HDL-C) levels in those presenting with acute coronary syndromes (ACS) .

Methods: Records from patients with ACS presenting to the Emergency Department of University of Florida Hospital Jacksonville from 2009-2012, were reviewed. Detailed medical history was obtained. Read More

View Article and Full-Text PDF

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.

Cancer Cell 2021 Apr 27. Epub 2021 Apr 27.

Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address:

Distinct T cell infiltration patterns, i.e., immune infiltrated, excluded, and desert, result in different responses to cancer immunotherapies. Read More

View Article and Full-Text PDF

Auditory brainstem response asymmetries in older adults: An exploratory study using click and speech stimuli.

PLoS One 2021 7;16(5):e0251287. Epub 2021 May 7.

École d'orthophonie et d'audiologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.

Background: Some evidence suggests that young adults exhibit a selective laterality of auditory brainstem response (ABR) elicited with speech stimuli. Little is known about such an auditory laterality in older adults.

Objective: The aim of this study was to investigate possible asymmetric auditory brainstem processing between right and left ear presentation in older adults. Read More

View Article and Full-Text PDF

Salient properties in bimanual haptic volume perception: influence of object shape, finger pair, and schizotypal personality traits.

IEEE Trans Haptics 2021 May 7;PP. Epub 2021 May 7.

Bimanual haptic volume perception refers to somatosensory access to volume information through both hands, and the characteristics that influence this perception remain unclear. The current study investigated the influence of target object shapes and finger pairs on bimanual haptic perception; in addition, associations of bimanual haptic impairment and schizotypal features in nonpsychotic individuals were investigated. Twenty blindfolded participants bimanually discriminated volume variations in regular solid objects under different shape (tetrahedron, cube, or sphere) and finger pair (high- or low-sensitivity pairs) conditions using a newly developed bimanual haptic volume presentation device. Read More

View Article and Full-Text PDF

Learning Prognostic Models using DiseaseProgression Patterns: Predicting the Need forNon-Invasive Ventilation in Amyotrophic LateralSclerosis.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 7;PP. Epub 2021 May 7.

Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease causing rapid degeneration of motor neurons and usually leading to death by respiratory failure. Since there is no cure, treatment's goal is to improve symptoms and prolong survival. Non-invasive Ventilation (NIV) is an effective treatment, leading to extended life expectancy and improved quality of life. Read More

View Article and Full-Text PDF