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Interindividual variability of functional connectome in schizophrenia.

Schizophr Res 2021 Jul 27;235:65-73. Epub 2021 Jul 27.

Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.

Schizophrenia is a complex psychiatric disorder that displays an outstanding interindividual variability in clinical manifestation and neurobiological substrates. A better characterization and quantification of this heterogeneity could guide the search for both common abnormalities (linked to lower intersubject variability) and the presence of biological subtypes (leading to a greater heterogeneity across subjects). In the current study, we address interindividual variability in functional connectome by means of resting-state fMRI in a large sample of patients with schizophrenia and healthy controls. Read More

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The chest radiographic scoring system in initial diagnosis of COVID-19: Is a radiologist needed?

Adv Clin Exp Med 2021 Jul 30. Epub 2021 Jul 30.

Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Background: Lung imaging, next to a polymerase chain reaction (PCR) test, is a key diagnostic tool in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The degree of abnormalities correlates with clinical outcome. Imaging of the lungs using chest radiography (CXR) at the peak of a pandemic is considered a basic diagnostic tool at the triage stage. Read More

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Prevalence and pain distribution of anterior knee pain in college basketball players.

J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

1La Trobe Sport and Exercise Medicine Research Centre; College of Science, Health and Engineering; La Trobe University; Australia.

Context: Causes of anterior knee pain (AKP) in jumping athletes include patellofemoral pain and patellar tendinopathy. Differential diagnosis of AKP is challenging, with variation in clinical presentations. No previous research has used pain location to describe AKP in basketball athletes. Read More

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Workplace noise exposure and the prevalence and 10-year incidence of age-related hearing loss.

PLoS One 2021 30;16(7):e0255356. Epub 2021 Jul 30.

Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, NSW, Australia.

There is paucity of population-based data on occupational noise exposure and risk of age-related hearing loss. Therefore, we assessed cross-sectional and longitudinal associations of past workplace noise exposure with hearing loss in older adults. At baseline, 1923 participants aged 50+ years with audiological and occupational noise exposure data included for analysis. Read More

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Cerebrospinal fluid inflammatory profile of cognitive impairment in newly diagnosed multiple sclerosis patients.

Mult Scler 2021 Jul 30:13524585211032510. Epub 2021 Jul 30.

Neurology Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Background: The cerebrospinal fluid (CSF) molecular milieu is a marker of diffuse intrathecal inflammation in the meninges that, in turn, targets the grey matter (GM) in multiple sclerosis (MS). Cognitive impairment (CI) is associated with brain damage in MS and is often present early in people with MS (pwMS).

Objective: To investigate whether a specific CSF inflammatory profile is associated with different degrees of CI in newly diagnosed pwMS. Read More

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Prevalence of coronary calcium deposits in Sheehan's syndrome patients on long term replacement treatment.

Pituitary 2021 Jul 30. Epub 2021 Jul 30.

Department of Internal Medicine and Endocrinology, Government Medical College, Srinagar, Jammu and Kashmir, India.

Purpose: Sheehan's Syndrome (SS) is one of the most important causes of hypopituitarism in developing countries with patients having varying degrees and severity of anterior pituitary hormone deficiency including growth hormone deficiency (GHD). SS is characterized by increased clustering of metabolic and proinflammatory risk factors predisposing them to increased cardiovascular morbidity and mortality. Coronary calcium deposits (CCD), a marker for significant coronary atherosclerosis, is used for evaluation in asymptomatic individuals of global cardiac risk to develop events related to coronary heart disease (CHD). Read More

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Symptom severity is associated with signs of central sensitization in patients with asthma.

Clin Respir J 2021 Jul 30. Epub 2021 Jul 30.

Department of Physical Therapy, Faculty of Health Sciences. University of Granada, Granada, Spain.

Introduction: Asthma is characterized by recurrent episodes of wheezing, dyspnea, chest tightness and cough. In addition to respiratory symptoms, previous studies have reported the presence of pain.

Objective: To analyse the nociceptive processing of young adults with well-controlled asthma. Read More

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AKAP12/Gravin is over-expressed in patients with ulcerative colitis.

Immunol Res 2021 Jul 30. Epub 2021 Jul 30.

Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Médicasy Nutrición Salvador Zubirán, Vasco de Quiroga #15, Col. Belisario Domínguez Sección XVI, CP, CDMX, 14080, Mexico City, Mexico.

The gene of A-kinase anchor protein 12 (AKAP12) regulates cell cycle progression, cell motility, and morphology through its multiple scaffolding domains. However, the role of AKAP12 expression in ulcerative colitis (UC) patients has not been yet described. The aim of the study was to describe the gene and protein of AKAP12 expression in patients with UC and its association regarding the disease severity. Read More

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Screening of Depression in Elderly Population Using a Geriatric Depression Scale in the Field Practice Area of Urban Health Training Centre Attached to SMS Medical College, Jaipur.

Cureus 2021 Jun 23;13(6):e15859. Epub 2021 Jun 23.

Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, IND.

Background And Objective: Depression is one of the most common illnesses worldwide, with more than 264 million people affected. Various studies in the elderly population have estimated the prevalence of depression across India, with results ranging from 6% to 62%. The objectives of this study were to estimate the prevalence of depression among the elderly population using a Geriatric Depression Scale (GDS) and to find out the association between various sociodemographic parameters and depression among elderly people. Read More

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Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study.

Prostate Cancer 2021 6;2021:3825525. Epub 2021 Jul 6.

Department of Surgery, College of Medicine, Jouf University, Sakaka, Saudi Arabia.

The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. . To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer's risk. Read More

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Association Between Smoking and COVID-19 Severity: Evidence from Bangladesh.

J Multidiscip Healthc 2021 23;14:1923-1933. Epub 2021 Jul 23.

Department of Public Health, North South University, Bashundhara, Dhaka, 1229, Bangladesh.

Purpose: Previous studies have explored several risk factors for coronavirus disease 2019 (COVID-19) severity, but there is still a lack of association with smoking. Our study aims to find out the association between smoking and COVID-19 severity.

Subjects And Methods: This comparative study was conducted among hospitalized severely and critically ill COVID-19 patients, as well as asymptomatic, mild, and moderate patients from the list of the city corporation (Dhaka, Bangladesh), as confirmed by reverse-transcription polymerase chain reaction (RT-PCR). Read More

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Quantitative assessment of atherosclerotic plaque, recent progress and current limitations.

J Cardiovasc Comput Tomogr 2021 Jul 16. Epub 2021 Jul 16.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

An important advantage of computed tomography coronary angiography (CCTA) is its ability to visualize the presence and severity of atherosclerotic plaque, rather than just assessing coronary artery stenoses. Until recently, assessment of plaque subtypes on CCTA relied on visual assessment of the extent of calcified/non-calcified plaque, or visually identifying high-risk plaque characteristics. Recent software developments facilitate the quantitative assessment of plaque volume or burden on CCTA, and the identification of subtypes of plaque based on their attenuation density. Read More

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Working at Home: The Impacts of COVID 19 on Health, Family-Work-Life Conflict, Gender, and Parental Responsibilities.

J Occup Environ Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Public Health, La Trobe University, Bundoora, Australia (Graham, Weale, Lambert, Kinsman, Stuckey, Oakman).

Objective: To examine the impact of working at home on general health, pain, stress, and work-family and family-work conflict, and differences based on gender and parental responsibilities.

Methods: A convenience sample of 658 adults completed an online questionnaire. Regression modelling examined the effects and interactions of gender and parental responsibility on general health, musculoskeletal discomfort/pain frequency and severity, stress, and work-family and family-work conflict. Read More

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Advances in pharmacotherapy for diabetic foot osteomyelitis.

Expert Opin Pharmacother 2021 Jul 29:1-11. Epub 2021 Jul 29.

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy.

: The diagnosis of diabetic foot osteomyelitis (DFO) is usually clinical. Its severity is related to the location and depth of the lesion, and the presence of necrosis or gangrene. The aetiology of diabetic foot osteomyelitis (DFO) is usually polymicrobial, and DFO is often associated with chronic or recurring ulceration. Read More

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Effect of systemic atherosclerosis on overactive bladder symptoms in men with benign prostatic hyperplasia.

Low Urin Tract Symptoms 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, Yonsei University College of Medicine, Seoul, South Korea.

Objective: Symptoms of male overactive bladder (OAB) may be caused by several systemic pathophysiological factors rather than a single-source etiology. We investigated the clinical factors associated with the severity of OAB symptoms in treatment-naïve men with coexisting benign prostatic hyperplasia.

Methods: We obtained records from a health promotion center database of male patients who visited between March 2019 and February 2020. Read More

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Serum vitamin B12 status of patients with type 2 diabetes mellitus on metformin: A single-center cross-sectional study from Bangladesh.

J Family Med Prim Care 2021 Jun 2;10(6):2225-2229. Epub 2021 Jul 2.

Department of Psychiatry, Cumilla Medical College Hospital, Cumilla, Bangladesh.

Background: Metformin use is a known cause of B12 deficiency in patients with type 2 DM (T2DM). Diabetic peripheral neuropathy (DPN) often has clinically indistinguishable clinical features of B12 deficiency-induced peripheral neuropathy (PN).

Objective: The present study aims to assess serum vitamin B12 levels in patients with T2DM on metformin. Read More

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A Case-Cohort Study of Exfoliation Risk Factors and Literature Review.

Middle East Afr J Ophthalmol 2021 Jan-Mar;28(1):36-50. Epub 2021 Apr 30.

Department of Ophthalmology, Medical University of Lodz, Lodz, Poland.

The purpose of the study is to evaluate the risk factors associated with exfoliation in a case-cohort setting and literature review. This single-center, prospective, case-cohort study was carried out from January 2010 to April 2020 on patients operated for cataract surgery by a single surgeon in Lebanon. Forty-nine consecutive patients with exfoliation syndrome (XFS) and 62 consecutive control patients were identified and further investigated for selected systemic (diabetes mellitus, systemic hypertension, asthma, or atopy) and ocular variables (baseline vision, severity of nuclear sclerosis, glaucoma, eye rubbing, history of dry eye, or allergic eye disease). Read More

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Oesophageal atresia: sonographic signs may prenatally predict surgical complexity.

Arch Dis Child Fetal Neonatal Ed 2021 Jul 28. Epub 2021 Jul 28.

Obstetrics and Gynecology, Sheba Medical Center at Tel HaShomer, Tel HaShomer, Israel.

Objective: Oesophageal atresia (OA) is a major anomaly of varying severity. The complexity of surgical correction highly depends on the gap length of missing oesophagus and the presence of a distal fistula. The aim of this study was to identify antenatal sonographic findings associated with presence of a distal fistula and type of surgical repair METHODS: Prenatal medical records of neonates postnatally diagnosed with OA were reviewed. Read More

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Fear Language in a Warning Is Beneficial to Risk Perception in Lower-Risk Situations.

Hum Factors 2021 Jul 28:187208211029444. Epub 2021 Jul 28.

6243 University of Central Florida, Orlando, USA.

Objective: The goal was to examine the effectiveness of fear language in the protective action recommendation of an emergency warning, which instructs people how to prepare and stay safe.

Background: Past work is limited because it has focused on describing the severity of the weather crisis, not improving the recommendation. Likewise, other research has examined fear appeals that overemphasize death, which leads to poor risk perceptions. Read More

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Impact of pharmacist involvement on medication safety in interprofessional transfer of care activity.

N Z Med J 2021 Jul 30;134(1539):9-20. Epub 2021 Jul 30.

Associate Dean Medical Education, University of Otago, Christchurch, Specialist Respiratory Physician, Canterbury District Health Board.

Aim: Any transition of patient care is a high-risk time for communication error. This paper explores whether the presence of a pharmacist as part of an interprofessional group provides additional benefit and safety in transitions of care.

Method: Six pharmacy interns and newly qualified pharmacists joined participants from seven other health professional training programmes to take part in an interprofessional education activity. Read More

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Efficacy of a combined chemical peel and topical salicylic acid-based gel combination in the treatment of active acne.

Lucia Calvisi

J Cosmet Dermatol 2021 Jul;20 Suppl 2:2-6

Private Practice, Cagliari, Italy.

Background: Acne vulgaris is a common skin condition affecting the pilosebaceous unit of the skin characterized by the presence of comedones, papules, pustules, nodules, and cysts, which might result in permanent scars. It commonly affects adolescents, but it can occur in any age-group with the second group of incidence in young women in their 30s. Acne vulgaris can highly affect a person's quality of life. Read More

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The Effect of Postamputation Pain and Phantom Sensations on Prosthesis Use, Body Image, and Quality of Life in Patients with Lower-extremity Amputation.

Agri 2021 Jul;33(3):183-189

Istanbul Physical Medicine And Rehabilitation Training And Research Hospital, Istanbul, Turkey.

Objective: The aim of this study was to investigate phantom limb pain (PLP), phantom limb sensation (PLS), and residual limb pain (RLP) after lower-extremity amputation and their effect on patients' effective prosthesis use, body image, and quality of life in prosthetic users.

Methods: Fifty-seven patients with lower-extremity amputation who used prosthesis for at least three months were included in our study. PLP, PLS, and RLP were evaluated via the prosthesis evaluation questionnaire (PEQ). Read More

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Delirium in COVID-19 patients: a multicentric observational study in Italy.

Neurol Sci 2021 Jul 28. Epub 2021 Jul 28.

Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.

Introduction: Although recent data show that SARS-CoV-2 infection seems to affect the central nervous system (CNS), little is known about the neuropsychiatric effects resulting from this condition. In addition to the well-known neurotrophism of coronaviruses, recent evidence shows also that the "cytokine storm" induced by the infection is at the basis of the neuroinflammation of the CNS. Furthermore, prolonged hospitalization, polypharmacotherapy, and isolation could be at the basis of the onset of delirium in hospitalized COVID patients. Read More

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Etiology and Outcomes of ARDS in the Elderly Population in an Intensive Care Unit in North India.

Indian J Crit Care Med 2021 Jun;25(6):648-654

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Whether age would impact the outcomes in subjects with acute respiratory distress syndrome (ARDS) remains unclear. Herein, we study the effect of age as a predictor of mortality in ARDS.

Materials And Methods: We categorized consecutive subjects with ARDS as either ARDS (age >65 years) or ARDSnon (age ≤65 years) admitted to the respiratory intensive care unit (ICU) of a tertiary care hospital in North India between January 2007 and December 2019. Read More

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Computed Tomography Findings in Intraabdominal Hypertension in Patients with Acute Pancreatitis.

Indian J Radiol Imaging 2021 Jan 23;31(1):150-156. Epub 2021 May 23.

Department of Gastroenterology, PGIMER, Chandigarh, India.

 Intraabdominal hypertension (IAH) in acute pancreatitis (AP) may reduce tissue perfusion and impair organ function and has been shown to portend poor prognosis. We investigated the computed tomography (CT) findings in patients with AP with IAH.  This retrospective study comprised of consecutive patients with AP from June 2016 to June 2018 in whom intraabdominal pressure (IAP) was measured. Read More

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January 2021

Impact of Systolic Blood Pressure on Heart Failure Symptoms With Moderate Aortic Stenosis.

Am J Cardiol 2021 Jul 24. Epub 2021 Jul 24.

Smidt Heart Institute, Cedars-Sinai Medical Center, California. Electronic address:

In patients with moderate aortic stenosis (AS), heart failure (HF) symptoms are often unrelated to the AS severity, and the causes of HF symptoms are often unclear. Hypertension is known as one of the most common comorbidities in degenerative AS. Therefore, we assessed the impact of systolic blood pressure (BP) on HF symptoms in patients with moderate AS. Read More

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Deletion of 2 amino acids in IHH in a Japanese family with brachydactyly type A1.

BMC Med Genomics 2021 Jul 27;14(1):190. Epub 2021 Jul 27.

Department of Pain Pharmacogenetics, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Brachydactyly type A1 (BDA1) is an autosomal dominant disorder characterized by uniform shortening of the middle phalanges in all digits. It is associated with variants in the Indian Hedgehog (IHH) gene, which plays a key role in endochondral ossification. To date, heterozygous pathogenic IHH variants involving several codons, which are restricted to a specific region of the N-terminal active fragment of IHH, have been reported. Read More

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Greater efficacy of a combination of conservative therapies for thumb base OA in individuals with lower radial subluxation - a pre-planned subgroup analysis of the COMBO trial.

Osteoarthritis Cartilage 2021 Jul 24. Epub 2021 Jul 24.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.

Objective: To investigate heterogeneous effects of a combination of conservative therapies compared with an education comparator for thumb base (TB) osteoarthritis (OA) according to clinically relevant characteristics.

Methods: Pre-planned subgroup analysis of the COMBO trial (n=204) which compared a combination of education on self-management and ergonomic principles, a prefabricated neoprene splint, hand exercises, and diclofenac sodium gel, with education alone for radiographic and symptomatic TB OA. Primary outcomes were change in pain (visual analogue scale [VAS], 0-100 mm) and hand function (Functional Index for Hand Osteoarthritis questionnaire, 0-30) from baseline to week-6. Read More

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Evaluation of predictors of severe-moderate COVID-19 infections at children: a review of 292 children.

J Med Virol 2021 Jul 27. Epub 2021 Jul 27.

Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.

Background: Although underlying disease is associated with a severe course in adults and laboratory abnormalities have been widely reported, there are not sufficient data on the clinical course of COVID-19 in children with pre-existing comorbid conditions and on laboratory findings. We aimed to describe the independent risk factors for estimating the severity of the COVID-19 in children METHODS: All children between one month to 18 years old who were hospitalized during the period of March 11 - December 31, 2020 resulting from COVID-19 were included in the study. Patients were categorized into mild (group 1) and moderate+severe/critically (group 2) of severity based on the criteria. Read More

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