Melanoma Res 2021 Aug 23. Epub 2021 Aug 23.
Department of Medicine, Surgery and Health Sciences, Dermatology Clinic, Maggiore Hospital, University of Trieste Department of Medicine, Surgery and Health Sciences, Plastic Surgery Unit, University Hospital of Cattinara, Trieste Department of Medical Oncology - Preventive Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
We present two patients with stage IV melanoma, the first with BRAF wild-type melanoma with multiple visceral metastases treated with immunotherapy (pembrolizumab) and the second with BRAFV600E melanoma with subcutaneous and lymph nodes metastasis treated with BRAF and MEK-inhibitors (dabrafenib/trametinib). Already after the second cycle of immunotherapy, the first patient developed a diffuse regression of nevi, perceptible only with the use of dermoscopy and 3 months later a clinically evident poliosis of the eyebrows. The second patient, treated with dabrafenib/trametinib, developed small areas of leukoderma on his chest and white halos around nevi with a dermoscopic globular or structureless pattern. Read More