10,064 results match your criteria presence melanoma

Primary sellar melanocytoma.

Pituitary 2021 Sep 13. Epub 2021 Sep 13.

Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.

Purpose: We present an up-to-date review of all published cases of sellar melanocytoma, a benign melanocytic neoplasm arising from melanocytes present in the leptomeninges surrounding the pituitary.

Methods: Both the Medline and Embase databases were searched for case reports or case series of patients with a sellar mass consisting of melanocytes.

Results: All 14 identified patients developed symptoms due to compression of the surrounding structures. Read More

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September 2021

Images of the month 1: 'Soy sauce' pleural effusion: what causes black pleural fluid?

Clin Med (Lond) 2021 Sep;21(5):e531-e532

East and North Hertfordshire NHS Trust, Stevenage, UK.

We present a case of black pleural fluid following thoracic trauma. The unusual dark colour most strikingly resembled soy sauce as independently commented upon by multiple treating physicians. The black colouration could not be fully accounted for by haemothorax or cholethorax, so other differential diagnoses were investigated, including infection and malignant melanoma. Read More

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September 2021

Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance.

Cell Biol Int 2021 Sep 10. Epub 2021 Sep 10.

Laboratory of Molecular Pathology, Department of Pathological Sciences, Londrina State University, UEL, Londrina, PR, Brazil.

Oxidative stress role on Metformin process of dacarbazine (DTIC) inducing resistance of B16F10 melanoma murine cells are investigated. To induce resistance to DTIC, murine melanoma cells were exposed to increasing concentrations of dacarabazine (DTIC-res group). Metformin was administered before and during the induction of resistance to DTIC (MET-DTIC). Read More

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September 2021

Prior Exposure to Coxsackievirus A21 Does Not Mitigate Oncolytic Therapeutic Efficacy.

Cancers (Basel) 2021 Sep 4;13(17). Epub 2021 Sep 4.

Department of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Oncolytic viruses (OVs) are being developed as a type of immunotherapy and have demonstrated durable tumor responses and clinical efficacy. One such OV, Coxsackievirus A21 (CVA21), exhibited therapeutic efficacy in early phase clinical trials, demonstrating the ability to infect and kill cancer cells and stimulate anti-tumor immune responses. However, one of the major concerns in using this common cold virus as a therapeutic is the potential for innate and adaptive immune responses to mitigate the benefits of viral infection, particularly in individuals that have been exposed to coxsackievirus prior to treatment. Read More

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September 2021

and Its Ligands Show Increased Expression in High-Risk Uveal Melanoma.

Cancers (Basel) 2021 Sep 3;13(17). Epub 2021 Sep 3.

Department of Ophthalmology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Uveal melanoma (UM) is a rare ocular malignancy which originates in the uveal tract, and often gives rise to metastases. Potential targets for immune checkpoint inhibition are lymphocyte-activation gene 3 (LAG3) and its ligands. We set out to analyse the distribution of these molecules in UM. Read More

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September 2021

The Characterization of Scaffolds Based on Dialdehyde Chitosan/Hyaluronic Acid.

Materials (Basel) 2021 Sep 1;14(17). Epub 2021 Sep 1.

Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toruń, Poland.

In this work, two-component dialdehyde chitosan/hyaluronic acid scaffolds were developed and characterized. Dialdehyde chitosan was obtained by one-step synthesis with chitosan and sodium periodate. Three-dimensional scaffolds were prepared by the lyophilization method. Read More

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September 2021

Circadian disruption induced by tumor development in a murine model of melanoma.

Chronobiol Int 2021 Sep 6:1-14. Epub 2021 Sep 6.

Laboratorio de Cronobiología, Universidad Nacional de Quilmes, Buenos Aires, Argentina.

The circadian system induces oscillations in most physiological variables, with periods close to 24 hours. Dysfunctions in clock-controlled body functions, such as sleep disorders, as well as deregulation of clock gene expression or glucocorticoid levels have been observed in cancer patients. Moreover, these disorders have been associated with a poor prognosis or worse response to treatment. Read More

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September 2021

Severity of Sepsis Determines the Degree of Impairment Observed in Circulatory and Tissue-Resident Memory CD8 T Cell Populations.

J Immunol 2021 Sep 3. Epub 2021 Sep 3.

Department of Pathology, University of Iowa, Iowa City, IA;

Sepsis reduces the number and function of memory CD8 T cells within the host, contributing to the long-lasting state of immunoparalysis. Interestingly, the relative susceptibility of memory CD8 T cell subsets to quantitative/qualitative changes differ after cecal ligation and puncture (CLP)-induced sepsis. Compared with circulatory memory CD8 T cells (T), moderate sepsis (0-10% mortality) does not result in numerical decline of CD8 tissue-resident memory T cells (T), which retain their "sensing and alarm" IFN-γ-mediated effector function. Read More

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September 2021

Ultrasound Assessment of Regional Lymph Nodes in Melanoma Staging.

Acta Dermatovenerol Croat 2021 Jul;29(2):80-87

Marija Delaš Aždajić, MD, Department of Dermatology and Venereology , Sestre milosrdnice University Hospital Center , Vinogradska cesta 29 , 10 000 Zagreb , Croatia ;

Background: Melanoma can early metastasize to regional lymph nodes. The sentinel lymph node (SLN) is the first lymph node draining directly from the site of primary melanoma, and the pathohistological status of the SLN is the most significant prognostic factor for overall survival prevalence and prognosis in patients with melanoma. Ultrasound is a very useful for the imaging of regional lymph node metastases, combined with Doppler and cytopuncture. Read More

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Vitiligo-like Depigmentation in a Patient Undergoing Treatment with Nivolumab for Advanced Renal-cell Carcinoma.

Acta Dermatovenerol Croat 2021 Apr;291(1):54-55

Inigo Navarro-Fernandez, MD, Calle Mirador del Candado, , 1 29018 Malaga (Spain),

Dear Editor, Nivolumab is a fully human monoclonal antibody that targets the programmed cell death 1 (PD-1) immune checkpoint. It has been approved for its use in several types of advanced solid tumors, including melanoma, lung cancer, and renal cell carcinoma (RCC). The inhibition of PD-1 leads to an enhanced adaptive immune response against tumor cells through the activation of T-cells. Read More

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Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination - What Is Responsible for Metastatic Cell Proliferation?

Acta Dermatovenerol Croat 2021 Apr;291(1):30-34

Leo Čabrijan, MD, PhD Department of Dermatology and Venereology, Clinical Hospital Centre Rijeka Krešimirova 42, 51000 Rijek,a Croatia;

The process of melanoma metastasis can be divided into two stages of metastatic cell dissemination and proliferation. The whole process should be observed and distinguished through the variable or prism of time. The fact that melanoma metastases are detected in visceral organs at the stage when they are macroscopically visible does not imply that their onset has occurred much earlier. Read More

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Label-Free Electrochemical Biosensors to Evaluate the Antioxidant Effect of Tocopherol in Ultraviolet Radiation.

Lixia Gao Yong Teng

Methods Mol Biol 2022 ;2343:241-246

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.

Electrochemical biosensors offer a sensitive, specific, and rapid detection platform for in situ real-time monitoring of intracellular and extracellular metabolites. These sensors have been widely used to evaluate the efficacy of preclinical drugs, especially for natural products with antioxidant potency. Ultraviolet (UV) radiation causes oxidative stress in cells and induces cells to release reactive oxygen species. Read More

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January 2022

Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.

Proc Natl Acad Sci U S A 2021 Sep;118(36)

Apoptosis, Cancer, and Development Laboratory, Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, 69008 Lyon, France;

Netrin-1, a secreted protein recently characterized as a relevant cancer therapeutic target, is the antiapoptotic ligand of the dependence receptors deleted in colorectal carcinoma and members of the UNC5H family. Netrin-1 is overexpressed in several aggressive cancers where it promotes cancer progression by inhibiting cell death induced by its receptors. Interference of its binding to its receptors has been shown, through the development of a monoclonal neutralizing antinetrin-1 antibody (currently in phase II of clinical trial), to actively induce apoptosis and tumor growth inhibition. Read More

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September 2021

Two-year results for ranibizumab for radiation retinopathy (RRR): a randomized, prospective trial.

Graefes Arch Clin Exp Ophthalmol 2021 Aug 31. Epub 2021 Aug 31.

Retina Consultants of Texas, Retina Consultants of America, Houston, TX, USA.

Purpose: To assess the efficacy of a treat-and-extend strategy with intravitreal ranibizumab for radiation-related macular edema.

Methods: Forty eyes with radiation-induced macular edema and decreased visual acuity were enrolled in the phase IIb, prospective clinical trial and randomized into 3 cohorts: (A) monthly ranibizumab, (B) monthly ranibizumab with targeted retinal photocoagulation (TRP), or (C) as-needed ranibizumab and TRP. In year 2, all subjects entered a treat-and-extend protocol for ranibizumab. Read More

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Melanoma: Staging and Follow-Up.

Dermatol Pract Concept 2021 Jul 1;11(Suppl 1):e2021162S. Epub 2021 Jul 1.

First Dermatology Department, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.

Cancer staging is the process determining to which extent a cancer has spread and where it is located in the body. A thorough staging is of utmost importance, not only because it provides the most accurate prognostic estimation, but also because several crucial decisions, such as the treatment choice and the follow-up strategy, vary according to the tumor's stage. The current staging system for melanoma is based on the 8 edition of TNM classification issued by the American Joint Committee on Cancer (AJCC) in 2017. Read More

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Effect of L- to D-Amino Acid Substitution on Stability and Activity of Antitumor Peptide RDP215 against Human Melanoma and Glioblastoma.

Int J Mol Sci 2021 Aug 6;22(16). Epub 2021 Aug 6.

Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50/III, A-8010 Graz, Austria.

The study investigates the antitumor effect of two cationic peptides, R-DIM-P-LF11-215 (RDP215) and the D-amino acid variant 9D-R-DIM-P-LF11-215 (9D-RDP215), targeting the negatively charged lipid phosphatidylserine (PS) exposed by cancer cells, such as of melanoma and glioblastoma. Model studies mimicking cancer and non-cancer membranes revealed the specificity for the cancer-mimic PS by both peptides with a slightly stronger impact by the D-peptide. Accordingly, membrane effects studied by DSC, leakage and quenching experiments were solely induced by the peptides when the cancer mimic PS was present. Read More

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Familial Melanoma and Susceptibility Genes: A Review of the Most Common Clinical and Dermoscopic Phenotypic Aspect, Associated Malignancies and Practical Tips for Management.

J Clin Med 2021 Aug 23;10(16). Epub 2021 Aug 23.

Department of Medical Sciences, Dermatology Clinic, University of Turin, 10126 Turin, Italy.

A family history of melanoma greatly increases the risk of developing cutaneous melanoma, a highly aggressive skin cancer whose incidence has been steadily increasing worldwide. Familial melanomas account for about 10% of all malignant melanomas and display an inheritance pattern consistent with the presence of pathogenic germline mutations, among which those involving are the best characterized. In recent years, a growing number of genes, such as , , , , , , , and , have been implicated in familial melanoma. Read More

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Expression of HDACs 1, 3 and 8 Is Upregulated in the Presence of Infiltrating Lymphocytes in Uveal Melanoma.

Cancers (Basel) 2021 Aug 18;13(16). Epub 2021 Aug 18.

Department of Ophthalmology, LUMC, 2333 ZA Leiden, The Netherlands.

In Uveal Melanoma (UM), an inflammatory phenotype is strongly associated with the development of metastases and with chromosome 3/BAP1 expression loss. As an increased expression of several Histone Deacetylases (HDACs) was associated with loss of chromosome 3, this suggested that HDAC expression might also be related to inflammation. We analyzed HDAC expression and the presence of leukocytes by mRNA expression in two sets of UM (Leiden and TCGA) and determined the T lymphocyte fraction through ddPCR. Read More

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MiRNAs Correlate with HLA Expression in Uveal Melanoma: Both Up- and Downregulation Are Related to Monosomy 3.

Cancers (Basel) 2021 Aug 10;13(16). Epub 2021 Aug 10.

Department of Ophthalmology, LUMC, 2333ZA Leiden, The Netherlands.

MicroRNAs are known to play a role in the regulation of inflammation. As a high HLA Class I expression is associated with a bad prognosis in UM, we set out to determine whether any miRNAs were related to a high HLA Class I expression and inflammation. We also determined whether such miRNAs were related to the UM's genetic status. Read More

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In Uveal Melanoma, Angiopoietin-2 but Not Angiopoietin-1 Is Increased in High-Risk Tumors, Providing a Potential Druggable Target.

Cancers (Basel) 2021 Aug 7;13(16). Epub 2021 Aug 7.

Department of Ophthalmology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Uveal melanoma (UM) metastasize haematogeneously, and tumor blood vessel density is an important prognostic factor. We hypothesized that proangiogenic factors such as angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2), two targetable cytokines, might play a role in tumor development and metastatic behavior. mRNA levels of ANG-1 and ANG-2 were determined in 64 tumors using an Illumina HT-12 v4 mRNA chip and compared to clinical, pathologic, and genetic tumor parameters. Read More

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Metastatic Cutaneous Melanoma in a White African Lioness ().

Vet Sci 2021 Aug 1;8(8). Epub 2021 Aug 1.

Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa.

Malignant melanomas tend to be locally destructive, aggressive tumours commonly associated with recurrence and/or metastasis. In this report, a 13-year-old captive white African lioness (), with a recent history of intermittent bouts of lethargy and inappetence, presented with a distended abdomen (due to ascites) and a small, round crusty lesion on the ear. An abdominal ultrasound showed the presence of masses on the liver and an exploratory laparotomy revealed multiple pale lesions on the liver and omentum. Read More

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Amelanotic Malignant Melanoma with a BRAF V600E Mutation Mimicking Primary Lung Cancer.

Intern Med 2021 Aug 24. Epub 2021 Aug 24.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.

Amelanotic melanoma is a rare type of melanoma that shows little or no melanin pigmentation. When tumor lesions are not detected in cutaneous sites, the presence of melanin is the hallmark sign of malignant melanoma. We herein report a case of amelanotic melanoma with a BRAF V600E mutation mimicking primary lung cancer that was finally diagnosed on an autopsy. Read More

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LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade.

Sci Transl Med 2021 Aug;13(608)

Department of Medicine, Memorial Sloan Kettering Cancer Center New York, NY 10065, USA.

Immune checkpoint blocking antibodies are a cornerstone in cancer treatment; however, they benefit only a subset of patients and biomarkers to guide immune checkpoint blockade (ICB) treatment choices are lacking. We designed this study to identify blood-based correlates of clinical outcome in ICB-treated patients. We performed immune profiling of 188 ICB-treated patients with melanoma using multiparametric flow cytometry to characterize immune cells in pretreatment peripheral blood. Read More

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Regression of nevi, vitiligo-like depigmentation and halo phenomenon may indicate response to immunotherapy and targeted therapy in melanoma.

Melanoma Res 2021 Aug 23. Epub 2021 Aug 23.

Department of Medicine, Surgery and Health Sciences, Dermatology Clinic, Maggiore Hospital, University of Trieste Department of Medicine, Surgery and Health Sciences, Plastic Surgery Unit, University Hospital of Cattinara, Trieste Department of Medical Oncology - Preventive Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

We present two patients with stage IV melanoma, the first with BRAF wild-type melanoma with multiple visceral metastases treated with immunotherapy (pembrolizumab) and the second with BRAFV600E melanoma with subcutaneous and lymph nodes metastasis treated with BRAF and MEK-inhibitors (dabrafenib/trametinib). Already after the second cycle of immunotherapy, the first patient developed a diffuse regression of nevi, perceptible only with the use of dermoscopy and 3 months later a clinically evident poliosis of the eyebrows. The second patient, treated with dabrafenib/trametinib, developed small areas of leukoderma on his chest and white halos around nevi with a dermoscopic globular or structureless pattern. Read More

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COVID-19 vaccination mimicking lymph-node progression in a patient with melanoma: a case report.

Melanoma Res 2021 10;31(5):490-493

Unit of Medical Oncology, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, Varese, Italy.

COVID-19 vaccination has been rapidly implemented among patients with cancer. We present the case of a patient with high-risk resected cutaneous melanoma, who was a candidate for adjuvant treatment, with postsurgery 18-fluorodeoxyglucose (FDG) PET/computed tomography (CT) scan showing positive axillary lymph nodes after COVID-19 vaccination. This report presents a 50-year-old man with a history of stage IIA cutaneous melanoma. Read More

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October 2021

Desmoplastic Neurotropic Melanoma Presenting as Pilonidal Sinus: A Rare Clinical Association.

Am J Case Rep 2021 Aug 25;22:e932922. Epub 2021 Aug 25.

Plastic Surgery Unit, Barzilai University Hospital Medical Center, Ashkelon, Israel.

BACKGROUND Pilonidal Sinus (PNS) is a small cutaneous orifice in the intergluteal region; symptoms include pain and swelling. Disparately, desmoplastic neurotropic melanoma (DNM) accounts for 1% of all melanomas and mostly occurs in the head and neck region. Because its appearance is generally benign, it typically comes to surgical attention only at an advanced stage or after recurrence. Read More

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Gender-specific Stratification of Survival Following Immune Checkpoint Inhibitor Therapy Based on Intratumoral Expression of a B cell Gene Signature.

Eur Urol Oncol 2021 Aug 20. Epub 2021 Aug 20.

Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Background: There is a great need to identify biomarkers that can accurately identify patients who will obtain the most clinical benefit from immune checkpoint inhibitor (ICI) therapy. While high intratumoral B cell gene expression correlated with an ICI response in melanoma, whether it adds predictive value in other cancers is unknown.

Objective: To examine the relationship between B cell gene signature (BCGS) expression and overall survival (OS) following ICI treatment. Read More

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Acute cardiac manifestations under immune checkpoint inhibitors-beware of the obvious: a case report.

Eur Heart J Case Rep 2021 Aug 12;5(8):ytab262. Epub 2021 Aug 12.

Department of Cardiology, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne, Switzerland.

Background: Immune checkpoint inhibitors (ICI) have revolutionized the management of many cancer types by drastically improving the median survival rate of patients. However, this efficiency comes at the cost of a high rate of immune-related adverse events, including lethal cardiac manifestations. Rapidly fatal cases of ICI-induced myocarditis have been reported and drawn considerable attention over the past years. Read More

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Quantitative Expression of , and Discriminates Between Canine Oral Malignant Melanomas and Soft Tissue Sarcomas.

Front Vet Sci 2021 6;8:701457. Epub 2021 Aug 6.

Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, Lansing, MI, United States.

Canine oral malignant melanomas (OMMs) exhibit a variety of morphologic phenotypes, including a spindloid variant. The microscopic diagnosis of spindloid OMMs is based on junctional activity and/or the presence of melanin pigment. In the absence of these features, spindloid OMMs are difficult to differentiate from soft tissue sarcomas (STS). Read More

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Exploratory analysis of clinical benefit of ipilimumab and nivolumab treatment in patients with metastatic melanoma from a single institution.

Clin Transl Oncol 2021 Aug 22. Epub 2021 Aug 22.

Department of Medical Oncology, Hospital Clinic, Barcelona, Spain.

Purpose: We retrospectively analysed overall survival (OS) and potential predictive biomarkers of OS in patients with metastatic melanoma treated with ipilimumab plus nivolumab in a single institution.

Methods And Patients: Electronic medical records of patients with advanced melanoma receiving ≥ 1 dose of a combined ipilimumab plus nivolumab regimen between March 3, 2016 and March 7, 2020 in a single institution, were reviewed. OS was analysed using the Kaplan-Meier method. Read More

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