20,936 results match your criteria prescribed dose


Buprenorphine use and disparities in access among emergency department patients with opioid use disorder: A cross-sectional study.

J Subst Abuse Treat 2021 Apr 20;130:108405. Epub 2021 Apr 20.

Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, United States of America; Cooper University Hospital, Department of Emergency Medicine, Keleman 152, 1 Cooper Plaza, Camden, NJ 08103, United States of America. Electronic address:

Background: Buprenorphine, a partial mu-opioid agonist and kappa-opioid antagonist, is an approved treatment for opioid use disorder (OUD). Studies demonstrate that buprenorphine decreases cravings for other opioids, effectively ameliorates withdrawal symptoms, and decreases opioid overdose and mortality. However, buprenorphine remains under-utilized. Read More

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Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain.

J Am Geriatr Soc 2021 Jun 12. Epub 2021 Jun 12.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

Background/objectives: Gabapentinoids are commonly prescribed to relieve pain. The development of edema, an established adverse effect of gabapentinoids, may lead to a potentially harmful prescribing cascade whereby individuals are subsequently prescribed diuretics and exposed to diuretic-induced adverse events. The frequency of this prescribing cascade is unknown. Read More

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Unexpected overdose of oral cyclosporine in a kidney transplant patient: a case report.

Eur J Hosp Pharm 2021 Jun 11. Epub 2021 Jun 11.

Univ Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

Cyclosporine is a widely used immunosuppressive agent to prevent rejection of solid organ transplant. Here, we describe the case of a 71-year-old man who received the prescribed dose of cyclosporine 10 times 6 days after a kidney transplantation because of a concentration miscalculation involving two galenic forms. The patient presented gastrointestinal and neurological disorders. Read More

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Integrating pharmacists into aged care facilities to improve the quality use of medicine (PiRACF Study): protocol for a cluster randomised controlled trial.

Trials 2021 Jun 11;22(1):390. Epub 2021 Jun 11.

Health Research Institute, Faculty of Health, University of Canberra, Bruce, ACT, Australia.

Background: Medication management in residential aged care facilities is an ongoing concern. Numerous studies have reported high rates of inappropriate prescribing and medication use in aged care facilities, which contribute to residents' adverse health outcomes. There is a need for new models of care that enhance inter-disciplinary collaboration between residential aged care facility staff and healthcare professionals, to improve medication management. Read More

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Effectiveness and Effect on Renal Parameters of Amlodipine vs. Other Dihydropyridine Calcium Channel Blockers in Patients with Essential Hypertension: Retrospective Observational Study Based on Real-World Evidence from Electronic Medical Records.

Cardiol Ther 2021 Jun 11. Epub 2021 Jun 11.

Heart and General Hospital, Jaipur, Rajasthan, India.

Introduction: The renoprotective effects of dihydropyridine calcium channel blockers (CCBs) have been established as non-inferior to other classes of antihypertensive drugs. Studying their effect on renal outcome parameters, specifically for amlodipine as monotherapy, in real-world settings can further help in expanding its usage among Indian patients. This study was performed to assess the effects of amlodipine and other dihydropyridine CCBs (cilnidipine, benidipine and azelnidipine) on renal parameters and effectiveness in blood pressure reduction in Indian patients. Read More

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Association of the 2016 US Centers for Disease Control and Prevention Opioid Prescribing Guideline With Changes in Opioid Dispensing After Surgery.

JAMA Netw Open 2021 Jun 1;4(6):e2111826. Epub 2021 Jun 1.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: While the 2016 US Centers for Disease Control and Prevention (CDC) guideline for prescribing opioids for chronic pain was not intended to address postoperative pain management, observers have noted the potential for the guideline to have affected postoperative opioid prescribing.

Objective: To assess changes in postoperative opioid dispensing after vs before the CDC guideline release in March 2016.

Design, Setting, And Participants: This cross-sectional study included 361 556 opioid-naive patients who received 1 of 8 common surgical procedures between March 16, 2014, and March 15, 2018. Read More

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Sociodemographic and clinical correlates of gabapentin receipt with and without opioids among a national cohort of patients with HIV.

AIDS Care 2021 Jun 11:1-11. Epub 2021 Jun 11.

Yale School of Medicine, New Haven, CT, USA.

Gabapentin is commonly prescribed for chronic pain, including to patients with HIV (PWH). There is growing concern regarding gabapentin's potential for harm, particularly in combination with opioids. Among PWH, we examined factors associated with higher doses of gabapentin receipt and determined if receipt varied by opioid use. Read More

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Cervical Endocrine Surgery With a Novel Opioid-Limited Perioperative Protocol.

Am Surg 2021 Jun 11:31348211025736. Epub 2021 Jun 11.

Department of General Surgery, 7005Beaumont Health System, Royal Oak, MI, USA.

Background: Recent studies have demonstrated that patients undergoing cervical endocrine surgery could be comfortably discharged with minimal opioid analgesia. However, no study to date has examined the efficacy of limiting administration of opioids intraoperatively. We have developed a novel protocol for patients undergoing cervical endocrine surgery that eliminates perioperative opioids. Read More

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Y-90 SIRT: evaluation of TCP variation across dosimetric models.

EJNMMI Phys 2021 Jun 10;8(1):45. Epub 2021 Jun 10.

Department of Radiation Oncology, University of Michigan, Ann Arbor, 48109, MI, USA.

Introduction: Much progress has been made in implementing selective internal radiation therapy (SIRT) as a viable treatment option for hepatic malignancies. However, there is still much need for improved options for calculating the amount of activity to be administered. To make advances towards this goal, this study examines the relationship between predicted biological outcomes of liver tumors via tumor control probabilities (TCP) and parenchyma via normal tissue complication probabilities (NTCP) given variations in absorbed dose prescription methodologies. Read More

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MRI-Directed Brachytherapy for Cancer of the Uterine Cervix: A Case Report, Review, and Perspective on the Importance of Widespread Use of This Technological Advance in the United States.

Cureus 2021 Jun 7;13(6):e15495. Epub 2021 Jun 7.

Radiation Oncology, University of Mississippi Medical Center, Jackson, USA.

Cervical cancer remains a major health challenge in the United States (US), especially among the low socioeconomic and African American populations. The demographics of Mississippi constitute a relatively high percentage of this high-risk population. External beam radiation therapy (EBRT) combined with concurrent chemotherapy and followed by brachytherapy is the gold standard of treatment for stage IB3 through IVA cervical cancer. Read More

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The effect of a Clinical Decision Support System on the frequency of dose adjustments of anticancer drugs in case of renal or hepatic dysfunction.

J Oncol Pharm Pract 2021 Jun 10:10781552211019453. Epub 2021 Jun 10.

Pharmacy Foundation of Haarlem Hospitals, Haarlem, the Netherlands.

Introduction: Dose adjustments in patients with renal or hepatic dysfunction using anticancer drugs are indicated according to guidelines. However, implementation depends on awareness of prescribing physicians. We implemented a Clinical Decision Support System (CDSS), recommending dose adjustments upon electronic prescriptions based on renal and hepatic function. Read More

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Characterization of Psychotropic PRN Medications in a Canadian Psychiatric Intensive Care Unit.

J Am Psychiatr Nurses Assoc 2021 Jun 10:1078390321994668. Epub 2021 Jun 10.

Rumi McGloin, BSc (Pharm), ACPR, PharmD, Surrey Memorial Hospital, Surrey, British Columbia, Canada; University of British Columbia, Vancouver, British Columbia, Canada.

Objective: Pro re nata (PRN) antipsychotics and benzodiazepines are routinely used for the rapid stabilization of acutely agitated patients. Despite the popular use of PRN medications in mental health units, primary literature supporting efficacy and safety is poor, and there is no single universally accepted practice guideline. PRN psychotropic medications have the potential to cause adverse effects when used inappropriately. Read More

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Comparison of Long-Term Outcomes of Monotherapy and Polytherapy in Seizure-Free Patients With Epilepsy Following Antiseizure Medication Withdrawal.

Front Neurol 2021 24;12:669703. Epub 2021 May 24.

Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.

The objectives of this study were to compare the risk and timing of seizure relapse in seizure-free patients with epilepsy following the withdrawal of monotherapy or polytherapy and to identify relevant influencing factors. Patients who had achieved at least a 2-year seizure remission and started the withdrawal of antiseizure medication (ASM) were enrolled in this study. All patients were followed for at least 3 years or until seizure relapse. Read More

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Impacts of diphenylamine NSAID halogenation on bioactivation risks.

Toxicology 2021 Jun 6:152832. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address:

Diphenylamine NSAIDs are highly prescribed therapeutics for chronic pain despite causing symptomatic hepatotoxicity through mitochondrial damage in five percent of patients taking them. Differences in toxicity are attributed to structural modifications to the diphenylamine scaffold rather than its inherent toxicity. We hypothesize that marketed diphenylamine NSAID substituents affect preference and efficiency of bioactivation pathways and clearance. Read More

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Effects of Lemborexant on the Pharmacokinetics of Oral Contraceptives: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Females.

Clin Pharmacol Drug Dev 2021 Jun 9. Epub 2021 Jun 9.

Eisai Inc., Woodcliff Lake, New Jersey, USA.

Lemborexant is a dual orexin receptor antagonist approved in multiple countries including the United States, Canada, and Japan for the treatment of insomnia in adults. As women of childbearing potential may be prescribed insomnia drugs, a drug-drug interaction study was conducted. This single-center, open-label, fixed-sequence study examined potential drug-drug interactions between lemborexant and an oral contraceptive (OC) in healthy females (18-44 years, n = 20). Read More

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Long-term outcomes of 170 brain arteriovenous malformations treated by frameless image-guided robotic stereotactic radiosurgery: Ramathibodi hospital experience.

Medicine (Baltimore) 2021 May;100(19):e25752

Department of Surgery, Division of Neurosurgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Abstract: This study was conducted to report long-term outcomes of the frameless robotic stereotactic radiosurgery (SRS) for brain arteriovenous malformation (AVM) at Ramathibodi Hospital.Retrospective data of patients with brain AVM (bAVM), who underwent CyberKnife SRS (CKSRS) at Ramathibodi Hospital from 2009 to 2014, were examined. Exclusion criteria were insufficient follow-up time (<36 months) or incomplete information. Read More

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Autopsy case of fatal hypoglycemia following ingestion of a therapeutic dose of tramadol.

Forensic Sci Med Pathol 2021 Jun 9. Epub 2021 Jun 9.

Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka 1-1, Yahatanishi, Kitakyushu, Japan.

An 86-year-old female was found unconscious the day after taking a prescribed tablet containing a combination of tramadol and acetaminophen. At admission to the hospital, marked hypoglycemia (blood glucose: 4 mg/dL) was confirmed, but serum insulin and C-peptide were within the normal range, which suggested that neither endogenous hyperinsulinemia nor exogenous insulin administration was responsible for the hypoglycemia. Despite resuscitation efforts, the woman subsequently died. Read More

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Developing Modern System in Healthcare to Detect Covid 19 Based on Internet of Things.

Mater Today Proc 2021 Jun 3. Epub 2021 Jun 3.

Department of computer science, University of Technology Alsina'a Street, 10066, Baghdad, Iraq.

In this paper, a medical platform has architecture that depends on middleware and database supports people with Coronavirus, and this platform mainly relies on three users. The first person is the administrator, who is separated into two groups of users: the doctor and the patient. The doctor has an app that questions through the patient so he knows the patient that is being visited and extracts the health identity from him, and he questions the patient for sending him an OTP in the event that the patient does not have a mobile screen or an Internet connection. Read More

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Evaluation of the dosimetric impact of heart function-based volumetric modulated arc therapy planning in patients with esophageal cancer.

Radiol Phys Technol 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Radiotherapy for esophageal cancer entails high-dose irradiation of the myocardium owing to its close anatomical proximity to the esophagus. This study aimed to evaluate the dosimetric impact of functional avoidance planning for the myocardium with volumetric-modulated arc therapy (VMAT) in patients with esophageal cancer and determine the feasibility of functional planning. Ten patients with early stage esophageal cancer were included in this study. Read More

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Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.

J Pharm Pract 2021 Jun 8:8971900211021054. Epub 2021 Jun 8.

Department of Pharmacy, Duke University Hospital, Durham, NC, USA.

Background: Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeutic levels in the kidney transplant population.

Objectives: To determine if a reliable weight-based dosing strategy could be utilized to transition kidney transplant patients from immediate-release to extended-release tacrolimus. Read More

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Inappropriate prescription of intravenous antibiotics at a tertiary children's hospital in China.

Minerva Pediatr (Torino) 2021 Jun 7. Epub 2021 Jun 7.

Department of Clinical Pharmacy, Children's Hospital of Fudan University, National Children's Medical Centre, Shanghai China -

Background: Antibiotics are one of the most frequently prescribed medication classes worldwide. Inappropriate prescription of antibiotics has increased the risk of drug-resistant infections and associated mortality. The aim of this study was to examine the patterns of intravenous antibiotics prescribing in emergency and outpatient departments of a tertiary children's hospital in China. Read More

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Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder.

J Subst Abuse Treat 2021 Apr 29;131:108454. Epub 2021 Apr 29.

Department of Obstetrics & Gynecology, Thomas Jefferson University, 833 Chestnut St., Philadelphia, PA 19107, United States of America; Department of Psychiatry & Human Behavior, Thomas Jefferson University, 1233 Locust St. Suite 401, Philadelphia, PA 19107, United States of America.

Background: Medications for opioid use disorder, including methadone, combined with comprehensive wraparound services, are the gold standard for treatment in pregnancy. Higher methadone doses are associated with treatment retention in pregnancy and relapse prevention. Given known inequities where individuals of color tend to be prescribed lower doses of opioids for other conditions, the purpose of this study was to determine whether there is racial inequity in methadone dose at delivery in pregnant women with opioid use disorder. Read More

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Radiation Necrosis from Stereotactic Radiosurgery-How Do We Mitigate?

Curr Treat Options Oncol 2021 Jun 7;22(7):57. Epub 2021 Jun 7.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.

Opinion Statement: Intracranial stereotactic radiosurgery (SRS) is an effective and convenient treatment for many brain conditions. Data regarding safety come mostly from retrospective single institutional studies and a small number of prospective studies. Variations in target delineation, treatment delivery, imaging follow-up protocols and dose prescription limit the interpretation of this data. Read More

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Received dose variability after administration of I-131 for treatment of hyperthyroidism in cats.

J Vet Intern Med 2021 Jun 6. Epub 2021 Jun 6.

School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Background: Injectable radioactive iodine (I-131) frequently is used to treat hyperthyroidism in cats. In human medicine, residual activity after injection of radionuclides has been reported, and the actual quantity administered is recorded after administration.

Objective: Our aim was to evaluate actual administered dose variability after administration of preprepared I-131 single unit doses for the treatment of hyperthyroidism in cats. Read More

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Antimicrobial consumption among hospitalized patients with COVID-19 in Pakistan.

SN Compr Clin Med 2021 May 28:1-5. Epub 2021 May 28.

Department of Pharmacy, University of Huddersfield, Huddersfield, UK.

The discovery of different antimicrobial agents has revolutionized the treatment against a variety of infections for many decades, but the emergence of antimicrobial resistance require rigorous measures, even amid the coronavirus disease 2019 (COVID-19) pandemic. This retrospective study aimed to examine the consumption of antibiotics in patients with COVID-19 admitted into the five hospitals in the province of Punjab, Pakistan. We collected data on the consumption of antibiotics, classified using the World Health Organization (WHO) AWaRe (Access, Watch, and Reserve), within two months-August and September, 2020, and the corresponding months in 2019. Read More

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Development of a practical dietitian road map for the nutritional management of phenylketonuria (PKU) patients on pegvaliase.

Mol Genet Metab Rep 2021 Sep 25;28:100771. Epub 2021 May 25.

University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The metabolic dietitian/nutritionist (hereafter 'dietitian') plays an essential role in the nutritional management of patients with phenylketonuria (PKU), including those on pegvaliase. Currently, more educational support and clinical experience is needed to ensure that dietitians are prepared to provide optimal nutritional management and counselling of pegvaliase-treated patients.

Methods: Via a face-to-face data-review meeting, followed by a virtual consolidation meeting, a group of expert dietitians and one paediatrician discussed and developed a series of recommendations on the nutritional evaluation and management of patients receiving pegvaliase. Read More

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September 2021

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.

Front Pharmacol 2021 21;12:688950. Epub 2021 May 21.

Institute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.

The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics. Apart from interindividual differences in the activity of the metabolising enzymes cytochrome P450 (CYP) 2D6 and 2C19, genetic polymorphism of the hepatic influx transporter organic cation transporter 1 (OCT1) could be contributing to interindividual variation in pharmacokinetics. Here, the impact of OCT1 genetic variation on the pharmacokinetics of amitriptyline and its active metabolite nortriptyline was studied as well as in healthy volunteers and in depressive disorder patients. Read More

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Late Toxicity and Long-Term Local Control in Patients With Ultra-Central Lung Tumours Treated by Intensity-Modulated Radiotherapy-Based Stereotactic Ablative Body Radiotherapy With Homogenous Dose Prescription.

Clin Oncol (R Coll Radiol) 2021 Jun 4. Epub 2021 Jun 4.

Department of Radiotherapy, Beacon Hospital, Dublin, Ireland.

Aims: To report late toxicity and long-term outcomes of intensity-modulated radiotherapy (IMRT)-based stereotactic ablative body radiotherapy (SABR) in patients with ultra-central lung tumours.

Materials And Methods: This is a single-institution retrospective analysis of patients treated with SABR for ultra-central tumours between May 2008 and April 2016. Ultra-central location was defined as tumour (GTV) abutting or involving trachea, main or lobar bronchi. Read More

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The impact of preoperative opioid use on complications, readmission, and cost following ankle fracture surgery.

Injury 2021 May 19. Epub 2021 May 19.

Emory University Department of Orthopaedics, 59 Executive Park South, Suite 200, Atlanta, GA 30329, United States. Electronic address:

Background: The incidence of ankle fractures requiring surgical fixation is increasing. Although there has been increasing evidence to suggest that preoperative opioid use negatively impacts surgical outcomes, literature focusing primarily on ankle fractures is scarce. The purpose of this study was to investigate the relationship between preoperative opioid use and outcomes following ankle fracture open reduction and surgical fixation (ORIF). Read More

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Radiation pneumonitis after palliative radiotherapy in cancer patients with interstitial lung disease.

Radiother Oncol 2021 Jun 2. Epub 2021 Jun 2.

Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan; Division of Radiation Oncology and Particle Therapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

Purpose: The risk of radiation pneumonitis (RP) after palliative radiotherapy (RT) in cancer patients with interstitial lung disease (ILD) remains unclear. This study aimed to investigate the incidence, severity, and predictive factors of RP among patients with ILD who received palliative RT.

Methods And Materials: The medical records of cancer patients with ILD who received palliative RT involving a lung field between January 2008 and December 2019 were retrospectively reviewed. Read More

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