17,669 results match your criteria preparation period


"The Worst Is the Worry": Importance of Preoperative Preparation of Preschool Children.

AANA J 2021 Aug;89(4):342-349

is employed by the University of South-Eastern Norway, Kongsberg, Norway.

Children often experience a high level of anxiety before anesthesia, which may lead to poor cooperation during anesthesia induction and negative consequences for the postoperative period. The aim of this study was to obtain knowledge that may improve practice in preparing preschoolers for anesthesia and surgery by analyzing nurse anesthetists' preoperative experiences with children. A focus group interview with nurse anesthetists was conducted. Read More

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Pediatric Medication Errors and Reduction Strategies in the Perioperative Period.

AANA J 2021 Aug;89(4):319-324

is an assistant professor (clinical) in the Wayne State University Nurse Anesthesia program.

Anesthesia providers are regularly responsible for assessing, diagnosing, and determining pharmacologic treatment of a problem. This critical workflow often includes medication preparation. Decision making in anesthesia frequently requires rapid intervention, and caring for the pediatric population poses additional challenges, such as needing to quickly calculate the weight-based dosing of medications. Read More

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Fast and Filtration-Free Method to Prepare Lactic Acid-Modified Cellulose Nanopaper.

ACS Omega 2021 Jul 15;6(29):19038-19044. Epub 2021 Jul 15.

Fibre and Particle Engineering Research Unit, University of Oulu, P.O. Box 4300, 90014 Oulu, Finland.

Dewatering in the preparation of cellulose nanopapers can take up to a few hours, which is a notable bottleneck in the commercialization of nanopapers. As a solution, we report a filtration-free method that is capable of preparing lactic acid-modified cellulose nanopapers within a few minutes. The bleached cellulose nanofibers (CNFs), obtained using a Masuko grinder, were functionalized by sonication-assisted lactic acid modification and centrifuged at 14 000 rpm to achieve a doughlike, concentrated mass. Read More

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Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor: A 2-Year Outcome Study of Chinese People.

Front Aging Neurosci 2021 14;13:697029. Epub 2021 Jul 14.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Essential tremor (ET) is a common movement disorder among elderly individuals worldwide and is occasionally associated with a high risk for mild cognitive impairment and dementia. This retrospective study aimed to determine the clinical outcome of unilateral magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in Chinese patients with ET. In total, 31 male and 17 female patients with drug-refractory ET were enrolled in this research study from January 2017 to September 2019. Read More

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The utility and complications of plasma administration in cirrhotic patients undergoing minimally invasive procedures.

Blood Coagul Fibrinolysis 2021 Jul 30. Epub 2021 Jul 30.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia Division of Hematology and Oncology, Department of Medicine Mount Sinai Medical Center Division of Liver Diseases, Department of Medicine, Recanati/Miller Transplantation Institute Department of Anatomic Pathology and Clinical Pathology, Mount Sinai Medical Center, New York, New York, USA.

Patients with cirrhosis have coagulopathy often necessitating correction with blood products, such as plasma products (fresh frozen plasma and plasma frozen within 24 h) prior to certain invasive procedures. However, plasma administration has the potential for substantial negative adverse effects such as volume overload, transfusion-related lung injury and allergic/anaphylactic reactions. In addition, its effectiveness in preventing bleeding is similarly unclear. Read More

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Chlorhexidine Versus Iodine for Vaginal Preparation Before Hysterectomy: A Randomized Clinical Trial.

Female Pelvic Med Reconstr Surg 2021 Jul 29. Epub 2021 Jul 29.

From the Divisions of Female Pelvic Medicine and Reconstructive Surgery Gynecology Oncology, TriHealth TriHealth Hatton Research Institute, Cincinnati, OH.

Objective: The American College of Obstetricians and Gynecologists does not provide a recommendation regarding the preferred vaginal preparation solution. We intended to compare the effectiveness of chlorhexidine versus iodine in decreasing vaginal bacterial counts.

Methods: In this institutional review board-approved study, participants undergoing total hysterectomy via vaginal or laparoscopic approach were randomized to 4% chlorhexidine or 10% iodine for presurgical vaginal preparation. Read More

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Comparison of Bite Force and the Influencing Factors Pre- and Post-cementation of Stainless Steel Crown in Children Using T-Scan.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):46-50

Department of Orofacial Pain Clinic, RajaRajeswari Dental College and Hospital, Kumbalgudu, Bengaluru, Karnataka, India.

Background: In children, stainless steel crowns (SSCs) have become an invaluable restorative option for grossly decayed primary teeth. The crowns are manufactured in different sizes with preformed anatomy which requires trimming or contouring as a necessary step to fit an individual tooth. Initially, this may produce variation in the occlusal contact points yet may not result in pain or discomfort. Read More

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Safety and efficacy of subcutaneous alpha-tocopherol in healthy adult horses.

Equine Vet Educ 2021 Apr 4;33(4):215-219. Epub 2020 Jun 4.

William R. Pritchard Veterinary Medical Teaching Hospital.

Vitamin E is essential for neuromuscular function. The primary treatment, oral supplementation with natural ('RRR') α-tocopherol, is not effective in all horses. The objectives of this pilot study were to evaluate the safety and efficacy of a subcutaneously administered RRR-α-tocopherol preparation. Read More

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A feasibility trial of an intervention in alcohol dependence for structured preparation before detoxification versus usual care: the SPADe trial results.

Pilot Feasibility Stud 2021 Jul 29;7(1):148. Epub 2021 Jul 29.

University of Sussex, School of Psychology, Falmer, Brighton, BN1 9RH, UK.

Background: Individuals who are 'moderately' or 'severely' dependent consume alcohol at levels that are likely to have a severe impact on their own health and mortality, the health and behaviours of others (family members) and to have economic and social implications. Treatment guidelines suggest that treatment needs to be planned with medically assisted withdrawal (also referred to as detoxification), and aftercare support but outcomes are poor with low proportions engaging in after care and high relapse rates. An approach of structured preparation before alcohol detoxification (SPADe) puts an emphasis on introducing lifestyle changes, development of coping strategies for cravings, stress and emotions as well as introducing changes to the immediate family and social environment in advance of alcohol cessation. Read More

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Efficacy of past, present, and future fluid strategies in an improved large animal model of non-compressible intra-abdominal hemorrhage.

J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S99-S106

From the Critical Innovations LLC (R.I.D., T.C.F., J.A., O.J.B., J.C.); Department of Emergency Medicine (R.I.D.), David Geffen School of Medicine at UCLA, Los Angeles; Department of Emergency Medicine (R.I.D.), Harbor-UCLA Medical Center, Torrance; Department of Epidemiology (R.I.D.), UCLA Fielding School of Public Health, Los Angeles, California; Charles T Dotter Department of Interventional Radiology (T.L.G., J.D.R.), Oregon Health and Science University, Portland, Oregon; and Military and Health Research Foundation (T.L.G., J.D.R.), Laurel, Maryland.

Background: Noncompressible hemorrhage is a leading cause of potentially survivable combat death, with the vast majority of such deaths occurring in the out-of-hospital environment. While large animal models of this process are important for device and therapeutic development, clinical practice has changed over time and past models must follow suit. Developed in conjunction with regulatory feedback, this study presents a modernized, out-of-hospital, noncompressible hemorrhage model, in conjunction with a randomized study of past, present, and future fluid options following a hypotensive resuscitation protocol consistent with current clinical practice. Read More

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A novel method for the development of plasmid DNA-loaded nanoliposomes for cancer gene therapy.

Drug Deliv Transl Res 2021 Jul 28. Epub 2021 Jul 28.

Drug Applied Research Center & Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

We aimed to develop a simple yet novel method to prepare plasmid DNA-loaded nanoliposomes for cancer gene therapy. Murine interleukin-12 (mIL-12) pDNA-loaded nanoliposomes were prepared via novel freeze-drying of a monophase solution method. The physicochemical characteristics, cytotoxicity, and transfection efficiency of the prepared nanoliposomes in murine CT-26 colon carcinoma cells were evaluated. Read More

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Students' acceptance of case-based blended learning in mandatory interdisciplinary lectures for clinical medicine and veterinary public health.

Vet Rec Open 2021 Dec 22;8(1):e14. Epub 2021 Jul 22.

Department of Veterinary Medicine Institute for Veterinary Epidemiology and Biostatistics Freie Universität Berlin Germany.

Background: In German veterinary education interdisciplinary lectures (ILs) are an important and mandatory part of the curriculum as their merging character builds a useful preparation for the future profession as a veterinarian. These lectures should enable students to work on practically-relevant and interdisciplinary cases, which should ideally be defined jointly by lecturers from different disciplines.

Methods: In order to give students the opportunity to work on these cases and at the same time have contact with their lecturers and fellow students, the Faculty of Veterinary Medicine, Freie Universität Berlin, has converted its former in-class ILs (face-to-face delivery format) into a blended learning format. Read More

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December 2021

Burden of Disease Among Exacerbating Patients with COPD Treated with Triple Therapy in Spain.

Int J Chron Obstruct Pulmon Dis 2021 21;16:2149-2161. Epub 2021 Jul 21.

CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Background: The cost of chronic obstructive pulmonary disease (COPD) in Spain has been studied from different perspectives, but parameters such as the patient's phenotype have seldom been considered. Our aim was to describe the disease burden of COPD patients with frequent exacerbator phenotype, treated with triple therapy.

Methods: An observational, multicenter study was carried out from December 2017 to November 2018 in pulmonology services among patients ≥40 years with COPD confirmed diagnosis receiving triple therapy (ICS/LAMA/LABA) and history of ≥2 moderate or ≥1 severe exacerbation in the 12 months prior to the inclusion visit. Read More

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Multi-tiered external facilitation: the role of feedback loops and tailored interventions in supporting change in a stepped-wedge implementation trial.

Implement Sci Commun 2021 Jul 27;2(1):82. Epub 2021 Jul 27.

VA HSR&D Center for Health Information and Communication (CHIC), Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA.

Background: Facilitation is a complex, relational implementation strategy that guides change processes. Facilitators engage in multiple activities and tailor efforts to local contexts. How this work is coordinated and shared among multiple, external actors and the contextual factors that prompt and moderate facilitators to tailor activities have not been well-described. Read More

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Anti-aging properties of phytoconstituents and phyto-nanoemulsions and their application in managing aging-related diseases.

Adv Drug Deliv Rev 2021 Jul 24:113886. Epub 2021 Jul 24.

School of Science, RMIT University, Melbourne, VIC 3083, Australia. Electronic address:

Aging is spontaneous and inevitable process in all living beings. It is a complex natural phenomenon that manifests as a gradual decline of physiological functions and homeostasis. Aging inevitably leads to age-associated injuries, diseases, and eventually death. Read More

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Experiences of nurses caring for respiratory patients during the first wave of the COVID-19 pandemic: an online survey study.

BMJ Open Respir Res 2021 Jul;8(1)

Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.

Background: Nurses have been at the forefront of the pandemic response, involved in extensive coordination of services, screening, vaccination and front-line work in respiratory, emergency and intensive care environments. The nature of this work is often intense and stress-provoking with an inevitable psychological impact on nurses and all healthcare workers. This study focused on nurses working in respiratory areas with the aim of identifying and characterising the self-reported issues that exacerbated or alleviated their concerns during the first wave of the COVID-19 pandemic. Read More

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Laser conversion of biomass into porous carbon composite under ambient condition for pH-Universal electrochemical hydrogen evolution reaction.

J Colloid Interface Sci 2021 Jul 16;604:885-893. Epub 2021 Jul 16.

Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, National & Local United Engineering Laboratory for Power Batteries, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Analysis and Testing Center, Department of Chemistry, Northeast Normal University, Changchun, Jilin Province 130024, China. Electronic address:

It is highly desirable to develop durable and advanced electrocatalysts for pH-universal hydrogen evolution reaction (HER). While it makes much progress so far, the development of an environmental-friendly and cost-effective method to upgrade earth-abundant biomass into high value-added products still remains a major challenge. Thermal pyrolysis method which requires high pyrolysis temperature and long synthesis period is considered as a general method for preparation of carbon-based electrocatalysts. Read More

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Major Burn Injury Successfully Treated with Cultured Epithelial Autografts, a Case Series Presentation: Establishing Standard Clinical Practices.

J Burn Care Res 2021 Jul 26. Epub 2021 Jul 26.

United States Army Institute of Surgical Research.

Cultured epithelial autografts have been an option for coverage of large surface area burns for over two decades. However, there remains extreme variability in clinical practice in wound bed preparation, application of cultured epithelial autografts, and post-operative wound care and rehabilitation practices, demonstrating the need for a standardized and multidisciplinary approach in the treatment of critically injured patients treated with cultured epithelial autografts. The purpose of this case series was to share the development of a clinical practice guideline and competency checklist in our institution where cultured epithelial autograft case volume is low. Read More

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Three-year review of a capacity building pilot for a sustainable regional network on food, nutrition and health systems education in India.

BMJ Nutr Prev Health 2021 1;4(1):59-68. Epub 2021 Feb 1.

NNEdPro Global Centre for Nutrition and Health, St John's Innovation Centre, Cambridge, UK.

Background: In Kolkata (India), there are high rates of malnourished children (45.9%) under the age of three, impacting growth, organ development, function, and cognition. Mothers have a major role to play during this crucial development stage, with research showing nutrition knowledge, attitudes and practices (KAP) of mothers are important determinants of childhood malnutrition. Read More

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February 2021

Study of a more than a hundred years old theriac jar' content: A famous thousand-year-old counter-poison.

Toxicol Rep 2021 17;8:1336-1345. Epub 2021 Jun 17.

EXPERTOX Laboratory, 75011, Paris, France.

The purpose of this article is to study the content of a 19th century white porcelain pot from the Pochet-Desroche fabric, offered to the National Order of Pharmacists and probably containing theriac. The aim is to identify the active ingredients of any substances that may still be present and to try to determine the preparation period of the panacea. All the analyzes were carried out according to the reference current methods. Read More

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CONTINUOUS PRODUCTION OF RALOXIFENE HYDROCHLORIDE LOADED NANOSTRUCTURED LIPID CARRIERS USING HOT-MELT EXTRUSION TECHNOLOGY.

J Drug Deliv Sci Technol 2021 Oct 5;65. Epub 2021 Jul 5.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, Mississippi 38677.

The aim of this study was to utilize a continuous process for the production of orally administered raloxifene hydrochloride (RX-HCl) loaded nanostructured lipid carrier (NLC) formulations for extended drug release using hot-melt extrusion (HME) technology coupled with probe sonication, and also to evaluate the characteristics of the prepared NLCs. Preparation of the NLCs using HME technology involved two main steps, first formation of a pre-emulsion after extrusion and then size reduction of the pre-emulsion using probe sonication to obtain the NLCs. A screw speed of 100 rpm and a barrel temperature of 85 °C, were used in the extrusion process. Read More

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October 2021

Phenotypic characterization of cell culture-derived hepatitis E virus subjected to different chemical treatments: Application in virus removal via nanofiltration.

J Virol Methods 2021 Jul 22;296:114244. Epub 2021 Jul 22.

Central Research Laboratory, Research & Development Division, Japan Blood Products Organization, Kobe, Japan.

Safety evaluation for the hepatitis E virus (HEV) is required for plasma fractionation products. Plasma-derived HEV (pHEV) is quite unique in that it is associated with a lipid membrane, which, when stripped during manufacturing processes, induces morphological changes in the virus, making it difficult to select proper HEV phenotypes for clearance studies. We developed a convenient system for the preparation of a high titer cell culture-derived HEV (cHEV). Read More

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Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions.

Int J Pharm Compd 2021 Jul-Aug;25(4):330-335

Department of Pharmacy, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Dexmedetomidine is a sedative medication with co-analgesic effects that has been used primarily in critical care and anesthesia as a continuous intravenous infusion. Its utility in the treatment of refractory agitated delirium is being investigated in other settings including palliative care, but continuous intravenous infusions are not always feasible during end-of-life care. Subcutaneous infusions are more commonly used in this setting, but smaller volumes and higher concentrations are typically required. Read More

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Efficacy and benefits of mock residency interviews.

Curr Pharm Teach Learn 2021 Aug 3;13(8):958-963. Epub 2021 Jul 3.

Texas Tech University Health Sciences Center, Jerry H. Hodge School of Pharmacy, 5920 Forest Park Road, Suite 500, Dallas, TX 75235, United States. Electronic address:

Introduction: Obtaining a residency has become more competitive as more pharmacy students seek postgraduate training. This is likely due to pharmacist positions increasing in clinical settings. To be fully prepared, students seeking residency positions should be trained for the interview process by their pharmacy school. Read More

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Continuous monitoring of colonoscopy performance in the Netherlands: first results of a nationwide registry.

Endoscopy 2021 Jul 22. Epub 2021 Jul 22.

Gastroenterology & Hepatology, Amsterdam University Medical Centres, Amsterdam, Netherlands.

Background: To optimize colonoscopy quality, several performance measures have been developed. These are usually assessed without distinction between the indications for colonoscopy. This study aims to assess the feasibility of linkage between two registries: a national colonoscopy registry and a national registry for adverse events of gastrointestinal endoscopies in the Netherlands, and to describe the results of colonoscopy quality per indication. Read More

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Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac.

Radiother Oncol 2021 Jul 20;162:162-169. Epub 2021 Jul 20.

University Medical Center Utrecht, Department of Radiotherapy, Utrecht, The Netherlands.

Purpose: To evaluate seminal vesicle (SV) intrafraction motion using cinematic magnetic resonance imaging (cine-MR) during the delivery of online adaptive MR-Linac radiotherapy fractions, in preparation of MR-guided extremely hypofractionated radiotherapy for intermediate to high-risk prostate cancer patients.

Material And Methods: Fifty prostate cancer patients were treated with 5 × 7.25 Gy on a 1. Read More

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Maternal and neonatal canine cortisol measurement in multiple matrices during the perinatal period: A pilot study.

PLoS One 2021 22;16(7):e0254842. Epub 2021 Jul 22.

Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.

Stress exposure during perinatal period may lead to maternal cortisol increase that negatively affects the offspring development. In recent years, the interest on non-invasive sampling methods to measure cortisol as a marker of stress is increasing in both humans and animals. Indeed, discomfort due to blood collection may compromise the diagnostic outcome, mainly in uncooperative patients. Read More

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Use of non-invasive intracranial pressure pulse waveform to monitor patients with End-Stage Renal Disease (ESRD).

PLoS One 2021 22;16(7):e0240570. Epub 2021 Jul 22.

Biological and Health Sciences Division, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil.

End-stage renal disease (ESRD) is treated mainly by hemodialysis, however, hemodialysis is associated with frequent complications, some of them involve the increased intracranial pressure. In this context, monitoring the intracranial pressure of these patients may lead to a better understanding of how intracranial pressure morphology varies with hemodialysis. This study aimed to follow-up patients with ESRD by monitoring intracranial pressure before and after hemodialysis sessions using a noninvasive method. Read More

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Lithosphere atmosphere ionosphere coupling associated with the 2019 M 7.1 California earthquake using GNSS and multiple satellites.

Environ Monit Assess 2021 Jul 22;193(8):501. Epub 2021 Jul 22.

Department of GNSS, Institute of Space Technology, Islamabad, Pakistan.

Global Navigation Satellite System (GNSS)-based Earthquake (EQ) anomalies in the ionosphere and troposphere provide explicit evidences to study the coupling between seismic events, atmosphere, and ionosphere in epicentral breeding regions consequent to the EQ day in the preparation period. EQs are still not predicted, but the space-based EQ anomalies aid in the development of monitoring pre- and post-seismic precursors around the seismogenic zone and associated fault lineament regions. In this paper, tropospheric and ionospheric anomalies are investigated for the July 06, 2019, M 7. Read More

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