73,136 results match your criteria prenatal treatment

Role of progesterone, cerclage and pessary in preventing preterm birth in twin pregnancies: A systematic review and network meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 24;261:166-177. Epub 2021 Apr 24.

Fetal Medicine Unit, Saint George's University of London, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, United Kingdom.

Objective: To determine the role of progesterone, pessary and cervical cerclage in reducing the risk of (preterm birth) PTB in twin pregnancies and compare these interventions using pairwise and network meta-analysis.

Study Design: Medline, Embase, CINAHL and Cochrane databases were explored. The inclusion criteria were studies in which twin pregnancies were randomized to an intervention for the prevention of PTB (any type of progesterone, cervical cerclage, cervical pessary, or any combination of these) or to a control group (e. Read More

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The Ex utero intrapartum treatment (EXIT) procedure: case report of a multidisciplinary team approach.

Acta Biomed 2021 Apr 30;92(S1):e2021142. Epub 2021 Apr 30.

Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Piazzale Aristide Stefani 1, 37126 Verona (VR), Italy.

Background And Aim Of The Work: The EXIT-to-airway procedure is aimed to provide the time required to secure airways when an extrinsic or intrinsic fetal mass raise concerns about airways control at delivery. Due to the rarity of the procedure, we aim to provide a summary of the appropriate prenatal planning by a multidisciplinary team.

Methods: Report of a case of EXIT-to-airway procedure. Read More

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Next-generation sequence-based preimplantation genetic testing for monogenic disease resulting from maternal mosaicism.

Mol Genet Genomic Med 2021 May 4:e1662. Epub 2021 May 4.

Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.

Background: Mosaicism poses challenges for genetic counseling and preimplantation genetic testing for monogenic disorders (PGT-M). NGS-based PGT-M has been extensively used to prevent the transmission of monogenic defects, but it has not been evaluated in the application of PGT-M resulting from mosaicism.

Methods: Four women suspected of mosaicism were confirmed by ultra-deep sequencing. Read More

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Risk of asthma in children diagnosed with bronchiolitis during infancy: protocol of a longitudinal cohort study linking emergency department-based clinical data to provincial health administrative databases.

BMJ Open 2021 May 3;11(5):e048823. Epub 2021 May 3.

Research Institute, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Introduction: The Canadian Bronchiolitis Epinephrine Steroid Trial (CanBEST) and the Bronchiolitis Severity Cohort (BSC) study enrolled infants with bronchiolitis during the first year of life. The CanBEST trial suggested that treatment of infants with a combined therapy of high-dose corticosteroids and nebulised epinephrine reduced the risk of admission to hospital. Our study aims to-(1) quantify the risk of developing asthma by age 5 and 10 years in children treated with high-dose corticosteroid and epinephrine for bronchiolitis during infancy, (2) identify risk factors associated with development of asthma in children with bronchiolitis during infancy, (3) develop asthma prediction models for children diagnosed with bronchiolitis during infancy. Read More

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Project Console: a quality improvement initiative for neonatal abstinence syndrome in a children's hospital level IV neonatal intensive care unit.

BMJ Open Qual 2021 May;10(2)

Neonatology, UCSF Benioff Children's Hospital Oakland, Oakland, California, USA.

Objective: To improve care for infants with neonatal abstinence syndrome.

Design: Infants with a gestational age of ≥35 weeks with prenatal opioid exposure were eligible for our quality improvement initiative. Interventions in our Plan-Do-Study-Act cycles included physician consensus, re-emphasis on non-pharmacological treatment, the Eat Sleep Console method to measure functional impairment, morphine as needed, clonidine and alternative soothing methods for parental unavailability (volunteer cuddlers and automated sleeper beds). Read More

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Postnatal Management in Congenital Lower Urinary Tract Obstruction With and Without Prenatal Vesicoamniotic Shunt.

Front Pediatr 2021 14;9:635950. Epub 2021 Apr 14.

Center for Pediatric, Adolescent and Reconstructive Urology, Medical Faculty Mannheim, University of Medical Center Mannheim, Heidelberg University, Heidelberg, Germany.

Congenital lower urinary tract obstruction (cLUTO) includes a heterogeneous group of conditions caused by a functional or mechanical outlet obstruction. Early vesicoamniotic shunting (VAS) possibly reduces the burden of renal impairment. Postpartum, pediatric urologists are confronted with neonates who have a shunt in place and a potentially impassable urethra with a narrow caliber. Read More

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Familiar del3p syndrome: The uncertainty of the prognosis. A case report.

Clin Case Rep 2021 Apr 9;9(4):2365-2368. Epub 2021 Mar 9.

Genetics Laboratory Centro Hospitalar de Trás-os-Montes e Alto Douro Vila Real Portugal.

The 3p deletion syndrome is an unusual condition. The few cases described are mainly de novo. We described a familial case detected in a prenatal diagnosis. Read More

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Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves' disease.

Clin Case Rep 2021 Apr 4;9(4):2281-2284. Epub 2021 Mar 4.

Department of Obstetrics and Gynecology FHU Prematurity Bichat Hospital Assistance publique-Hôpitaux de Paris Paris University Paris France.

We present a rare documented case with consecutive hypo- and hyperthyroidism during fetal life. First, hypothyroidism was due to transplacental passage of antithyroid drugs. After the mother's thyroidectomy, fetal hyperthyroidism was due to transplacental passage of persistent anti-thyrotropin receptor antibodies. Read More

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From Womb to Neighborhood: A Racial Analysis of Social Determinants of Psychosis in the United States.

Am J Psychiatry 2021 May 3:appiajp202020071091. Epub 2021 May 3.

Department of Psychology, City College of New York, City University of New York, New York (Anglin, Thayer); Graduate Center, City University of New York (Anglin); Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento (Ereshefsky, Niendam, Bolden, Grattan); Department of Psychology, University of Maryland, Baltimore County (Klaunig, Bridgwater, Schiffman); Department of Psychology, Temple University, Philadelphia (Ellman, Lipner); Graduate School of Social Service, Fordham University, New York (DeVylder); Department of Psychology (Musket) and Department of Psychiatry (Bachman), University of Pittsburgh, Pittsburgh; ISN Innovations, Institute for Social Neuroscience, Ivanhoe, Australia (Grattan); Department of Psychological Sciences, Case Western Reserve University, Cleveland (Lincoln); Department of Psychological Science, University of California, Irvine (Schiffman); Department of Psychiatry, Icahn School of Medicine, New York, and James J. Peters VA Medical Center, Bronx, N.Y. (Corcoran); Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil (Mota); Mailman School of Public Health, Columbia University, New York (van der Ven); School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands (van der Ven); Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit (VU) Amsterdam, Amsterdam (van der Ven).

The authors examine U.S.-based evidence that connects characteristics of the social environment with outcomes across the psychosis continuum, from psychotic experiences to schizophrenia. Read More

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Elevated glucocorticoids during gestation suggest sex-specific effects on offspring telomere lengths in a wild lizard.

Comp Biochem Physiol A Mol Integr Physiol 2021 Apr 29:110971. Epub 2021 Apr 29.

Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, United States of America; Intercollege Graduate Degree Program in Ecology, The Pennsylvania State University, University Park, PA 16802, United States of America.

The effects of maternal glucocorticoids (e.g. corticosterone, CORT) on offspring interest biologists due to increasing environmental perturbations. Read More

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Engineering alginate microparticles for optimized accumulation in Fetal Rat Myelomeningocele.

J Pediatr Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Introduction: Intraamniotic microparticle injection is a novel technique for the treatment of myelomeningocele (MMC) in which microparticles are delivered in-utero in a minimally invasive fashion to bind to and protect the exposed spinal cord. This technique could offer earlier intervention and greater access to prenatal treatment of MMC. Here we demonstrate progress on the engineering of the microparticles to promote binding to the MMC defect. Read More

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Third trimester repeat HIV testing: It's time we make it universal.

Am J Obstet Gynecol 2021 Apr 28. Epub 2021 Apr 28.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Since the 1990s, perinatal transmission of HIV has decreased substantially, largely as a result of improved detection secondary to routine HIV screening in pregnancy and the use of antiretroviral therapy. However, despite reductions, elimination of perinatal transmission, defined as an incidence of perinatal HIV infection of less than 1:100,000 live births and a transmission rate < 1%, remains elusive. An estimated 80% of perinatal transmissions occur after 36 weeks' gestation, which highlights the importance of diagnosis and treatment of maternal HIV infection prior to the highest risk time period for perinatal transmission. Read More

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Open fetal myelomeningocele repair at a university hospital: surgery and pregnancy outcomes.

Arch Gynecol Obstet 2021 May 1. Epub 2021 May 1.

Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Avenida Dr. Eneas de Carvalho Aguiar, 255 - 10° andar - Cerqueira Cesar, Sao Paulo, CEP 05403-000, Brazil.

Purpose: Myelomeningocele (MMC) is an open neural tube defect that causes great morbidity. Prenatal open repair is the standard treatment; however, there are many complications related to the procedure. This study reports preliminary findings of open in utero repair of MMC in a public tertiary hospital in Brazil and describes factors that could be associated with increased surgical morbidity. Read More

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J Clin Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Biochemical Genetics, Children's Health Ireland at Temple Street, Dublin, Ireland.

Hypophosphatasia (HPP) is a group of inherited disorders characterised by the impaired mineralisation of bones and/or teeth and low serum alkaline phosphatase (ALP) activity. It is caused by a mutation in the ALPL gene encoding the tissue-non-specific isoenzyme of ALP (TNSALP) resulting in a loss of function. The disease is highly heterogenous in its clinical expression ranging from stillbirth without mineralised bone to the mild form of late adult onset with symptoms and signs such as musculoskeletal pain, arthropathy, lower-extremity fractures, premature loss of teeth or an incidental finding of reduced serum ALP activity. Read More

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Sensory Stimulation in the NICU Environment: Devices, Systems, and Procedures to Protect and Stimulate Premature Babies.

Children (Basel) 2021 Apr 25;8(5). Epub 2021 Apr 25.

Neonatal Pathology/NICU, Ospedale Civile Padova-AOPD, 35128 Padova, Italy.

Prematurity deprives infants of the prenatal sensory stimulation essential to their correct development; in addition, the stressful environment of the NICU impacts negatively on their growth. The purpose of this review was to investigate the effects of NICU noise pollution on preterm infants and parents. We focused on the systems and projects used to control and modulate sounds, as well as on those special devices and innovative systems used to deliver maternal sounds and vibrations to this population. Read More

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Genetic Profiling of Idiopathic Antenatal Intracranial Haemorrhage: What We Know?

Genes (Basel) 2021 Apr 15;12(4). Epub 2021 Apr 15.

Department of Obstetrics and Gynaecology, Santo Eugenio Hospital, ASL Roma 2, 00100 Rome, Italy.

Intracranial hemorrhage (ICH) is reported in premature infants and rarely, in prenatal life. Fetal ICH can be accurately identified in utero and categorized by antenatal sonography and/or MRI. Infectious disease, maternal drug exposure, alloimmune thrombocytopenia, maternal trauma, coagulation disorders and twin-to-twin transfusion syndrome can cause fetal ICH. Read More

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Comprehensive Profiling of Secretome Formulations from Fetal- and Perinatal Human Amniotic Fluid Stem Cells.

Int J Mol Sci 2021 Apr 2;22(7). Epub 2021 Apr 2.

Experimental Biology Unit, Department of Experimental Medicine (DIMES), University of Genova, 16132 Genova, Italy.

We previously reported that c-KIT+ human amniotic-fluid derived stem cells obtained from leftover samples of routine II trimester prenatal diagnosis (fetal hAFS) are endowed with regenerative paracrine potential driving pro-survival, anti-fibrotic and proliferative effects. hAFS may also be isolated from III trimester clinical waste samples during scheduled C-sections (perinatal hAFS), thus offering a more easily accessible alternative when compared to fetal hAFS. Nonetheless, little is known about the paracrine profile of perinatal hAFS. Read More

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[Maternal-fetal therapy: from saving the fetus towards a better life for the future child].

Ned Tijdschr Geneeskd 2021 04 8;165. Epub 2021 Apr 8.

Universiteit Maastricht, Care and Public Health Research Institute (CAPHRI), Maastricht.

Maternal-fetal therapy (MFT) is special because treatment of the fetus is exclusively possible through the body of another person, the pregnant woman. MFT is a broad specialty with diverse interventions. In this manuscript several examples of innovations in MFT are discussed to illustrate the shift of lifesaving interventions to interventions aiming to improve morbidity of the future child. Read More

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A Novel Mutation p.L461P in Causing Localized Epidermolysis Bullosa Simplex.

Ann Dermatol 2021 Feb 30;33(1):11-17. Epub 2020 Dec 30.

State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China.

Background: Epidermolysis bullosa (EB) is a rare genetic disease with widely different clinical manifestations, but the relationship between genotype and phenotype is not fully understood. In the present study, we recruited a Chinese family in which two members had been diagnosed with localized EB simplex (EBS), with clinical manifestation, including blisters and erosions on the soles of the feet since infancy.

Objective: To identify and confirm the genetic variation in a Chinese family diagnosed as localized EBS. Read More

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February 2021

Prenatal transplantation of human amniotic fluid stem cell could improve clinical outcome of type III spinal muscular atrophy in mice.

Sci Rep 2021 Apr 28;11(1):9158. Epub 2021 Apr 28.

Prenatal Cell and Gene Therapy Group, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, WC1E 6HU, UK.

Spinal muscular atrophy (SMA) is a single gene disorder affecting motor function in uterus. Amniotic fluid is an alternative source of stem cell to ameliorate SMA. Therefore, this study aims to examine the therapeutic potential of Human amniotic fluid stem cell (hAFSC) for SMA. Read More

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Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2.

Turk J Biol 2021 20;45(2):187-195. Epub 2021 Apr 20.

School of Life Sciences, Nantong University, Nantong, Jiangsu China.

Heterogeneous nuclear ribonucleoprotein (HNRNP) A1 and A2 are the most abundant HNRNPs with nearly identical functions, and play important roles in regulating gene expression at multiple levels (i.e. transcription, posttranscription, and translation). Read More

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Doppler ultrasound in pregnancy - quality requirements of DEGUM and clinical application (part 2).

Ultraschall Med 2021 Apr 27. Epub 2021 Apr 27.

Obstetrics and Prenatal Medicine, University Hospital, Bonn, Germany.

This second part on Doppler sonography in prenatal medicine and obstetrics reviews its clinical applications. While this has not become the initially anticipated screening tool, it is used for the diagnosis and surveillance of a variety of fetal pathologies. For example, the sonography-based determination of uterine artery blood flow indices is an important parameter for the first trimester multimodal preeclampsia risk assessment, increasing accuracy and providing indication for the prophylactic treatment with aspirin. Read More

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Prenatal Diagnosis of Fetal Oral Masses by Ultrasound Combined With Magnetic Resonance Imaging.

J Ultrasound Med 2021 Apr 26. Epub 2021 Apr 26.

Department of Medical Ultrasonic, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Objectives: To analyze the imaging manifestations of common fetal oral masses by ultrasound combined with magnetic resonance imaging (MRI) and to discuss their differential diagnoses.

Methods: A retrospective study of 6 fetuses with oral masses was performed at a tertiary referral center. The imaging features of prenatal ultrasonography and MRI in the diagnosis of fetal oral masses were analyzed. Read More

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Improved Maternal and Infant Outcomes with Serial, Self-Reported Early Prenatal Substance Use Screening.

Matern Child Health J 2021 Apr 27. Epub 2021 Apr 27.

Division of Neonatology, Department of Pediatrics, Froedtert Health & the Medical College of Wisconsin, 8701 W Watertown Plank Rd, Wauwatosa, WI, 53226, USA.

Introduction: Most screening tools identifying women with substance use are not validated, used once in pregnancy, and are not reflective of continued substance use. We hypothesized that serial early prenatal substance screening leads to decreased substance use by the end of pregnancy and improved outcomes.

Methods: This is a retrospective cohort study of mothers and their infants between 1/2015 and 12/2017. Read More

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Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.

Food Funct 2021 Apr 27. Epub 2021 Apr 27.

College of Life Sciences, Shaanxi Normal University. Xi'an, Shaanxi, 710119, China.

Maternal vitamin supplementation has been demonstrated to reduce the risks of a number of neurodevelopmental diseases in children. Autism spectrum disorder (ASD) is a group of neurodevelopment defects with high prevalence but without satisfactory therapy. The present work detected the effects of pregnancy supplementation with folic acid (FA) at different doses on rat models of ASD induced by prenatal exposure to valproic acid (VPA), an anti-epileptic increasing the risk of ASD when administered during pregnancy. Read More

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[Feasibility and safety of fetal intravascular transfusion via the intrahepatic vein in the treatment of fetal anemia].

Zhonghua Fu Chan Ke Za Zhi 2021 Apr;56(4):244-250

Fetal Medicine Unit and Prenatal Diagnosis Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China.

To investigate the feasibility and safety of fetal intravascular transfusion via the intrahepatic vein in the treatment of fetal anemia. This was a retrospective analysis of all fetuses requiring intrauterine transfusion (IUT) in the Shanghai First Maternity and Infant Hospital between January 2010 and December 2019. According to the different ways of IUT, they were divided into intrahepatic venous transfusion group and umbilical venous transfusion group, fetal outcomes and the incidence of procedure-related complications between the two groups were compared. Read More

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Neurocognitive outcomes following fetal exposure to chemotherapy for gestational breast cancer: A Canadian multi-center cohort study.

Breast 2021 Apr 15;58:34-41. Epub 2021 Apr 15.

CHES, Research Institute, The Hospital for Sick Children, Toronto, Toronto, ON, Canada. Electronic address:

Background: Limited knowledge exists on outcomes of children exposed prenatally to chemotherapy for breast cancer (BC). The purpose of this study was to compare long-term neurocognitive, behavioral, developmental, growth, and health outcomes of children exposed in-utero to chemotherapy for BC.

Methods: This is a multi-center matched cross-sectional cohort study involving seven cancer centers across the region of Southern Ontario (Canada), and the Hospital for Sick Children (Toronto, Ontario). Read More

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