6,866 results match your criteria premature puberty


Assessment of rapidly advancing bone age during puberty on elbow radiographs using a deep neural network model.

Eur Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Korea University Anam Hospital, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Objectives: Bone age is considered an indicator for the diagnosis of precocious or delayed puberty and a predictor of adult height. We aimed to evaluate the performance of a deep neural network model in assessing rapidly advancing bone age during puberty using elbow radiographs.

Methods: In all, 4437 anteroposterior and lateral pairs of elbow radiographs were obtained from pubertal individuals from two institutions to implement and validate a deep neural network model. Read More

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Insulin-like Growth Factor 1, but Not Insulin-Like Growth Factor-Binding Protein 3, Predicts Central Precocious Puberty in Girls 6-8 Years Old: A Retrospective Study.

Horm Res Paediatr 2021 Jun 7:1-8. Epub 2021 Jun 7.

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Background: Central precocious puberty (CPP) in females is characterized by thelarche before 8 years of age. Evidence of reproductive axis activation confirms the diagnosis (basal serum luteinizing hormone (LH) ≥0.3 IU/L or LH-releasing hormone (LHRH)-stimulated LH ≥5 IU/L). Read More

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Is there an association between prostate-specific antigen and androgen levels in 46, XX patients with congenital adrenal hyperplasia?

J Pediatr Urol 2021 May 7. Epub 2021 May 7.

Multidisciplinary Clinic for Disorders of Sexual Development, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Introduction: Congenital adrenal hyperplasia (CAH), a genetic disease characterized by defective cortisol synthesis and excessive levels of sex hormones, can cause precocious puberty in both sexes in untreated individuals and virilization in female patients with a 46, XX karyotype. The female paraurethral (Skene's) gland has been reported as prostate analogous. Growth of prostate tissue is associated with androgen production; therefore, prostate-specific antigen (PSA) levels may represent a marker of virilization in 46, XX patients with CAH. Read More

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Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache.

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

In the present study, the results of brain magnetic resonance imaging (MRI) in girls with central precocious puberty (CPP) were compared those in with girls evaluated for headaches. A total of 295 girls with CPP who underwent sellar MRI were enrolled. A total of 205 age-matched girls with chronic or recurrent headaches without neurological abnormality who had brain MRI were included as controls. Read More

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Self-consciousness and depression in precocious pubertal children.

J Int Med Res 2021 May;49(5):3000605211020227

Department of Pediatric Genetics, Metabolism and Endocrinology, West China Second University Hospital, School of Nursing, Sichuan University, Chengdu, Sichuan, China.

Objective: To explore self-consciousness and depression in children with precocious puberty (PP) and analyse its effect on children of both sexes.

Methods: Sixty children with PP and 60 non-PP children matched for sex and age participated in the study. Children were assessed using the Birleson Depression Self-Rating Scale for Children and the Piers-Harris Children's Self-Concept Scale. Read More

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Peripheral Precocious Puberty of Ovarian Origin in a Series of 18 Girls: Exome Study Finds Variants in Genes Responsible for Hypogonadotropic Hypogonadism.

Front Pediatr 2021 7;9:641397. Epub 2021 May 7.

Human Developmental Genetics Unit, Institut Pasteur, Paris, France.

Peripheral precocious puberty of ovarian origin is a very rare condition compared to central form. It may be associated with an isolated ovarian cyst (OC). The causes of OC in otherwise healthy prepubertal girls is currently unknown. Read More

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Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty.

Case Rep Pathol 2021 22;2021:5545645. Epub 2021 Apr 22.

Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan.

Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty. The patient is a 7-year-old girl who presented with a breast development in Tanner stage 3. Read More

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Intermittent fasting ameliorates di-(2-ethylhexyl) phthalate-induced precocious puberty in female rats: A study of the hypothalamic-pituitary-gonadal axis.

Reprod Biol 2021 May 17;21(3):100513. Epub 2021 May 17.

Fujian Provincial Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou, 350001, China; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China; Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, 350001, China. Electronic address:

Di-(2-ethylhexyl) phthalate has been reported to interfere with the development and function of animal reproductive systems. However, hardly any studies provide methods to minimize or prevent the adverse effects of DEHP on reproduction. The energy balance state of mammals is closely related to reproductive activities, and the reproductive axis can regulate reproductive activities according to changes in the body's energy balance state. Read More

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Fertility in McCune Albright syndrome female: A case study focusing on AMH as a marker of ovarian dysfunction and a literature review.

J Gynecol Obstet Hum Reprod 2021 May 25;50(9):102171. Epub 2021 May 25.

INSERM U1256, Université de Lorraine, Vandœuvre-lès-Nancy, France; Department of Pathology, CHRU de Nancy, Université de Lorraine, Nancy, France.

Background: The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility. Read More

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Central precocious puberty after resection of a virilising adrenocortical oncocytic tumour.

BMJ Case Rep 2021 May 27;14(5). Epub 2021 May 27.

The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Adrenocortical oncocytic tumours are a histological subtype of adrenal neoplasms with a distinctive morphological appearance. Since these tumours are composed of cells of the adrenal cortex, they may act as functional tumours with excess hormone production. They may cause Cushing's syndrome, inappropriate virilisation or precocious puberty. Read More

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Dental Age in Precocious and Delayed Puberty Periods.

Eur J Dent 2021 May 26. Epub 2021 May 26.

Department of Pedodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Objectives:  Precocious puberty indicates quick growth inception and delayed puberty indicates retardation in growth. This study aims to investigate whether dental development is synchronous with somatic development.

Materials And Methods:  In this study, 62 girls and 34 boys with precocious puberty aged 5 to 9, 29 girls with delayed puberty aged 13 to 16, and 43 boys with delayed puberty aged 14 to 17; 169 children (91 girls and 78 boys) with normal development were compared about their dental ages through their panoramic radiographs by using the Demirjian method and skeletal ages from hand-wrist radiographs by using Greulich-Pyle atlas. Read More

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Central nervous system imaging in girls with central precocious puberty: when is necessary?

Arch Endocrinol Metab 2021 May;64(5):591-596

Hacettepe University Medical School, Department of Pediatrics, Division of Pediatric Endocrinology, Ankara, Turkey.

Objective: The determinants of an increased risk of an organic pathology underlying central precocious puberty (CPP) in girls remain contentious. The present study aimed to determine the clinical and hormonal findings that can be used to differentiate organic and idiopathic CPP in girls as a screening method so that only those considered likely to have organic CPP undergo cranial magnetic resonance imaging (MRI).

Methods: The medical records of 286 girls that received GnRH agonist (GnRHa) therapy for CPP were retrospectively evaluated. Read More

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Primary chronic osteomyelitis of the jaw: Rapid improvement after hormonal suppression in a girl with precocious puberty.

Bone Rep 2021 Jun 7;14:101089. Epub 2021 May 7.

Unit of Cranio- & Maxillofacial Surgery, Karolinska University Hospital, Stockholm, Sweden.

Primary chronic osteomyelitis (PCO) of the jaw is a non-infectious, inflammatory state of the jawbone of unknown etiology. In recurrent periods, these patients often exhibit swelling of the cheek, impaired ability to open their mouth as well as pain. Available treatments today include anti-inflammatory or antiresorptive drugs, hyperbaric oxygen, surgical decortication or resection followed by reconstruction where none of them have been described to lead to restored anatomy and complete relief of symptoms. Read More

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Integrated Pharmacological Analysis on the Mechanism of Fuyou Formula in Treating Precocious Puberty.

Front Pharmacol 2021 7;12:649732. Epub 2021 May 7.

Department of Pharmacy, National Center for Children Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Fu-you formula (FY), a Traditional Chinese Medicine (TCM) formula composed of 12 herbs, as an in-hospital preparation, has been used treat to precocious puberty (PP) for decades. However, the lack of phytochemical characterization and mechanism of FY remains the main limitation for its spreading. In this study, we analyze the components and mechanisms of FY in PP, based on the integrated pharmacology. Read More

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Comparison of short-term efficacy between 1-month and 3-month depot gonadotropin-releasing hormone agonist in girls with central precocious puberty.

Ann Pediatr Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Pediatrics, Seoul National University Bundang Hospital, Seongman, Gyeonggi-do, Korea.

Purpose: Gonadotropin-releasing hormone agonist (GnRHa) has been the mainstay of central precocious puberty (CPP) treatment for decades, although there have been few reports comparing the efficacy between 1-month and 3-month depot GnRHa formulations. This study aimed to investigate the short-term efficacy of 1-month and 3-month depot GnRHa in girls with CPP.

Methods: Overall, 150 girls with CPP were included from a retrospective review of their medical records. Read More

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Single random measurement of urinary gonadotropin concentration for screening and monitoring of girls with central precocious puberty.

Ann Pediatr Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Pediatrics, Chungnam National University Hospital, Daejeon, Korea.

Purpose: The gold standard for assessing pubertal activation is the gonadotropin-releasing hormone (GnRH) stimulation test (GnRHST), which is invasive, time-consuming and inconvenient. This study evaluated whether a single random measurement of urinary luteinizing hormone (LH) concentration could substitute for the GnRHST in diagnosing and monitoring central precocious puberty (CPP) in girls.

Methods: Fifty-five girls with breast buds before 8 years of age were assessed by both the GnRHST and urinary gonadotropin assays. Read More

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Myhre syndrome: the first case in Korea.

Ann Pediatr Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea.

Myhre syndrome (MS) is a rare autosomal dominant disorder characterized by short stature, intellectual disability, skeletal anomalies, restricted joint mobility, distinctive facial dysmorphism, and deafness. Early diagnosis of MS is difficult because its features progress and become noticeable at school age. Recently, the SMAD4 gene was identified as the major gene responsible for MS. Read More

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Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty.

Ann Pediatr Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Pediatric Endocrinology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Purpose: This study aimed to evaluate the time interval to menarche after gonadotropin-releasing hormone agonist (GnRHa) treatment in females with central precocious puberty (CPP) and identify factors contributing to timing of menarche.

Methods: We retrospectively reviewed medical records of 39 females with CPP who reached menarche after GnRHa treatment (leuprolide or histrelin). CPP diagnostic criteria were: breast development <8 years, pubertal luteinizing hormone and/or estradiol concentrations, and bone age advancement. Read More

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Effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys with idiopathic central precocious puberty.

Ann Pediatr Endocrinol Metab 2021 May 20. Epub 2021 May 20.

Department of Pediatrics, Chosun University Hospital, Gwangju, Korea.

Purpose: There are few reports on the therapeutic effects of gonadotropin-releasing hormone agonists in boys with central precocious puberty, and no studies have been reported in Korea. We aimed to assess the significance of clinical factors and the effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys diagnosed with central precocious puberty.

Methods: We retrospectively evaluated the medical records of 18 boys treated for idiopathic central precocious puberty between 2007 and 2018 at Chosun University Hospital. Read More

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Central Precocious Puberty in an Infant with Sotos Syndrome and Response to Treatment.

J Clin Res Pediatr Endocrinol 2021 May 20. Epub 2021 May 20.

Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.

Sotos syndrome is characterized by overgrowth, distinctive facial appearance, and learning disability. It is caused by heterozygous mutations, including deletions of NSD1 located at chromosome 5q35. While advanced bone age can occur in some cases, precocious puberty (PP) is reported only in three cases until now. Read More

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Precocious Puberty in Boys: A Study Based on 5 Years of Data From a Single Center in Northern China.

J Clin Res Pediatr Endocrinol 2021 May 20. Epub 2021 May 20.

Department of Endocrinology, Children's Hospital Capital Institute of Pediatrics, Beijing, China.

Aims: To evaluate the clinical features and etiology of precocious puberty in Chinese boys.

Methods: In this study, data from boys who were referred for the evaluation of precocious puberty from 2015 to 2020 at a tertiary hospital in Northern China were retrospectively analyzed.

Results: Eighty-two boys were diagnosed with precocious puberty (PP) from 2015 to 2020. Read More

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A comparison of the growth status, level of blood glucose, and lipid metabolism in small for gestational age and appropriate for gestational age girls with central precocious puberty: a retrospective study.

Transl Pediatr 2021 Apr;10(4):783-789

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: To compare the physical development status, level of blood glucose and lipid metabolism in small for gestational age (SGA) and appropriate for gestational age (AGA) groups with central precocious puberty (CPP).

Methods: This was a retrospective study. Three hundred and twenty-two girls with CPP were divided into the AGA group (304 cases) and the SGA group (18 cases). Read More

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Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.

PLoS One 2021 18;16(5):e0251241. Epub 2021 May 18.

Department of Internal Medicine, São Paulo State University (UNESP), Medical School, Botucatu, Sao Paulo, Brazil.

The objective of this systematic review was to evaluate the association between a soy-based infant diet and the onset of puberty. We included studies in which children were fed a soy-based diet, and we compared them with those who were not. The primary outcomes were the onset of puberty in girls (thelarche, pubarche, and menarche age), boys (pubarche, voice change, testicular and penis enlargement age), and both (risk of delayed and precocious puberty [PP]). Read More

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Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.

J Pediatr Hematol Oncol 2021 May 18. Epub 2021 May 18.

Departments of Pediatric Endocrinology Pediatric Haematology and Oncology Histopathology Pediatric Surgery Radiology, Cambridge University Hospitals NHS Foundation Trust Department of Pathology, University of Cambridge Department of Pediatrics, East Suffolk and North Essex NHS Foundation Trust, Essex, UK.

Background: Adrenal masses are rare in children and most commonly present with clinical features of virilization in the absence of activation of the pituitary axis-gonadotrophin-independent precocious puberty.

Observations: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. Read More

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Use of gonadotropin-releasing hormone analogs in children.

Curr Opin Pediatr 2021 May 17. Epub 2021 May 17.

Division of Endocrinology and Diabetes, Department of Pediatrics, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Purpose Of Review: In this review, we outline the usage and formulations of gonadotropin-releasing hormone analogs (GnRHas) in central precocious puberty (CPP), short stature, and gender diverse individuals, as well as adverse effects, long-term outcomes, and monitoring of therapy. There is a particular focus on citing references published within the last 24 months.

Recent Findings: Long-acting formulations of GnRHa now include Federal Drug Administration approval for subcutaneous injections. Read More

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Fifteen-minute consultation: Clinical pubertal assessment.

Arch Dis Child Educ Pract Ed 2021 May 14. Epub 2021 May 14.

Department of Paediatric Endocrinology, The Royal London Hospital, London, UK

A pubertal assessment is an important part of the clinical examination of a young person. Clinicians must be empowered to do this confidently and in a sensitive manner. Tanner staging allows an objective measurement of pubertal status, including pubic and axillary hair growth, and breast or genital development. Read More

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The effects of phthalate ester exposure on human health: A review.

Sci Total Environ 2021 Sep 28;786:147371. Epub 2021 Apr 28.

Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan; Research Center of Environmental Trace Toxic Substances, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

Phthalate esters (PAEs) are one of the most widely used plasticizers in polymer products and humans are increasingly exposed to them. The constant exposure to PAEs-contained products has raised some concerns against human health. Thus, the impacts of PAEs and their metabolites on human health require a comprehensive study for a better understanding of the associated risks. Read More

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September 2021

Study of Xbal and Pvull polymorphisms of estrogen receptor alpha (ERα) gene in girls with precocious/early puberty.

Endocrine 2021 May 4. Epub 2021 May 4.

Pediatric Endocrinology Unit, Third Department of Pediatrics, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Studies examining association of estrogen receptor alpha (ERα) polymorphisms with early puberty are scarce and results are controversial; data in Caucasian girls are lacking. Main objective was to determine association of Xbal and Pvull polymorphisms of ERα gene in Greek girls with precocious/early puberty METHODS: We studied 107 girls with idiopathic precocious/early puberty and 81 young women with pubertal maturation within normal age (controls). Pubertal stage, height SDS (HSDS), and BMI z-score were determined in patients. Read More

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