93,234 results match your criteria premature neonate

Evaluation of pain and physiological stress during targeted neonatal echocardiography.

J Neonatal Perinatal Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Neonatology, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, India.

Background: Targeted neonatal echocardiography (Tn-Echo) is a non-invasive examination which may cause pain/discomfort and physiological instability in neonates, but there is little evidence for the same. We conducted this study to evaluate whether targeted neonatal echocardiography causes pain or physiological stress to newborn infants.

Methods: This cross-sectional study was conducted in a tertiary level NICU. Read More

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Correlation of facial anthropometry data of late preterm newborns and oral feeding readiness.

Rev Bras Enferm 2021 23;74(5):e20201120. Epub 2021 Jul 23.

Universidade Federal de Alagoas. Maceió, Alagoas, Brazil.

Objective: To correlate nine facial anthropometric measurements with the readiness for oral feeding of late preterm newborns using an orogastric tube.

Methods: Observational study, carried out in two institutions in Maceió, Alagoas. Fifty-two newborns participated. Read More

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Management of a premature low birth weight neonate with Ebstein anomaly and persistent circular shunt using modified Starnes procedure.

JTCVS Tech 2021 Jun 6;7:208-211. Epub 2021 Feb 6.

Division of Cardiovascular Surgery, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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Neonatal Platelet Transfusions: Starting Again.

Transfus Med Rev 2021 Jun 29. Epub 2021 Jun 29.

Department of Neonatology, National Maternity Hospital, Dublin 2, D02YH21, Ireland.

Preterm neonates with severe thrombocytopenia are frequently prescribed prophylactic platelet transfusions despite no evidence of benefit. Neonatal platelet transfusion practice varies, both nationally and internationally. Volumes and rates of transfusion in neonatology are based on historic precedent and lack an evidence base. Read More

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Effects of early respiratory physiotherapy on spontaneous respiratory activity of preterm infants: study protocol for a randomized controlled trial.

Trials 2021 Jul 26;22(1):492. Epub 2021 Jul 26.

Dipartimento Universitario Scienze della Vita e Sanità Pubblica. Unità Operativa Complessa di Neonatologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy.

Background: Tactile maneuvers stimulating spontaneous respiratory activity in preterm infants are recommended since birth, but data on how and how often these maneuvers are applied in clinical practice are unknown. In the last years, most preterm newborns with respiratory failure are preferentially managed with non-invasive respiratory support and by stimulating spontaneous respiratory activity from the delivery room and in neonatal intensive care unit (NICU), in order to avoid the risks of intubation and prolonged mechanical ventilation.

Methods: Preterm infants with gestational age < 31 weeks not intubated in the delivery room and requiring non-invasive respiratory support at birth will be eligible for the study. Read More

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Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to a ankyrin mutation: A case report.

World J Clin Cases 2021 Jul;9(19):5245-5251

Department of Neonatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Background: Hereditary spherocytosis (HS) is a common type of hemolytic anemia caused by a red cell membrane disorder. HS type 1 (HS1) is mostly caused by mutations in ankyrin (). Newborns with HS1 usually only exhibit anemia and mild jaundice. Read More

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Fertility preservation immediately after therapeutic abortion results in multiple normal follicular growth with the absence of mature oocytes due to early luteinization: a case report and literature review.

Gynecol Endocrinol 2021 Jul 24:1-4. Epub 2021 Jul 24.

Reproductive Medical Center, Yokohama City University Medical Center, Yokohama, Japan.

Cancer therapy has priority over fertility preservation. The time available for fertility preservation in patients with cancer is often very limited and depends on the condition of the underlying disease. This case report presents the results of two rounds of controlled ovarian stimulations (COSs) performed after an induced abortion. Read More

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The Urinary Uric Acid / Cr ratio as a marker of morbidity and mortality of preterm infants: a case-control study.

BMC Pediatr 2021 Jul 24;21(1):325. Epub 2021 Jul 24.

Department of Pediatrics, School of Medicine, Ayatollah Moussavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Perinatal asphyxia is one of the main causes of preterm infant mortality. Some studies have shown that The Urinary Uric Acid / Cr (UUA/Cr) ratio may be used as an additional marker for perinatal asphyxia.This study intend to investigate the relationship of this ratio with outcomes of preterm infants admitted to NICU. Read More

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Newborn Screening for Severe Combined Immunodeficiency: Do Preterm Infants Require Special Consideration?

Int J Neonatal Screen 2021 Jul 8;7(3). Epub 2021 Jul 8.

Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

The Wisconsin Newborn Screening (NBS) Program began screening for severe combined immunodeficiency (SCID) in 2008, using real-time PCR to quantitate T-cell receptor excision circles (TRECs) in DNA isolated from dried blood NBS specimens. Prompted by the observation that there were disproportionately more screening-positive cases in premature infants, we performed a study to assess whether there is a difference in TRECs between full-term and preterm newborns. Based on de-identified SCID data from 1 January to 30 June 2008, we evaluated the TRECs from 2510 preterm newborns (gestational age, 23-36 weeks) whose specimens were collected ≤72 h after birth. Read More

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Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review.

J Int Med Res 2021 Jul;49(7):3000605211028026

Global Evidence and Outcomes, Takeda, Lexington, MA, USA.

Objective: Neurodevelopmental impairment (NDI) is a major complication of extreme prematurity. This systematic review was conducted to summarize the worldwide long-term prevalence of NDI associated with extreme prematurity.

Methods: Embase and MEDLINE databases were searched for epidemiologic and observational/real-world studies, published in English between 2011 and 2016, reporting long-term prevalence of NDI (occurring from 1 year) among extremely preterm infants born at gestational age (GA) ≤28 weeks. Read More

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The Frequency of Intraventricular Hemorrhage and its Risk Factors in Premature Neonates in a Hospital's NICU.

Iran J Child Neurol 2021 ;15(3):109-118

Department of neonatology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: Intra-ventricular hemorrhage (IVH) is the leading cause of mortality and disability in premature neonates. The present study aimed to determine the frequency of IVH and its risk factors in the premature newborns admitted to the Neonatal Intensive Care Unit (NICU)at Fatemieh Hospital in Hamadan, Iran, in 2016.

Methods & Materials: This retrospective cross-sectional study was conducted on178 neonates with a gestational age of ≤ 32 weeks admitted to Fatemieh Hospital affiliated to the Hamadan University of Medical Sciences, Hamadan, Iran, in 2016. Read More

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January 2021

Preterm Labor Using Tocolysis as a Possible Risk Factor for Postpartum Depression: A 14-Year Population-Based Study in Taiwan.

Int J Environ Res Public Health 2021 07 5;18(13). Epub 2021 Jul 5.

Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Postpartum depression (PPD) is associated with negative physical and mental health outcomes for the mother and infant. Women often experience elevated symptoms of PPD, and the incidence of PPD has increased in recent years. There were lack of studies to investigate the effects of medications during pregnancy. Read More

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Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands.

Int J Environ Res Public Health 2021 07 2;18(13). Epub 2021 Jul 2.

Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.

Having an infant in the neonatal intensive care unit (NICU) elicits maternal anxiety, which may hamper parent-child bonding. We performed a prospective cohort study to describe anxiety in mothers of infants born before 30 weeks of gestation during NICU stay in The Netherlands, and investigated the influence of infant stress and gestational age. Second, we performed a randomized-controlled live-performed music therapy trial (LPMT trial) to investigate whether music therapy applied to the infant alleviated maternal anxiety. Read More

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Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity.

Int J Environ Res Public Health 2021 07 1;18(13). Epub 2021 Jul 1.

Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.

Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder attributed to an ischaemic stimulus in preterm infants. Haemoglobin, the main component for oxygen transportation, may be implicated in ROP development. This retrospective study compared the mean weekly haemoglobin levels between infants with and without ROP over the first six weeks of life. Read More

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Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates.

Bosn J Basic Med Sci 2021 Jul 19. Epub 2021 Jul 19.

Hormone Laboratory, Medical School, National and Kapodistrian University of Athens, "Aretaieio" Hospital, Athens, Greece.

Neonatal brain injury is a serious adverse outcome of prematurity. Early detection of high risk premature neonates to develop neonatal brain injury is not currently feasible. The predictive value of many biomarkers has been tested, but none is used currently in clinical practice. Read More

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[Morphopathology of myocardial hypoxic-ischemic injuries in newborns at 22-27 weeks' gestation].

Arkh Patol 2021 ;83(4):29-34

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood of the Ministry of Health of Russia, Ivanovo, Russia.

Objective: To determine the parameters of myocardial structural injuries developed in chronic intrauterine hypoxia conditions in newborns at 22-27 weeks' gestation.

Material And Methods: A battery of morphological techniques, including organometry studies and separate weighing of the heart; 3D histology; morphometry with the determination of the area of cardiomyocyte nuclei, the specific area of the muscular and interstitial components of the right ventricular myocardium; immunohistochemistry with monoclonal antibodies to transforming growth factor βı (TGF-βı), cardiac troponin T (cTnT), and transmission electron microscopy, was used to examine heart samples from 30 deceased newborns at 22-27 weeks' gestation who developed in chronic intrauterine hypoxia conditions. A control group consisted of hearts from 20 extremely low body weight (ELBW) newborns, the main cause of whose death was asphyxia caused by the premature detachment of a normally positioned placenta. Read More

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Development of brain white matter and math computation ability in children born very preterm and full-term.

Dev Cogn Neurosci 2021 Jul 12;51:100987. Epub 2021 Jul 12.

Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia; Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Children born very preterm (VPT; <32 weeks' gestation) have alterations in brain white matter and poorer math ability than full-term (FT) peers. Diffusion-weighted magnetic resonance imaging studies suggest a link between white matter microstructure and math in VPT and FT children, although longitudinal studies using advanced modelling are lacking. In a prospective longitudinal cohort of VPT and FT children we used Fixel-Based Analysis to investigate associations between maturation of white matter fibre density (FD), fibre-bundle cross-section (FC), and combined fibre density and cross-section (FDC) and math computation ability at 7 (n = 136 VPT; n = 32 FT) and 13 (n = 130 VPT; n = 44 FT) years, as well as between change in white matter and math computation ability from 7 to 13 years (n = 103 VPT; n = 21 FT). Read More

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Role of Intravenous Magnesium Sulphate in Term Neonates with Hypoxic Ischemic Encephalopathy (HIE) in a Low-income Country: A Randomised Clinical Trial.

J Coll Physicians Surg Pak 2021 Jul;30(7):817-820

Department of Paediatric Medicine Unit-II, Services Hospital, Lahore, Pakistan.

Objective: To determine the effects of magnesium sulphate in term neonates with hypoxic ischemic encephalopathy (HIE) in reducing mortality and morbidity.

Study Design: Randomised clinical trial.

Place And Duration Of Study: Department of Neonatology, Services Hospital, Lahore, Pakistan from April to December 2019. Read More

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[From Nidcap in neonatology to home support by the PMI nursery nurse].

Soins Pediatr Pueric 2021 Jul-Aug;42(321):23-29. Epub 2021 May 24.

Service local de solidarité de Meylan, 2 allée des Mitaillères, 38240 Meylan, France.

Prematurity puts children born too early at risk of developmental problems. New care strategies, of which the Newborn Individualized Developmental Care Assessment Program is a part, make it possible to reduce this risk and to accompany the baby in its development by optimising its skills. This specific work, which is based on verified scientific data, can be continued at home by the mother and child protection nurse in a long-term project. Read More

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[Research advances in the effect of long-chain polyunsaturated fatty acids on neonates].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):755-760

Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361001, China.

Adequate supply of long-chain polyunsaturated fatty acids (LCPUFAs) is of great importance for neonates, especially preterm infants. In particular, -3 LCPUFAs and -6 LCPUFAs play a key role in brain development, immune regulation, and disease prevention. Lack of LCPUFAs may lead to neurodevelopmental impairment, affect the development of neonatal immune system, and result in neonatal diseases. Read More

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[Association between time of birth and resuscitation outcomes in extremely preterm infants].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):702-706

Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China.

Objective: To study whether there are differences in the resuscitation process and early outcomes between the extremely preterm infants delivered on off-hours (6 pm to 8 am of working days, weekends, and national holidays) and those delivered on working hours.

Methods: A retrospective analysis was performed on the medical data of extremely preterm infants who were born in the Peking University Third Hospital from January 1, 2010 to December 31, 2020 and transferred to the neonatal intensive care unit (NICU). According to the time of birth, they were divided into two groups:working hours (=77) and off-hours (=98). Read More

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[Enteral feeding in extremely low birth weight infants with a gestational age of <28 weeks versus ≥ 28 weeks].

Ying Li Fan Wu

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):690-695

Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.

Objective: To investigate the condition of enteral feeding and the incidence of feeding intolerance (FI) in extremely low birth weight (ELBW) infants with a gestational age (GA) of < 28 weeks versus ≥ 28 weeks.

Methods: A retrospective analysis was performed for the ELBW infants who were admitted to the Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, from January 2018 to January 2020. According to GA, they were divided into two groups:GA < 28 weeks (=41) and GA ≥ 28 weeks (=38). Read More

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[Efficacy and safety of lactase additive in preterm infants with lactose intolerance: a prospective randomized controlled trial].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):671-676

Department of Neonatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

Objective: To study the efficacy and safety of lactase additive in improving lactose intolerance in preterm infants.

Methods: A total of 60 preterm infants with lactose intolerance who were admitted to the Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2018 to December 2019 were randomly divided into a lactase treatment group and a control group, with 30 infants in each group. The infants in the lactase treatment group were given 4 drops of lactase additive (180 mg) added into preterm formula or breast milk, and those in the control group were given placebo, oral administration of probiotics (live combined , and powder) at half an hour after feeding (1 g each time, twice a day), and clockwise abdominal massage around the belly button at 1 hour after feeding for 15 minutes each time, 3 times a day. Read More

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Prescription opioid use during pregnancy and risk for preterm birth or term low birthweight.

J Opioid Manag 2021 May-Jun;17(3):215-225

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Preven-tion, Atlanta, Georgia. ORCID: https://orcid.org/0000-0001-6428-8523.

Objective: Examine the relationship between prescription opioid analgesic use during pregnancy and preterm birth or term low birthweight.

Design, Setting, And Participants: We analyzed data from the National Birth Defects Prevention Study, a US multisite, population-based study, for births from 1997 to 2011. We defined exposure as self-reported prescription opioid use between one month before conception and the end of pregnancy, and we dichotomized opioid use duration by ≤7 days and >7 days. Read More

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Listening to Mom in the NICU: effects of increased maternal speech exposure on language outcomes and white matter development in infants born very preterm.

Trials 2021 Jul 13;22(1):444. Epub 2021 Jul 13.

Division of Developmental-Behavioral Pediatrics, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Background: Infants born very preterm (< 32 weeks gestational age (GA)) are at risk for developmental language delays. Poor language outcomes in children born preterm have been linked to neurobiological factors, including impaired development of the brain's structural connectivity (white matter), and environmental factors, including decreased exposure to maternal speech in the neonatal intensive care unit (NICU). Interventions that enhance preterm infants' exposure to maternal speech show promise as potential strategies for improving short-term health outcomes. Read More

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Severe haemophilia A in a preterm girl with Turner syndrome: case report - a diagnostic and therapeutic challenge for a paediatrician (Part 2).

Ital J Pediatr 2021 Jul 13;47(1):157. Epub 2021 Jul 13.

Department of Obstetric and Pathology of Pregnancy, Medical University of Lublin, Staszica 16, 20-081, Lublin, Poland.

Background: Haemophilia A is an X-linked genetic condition which manifests itself mainly in male children in the first 2 years of life, during gross motor skill development. This disorder is rare in females. The clinical manifestation of severe haemophilia in preterm infants poses a great challenge to the therapeutic team. Read More

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Association Between Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes.

JAMA 2021 07;326(2):145-153

The Ritchie Centre, Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia.

Importance: Timely delivery of infants suspected of having fetal growth restriction (FGR) is a balance between preventing stillbirth and minimizing prematurity, particularly because many infants with suspected FGR have normal growth.

Objective: To explore the association between iatrogenic delivery for suspected FGR and childhood school outcomes.

Design, Setting, And Participants: A retrospective whole-population cohort study linking perinatal data from births 32 weeks' or more gestation between January 1, 2003, to December 31, 2013, to developmental and educational test scores at preparatory school, and at school grades 3, 5, and 7 in Victoria, Australia. Read More

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End-organ saturations correlate with aortic blood flow estimates by echocardiography in the extremely premature newborn - an observational cohort study.

BMC Pediatr 2021 Jul 12;21(1):312. Epub 2021 Jul 12.

Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Palo Alto, USA.

Background: Near-infrared spectroscopy (NIRS) measures of cerebral saturation (Csat) and renal saturation (Rsat) in extreme premature newborns may be affected by systemic blood flow fluctuations. Despite increasing clinical use of NIRS to monitor tissue saturation in the premature infant, validation of NIRS measures as a correlate of blood flow is still needed. We compared echocardiography (ECHO) derived markers of ascending aorta (AscAo) and descending aorta (DesAo) blood flow with NIRS measurements obtained during the ECHO. Read More

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Pregnancy in women with cystic fibrosis: 14 case reports and literature review

Orv Hetil 2021 07 11;162(28):1129-1136. Epub 2021 Jul 11.

4 Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház, Szülészeti és Nőgyógyászati Osztály, Miskolc.

Összefoglaló. A cystás fibrosisban szenvedő betegek várható élettartama jelentősen megnőtt az utóbbi évtizedben, egyre több beteg képes saját gyermeket vállalni. Célunk a cystás fibrosisban szenvedő várandós nők perinatalis és anyai történéseinek felmérése saját eseteink és az irodalmi adatok alapján. Read More

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Determinants of neonatal sepsis among neonates delivered in Southwest Ethiopia 2018: A case-control study.

SAGE Open Med 2021 24;9:20503121211027044. Epub 2021 Jun 24.

Midwifery Department, College of Health Sciences, Mettu University, Mettu, Ethiopia.

Introduction: Neonatal sepsis is one of the principal causes of neonatal morbidity and mortality. In spite of interventions with different preventive methods, the burden of neonatal sepsis is being reported in different parts of Ethiopia. For further interventions, identifying its determinants is found to be essential. Read More

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