212,283 results match your criteria premature

Obstetrics outcome in pulmonary tuberculosis.

Indian J Tuberc 2022 Jul 7;69(3):305-310. Epub 2021 Jan 7.

Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.

Background: To evaluate the maternal and perinatal outcome in pulmonary tuberculosis cases as compared to low risk pregnancies in a tertiary referral hospital.

Methods: A total of 15 cases of pulmonary tuberculosis over a period of two years who delivered in our unit was studied in the retrospective study. The maternal and perinatal outcome in them was compared with 191 low risk pregnancies who delivered at the same time in the hospital after taking into account inclusion and exclusion criteria. Read More

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Primary microglia dysfunction or microgliopathy: A cause of dementias and other neurological or psychiatric disorders.

Neuroscience 2022 Jun 24. Epub 2022 Jun 24.

Basic Research and Advanced Investigations in Neurosciences (BRAIN), Universidade Federal do Rio Grande do Sul, Brazil.

Microglia are unique cells in the central nervous system (CNS), being considered a sub-type of CNS macrophage. These cells monitor nearby micro-regions, having roles that far exceed immunological and scavengering functions, being fundamental for developing, protecting and maintaining the integrity of grey and white matter. Microglia might become dysfunctional, causing abnormal CNS functioning early or late in the life of patients, leading to neurologic or psychiatric disorders and premature death in some patients. Read More

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Mech Ageing Dev 2022 Jun 24:111692. Epub 2022 Jun 24.

Department of Genetics, Physiology and Microbiology (Physiology Unit), School of Biology, Complutense University of Madrid; Institute of Investigation of Hospital 12 de Octubre (i+12), Madrid, Spain. Electronic address:

Among the age-associated changes in the immune system, the most evident is the decrease in proliferative responses of lymphocytes to mitogenic stimuli, which is accompanied by the loss of cytokine network homeostasis. Chronic low-grade inflammatory stress, termed as sterile inflammation, is also observed during aging. In chronologically and prematurely aging mice, cohabitation with adult animals for two months favored improvements in several immune functions. Read More

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Surface Cranial Ultrasound: The Natural Heir to X-Ray for the Screening of Skull Deformities in Infants.

Ultraschall Med 2022 Jun 27. Epub 2022 Jun 27.

Neurosurgical Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

Purpose: Volumetric tomography (3D-CT) is currently considered the gold standard for the diagnosis of craniosynostosis, but its use as the first-line examination for cranial deformities is a topic of debate, because of skull X-ray radiation and low sensitivity and specificity. Cranial ultrasound is an emerging noninvasive radiation-free alternative, but its diagnostic accuracy still needs confirmation.

Materials And Methods: The present prospective study included 350 infants with skull deformities, who underwent cranial ultrasound as the first-line examination, followed by 3D-CT if the echography results was positive or unclear. Read More

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Comparison of fluoxetine with other selective serotonin reuptake inhibitors in the treatment of premature ejaculation: A systematic review and meta-analysis.

Andrologia 2022 Jun 27:e14500. Epub 2022 Jun 27.

The Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The primary goal of this systematic review and meta-analysis was to compare the efficacy and safety of fluoxetine with other oral pharmaceuticals in the treatment of premature ejaculation (PE). We searched through databases including CNKI, PubMed, EMBASE and Cochrane to find research published up to 31 March 2022. PROSPERO was used to pre-register this meta-analysis (registration number CRD42022315459). Read More

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Neurodevelopmental Outcome and Epigenetic Changes at 2 Years Associated with the Oxygen Load Received upon Postnatal Stabilization: A Pilot Study.

Neonatology 2022 Jun 27:1-10. Epub 2022 Jun 27.

Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain.

Introduction: The oxygen load provided to preterm infants during postnatal stabilization caused significant modifications of DNA methylation in the preterm epigenome. We aimed to assess if there was an association between DNA methylation changes and neurodevelopmental outcomes.

Methods: Preterm infants were followed until 2 years after birth. Read More

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[Changes in the telomeres length in patients with obstructive sleep apnea after continuous positive airway pressure therapy: a pilot study].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):52-57

Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Objective: To evaluate a relative telomere length in patients with obstructive sleep apnea (OSA) before and after a 6-month course of continuous positive airway pressure (CPAP) therapy.

Material And Methods: Seventy-five men participated in the study, including 50 men with OSA (the main group 1) and 25 men without OSA (the control group). The average age in the total group was 53. Read More

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January 2022

Risk factors for clinically significant intra-ventricular hemorrhage in pregnancies complicated by preterm premature rupture of membranes.

J Pregnancy Neonatal Med 2021 ;5(4)

Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, USA.

Objectives: Preterm birth is a major cause of adverse perinatal outcomes, including intraventricular hemorrhage (IVH). IVH has been shown to contribute to lasting neurological disability, however the role of maternal characteristics and potentially modifiable risk factors that contribute to these outcomes have not been well defined. We sought to determine predictors of IVH in pregnancies complicated by early preterm premature rupture of membranes (PPROM). Read More

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January 2021

The Effect of Preterm Birth on Maximal Aerobic Exercise Capacity and Lung Function in Healthy Adults: A Systematic Review and Meta-analysis.

Sports Med 2022 Jun 27. Epub 2022 Jun 27.

Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

Background: A negative impact of premature birth on health in adulthood is well established. However, it is not clear whether healthy adults who were born prematurely but have similar physical activity levels compared to adults born at term have a reduced maximal aerobic exercise capacity (maximum oxygen consumption [VOmax]).

Objective: We aimed to determine the effect of premature birth on aerobic exercise capacity and lung function in otherwise healthy, physically active individuals. Read More

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Interleukin-6 and C-Reactive Protein: their association with vitamin D in women with recurrent infections of reproductive system.

Egypt J Immunol 2022 Jul;29(3):1-8

Department of Biology, Laboratory of Postgraduates, College of Science, University of Kerbala, Karbala, Iraq.

Aerobic bacteria can colonize the female reproductive system with harmful effects, which may lead to miscarriages, premature deliveries or continue of its growing to cause adverse reproductive systems issues. Increasing in the levels of inflammatory markers may be considered a herald of danger. High vaginal swabs were obtained from 85 women. Read More

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Premature Fusion of the Posterior Intraoccipital Synchondrosis, A Minor Suture Mimic of Lambdoid Craniosynostosis.

J Craniofac Surg 2022 Jun 27. Epub 2022 Jun 27.

Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Health, Winston-Salem, NC.

Abstract: The posterior intraoccipital synchondrosis (PIOS) is a cartilaginous division separating the exoccipital and supraoccipital bones, allowing for flexibility of the cranial base at birth and which later ossifies in adolescence. The authors report a case of right PIOS synostosis that resembled right lambdoid synostosis, with left occipital bossing in a healthy, six-month-old female with an unremarkable birth history and no antecedent trauma. An initial referral was made from the pediatrician to oncology because of a concern over the presence and growth of a possible mass at the left occiput. Read More

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Reared-Apart and Reunited: Extraordinary Dynamics/Twin Research Reviews: Twin Bereavement and Lifespan Associations; Identifying Novel Mutations in Twins; Parenting Premature Multiples; Conjoined Twins in Cross-Cultural Context/In the News: Madeline Albright, Mother of Twins, Passes Away; Identical Twin Songwriters Compose New Musical; Visually Impaired Twin Skiers; Identical Twin Brothers Undergo Heart Transplants; Naming the Genain Quadruplets.

Nancy L Segal

Twin Res Hum Genet 2022 Jun 27:1-6. Epub 2022 Jun 27.

Department of Psychology, California State University, Fullerton, California, USA.

The focus of this article is on insights gained from the extraordinary dynamics that took place between a pair of reunited monozygotic female twins from Greece. Topics include visualizing the co-twin prior to meeting, the unique love and attraction between the twins, a mother's response to discovering her child's cotwin and the challenges posed by insufficient kinship categories. The following section of this article surveys four recent twin research reports. Read More

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Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria.

Front Endocrinol (Lausanne) 2022 10;13:867073. Epub 2022 Jun 10.

Molecular Endocrinology and Rare Diseases, Hospices Civils de Lyon, Lyon University Hospital, Bron-Lyon, France.

Background: 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) deficiency is a rare form of congenital adrenal hyperplasia (CAH), with fewer than 200 cases reported in the world literature and few data on outcomes.

Patients And Methods: We report a mixed longitudinal and cross-sectional study from a single Algerian center between 2007 and 2021. Virilization and under-masculinization were assessed using Prader staging and the external masculinization score (EMS), pubertal development staged according to the system of Tanner. Read More

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Risk Factors for Post-infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis.

Front Pediatr 2022 9;10:881908. Epub 2022 Jun 9.

Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China.

Background: Post-infectious bronchiolitis obliterans (PIBO) is a long-term sequela after an initial insult to the lower respiratory tract. A comprehensive understanding of the factors that contribute to a high risk of developing PIBO is important to help define therapeutic strategies and improve prognosis.

Methods: We performed a systematic review of published literature available in the online databases including PubMed, Embase, Web of Science, CNKI, Wan Fang, and VIP, with the last search updated on 27 January 2022. Read More

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Pharmacometabolomics Profiling of Preterm Infants Validates Patterns of Metabolism Associated With Response to Dexamethasone Treatment for Bronchopulmonary Dysplasia.

Front Pediatr 2022 10;10:898806. Epub 2022 Jun 10.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, United States.

Bronchopulmonary dysplasia (BPD) is one of the most common health complications of premature birth. Corticosteroids are commonly used for treatment of BPD, but their use is challenging due to variability in treatment response. Previous pharmacometabolomics study has established patterns of metabolite levels with response to dexamethasone. Read More

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Ten Rules for the Management of Moderate and Severe Traumatic Brain Injury During Pregnancy: An Expert Viewpoint.

Front Neurol 2022 9;13:911460. Epub 2022 Jun 9.

Anesthesia and Intensive Care, Policlinico San Martino Hospital, IRCCS for Oncology and Neuroscience, Genova, Italy.

Moderate and severe traumatic brain injury (TBI) are major causes of disability and death. In addition, when TBI occurs during pregnancy, it can lead to miscarriage, premature birth, and maternal/fetal death, engendering clinical and ethical issues. Several recommendations have been proposed for the management of TBI patients; however, none of these have been specifically applied to pregnant women, which often have been excluded from major trials. Read More

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Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency.

Reprod Med Biol 2022 Jan-Dec;21(1):e12471. Epub 2022 Jun 15.

Advanced Reproductive Medicine Research Center International University of Health and Welfare School of Medicine Chiba Japan.

Purpose: This study evaluated the reproductive potential of premature ovarian insufficiency (POI) patients with abnormal karyotypes undergoing infertility treatments.

Methods: A retrospective analysis of infertility treatments in POI patients with an abnormal karyotype treatment. Clinical and laboratory data were analyzed. Read More

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Multi-level hypothalamic neuromodulation of self-regulation and cognition in preterm infants: Towards a control systems model.

Compr Psychoneuroendocrinol 2022 Feb 31;9:100109. Epub 2021 Dec 31.

Department of Psychology and the Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

Preterm infants, age-corrected for prematurity, score on average, 10 points lower on IQ tests than full-term infants tested at comparable ages. This review focuses on the potential contribution of the hypothalamus to cognitive neuro-regulatory development in preterm infants through its bidirectional neural connections with the prefrontal cortex and its neuroendocrine activity. It aims to clarify the central role of the hypothalamus in preterm high stress situations and in influencing cognitive development via its connectivity to the cerebral cortex. Read More

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February 2022

The value of QRS onset of the outflow tract PVC in V1 and V2 leads recorded in fourth, third, and second intercostal spaces to differentiate main origins of premature ventricular contraction-A prospective cohort study.

Health Sci Rep 2022 Jul 16;5(4):e670. Epub 2022 Jun 16.

Cardiology Department Shiraz University of Medical Sciences Shiraz Iran.

Background: Electrocardiography (ECG) is now proposed as a simple and cost-effective tool to determine the location of arrhythmias before ablation. We aimed to examine the value of the QRS onset of outflow tract PVC in V1 and V2 leads recorded in fourth, third, and second intercostal spaces to differentiate two main origins for premature ventricular contraction (PVC) including right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT).

Methods: In this prospective cohort study, a total of 58 patients were studied, from whom a surface ECG was obtained using V1 and V2 leads in the fourth, third, and second intercostal spaces. Read More

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Chemical synthesis of plant pollen tube attractant proteins by KAHA ligation.

RSC Chem Biol 2022 Jun 18;3(6):721-727. Epub 2022 Mar 18.

Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University Chikusa Nagoya 464-8601 Japan

The synthesis of secreted cysteine-rich proteins (CRPs) is a long-standing challenge due to protein aggregation and premature formation of inter- and intramolecular disulfide bonds. Chemical synthesis provides reduced CRPs with a higher purity, which is advantageous for folding and isolation. Herein, we report the chemical synthesis of pollen tube attractant CRPs LURE (TfLURE) and LURE (TcLURE) and their chimeric analogues α-ketoacid-hydroxylamine (KAHA) ligation. Read More

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Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer's Disease Consistent With Cerebral Pantothenate Deficiency.

Front Aging Neurosci 2022 10;14:893159. Epub 2022 Jun 10.

School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand.

Sporadic Alzheimer's disease (sAD) is the commonest cause of age-related neurodegeneration and dementia globally, and a leading cause of premature disability and death. To date, the quest for a disease-modifying therapy for sAD has failed, probably reflecting our incomplete understanding of aetiology and pathogenesis. Drugs that target aggregated Aβ/tau are ineffective, and metabolic defects are now considered to play substantive roles in sAD pathobiology. Read More

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Oral Phenotype of Singleton-Merten Syndrome: A Systematic Review Illustrated With a Case Report.

Front Genet 2022 9;13:875490. Epub 2022 Jun 9.

Centre de Recherche des Cordeliers, UMRS 1138, Molecular Oral Pathophysiology, Université de Paris, INSERM, Sorbonne Université, Paris, France.

Singleton-Merten syndrome type 1 (SGMRT1) is a rare autosomal dominant disorder caused by variations with blood vessel calcifications, teeth anomalies, and bone defects. We aimed to summarize the oral findings in SGMRT1 through a systematic review of the literature and to describe the phenotype of a 10-year-old patient with SGMRT1 diagnosis. A total of 20 patients were described in the literature, in nine articles. Read More

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A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission.

iScience 2022 Jul 6;25(7):104536. Epub 2022 Jun 6.

Genome Stability Laboratory, Centre for Chromosome Biology, Biochemistry & School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.

Abscission, the final stage of cytokinesis, occurs when the cytoplasmic canal connecting two emerging daughter cells is severed either side of a large proteinaceous structure, the midbody. Here, we expand the functions of ATR to include a cell-cycle-specific role in abscission, which is required for genome stability. All previously characterized roles for ATR depend upon its recruitment to replication protein A (RPA)-coated single-stranded DNA (ssDNA). Read More

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Type 1 neurofibromatosis in a threeyearold girl with Blineage acute lymphocytic leukemia: A case report.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Nov;45(11):1378-1383

Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Neurofibromatosis 1 (NF1) is an autosomal dominant genetic disease first manifesting in childhood, which affects multiple organs, childhood development and neurocognitive status. These patients have a high predisposition to develop both benign and malignant tumors. On September 30, 2018, a rare case of NF1 with B-lineage acute lymphocytic leukemia (ALL) was treated in the Department of Pediatrics, Third Xiangya Hospital, Central South University. Read More

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November 2020

The dynamics of cardiovascular and respiratory deaths attributed to long-term PM exposures in global megacities.

Sci Total Environ 2022 Jun 23:156951. Epub 2022 Jun 23.

Institute of Surface-Earth System Science, School of Earth System Science, Tianjin University, Tianjin, China.

Exposure to ambient fine particulate matter (PM) air pollution is a significant driver of premature deaths. We estimate the number of cardiovascular and respiratory (CR) premature deaths attributed to long-term exposure to PM in 33 global megacities based on long-term remotely sensed observations from 2000 to 2019. Our analysis uses high-resolution (0. Read More

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Global Trends and The Impact of Chronic Hepatitis B and C on Disability-Adjusted Life Years.

Liver Int 2022 Jun 26. Epub 2022 Jun 26.

Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA.

Background And Aims: Advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) therapies have improved morbidity and mortality, but global disparities in viral hepatitis outcomes remain. We evaluate global trends in the impact of HBV and HCV on disability adjusted life years (DALYs).

Methods: Using data from the 2010-2019 Global Burden of Diseases Study (GBD), overall all-cause DALYs for patients with acute HBV or HCV, HBV- or HCV-related cirrhosis, and HBV- or HCV-related hepatocellular carcinoma (HCC) were calculated as the sum of years of life lost due to premature death and years lived with disability. Read More

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THE CASE AGAINST urethral failure is not a critical factor in female urinary incontinence. Now what? The integral theory system.

Peter Petros

Neurourol Urodyn 2022 Jun 26. Epub 2022 Jun 26.

Mechanical and biomechanical engineering, University of Western Australia School of Engineering and Mathematical Sciences, Perth, Western Australia, Australia.

SUBJECT OF THE DEBATE: "Urethral failure is a critical factor in female urinary incontinence Now what?" The CASE FOR by Hokanson, DeLancey pinpointed inadequacy of bladder causation for urgency urinary incontinence (UUI) and poor urethral support for stress urinary incontinence (SUI) as responsible for long-standing lack of progress in incontinence science. They proposed "Urethral failure" as causation for SUI and UUI. The CASE AGAINST, by Peter Petros agrees "abnormal detrusor function as cause for (UUI) is a failed concept, and SUI surgery results are sometimes suboptimal, but rejects "urethral failure" as cause for UUI and SUI. Read More

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Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility.

Andrology 2022 Jun 25. Epub 2022 Jun 25.

Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.

Background: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single-nucleotide polymorphisms (SNPs) in the development of male infertility as a consequence of severe spermatogenic failure (SpF).

Objectives: The main objective of the present study is to evaluate the effect of the common genetic variation of KATNAL1 in a large and phenotypically well-characterized cohort of infertile men due to SpF. Read More

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Effect of single ventricular premature contractions on response to cardiac resynchronization therapy.

BMC Cardiovasc Disord 2022 Jun 25;22(1):289. Epub 2022 Jun 25.

Heart and Vascular Center, Semmelweis University, Varosmajor 68, Budapest, 1122, Hungary.

Background: We lack data on the effect of single premature ventricular contractions (PVCs) on the clinical and echocardiographic response after cardiac resynchronization therapy (CRT) device implantation. We aimed to assess the predictive value of PVCs at early, 1 month-follow up on echocardiographic response and all-cause mortality.

Methods: In our prospective, single-center study, 125 heart failure patients underwent CRT implantation based on the current guidelines. Read More

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Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome.

Geroscience 2022 Jun 25. Epub 2022 Jun 25.

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro, 3., 28029, Madrid, Spain.

Clonal hematopoiesis of indeterminate potential (CHIP), defined as the presence of somatic mutations in cancer-related genes in blood cells in the absence of hematological cancer, has recently emerged as an important risk factor for several age-related conditions, especially cardiovascular disease. CHIP is strongly associated with normal aging, but its role in premature aging syndromes is unknown. Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic condition driven by the accumulation of a truncated form of the lamin A protein called progerin. Read More

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