Mech Ageing Dev 2022 Jun 24:111692. Epub 2022 Jun 24.
Department of Genetics, Physiology and Microbiology (Physiology Unit), School of Biology, Complutense University of Madrid; Institute of Investigation of Hospital 12 de Octubre (i+12), Madrid, Spain. Electronic address:
Among the age-associated changes in the immune system, the most evident is the decrease in proliferative responses of lymphocytes to mitogenic stimuli, which is accompanied by the loss of cytokine network homeostasis. Chronic low-grade inflammatory stress, termed as sterile inflammation, is also observed during aging. In chronologically and prematurely aging mice, cohabitation with adult animals for two months favored improvements in several immune functions. Read More