28,624 results match your criteria pregnancy reduce


Contemporary Clinical Use of Aspirin: Mechanisms of Action, Current Concepts, Unresolved Questions, and Future Perspectives.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

The ability of aspirin to inhibit platelet aggregation has positioned this agent within the most frequently used drugs worldwide. The aim of this article is to review the contemporary clinical use of aspirin and also to discuss unresolved issues not yet translated into clinical practice. Results from several clinical trials have led to strong guideline recommendations for aspirin use in the acute management and secondary prevention of cardiovascular disease. Read More

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The association between history of prenatal loss and maternal psychological state in a subsequent pregnancy: an ecological momentary assessment (EMA) study.

Psychol Med 2021 Jun 15:1-11. Epub 2021 Jun 15.

Institute of Medical Psychology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Background: Prenatal loss which occurs in approximately 20% of pregnancies represents a well-established risk factor for anxiety and affective disorders. In the current study, we examined whether a history of prenatal loss is associated with a subsequent pregnancy with maternal psychological state using ecological momentary assessment (EMA)-based measures of pregnancy-specific distress and mood in everyday life.

Method: This study was conducted in a cohort of N = 155 healthy pregnant women, of which N = 40 had a history of prenatal loss. Read More

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Historical Analysis of the Risk of Hepatitis E and Its Complications in Pregnant Women in Nepal, 1996-1998.

Am J Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

6Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland.

Hepatitis E (HE) during pregnancy can be fatal; there are no prospective risk estimates for HE and its complications during pregnancy. We followed 2,404 pregnant women for HE and pregnancy outcomes from 1996 to 1998. Subjects from Nepal were enrolled at an antenatal clinic with pregnancy of ≤ 24 weeks. Read More

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Promotion of Pre-natal Education Courses Is Associated With Reducing the Rates of Caesarean Section: A Case-Control Study.

Front Public Health 2021 28;9:666337. Epub 2021 May 28.

The Hospital of Obstetrics & Gynaecology of Fudan University, Shanghai, China.

The number of women having a caesarean section has significantly increased worldwide, in particular in China. Maternal requestion makes a moderate contribution to this increased rate in China. Reducing the caesarean section rate is now becoming a big challenge to midwives and obstetricians as well as health policymakers in China. Read More

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Prediction of delivery after 40 weeks by antepartum ultrasound in singleton multiparous women: a prospective cohort study.

J Matern Fetal Neonatal Med 2021 Jun 13:1-7. Epub 2021 Jun 13.

Department of Obstetrics and Gynecology, University of Chieti, Chieti, Italy.

Objective: Universal elective induction of labor (IOL) in singleton parous pregnancies has been advocated to reduce the rate of cesarean section (CD), without impacting on maternal outcome. However, about 50% of women deliver after 40 weeks; therefore, an accurate estimation of the time of delivery might avoid unnecessary early IOL. The aim of this study was to test the diagnostic accuracy of ultrasound in predicting delivery ≥40 weeks of gestation in singleton parous women. Read More

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Antigen matching for transfusion support in Brazilian female patients with sickle cell disease to reduce RBC alloimmunization.

Transfusion 2021 Jun 14. Epub 2021 Jun 14.

Departamento de Ginecologia, Unifesp (Universidade Federal de São Paulo), São Paulo, Brazil.

Background: Red blood cell (RBC) alloimmunization is a complication of patients with sickle cell disease (SCD) and it has a greater impact on pregnancy, leading to a risk of hemolytic disease of the newborn and reducing blood availability for pregnant women. This study proposed to evaluate antigen matching transfusion protocols, aiming to reduce RBC alloimmunization in Brazilian female patients with SCD.

Methods: Samples from female patients with SCD (153) and self-declared Afro-Brazilian donors (307) were genotyped for RBC antigens and RH variants were investigated. Read More

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Impact of a manager-oriented intervention on occupational exposures and well-being among pregnant hospital and day-care employees: A cluster randomised trial.

Scand J Public Health 2021 Jun 14:14034948211018387. Epub 2021 Jun 14.

Department of Occupational and Environmental Medicine, Copenhagen University Hospital Bispebjerg, Bispebjerg and Frederiksberg Hospital, Denmark.

Background: Pregnancy can make it difficult to cope with demands at work and may affect women's well-being. We investigated if a manager-targeted educational intervention reduced demanding occupational exposures and improved the psychosocial work environment and well-being among pregnant employees.

Methods: Data came from a cluster randomised trial in Danish hospitals and day-care institutions. Read More

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Metabolic syndrome following hypertensive disorders in pregnancy in a low-resource setting: A cohort study.

Pregnancy Hypertens 2021 Jun 4;25:129-135. Epub 2021 Jun 4.

Julius Global Health, Julius Center for Health Science and Primary Care, UMC Utrecht, Utrecht University, the Netherlands.

Objectives: Hypertensive disorders in pregnancy (HDPs) are associated with risk of future metabolic syndrome. Despite the huge burden of HDPs in sub-Saharan Africa, this association has not been adequately studied in this population.

Study Design: This was a prospective cohort study on pregnant women recruited between August 2017 - April 2018 and followed up to one year after their deliveries and evaluated for presence of metabolic syndrome at delivery, nine weeks, six months and one year. Read More

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Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study.

J Subst Abuse Treat 2021 Jun 3;130:108521. Epub 2021 Jun 3.

Humankind Charity, Inspiration House, Unit 22, Bowburn North Industrial Estate, Durham DH6 5PF, United Kingdom.

Background: Methadone use for the management of opioid dependency during pregnancy is commonplace. Methadone levels are altered during pregnancy due to changes in maternal physiology. Despite this, a paucity of data exist regarding the most appropriate optimal dosing regimens during pregnancy. Read More

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Hirschsprung disease with Edward syndrome: A rare association: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106084. Epub 2021 Jun 9.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal. Electronic address:

Introduction And Importance: Edward's syndrome (ES) occurs as a result of trisomy of chromosome 18 and is associated with multisystem congenital anomalies. The association of ES with various gastrointestinal malformations but Hirschsprung disease (HD) is well documented.

Case Presentation: A female infant on her 5th day of life presented with episodes of bilious vomiting along with abdominal distension and no passage of stool. Read More

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Epidemic preparedness: Prenatal Zika virus screening during the next epidemic.

BMJ Glob Health 2021 Jun;6(6)

Health Equity Action Lab, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK

Zika virus (ZIKV) is a vectorborne infectious agent of global public health significance due to its potential to cause severe teratogenic outcomes. The question of whether health systems should consider adopting screening programmes for ZIKV infections during pregnancy warrants consideration. In this analysis, we apply the Wilson-Jungner framework to appraise the potential utility of a prenatal ZIKV screening programme, outline potential screening strategies within the case-finding pathway, and consider other epidemiological factors that may influence the planning of such a screening programme. Read More

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Access to treatment for pregnant incarcerated people with opioid use disorder: Perspectives from community opioid treatment providers.

J Subst Abuse Treat 2021 Jul 25;126:108338. Epub 2021 Feb 25.

Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Johns Hopkins Bayview Hospital, 4940 Eastern Ave, A121, Baltimore, MD 21224, United States; Johns Hopkins Bloomberg School of Public Health, Department of Health, Behavior and Society, 24 N. Broadway, Hampton House 737, Baltimore, MD 21205, United States. Electronic address:

Background And Aims: Many jail facilities provide limited access to medications for opioid use disorder (MOUD) for pregnant people with opioid use disorder (OUD), despite it being the standard of care. We aim to explore the perspectives of opioid treatment providers (OTPs) on access to MOUD for pregnant people while incarcerated and postincarceration.

Methods: We conducted 16 semistructured phone interviews with providers and administrators representing 16 unique OTPs in various U. Read More

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Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.

Biol Psychiatry 2021 Apr 14. Epub 2021 Apr 14.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Background: This study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitor (SSRI) use during preconception and pregnancy with risk of neurodevelopmental disorders in offspring.

Methods: We used data from the Study to Explore Early Development, a multisite case-control study conducted in the United States among children born between 2003 and 2011. Final study group classifications of autism spectrum disorder (ASD) (n = 1367), developmental delays or disorders (DDs) (n = 1750), and general population controls (n = 1671) were determined by an in-person standardized developmental assessment. Read More

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Improving the experience of facility-based delivery for vulnerable women through obstetric care navigation: a qualitative evaluation.

BMC Pregnancy Childbirth 2021 Jun 11;21(1):425. Epub 2021 Jun 11.

Wuqu' Kawoq | Maya Health Alliance, 2da Avenida 3-48 Zona 3, Barrio Patacabaj, Tecpán, Chimaltenango, Guatemala.

Background: Global disparities in maternal mortality could be reduced by universal facility delivery. Yet, deficiencies in the quality of care prevent some mothers from seeking facility-based obstetric care. Obstetric care navigators (OCNs) are a new form of lay health workers that combine elements of continuous labor support and care navigation to promote obstetric referrals. Read More

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Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial.

Reprod Biomed Online 2021 May 7. Epub 2021 May 7.

Recurrent Pregnancy Loss Unit, Copenhagen University Hospitals, Rigshospitalet, Fertility Clinic 4071, Copenhagen Ø, Denmark and Hvidovre Hospital, Department of Obstetrics and Gynaecology, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

Research Question: Can participating in a tailored 7-week meditation and mindfulness programme with additional standard supportive care versus standard supportive care only reduce perceived stress for women with recurrent pregnancy loss (RPL)?

Design: A two-armed randomized controlled trial (RCT) with 12-month follow-up. In total 76 patients were enrolled and randomly assigned to either standard supportive care or to a 7-week meditation and mindfulness programme led by an instructor in addition to standard supportive care.

Results: At intervention completion (after 7 weeks), perceived stress decreased significantly both in the intervention group (P = 0. Read More

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Impact of COVID-19 pandemic on time series of maternal mortality ratio in Bahia, Brazil: analysis of period 2011-2020.

BMC Pregnancy Childbirth 2021 Jun 10;21(1):423. Epub 2021 Jun 10.

Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.

Background: Most studies on the effects of SARS-CoV-2 infection have been conducted with adults and non-pregnant women. Thus, its impacts on maternal health are not yet fully established. This study aimed to verify the relationship between the maternal mortality ratio and the incidence of COVID-19 in the State of Bahia, Brazil, 2020. Read More

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Pre-eclampsia: incidence, determinants, and pregnancy outcomes from maternity hospitals in Qatar: a population-based case-control study.

J Matern Fetal Neonatal Med 2021 Jun 10:1-9. Epub 2021 Jun 10.

Women's Wellness and Research Center, Doha, Qatar.

Background: We aimed to study the maternal characteristics and obstetric and neonatal outcomes in pregnant mothers with pre-eclampsia (PE) compared to normotensive.

Methods: This was a population-based retrospective data analysis. Data were obtained from the PEARL-Peristat Study perinatal registry (Perinatal Neonatal Outcomes Research Study in the Arabian Gulf) Qatar. Read More

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Maternal and Fetal Vascular Lesions of Malperfusion in the Placentas Associated with Fetal and Neonatal Death: Results of a Prospective Observational Study.

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Columbia University, New York NY USA.

Background: Fetal death, one of the major adverse pregnancy outcomes, is especially common in low and middle-income countries. Placental lesions may play an important role in the etiology of fetal and possibly neonatal death. Prior research relating placental lesions to fetal death causation was often hindered by the lack of agreement on a placental classification scheme. Read More

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Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review.

Arch Physiol Biochem 2021 Jun 10:1-6. Epub 2021 Jun 10.

Université Clermont Auvergne, CRNH, AME2P, Clermont-Ferrand, France.

Context: Independently of the total body fat mass, upper body fat mass deposition is strongly associated with cardiometabolic comorbidities. The mechanisms underlying fat mass localisation are not fully understood, but evidences indicate sex-specific fat mass distribution. Currently, data on women are scarce and the link between hormonal status changes during their life and fat mass distribution is overlooked. Read More

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Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning.

J Anim Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Animal Science, Purdue University, West Lafayette, IN, USA.

A marker indicative of fertility potential of replacement gilts early in development would decrease culling rates in the sow herd, improve sow herd reproductive efficiency, and reduce production costs. The objective of this study was to determine if vaginal lipid profiles at 21 d postnatal (PN) could predict sow reproductive performance. Vaginal swabs of the anterior vagina were taken at 21 ± 4 d PN from gilts born on a commercial sow production facility for lipidomic analysis. Read More

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Cultural Sensitivity in Interventions Aiming to Reduce or Prevent Intimate Partner Violence During Pregnancy: A Scoping Review.

Trauma Violence Abuse 2021 Jun 10:15248380211021788. Epub 2021 Jun 10.

Department of Nursing and Health Promotion, Oslo Metropolitan University, Norway.

Intimate partner violence (IPV) around the time of pregnancy is a recognized global health problem. Ethnic minorities and immigrant pregnant women experiencing IPV require culturally responsive health services. The aim of this scoping review was to identify aspects of cultural sensitivity in interventions to prevent or reduce IPV among ethnic minorities and immigrant pregnant women in high-income countries. Read More

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Post-abortion family planning use, method preference, and its determinant factors in Eastern Africa: a systematic review and meta-analysis.

Syst Rev 2021 Jun 9;10(1):172. Epub 2021 Jun 9.

School of Midwifery, College of Health Sciences, Woldia University, P.O.Box: 400, Woldia, Ethiopia.

Background: Utilization of post-abortion family planning is very critical to reduce high levels of unintended pregnancy, which is the root cause of induced abortion. In Eastern Africa, it is estimated that as many as 95% of unintended pregnancies occurred among women who do not practice contraception at all. Therefore, this meta-analysis aimed to assess post-abortion family planning utilization and its determinant factors in Eastern Africa. Read More

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The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes.

Ann Palliat Med 2021 May;10(5):5652-5658

Obstetrics Department, Haikou Hospital of the Maternal and Child Health, Haikou, China.

Background: To investigate the effects of vitamin D and omega-3 fatty acids on glucose and blood lipid metabolism in gestational diabetes (GDM) women.

Methods: A total of 150 patients with GDM aged 18-40 who were admitted to our hospital from May 2019 to December 2020 were enrolled in this study. The subjects were divided into test and control groups according to whether they took vitamin D and omega-3 fatty acids. Read More

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Adaptation of a gender-transformative sexual and reproductive health intervention for adolescent boys in South Africa and Lesotho using intervention mapping.

Glob Health Action 2021 Jan;14(1):1927329

Institute for Life Course Health Research, Stellenbosch University, Cape Town, South Africa.

: Rates of adolescent HIV and unintended pregnancy in southern Africa are amongst the highest in the world. Gender-transformative interventions that address underlying gender inequalities and engage both males and females have been emphasised by the World Health Organisation, amongst others, to target prevention. However, few such gender-transformative interventions have been rigorously developed or evaluated. Read More

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January 2021

[Genetic Diagnosis of Thalassemia in Baise, Guangxi Zhuang Autonomous Region].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):865-868

Genetic Laboratory of Baise Maternal and Child Health Hospital;Baise 533000, Guangxi Zhuang Autonomous Region, China,E-mail:

Objective: To understand the genotypes and distribution characteristics of thalassemia in Baise, Guangxi Zhuang Autonomous Region, to provide references for the prevention and diagnosis of thalassemia in the region and improve the quality of eugenics.

Methods: 3 482 pregnant women and their spouses from January 2019 to August 2019 in Baise Maternal and Child Health Hospital for prenatal genetic diagnosis were selected, α, β- thalassemia genes were detected by Gap-PCR, PCR and DNA reverse dot hybridization, cases carrying thalassemia gene were confirmed and statistical analyzed.

Results: 2 260 samples (64. Read More

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Immunological Comparison of Pregnant Dahl Salt-Sensitive and Sprague Dawley Rats Commonly Used to Model Characteristics of Preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmacology and Toxicology, grid.410721.1University of Mississippi Medical Center, Jackson, MS, United States.

The pregnant Dahl salt-sensitive (S) rat is an established pre-clinical model of superimposed spontaneous preeclampsia characterized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying immune system dysfunction present in preeclamptic pregnancies in humans, we hypothesized that the pregnant Dahl S rat would also have an altered immune status. Immune system activation was assessed during late pregnancy in the Dahl S model and compared to healthy pregnant Sprague Dawley (SD) rats subjected to either a sham procedure or a procedure to reduce uterine perfusion pressure (RUPP). Read More

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The magnitude and determinants of antepartum depression among women attending antenatal clinic at a tertiary hospital, in Mwanza Tanzania: a cross-sectional study.

Pan Afr Med J 2021 12;38:258. Epub 2021 Mar 12.

Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Introduction: there is an increased vulnerability for the development of common mental disorders during the peripartum period as evidenced in depressive disorder.

Methods: a cross sectional study was used to determine the prevalence and risk factors associated with depression among pregnant women attending antenatal clinic (ANC) at Bugando Medical Centre (BMC), a tertiary level hospital in Mwanza Tanzania. A total of 380 pregnant women were recruited and interviewed by using Edinburg Postnatal Depression Scale. Read More

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Antenatal care and determinants of obstetric danger signs awareness of immediate postpartum women at Buea Regional Hospital, Cameroon.

Pan Afr Med J 2021 8;38:247. Epub 2021 Mar 8.

Department of Public Health and Hygiene, Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Introduction: a significant proportion of pregnancy related deaths result from delay in decision to seek care and this often stems from failure to identify obstetric danger signs earlier. Early identification of these danger signs will therefore reduce maternal mortality. However, studies on obstetric danger signs awareness are lacking in Cameroon. Read More

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Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers.

Int J Med Sci 2021 13;18(12):2653-2660. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Korea University Medicine, Seoul 02841, Korea.

Macrosomic birth weight has been implicated as a significant risk factor for developing various adult metabolic diseases such as diabetes mellitus and coronary heart diseases; it has also been associated with higher incidences of complicated births. This study aimed to examine the predictability of macrosomic births in hyperglycemic pregnant women using maternal clinical characteristics and serum biomarkers of aneuploidy screening performed in the first half of pregnancy. A retrospective observational study was performed on a cohort of 1,668 pregnant women who 1) had positive outcomes after undergoing 50-g oral glucose challenge test (OGCT) at two university-based hospitals and 2) underwent any one of the following maternal biomarker screening tests for fetal aneuploidy: triple test, quadruple test, and integrated test. Read More

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