189,695 results match your criteria pregnancy outcomes


The road (not) taken - Placental transfer and interspecies differences.

Placenta 2021 Sep 22;115:70-77. Epub 2021 Sep 22.

Placenta Lab, Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.

Species differences are among the main reasons for the high failure rate of preclinical studies. A better awareness and understanding of these differences might help to improve the outcome of preclinical research. In reproduction, the placenta is the central organ regulating fetal exposure to a substance circulating in the maternal organism. Read More

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September 2021

Marijuana use and perinatal outcomes in obstetric patients at a safety net hospital.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 16;266:36-41. Epub 2021 Sep 16.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: To characterize the association between antepartum marijuana exposure and maternal and neonatal outcomes at our institution.

Study Design: Retrospective chart review identified an obstetric cohort of singleton gestations. Women with self-reported marijuana use were compared with non-users. Read More

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September 2021

Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: a systematic review.

Brain Behav Immun 2021 Sep 22. Epub 2021 Sep 22.

Kids Neuroscience Centre, The Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Molecular Neurobiology Research Laboratory, Kids Research, Children's Hospital at Westmead, and The Children's Medical Research Institute, Westmead, New South Wales, Australia. Electronic address:

Inflammation is increasingly recognised to play a major role in gene-environment interactions in neurodevelopmental disorders (NDDs). The effects of aberrant immune responses to environmental stimuli in the mother and in the child can affect neuroimmune signalling that is central to brain development. Toll-like receptors (TLR) are the best known innate immune pattern and danger recognition sensors to various environmental threats. Read More

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September 2021

Associations of perinatal exposure to PM with gestational weight gain and offspring birth weight.

Environ Res 2021 Sep 22:112087. Epub 2021 Sep 22.

Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA.

Background: PM have been associated with weight change in animal models and non-pregnant populations. Evidence of associations between PM and gestational weight gain (GWG), an important determinant of course and outcomes of pregnancy, and subsequent birth outcomes is limited.

Methods: The study was conducted among a subset of participants from the Omega Study, a prospective pregnancy cohort. Read More

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September 2021

Emerging placental biomarkers of health and disease through advanced magnetic resonance imaging (MRI).

Exp Neurol 2021 Sep 22:113868. Epub 2021 Sep 22.

Department of Neonatology, Children's National, Washington DC, USA. Electronic address:

Placental dysfunction is a major cause of fetal demise, fetal growth restriction, and preterm birth, as well as significant maternal morbidity and mortality. Infant survivors of placental dysfunction are at elevated increased risk for lifelong neuropsychiatric morbidity. However, despite the significant consequences of placental disease, there are no clinical tools to directly and non-invasively assess and measure placental function in pregnancy. Read More

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September 2021

Brief Hydromorphone Exposure During Pregnancy Sufficient to Induce Maternal and Neonatal Microbial Dysbiosis.

J Neuroimmune Pharmacol 2021 Sep 25. Epub 2021 Sep 25.

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Prenatal opioid exposure is associated with significantly adverse medical, developmental, and behavioral outcomes in offspring, though the underlying mechanisms driving these impairments are still unclear. Accumulating evidence implicates gut microbial dysbiosis as a potential modulator of these adverse effects. However, how opioid exposure during pregnancy alters the maternal and neonatal microbiome remain to be elucidated. Read More

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September 2021

Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.

Am J Clin Nutr 2021 Sep 25. Epub 2021 Sep 25.

Dorothy J and Gerald R Friedman School of Nutrition and Science Policy at Tufts University.

Background: Maternal intake of several nutrients during pregnancy is linked to offspring cognition. The relationship between maternal dietary patterns and offspring cognition is less established.

Objective: To examine associations of maternal diet quality during pregnancy with child cognition and behavior. Read More

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September 2021

Estimating perinatal critical windows of susceptibility to environmental mixtures via structured bayesian regression tree pairs.

Biometrics 2021 Sep 25. Epub 2021 Sep 25.

Department of Statistics, Colorado State University, Fort Collins, CO, USA.

Maternal exposure to environmental chemicals during pregnancy can alter birth and children's health outcomes. Research seeks to identify critical windows, time periods when exposures can change future health outcomes, and estimate the exposure-response relationship. Existing statistical approaches focus on estimation of the association between maternal exposure to a single environmental chemical observed at high temporal resolution (e. Read More

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September 2021

Predictive value of peripheral blood α1-acid glycoprotein in medical abortion outcomes with mifepristone and relativity of concentration.

Int J Gynaecol Obstet 2021 Sep 24. Epub 2021 Sep 24.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.

Objective: Mifepristone, in combination with misoprostol, is the most common method of medical abortion, with α1-acid glycoprotein (AAG) as the transporter of mifepristone. Ultrasound and serial β-hCG measurements provide definitive evidence of pregnancy termination. Our current study aimed to illustrate the predictive value of peripheral blood α1-acid glycoprotein (AAG) in abortion outcomes with mifepristone and the relativity of concentration. Read More

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September 2021

Association of vaginal dysbiosis and gestational diabetes mellitus with adverse perinatal outcomes.

Int J Gynaecol Obstet 2021 Sep 24. Epub 2021 Sep 24.

Interdisciplinary Biotechnology Unit, Faculty of Life Sciences, AMU, Aligarh, UP, India.

Objective: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes and is an independent risk factor for vaginal dysbiosis. Understanding vaginal microbiota in health and disease is essential to screen, detect and manage complications of pregnancy. So, we planned this study with the aim to assess and compare the vaginal dysbiosis in pregnancies with and without GDM and examine its impact on perinatal outcomes in our population. Read More

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September 2021

Duration of estradiol supplementation in luteal phase support for frozen embryo transfer in hormone replacement treatment cycles: a randomized, controlled phase III trial.

Arch Gynecol Obstet 2021 Sep 24. Epub 2021 Sep 24.

Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Purpose: In this study, we intend to evaluate pregnancy outcomes in women who undergo artificial frozen embryo transfer (FET) and stop estradiol (E2) after vaginal ultrasound observation of a gestational sac and heartbeat.

Methods: In this randomized phase III clinical trial, we recruited 291 patients who underwent FET. We randomly assigned 64 pregnant women to a study or a control group after observation of a gestational sac and heartbeat at 6-week gestational age. Read More

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September 2021

Fetal and Neonatal Outcomes Following Maternal Aortic Balloon Occlusion for Hemorrhage in Pregnancy: A Review of the Literature.

J Trauma Acute Care Surg 2021 Sep 24. Epub 2021 Sep 24.

University of California Davis Medical Center, 2335 Stockton Blvd Room 5107, Sacramento, CA, 95817, USA University of California Davis Medical Center, 2335 Stockton Blvd Room 5107, Sacramento, CA, 95817, USA. Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick, NJ, 08901, USA. University of California Davis Medical Center, 2335 Stockton Blvd Room 5107, Sacramento, CA, 95817, USA. University of California Davis Medical Center, 2335 Stockton Blvd Room 5107, Sacramento, CA, 95817, USA.

Background: Hemorrhage is a leading cause of maternal death worldwide, with increased risk in women with abnormal placentation. Aortic balloon occlusion (ABO), including resuscitative endovascular balloon occlusion (REBOA), has been used for obstetrical hemorrhage for 20 years, and is associated with decreased operative blood loss, fewer transfusions, and lower rates of hysterectomy. However, the effect of aortic occlusion on fetal/neonatal outcomes is not well known. Read More

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September 2021

Nomogram to predict pregnancy outcomes of emergency oocyte freeze-thaw cycles.

Chin Med J (Engl) 2021 Sep 21. Epub 2021 Sep 21.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.

Background: Existing clinical prediction models for in vitro fertilization are based on the fresh oocyte cycle, and there is no prediction model to evaluate the probability of successful thawing of cryopreserved mature oocytes. This research aims to identify and study the characteristics of pre-oocyte-retrieval patients that can affect the pregnancy outcomes of emergency oocyte freeze-thaw cycles.

Methods: Data were collected from the Reproductive Center, Peking University Third Hospital of China. Read More

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September 2021

Maternal and newborn effects of gestational diabetes mellitus: A prospective cohort study.

Prim Care Diabetes 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Laboratory Sciences, Bahir Dar University, Ethiopia; Institute of Clinical Immunology, Medical Faculty, University Hospital, University of Leipzig, Germany.

Background: Gestational diabetes mellitus (GDM) is a high glucose level detected during pregnancy and usually it disappears after 42 days of post partum. The aim of this research was to assess the maternal and newborn effects of GDM in resource limited settings.

Methods: A prospective cohort was implemented in the five referral hospitals of Amhara region. Read More

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September 2021

Frequency and severity of prehospital obstetric events encountered by emergency medical services in the United States.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):655. Epub 2021 Sep 24.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Prehospital obstetric events encountered by emergency medical services (EMS) can be high-risk patient presentations for which suboptimal care can cause substantial morbidity and mortality. The frequency of prehospital obstetric events is unclear because existing descriptions have reported obstetric and gynecological conditions together, without delineating specific patient presentations. Our objective was to identify the types, frequency, and acuity of prehospital obstetric events treated by EMS personnel in the US. Read More

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September 2021

A first trimester prediction model for large for gestational age infants: a preliminary study.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):654. Epub 2021 Sep 24.

Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy.

Background: Large for gestational age infants (LGA) have increased risk of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical, biophysical, anamnestic, and clinical maternal characteristics available at first trimester.

Methods: Prospective study that included all singleton pregnancies attending the first trimester aneuploidy screening at the Obstetric Unit of the University Hospital of Modena, in Northern Italy, between June 2018 and December 2019. Read More

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September 2021

Maternal and neonatal outcomes in mothers with diabetes mellitus in qatari population.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):651. Epub 2021 Sep 24.

Neonatal Intensive Care Unit (NICU), Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), Doha, P.O. Box 3050, Qatar.

Background: Diabetes Mellitus (DM) is a major cause of maternal, fetal, and neonatal morbidities. Our objective was to estimate the effect of both pre-pregnancy and gestational DM on the growth parameters of newborns in the Qatari population.

Methods: In this population-based cohort study, we compared the data of neonates born to Qatari women with both pre-pregnancy and gestational diabetes mellitus in 2017 with neonates of healthy non-diabetic Qatari women. Read More

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September 2021

Down regulatory response of reproductive potentials in stress-induced rats supplemented with clomifene citrate: The fate of infertility.

Biomed Pharmacother 2021 Sep 21;143:112208. Epub 2021 Sep 21.

Department of Human Physiology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.

This study was designed to physiologically investigate the fate of stress related infertility conditions to focus on the regulatory response of reproductive potentials in stress-induced female Wistar rats supplemented with clomifene citrate. 42 apparently healthy female Wistar rats weighing about 120-160 g were used in the study. The animals were randomly distributed into 3 groups after acclimatization for 2 weeks. Read More

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September 2021

Current understanding of autophagy in intrahepatic cholestasis of pregnancy.

Placenta 2021 Sep 20;115:53-59. Epub 2021 Sep 20.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, 610041, China. Electronic address:

Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease during pregnancy. Manifested with pruritus and elevation in bile acids, the etiology of ICP is still poorly understood. Although ICP is considered relatively benign for the mother, increased rates of adverse fetal outcomes including sudden fetal demise are possible devastating outcomes associated with ICP. Read More

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September 2021

Gestational triclosan exposure and infant birth weight: A systematic review and meta-analysis.

Environ Int 2021 Sep 21;157:106854. Epub 2021 Sep 21.

Brown University School of Public Health, 121 S. Main Street, Providence, RI 02912, United States. Electronic address:

Background: Exposure to triclosan, an antimicrobial chemical used in some personal care and cleaning products, has been associated with reduced birth weight in some, but not all epidemiological studies.

Objectives: We conducted a systematic review and meta-analysis to characterize the relation of gestational triclosan exposure with infant birth weight and identify sources of heterogeneity between studies.

Methods: We identified original studies measuring urinary triclosan concentrations during pregnancy and reporting their association with infant birth weight, gestational age (GA) adjusted birth weight (g), or GA-standardized birth weight z-scores. Read More

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September 2021

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism related placental mRNAs in obese pregnant women: The DALI Lifestyle Randomized Controlled Trial.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Institute of Human Movement Science, Sport and Health, University of Graz, Austria.

Objectives: To explore i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with placental expression of genes related to glucose and lipid metabolism in obese pregnant women; ii) maternal metabolic factors mediating changes in these placental transcripts; and iii) cord blood markers related to these mRNAs mediating neonatal adiposity.

Study Design: Multicentre-randomized controlled trial.

Setting: Hospitals; 9-European countries. Read More

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September 2021

Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, 14049-900, Brazil.

Objective: To assess the risk of spontaneous preterm birth (sPTB) associated with genital mycoplasma infection asymptomatic women.

Design: Prospective cohort.

Setting: Public and private health services in Ribeirão Preto-SP, Brazil. Read More

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September 2021

Instruments for assisted vaginal birth.

Cochrane Database Syst Rev 2021 Sep 24;9:CD005455. Epub 2021 Sep 24.

Keele University & Department of Obstetrics and Gynaecology, University Hospitals of North Midlands, Stoke-on-Trent, UK.

Background: Assisted vaginal births are carried out to expedite birth for the benefit of mothers and babies but are sometimes associated with significant morbidity for both. Various instruments are available, broadly divided into forceps and vacuum cups, and choice may be influenced by clinical circumstances, operator preference, experience and availability.  OBJECTIVES: To evaluate the different instruments in terms of success in achieving a vaginal birth, and the risk of morbidity for mother and baby. Read More

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September 2021

Effects of Olive Oil on Striae Gravidarum in Primiparous Women: A Randomized Controlled Clinical.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Context: The development of striae gravidarum (SG), stretch marks, is one of the most common skin changes during pregnancy. The number of studies conducted on the reduction or prevention of SG, especially on the effects of olive oil, is limited.

Objective: The study intended to evaluate the clinical efficacy of olive oil in reducing the severity and preventing the progression of SG when used from the third trimester of pregnancy to the child's birth. Read More

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September 2021

Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period.

Cochrane Database Syst Rev 2021 Jan 8;1:CD008407. Epub 2021 Jan 8.

Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, University of Liverpool, Liverpool, UK.

Background: Perineal pain is a common but poorly studied adverse outcome following childbirth. Pain may result from perineal trauma due to bruising, spontaneous tears, surgical incisions (episiotomies), or in association with operative vaginal births (ventouse or forceps-assisted births). This is an update of a review last published in 2013. Read More

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January 2021

Postnatal assessment for renal dysfunction in women with hypertensive disorders of pregnancy : A prospective observational study.

J Nephrol 2021 Sep 24. Epub 2021 Sep 24.

Antenatal Hypertension Clinic, King's College Hospital, London, UK.

Background: Hypertensive disorders of pregnancy are associated with chronic kidney disease. Early detection of renal dysfunction enables implementation of strategies to prevent progression. International guidelines recommend review at 6-8 weeks postpartum to identify persistent hypertension and abnormal renal function, but evidence for the efficacy of this review is limited. Read More

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September 2021

Maternal fish and shellfish consumption and preterm birth: A retrospective study in urban China.

Br J Nutr 2021 Sep 24:1-31. Epub 2021 Sep 24.

Department of Pediatric Comprehensive Medicine,Gansu Provincial Maternity and Child Care Hospital, Lanzhou, 730050, China.

Preterm birth is the leading cause of perinatal mortality and morbidity. Some prospective cohort studies suggested that fish and shellfish consumption may affect the incidence of preterm birth. However, conflicting evidence exists on the relationship between fish and shellfish consumption and preterm birth. Read More

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September 2021

Outcomes of pregnant broodmares treated for colic at a tertiary care facility.

Vet Surg 2021 Sep 23. Epub 2021 Sep 23.

Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Objective: To evaluate, following colic admission during pregnancy, (1) broodmare survival; (2) the frequency of recurrent colic in broodmares and its associated variables, and (3) pregnancy outcome and the variables associated with a negative pregnancy outcome.

Study Design: Ambidirectional observational cohort study.

Animals: One hundred and four client-owned broodmare admissions. Read More

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September 2021

Circulating trace elements for the prediction of preeclampsia and small for gestational age babies.

Metabolomics 2021 Sep 23;17(10):90. Epub 2021 Sep 23.

School of Medical Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia.

Introduction: Poor gestational outcomes due to placental insufficiency can have lifelong consequences for mother and child.

Objective: There is a need for better methods of diagnosis, and elemental metabolomics may provide a means to determine the risk of gestational disorders.

Methods: This study used blood plasma samples collected at 36 weeks' gestation from women who later developed preeclampsia (n = 38), or small-for-gestational age babies (n = 91), along with matched controls (n = 193). Read More

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September 2021

Partners of female patients with rheumatoid arthritis and reproductive decision-making: a constructivist grounded theory study.

Rheumatol Adv Pract 2021 21;5(3):rkab040. Epub 2021 Jun 21.

Faculty of Pharmaceutical Sciences, University of British Columbia.

Objective: Partners of patients with RA often take on supportive roles given the debilitating nature of RA. Our objective was to explore the perspectives, attitudes and experiences of partners of female patients with RA regarding reproductive experiences and decision-making.

Methods: We conducted a qualitative study involving semi-structured interviews with partners of female patients with RA. Read More

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