4,985 results match your criteria pregnancy epileptic

Maternal epilepsy- perinatal outcome and long-term neurological morbidity of the offspring: a population-based cohort study.

Arch Gynecol Obstet 2021 Jun 7. Epub 2021 Jun 7.

Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Purpose: The current study was aimed to assess whether maternal epilepsy is linked to long-term neurological morbidity of the offspring, and to examine whether maternal epilepsy is associated with adverse pregnancy outcomes.

Methods: A population-based cohort study was conducted comparing perinatal outcomes of women with and without epilepsy, including long-term neurological morbidity of the offspring. Both the exposed and unexposed groups were followed up to 18 years of age for neurological-related morbidity. Read More

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Two-Year-Old Cognitive Outcomes in Children of Pregnant Women With Epilepsy in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study.

JAMA Neurol 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: The neurodevelopmental risks of fetal exposure are uncertain for many antiseizure medications (ASMs).

Objective: To compare children at 2 years of age who were born to women with epilepsy (WWE) vs healthy women and assess the association of maximum ASM exposure in the third trimester and subsequent cognitive abilities among children of WWE.

Design, Setting, And Participants: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is a prospective, observational, multicenter investigation of pregnancy outcomes that enrolled women from December 19, 2012, to January 13, 2016, at 20 US epilepsy centers. Read More

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Impact of Changes in Free Concentrations and Drug-Protein Binding on Drug Dosing Regimens in Special Populations and Disease States.

J Pharm Sci 2021 Jun 2. Epub 2021 Jun 2.

Albany College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, 106 New Scotland Avenue, Albany, NY 12208. Electronic address:

Over the last few decades, scientists and clinicians have often focused their attention on the unbound fraction of drugs as an indicator of efficacy and the eventual outcome of drug treatments for specific illnesses. Typically, the total drug concentration (bound and unbound) in plasma is used in clinical trials to assess a compound's efficacy. However, the free concentration of a drug tends to be more closely related to its activity and interaction with the body. Read More

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Contemporary trends in antiepileptic drug treatment among women of childbearing age with epilepsy in the United States: 2004-2015.

J Neurol Sci 2021 May 18;427:117500. Epub 2021 May 18.

Department of Neurology, Penn State University Hershey Medical Center, Hershey, PA, USA.

Objective: Certain antiepileptic drugs are associated with an increased risk for major congenital malformations (MCM). However, little is known regarding recent patterns of antiepileptic drug (ASM) prescriptions to women of childbearing age with epilepsy (WCE) in the United States.

Methods: Data from the Medical Expenditure Panel Survey was analyzed between the years 2004-2015 to determine trends in national antiepileptic drug prescriptions for WCE. Read More

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Risk Factors for Cerebral Palsy in Moldova.

Medicina (Kaunas) 2021 May 28;57(6). Epub 2021 May 28.

Norwegian Quality and Surveillance Registry for Cerebral Palsy (NorCP), Vestfold Hospital Trust, P.O. Box 2168, 3103 Tonsberg, Norway.

This is the first study assessing risk factors for cerebral palsy (CP) among children born in Moldova. The aim of this study was to identify and describe risk factors for cerebral palsy (CP) among children born in Moldova, which is one of the low-middle income countries in Europe. We identified 351 children with CP born during 2009 and 2010 in Moldova. Read More

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Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring.

Epilepsy Behav 2021 May 27;121(Pt A):108038. Epub 2021 May 27.

Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan. Electronic address:

Febrile seizures, which are convulsion in children, are caused by an abrupt increase in body temperature. They are sometimes recurrent, and the more seizures are triggered, the higher the risk of epilepsy and psychiatric disorders increase after growing up. Prevention of febrile seizure is considered to be one of the effective countermeasures in protecting the future health of children; however, pharmacological prevention in the developmental stage is not realistic from the health aspects of the offspring. Read More

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Anti-epileptic drug exposure during pregnancy and neonatal birth weight outcomes: protocol for a systematic review and meta-analysis.

Syst Rev 2021 May 29;10(1):159. Epub 2021 May 29.

College of Pharmacy, University of Manitoba, 750 McDermot Ave W, Winnipeg, MB, R3E 0T5, Canada.

Background: The prevalence of epilepsy in pregnant women is estimated at 0.3-1%. Anti-epileptic drug (AED) exposure in-utero has been associated with various adverse health outcomes in neonates, including adverse birth weight outcomes. Read More

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An online tool for information to women with epilepsy and therapeutic drug monitoring in pregnancy: Design and pilot study.

Epilepsia Open 2021 Jun 20;6(2):339-344. Epub 2021 Feb 20.

Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Objective: Information to women with epilepsy on pregnancy-related antiseizure medication (ASM) issues and reliable tools for therapeutic drug monitoring (TDM) are important aspects of epilepsy care. We aimed to develop and test an online tool for patient education on pregnancy-related issues and communication with epilepsy nurses during pregnancy for women with epilepsy.

Methods: An existing national platform for online communication (1177. Read More

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Is vagal-nerve stimulation safe during pregnancy? A mini review.

Epilepsy Res 2021 Aug 14;174:106671. Epub 2021 May 14.

Ningxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, 750004, China; Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, 750004, China. Electronic address:

Background: Vagus-nerve stimulation (VNS) is the most common neuromodulation technique and has been approved by the FDA for treating refractory epilepsy and refractory depression. Although VNS has been used for nearly 32 years, the impact of VNS on the safety of pregnant women and neonate remains to be evaluated.

Methods: We first analyze the relationship between the vagus nerve and the reproductive system (ovary and uterus) and then determine whether harm is inflicted to the reproductive system, thereby affecting the pregnancy. Read More

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Effects of antiseizure medications on placental cells: Focus on heterodimeric placental carriers.

Epilepsy Res 2021 Aug 8;174:106664. Epub 2021 May 8.

Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address:

Objective: Appropriate placental nutrient transfer is essential for optimal fetal development. We have previously shown that antiseizure medications (ASMs) can alter the expression of placental carriers for folate and thyroid hormones. Here we extended our analysis to heterodimeric carriers that mediate the placental uptake of amino acids and antioxidant precursors. Read More

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Seizure as a presenting manifestation of Wernicke's encephalopathy induced by hyperemesis gravidarum.

J Family Med Prim Care 2021 Jan 30;10(1):567-571. Epub 2021 Jan 30.

Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education & Research and SSKM Hospital, Kolkata, West Bengal, India.

Wernicke's encephalopathy (WE) is an acute neurological condition characterized by the triad of ophthalmoparesis with nystagmus, ataxia, and global confusion. WE is a life-threatening illness caused by thiamine deficiency, primarily affecting the peripheral and central nervous systems. Thiamine deficiency is predominantly associated with chronic alcoholism, but various other causes have also been reported, including severe malnutrition, prolonged parenteral nutrition, malignancies, immunodeficiency syndromes, liver disease, hyperthyroidism and severe anorexia nervosa, and hyperemesis gravidarum. Read More

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January 2021

Pregnancy and the Control of Epileptic Seizures: A Review.

Mervyn J Eadie

Neurol Ther 2021 May 14. Epub 2021 May 14.

School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD, 4027, Australia.

Over the past 50 years, published studies have provided quantitative data on the control of epileptic seizures during pregnancy. The studies have varied in quality, and particularly in the ways in which seizure control has been assessed. However, most studies have shown that seizure occurrence rates are more likely to worsen than improve during pregnancy, though in most pregnancies the rates have been unaltered. Read More

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Stiripentol (Diacomit) for Dravet syndrome.


Med Lett Drugs Ther 2021 03 22;63(1620):e48-e50. Epub 2021 Mar 22.

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Effects of the Menstrual Cycle on Neurological Disorders.

Curr Neurol Neurosci Rep 2021 05 10;21(7):34. Epub 2021 May 10.

Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Purpose Of Review: The menstrual cycle involves recurrent fluctuations in hormone levels and temperature via neuroendocrine feedback loops. This paper reviews the impact of the menstrual cycle on several common neurological conditions, including migraine, seizures, multiple sclerosis, stroke, and Parkinson's disease.

Recent Findings: The ovarian steroid hormones, estrogen and progesterone, have protean effects on central nervous system functioning that can impact the likelihood, severity, and presentation of many neurological diseases. Read More

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A survey of child neurologists about reproductive healthcare for adolescent women with epilepsy.

Epilepsy Behav 2021 Jul 5;120:108001. Epub 2021 May 5.

UPMC Children's Hospital of Pittsburgh, Division of Adolescent and Young Adult Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, United States; Center for Women's Health Research and Innovation, University of Pittsburgh, 4200 Fifth Avenue, Pittsburgh, PA 15260, United States.

Objective: To evaluate child neurologists' knowledge, attitudes, and practices regarding sexual and reproductive health (SRH) care for adolescent and young adult women with epilepsy (WWE).

Methods: Child neurologists (including attending physicians, residents, fellows, and advanced practitioners) completed an online survey distributed through subspecialty listservs. We analyzed results using descriptive statistics, chi-square, and logistic regression. Read More

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Predictors of successful valproate withdrawal in women with epilepsy.

Epilepsy Behav 2021 Jun 3;119:107980. Epub 2021 May 3.

Istanbul University, Istanbul Faculty of Medicine, Departments of Neurology and Clinica Neurophysiology, Istanbul, Turkey.

Objective: Valproate (VPA) use was restricted due to its teratogenic risks in women with epilepsy (WWE). We aimed to assess the outcome and predictors of treatment decisions of withdrawal/switch or continuation of VPA in WWE.

Methods: We included 214 consecutive WWE with a follow-up time of 9. Read More

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The long-term prognosis of hippocampal neurogenesis and behavioral changes of offspring from rats exposed to valproic acid during pregnancy.

Neuropsychopharmacol Rep 2021 Jun 5;41(2):260-264. Epub 2021 May 5.

Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan.

Aim: In pregnant women with epilepsy, it is essential to balance maternal safety and the potential teratogenicity of anticonvulsants. Recently, growing evidence has indicated that valproic acid (VPA) can produce postnatal congenital malformations and impair cognitive function. However, the mechanisms underlying cognitive dysfunction in long-term prognoses remain unclear. Read More

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A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury.

Int J Environ Res Public Health 2021 04 30;18(9). Epub 2021 Apr 30.

Dental and Nursing Medical Department, Faculty of Medicine, Lucian Blaga University Sibiu, 550169 Sibiu, Romania.

Neonatal brain injury or neonatal encephalopathy (NE) is a significant morbidity and mortality factor in preterm and full-term newborns. NE has an incidence in the range of 2.5 to 3. Read More

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Urinary tract infection in women.

Prz Menopauzalny 2021 Apr 21;20(1):40-47. Epub 2021 Apr 21.

Department of Obstetrics and Gynaecology Didactics, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland.

Urinary tract infection (UTI) is one of the most common infections afflicting women. UTI often accompanies vaginal infections and is frequently caused by pathogens originating in the digestive tract. The paper discusses the prevalence of UTI in various patient populations, including postmenopausal, pregnant, diabetic, epileptic, and perioperative female patients. Read More

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Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation.

Epileptic Disord 2021 Apr;23(2):426-431

Dept. of Neurology and Clinical Neurophysiology, St. Olav University Hospital, Trondheim, Norway, Dept. of Neuromedicine and Movement Science, The Norwegian University of Science and Technology, Trondheim, Norway.

We present pharmacokinetic data during pregnancy and lactation for brivaracetam, lacosamide and perampanel based on two case studies. Patient 1 used brivaracetam as monotherapy and gave birth to twins. Patient 2 used a combination of brivaracetam, lacosamide and perampanel. Read More

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Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.

Food Funct 2021 May 27;12(10):4544-4555. Epub 2021 Apr 27.

Key Laboratory of Modern Teaching Technology, Ministry of Education, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.

Maternal vitamin supplementation has been demonstrated to reduce the risks of a number of neurodevelopmental diseases in children. Autism spectrum disorder (ASD) is a group of neurodevelopment defects with high prevalence but without satisfactory therapy. The present work detected the effects of pregnancy supplementation with folic acid (FA) at different doses on rat models of ASD induced by prenatal exposure to valproic acid (VPA), an anti-epileptic increasing the risk of ASD when administered during pregnancy. Read More

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Premature Mortality, Risk Factors, and Causes of Death Following Childhood-Onset Neurological Impairments: A Systematic Review.

Front Neurol 2021 9;12:627824. Epub 2021 Apr 9.

Kenya Medical Research Institute (KEMRI-Wellcome Trust Research Programme), Clinical Research (Neurosciences), Kilifi, Kenya.

Neurological impairment (NI) and disability are associated with reduced life expectancy, but the risk and magnitude of premature mortality in children vary considerably across study settings. We conducted a systematic review to estimate the magnitude of premature mortality following childhood-onset NI worldwide and to summarize known risk factors and causes of death. We searched various databases for published studies from their inception up to 31st October 2020. Read More

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Diagnostic and therapeutic difficulties in patient with cerebral venous thrombosis - a case report.

Pol Merkur Lekarski 2021 Apr;49(290):146-149

Department of Radiological Diagnostics and and Isotope Therapy, University Clinical Hospital of the Military Medical Academy - Central Veterans Hospital, Łódź, Poland.

Cerebral venous infarction also known as cerebral venous thrombosis (CVT) is a rare disease. It is more common in young adults, but three times more common in women than in men. The clinical picture of CVT may vary and non-specific manifestations often delay correct diagnosis. Read More

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Psychoses of Epilepsy in Pregnancy: A Case Report.

Clin Psychopharmacol Neurosci 2021 May;19(2):388-390

Office of Mental Health, Hutchings Psychiatric Center, Syracuse, NY, USA.

To discuss the unique relationship between psychosis and seizures in a young individual, who is also pregnant. Psychosis of epilepsy can present in multitude of ways, including pre-ictal, ictal, post-ictal, chronic interictal, and forced normalization psychosis. Read More

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Childhood neurodevelopmental disorders and maternal hypertensive disorder of pregnancy.

Dev Med Child Neurol 2021 Apr 21. Epub 2021 Apr 21.

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.

Aim: To examine the association of maternal chronic hypertension and pregnancy-induced hypertension (PIH)/preeclampsia with childhood neurodevelopmental disorders (NDDs) in a large-scale population-based cohort.

Method: We conducted a linked Taiwan National Health Insurance Research Database cohort study of children born between 2004 and 2008 (n=877 233). Diagnoses of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, cerebral palsy (CP), and epilepsy/infantile spasms were identified from birth to the end of 2015. Read More

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Prenatal, perinatal, and postnatal factors associated with autism spectrum disorder cases in Xuzhou, China.

Transl Pediatr 2021 Mar;10(3):635-646

Children's Neurological Rehabilitation Center, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background: The aim of the present study was to explore the prenatal, perinatal, and postnatal risk factors in children with autism spectrum disorder (ASD) from Xuzhou, China by comparing them with healthy children.

Methods: Children with ASD who received rehabilitation training at special education schools and rehabilitation institutions in Xuzhou were selected as the ASD group, and healthy children during the same period were selected as the healthy non-ASD group. A questionnaire based on the possible causes and susceptibility factors of ASD in children was issued and given to all children in this study. Read More

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Estrogen profile- and pharmacogenetics-based lamotrigine dosing regimen optimization: Recommendations for pregnant women with epilepsy.

Pharmacol Res 2021 Apr 20;169:105610. Epub 2021 Apr 20.

Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address:

During pregnancy, various physiological changes occur that can alter the pharmacokinetics of antiepileptic drugs, such as lamotrigine (LTG). Anticipating the change in LTG dose required to achieve a pre-pregnancy target concentration is challenging. This study aimed to develop a refined population pharmacokinetic (PopPK) model of LTG in pregnant women with epilepsy (WWE) to identify factors explaining the variability in pharmacokinetics and to establish a model-informed individualized dosing regimen. Read More

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Super-refractory status epilepticus in a 29-year-old pregnant female.

SAGE Open Med Case Rep 2021 23;9:2050313X211000455. Epub 2021 Mar 23.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Super-refractory status epilepticus is a rare medical and neurological emergency due to the high mortality and morbidity associated with this condition. Furthermore, there is very little data regarding its incidence, etiology, and management in the pregnant population with super-refractory status epilepticus. The treatment of super-refractory status epilepticus during pregnancy is specifically a major challenge as there are limited available therapeutic options due to the well-established teratogenicity of most antiepileptic drugs and the unknown safety profile of some of the anesthetics commonly used for seizure control. Read More

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The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy.

Epilepsy Behav 2021 05 11;118:107941. Epub 2021 Apr 11.

Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland 4027, Australia.

Purpose: To assess the possible contribution of factors in additional to intrauterine anti-seizure medication (ASM) exposure in the occurrence of fetal malformation in women with ASM-treated epilepsy.

Results: Logistic regression analysis showed that maternal age over 31 years, family histories of fetal malformation, and conception after assisted fertility treatment, and also dosage of valproate, carbamazepine, and topiramate, made statistically significant (P<0.05) contributions to the fetal malformation rate in 2223 pregnancies in Australian women with epilepsy. Read More

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