90 results match your criteria prednisolone-treated groups


Genotype characterization and delayed loss of ambulation by glucocorticoids in a large cohort of patients with Duchenne muscular dystrophy.

Orphanet J Rare Dis 2021 Apr 28;16(1):188. Epub 2021 Apr 28.

Department of Neurology, First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.

Background: Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease in human. We aimed to describe the genotype distribution in a large cohort of Chinese DMD patients and their delayed loss of ambulation by glucocorticoid (GC) treatments. This is to facilitate protocol designs and outcome measures for the emerging DMD clinical trials. Read More

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Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration.

J Nutr Biochem 2021 Apr 31;90:108572. Epub 2020 Dec 31.

Laboratory of Investigation in Chronic Diseases - LIDoC, Department of Physiological Sciences, Centre of Biological Sciences, Federal University of Santa Catarina - UFSC, Florianópolis, Santa Catarina, Brazil; Multicentre Graduate Program in Physiological Sciences, Centre of Biological Sciences, Federal University of Santa Catarina - UFSC, Florianópolis, Santa Catarina, Brazil. Electronic address:

We investigated whether combined long-term fructose and prednisolone intake would be more detrimental to the glucose homeostasis than if ingested separately. We also evaluated whether fish oil administration or interruption of treatments has any positive impact. For this, male adult Wistar rats ingested fructose (20%) (F) or prednisolone (12. Read More

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Betaine effects against asthma-induced oxidative stress in the liver and kidney of mice.

Mol Biol Rep 2020 Aug 24;47(8):5729-5735. Epub 2020 Aug 24.

Department of Pathobiology, School of Veterinary Medicine, Lorestan University, P. O. Box: 465, Khorramabad, Iran.

Allergic asthma is a chronic inflammatory airway disease concomitant with oxidative stress. The aim of this study was to evaluate the effects of betaine against asthma-induced oxidative stress in experimentally animal model. 32 BALB/C mice were divided into four equal groups as: control, asthma, prednisolone and betaine groups. Read More

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Safety and Efficacy of 0.1% Nepafenac versus 1% Prednisolone Acetate Eye Drops after Laser Peripheral Iridotomy: A Prospective, Randomized Trial.

Ophthalmol Glaucoma 2020 May - Jun;3(3):174-180. Epub 2020 Feb 29.

Glaucoma Department, Aravind Eye Hospital, Pondicherry, India. Electronic address:

Purpose: To compare 0.1% nepafenac, a topical nonsteroidal anti-inflammatory drop, with 1% prednisolone acetate in controlling inflammation after neodymium:yttrium-aluminum-garnet laser peripheral iridotomy (LPI) in primary angle-closure suspects (PACS).

Design: Randomized controlled trial. Read More

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February 2020

Deflazacort vs prednisone treatment for Duchenne muscular dystrophy: A meta-analysis of disease progression rates in recent multicenter clinical trials.

Muscle Nerve 2020 01 7;61(1):26-35. Epub 2019 Nov 7.

Analysis Group, Inc, Boston, Massachusetts.

Introduction: In this study we characterized disease progression over 48 weeks among boys receiving deflazacort vs prednisone/prednisolone placebo arm treatment in two recent Duchenne muscular dystrophy (DMD) clinical trials.

Methods: Ambulatory boys with DMD receiving placebo in the phase 3 ataluren (N = 115) and tadalafil (N = 116) trials were included. The trials required at least 6 months of prior corticosteroid use and stable baseline dosing. Read More

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January 2020

Clinicopathologic, hemodynamic, and echocardiographic effects of short-term oral administration of anti-inflammatory doses of prednisolone to systemically normal cats.

Am J Vet Res 2019 Aug;80(8):743-755

Objective: To evaluate the clinicopathologic, hemodynamic, and echocardiographic effects of short-term administration of anti-inflammatory dosages of prednisolone to systemically normal cats.

Animals: 10 cats with allergic dermatitis and 10 healthy control cats.

Procedures: Cats with allergic dermatitis were randomly allocated to 2 groups and received 2 dosages of prednisolone (1 and 2 mg/kg/d, PO, for 7 days) in a crossover design followed by 9-day tapering and 14-day washout periods. Read More

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Comparison of Topical Application of TSG-6, Cyclosporine, and Prednisolone for Treating Dry Eye.

Cornea 2016 Apr;35(4):536-42

*Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea; and †Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.

Purpose: To compare the therapeutic effects of topical tumor necrosis factor (TNF)-α-stimulated gene/protein-6 (TSG-6) with those of cyclosporine and prednisolone eye drops in NOD.B10.H2 mice, a model for inflammation-mediated dry eye. Read More

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The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial.

Health Technol Assess 2015 Dec;19(102):1-104

Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Background: Alcoholic hepatitis (AH) is a distinct presentation of alcoholic liver disease arising in patients who have been drinking to excess for prolonged periods, which is characterised by jaundice and liver failure. Severe disease is associated with high short-term mortality. Prednisolone and pentoxifylline (PTX) are recommended in guidelines for treatment of severe AH, but trials supporting their use have given heterogeneous results and controversy persists about their benefit. Read More

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December 2015

Oral budesonide for induction of remission in ulcerative colitis.

Cochrane Database Syst Rev 2015 Oct 26(10):CD007698. Epub 2015 Oct 26.

Division of Gastroenterology & Nutrition, McMaster Children's Hospital, Hamilton Health Sciences, 1280 Main Street West, Hamilton, ON, Canada.

Background: Corticosteroids are first-line therapy for induction of remission in ulcerative colitis. Although corticosteroids may improve symptoms, they have significant adverse effects. Steroids which act topically, with less systemic side-effects may be more desirable. Read More

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October 2015

Quantifying not only bone loss, but also soft tissue swelling, in a murine inflammatory arthritis model using micro-computed tomography.

Scand J Immunol 2015 Feb;81(2):142-50

Medical Device Research Institute, School of Computer Science, Engineering & Mathematics, Flinders University, Bedford Park, SA, Australia.

In rodent models of inflammatory arthritis, bone erosion has been non-invasively assessed by micro-computed tomography (micro-CT). However, non-invasive assessments of paw swelling (oedema) are still based on clinical grading by visual evaluation, or measurements by callipers, not always reliable for the tiny mouse paws. The aim of this work was to demonstrate a novel straightforward 3D micro-CT analysis protocol capable of quantifying not only joint bone erosion, but also soft tissue swelling, from the same scans, in a rodent inflammatory arthritis model. Read More

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February 2015

Moderate zinc supplementation during prolonged steroid therapy exacerbates bone loss in rats.

Biol Trace Elem Res 2014 Sep 15;160(3):383-91. Epub 2014 Jul 15.

Centre for Nuclear Medicine, University Institute of Emerging Areas in Science and Technology (UIEAST), Panjab University, Chandigarh, 160014, India.

The present study was conducted to understand the influence of zinc on bone mineral metabolism in prednisolone-treated rats. Disturbance in bone mineral metabolism was induced in rats by subjecting them to prednisolone treatment for a period of 8 weeks. Female rats aged 6-8 weeks weighing 150 to 200 g were divided into four treatment groups, viz. Read More

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September 2014

Low-dose prednisolone treatment of early rheumatoid arthritis and late cardiovascular outcome and survival: 10-year follow-up of a 2-year randomised trial.

BMJ Open 2014 Apr 7;4(4):e004259. Epub 2014 Apr 7.

Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.

Objective: To examine the long-term effects of early low-dose prednisolone use in patients with rheumatoid arthritis (RA) on cardiovascular (CV) morbidity and mortality.

Design: Retrieval of data from a 2-year open randomised trial comparing prednisolone 7.5 mg/day in addition to disease-modifying antirheumatic drugs (DMARDs) with DMARD therapy alone. Read More

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Efficacy of perioperative high-dose prednisolone therapy during thymectomy in myasthenia gravis patients.

J Cardiothorac Surg 2013 Dec 10;8:226. Epub 2013 Dec 10.

Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Background: This study aimed to investigate the benefits of administering perioperative high-dose prednisolone in conjunction with thymectomy in patients with myasthenia gravis.

Methods: We retrospectively reviewed data from patients with Myasthenia Gravis Foundation of America Clinical Class I to IIIB who had undergone an extended thymectomy between 1992 and 2009. Perioperative high-dose prednisolone was administered at starting doses of 10 to 20 mg and escalated up to 100 mg on alternate days. Read More

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December 2013

The role of zinc on anti-Newcastle disease virus specific antibody response and agranulocytes count in rabbits treated with methotrexate and prednisolone.

Pak J Pharm Sci 2012 Oct;25(4):845-9

Lahore College of Pharmaceutical Sciences, Lahore, Pakistan.

Zinc (Zn) plays a pivotal role in highly proliferative tissues including immune system. The long-term therapy of neoplastic and autoimmune disorders is associated with immunosuppression and myleosuppression. In the current study role of Zn on anti-Newcastle disease virus response and agranulocytes count of methotrexate and prednisolone treated rabbits. Read More

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October 2012

Bell's palsy - the effect of prednisolone and/or valaciclovir versus placebo in relation to baseline severity in a randomised controlled trial.

Clin Otolaryngol 2012 Aug;37(4):283-90

Department of Otorhinolaryngology and Head & Neck Surgery, Lund University Hospital, Lund, Sweden.

Objectives: To evaluate the treatment effect of prednisolone and/or valaciclovir in Bell's palsy patients with different baseline severity of palsy.

Design: Patient data were collected from the Scandinavian Bell's Palsy Study, a prospective, randomised, double-blind, placebo-controlled, multi-centre trial.

Setting: Sixteen otorhinolaryngological centres in Sweden and one in Finland. Read More

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Screening for diabetes in patients with inflammatory rheumatological disease administered long-term prednisolone: a cross-sectional study.

Rheumatology (Oxford) 2012 Jun 12;51(6):1112-9. Epub 2012 Feb 12.

Southern Adelaide Diabetes and Endocrine Services, Repatriation General Hospital, Daw Park, Adelaide 5041, Australia.

Objective: The aim of the study was to assess the effect of long-term prednisolone on fasting and post-glucose load glucose concentration in patients with inflammatory rheumatological disease. We hypothesized that prednisolone would predominantly increase post-glucose load glucose concentration and that fasting glucose would have poor sensitivity as a screening test for diabetes in patients receiving chronic prednisolone therapy.

Methods: In a cross-sectional study of subjects with inflammatory rheumatological disease but without known diabetes, 60 subjects [age = 70 (±10) years, 62% female] who were receiving chronic (>6 months) prednisolone [6. Read More

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HIV patients treated with low-dose prednisolone exhibit lower immune activation than untreated patients.

BMC Infect Dis 2012 Jan 20;12:14. Epub 2012 Jan 20.

University of Wuerzburg, Institute of Virology und Immunobiology, 97078 Wuerzburg, Germany.

Background: HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression.

Methods: In an observational study, we determined immune activation in HIV patients receiving low-dose (5 mg/day) prednisolone with or without highly-active antiretroviral therapy (HAART) compared to patients without prednisolone treatment. Read More

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January 2012

Long-term effect of prednisolone on functional blink recovery after transient peripheral facial motor paralysis.

Otolaryngol Head Neck Surg 2012 Mar 7;146(3):448-54. Epub 2011 Nov 7.

Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands.

Objective: To determine the functional recovery in patients with severe transient peripheral facial motor paralysis (Bell palsy).

Study Design: Prospective controlled trial.

Setting: Academic medical center. Read More

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Effects of low-dose dexamethasone and prednisolone long term administration in beef calf: chemical and morphological investigation.

Anal Chim Acta 2011 Aug 11;700(1-2):95-104. Epub 2010 Dec 11.

Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Grugliasco (TO), Italy.

An analytical, pharmacokinetic and histopathologic investigation was conducted by two experimental trials on beef cattle in order to determine fate and effects of dexamethasone and prednisolone, administered to distinct cattle groups at low dosage for long periods of time. In trial 1, eighteen Charolaise beef cattle, male, 17-22-months-old, were divided in three groups: to group A (n=6) dexamethasone-21-sodium-phosphate 0.7 mg day(-1) per os for 40 days was administered; group B (n=6) was orally treated with prednisolone 15 mg day(-1) for 30 days, while group C (n=6) served as negative control. Read More

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[Prednisolone treatment for Duchenne muscular dystrophy].

No To Hattatsu 2011 Jan;43(1):24-9

Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga.

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder and is the most common form of muscular dystrophy. Affected children develop muscle weakness in early childhood. Only steroids have been shown with evidence to improve muscle function in patients with DMD. Read More

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January 2011

Evaluation of therapeutic interventions for vaccinia virus keratitis.

J Infect Dis 2011 Mar 28;203(5):683-90. Epub 2011 Jan 28.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, WI 53706, USA.

Background: Vaccinia virus keratitis (VACVK) is a complication of smallpox vaccination that can result in blindness. There are no Food and Drug Administration-approved treatments for VACVK, and vaccinia immunoglobulin (VIG) is contraindicated in isolated VACVK. We used a rabbit model of infection to compare several therapeutic options for VACVK. Read More

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The effects of dexamethasone and prednisolone on pituitary and ovarian function in the mare.

Equine Vet J 2010 Jul;42(5):438-43

Equine Reproduction Laboratory, Colorado State University, USA.

Reasons For Performing Study: Persistent mating induced endometritis is among the most common causes of infertility in the mare. Recently, improved pregnancy rates have been reported when corticosteroids were administered to 'problem mares' specifically, to modulate the post mating inflammatory response; however, the effect of treatment on pituitary and ovarian function requires further study.

Objectives: To evaluate the effects of prolonged treatment with glucocorticoids on pituitary and ovarian function. Read More

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Acute viral myocarditis: role of immunosuppression: a prospective randomised study.

Cardiol Young 2010 Oct 28;20(5):509-15. Epub 2010 Jun 28.

Department of Paediatric Cardiology, National Institute of Cardiovascular Diseases, Karachi, Pakistan.

Objective: To conduct a prospective randomised study to show the efficacy of immune suppression with prednisolone, administered at the 3-month duration of acute myocarditis.

Methods: The diagnosis of acute viral myocarditis was made based on echocardiography and serum viral antibodies. The inclusion criterion was acute myocarditis of 3 months duration. Read More

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October 2010

Effects of steroidal and nonsteroidal drugs on tooth movement and root resorption in the rat molar.

Angle Orthod 2009 Jul;79(4):715-26

Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Objective: To test the hypothesis that the administration of aspirin, acetaminophen, meloxicam, celecoxib, and prednisolone have no effect on root resorption and tooth movement.

Materials And Methods: A mesial force of 50 g was applied to the left maxillary first molars of sixty 10-week-old male Wistar rats using nickel titanium closed coil springs attached to the cervical area of the incisors. The rats were randomly divided into 12 groups of 5 each. Read More

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Long-term renal prognosis of IgA nephropathy with therapeutic trend shifts.

Intern Med 2009 1;48(11):883-90. Epub 2009 Jun 1.

Department of Internal Medicine, University of Tokyo, Tokyo.

Objective: We compared the effect of treatments in the long-term renal survival of IgA nephropathy.

Methods: One hundred and fourteen patients with biopsy-proven IgA nephropathy were retrospectively divided into 4 groups, reflecting shifts in treatment trends from 1985 to 2005: patients without treatment (no treatment group; n=36), patients treated only with anti-platelet drugs (anti-platelet group; n=12), those treated mainly with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) (ACEI/ARB group; n =29), and prednisolone-treated patients (PSL group; n =37).

Results: Baseline blood pressure, serum creatinine and renal histological findings were similar among the 4 groups; however, the urinary protein level was significantly severer in the PSL group. Read More

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Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats.

Growth Horm IGF Res 2009 Oct 23;19(5):426-31. Epub 2009 Feb 23.

Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark.

Objectives: Growth hormone (GH) reduces the catabolic side effects of steroid treatment via effects on the amino-nitrogen metabolism. Ipamorelin is a synthetic peptide with GH releasing properties. We wished to study the metabolic effects of Ipamorelin and GH on selected hepatic measures of alpha-amino-nitrogen conversion during steroid-induced catabolism. Read More

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October 2009

Anti-inflammatory properties of desipramine and fluoxetine.

Respir Res 2007 May 3;8:35. Epub 2007 May 3.

Inserm, U454, Montpellier, France.

Background: Antidepressants are heavily prescribed drugs and have been shown to affect inflammatory signals. We examined whether these have anti-inflammatory properties in animal models of septic shock and allergic asthma. We also analysed whether antidepressants act directly on peripheral cell types that participate in the inflammatory response in these diseases. Read More

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Benefits of Zataria multiflora Boiss in Experimental Model of Mouse Inflammatory Bowel Disease.

Evid Based Complement Alternat Med 2007 Mar 14;4(1):43-50. Epub 2006 Sep 14.

Laboratory of Toxicology, Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Laboratory of Pharmacognosy, Faculty of Pharmacy and Medicinal Plants Research Center and Laboratory of Histopathology, School of Medicine, Tehran University of Medical Sciences Tehran, Iran.

Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested to examine the effect of total extract from Zataria multiflora Boiss, a folk medicinal plant on prevention and treatment of experimental IBD. Z. Read More

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Beneficial effect of phosphodiesterase-5 inhibitor in experimental inflammatory bowel disease; molecular evidence for involvement of oxidative stress.

Toxicol Mech Methods 2007 ;17(5):281-8

Laboratory of Toxicology, Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran, Iran.

ABSTRACT Inflammatory bowel disease (IBD) is a common and chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. Reactive oxygen metabolites (ROMs) play a pathogenic role in IBD. We aimed to examine the protective effect of sildenafil, a cGMP phosphodiesterase inhibitor, in the experimental mouse model of IBD. Read More

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October 2012

Protection by Ziziphora clinopoides of acetic acid-induced toxic bowel inflammation through reduction of cellular lipid peroxidation and myeloperoxidase activity.

Hum Exp Toxicol 2006 Jun;25(6):325-32

Department of Toxicology and Pharmacology, Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involving multiple immune, genetic and environmental factors. We were interested in examining the effect of a total extract from Ziziphora clinopoides, an Iranian folk herbal medicine, in the prevention and control of experimental mouse IBD. Z. Read More

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