3,410 results match your criteria predisposed increased

Inhibitory G protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart.

Heart Rhythm 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmacology, Hebei Medical University; The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province. Electronic address:

Background: Slow delayed rectifier potassium current (I) is an important component of repolarization reserve during sympathetic nerve excitement. However, little is known about age-related functional changes of I and its involvement in age-dependent arrhythmogenesis.

Objective: To investigate age-related alteration of the I response to β-adrenergic receptor (βAR) activation. Read More

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September 2021

Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation.

Hepatol Commun 2021 Aug 25. Epub 2021 Aug 25.

Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA.

Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetically mediated remain unclear due in part to a lack of appropriate, patient-specific, in vitro models. Recently, our group developed systems to create induced pluripotent stem cell (iPSC)-derived cholangiocytes (iDCs) and biliary epithelial organoids (cholangioids). Read More

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Preclinical and clinical evidence of NAD precursors in health, disease, and ageing.

Mech Ageing Dev 2021 Sep 10;199:111567. Epub 2021 Sep 10.

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478, Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway. Electronic address:

NAD is a fundamental molecule in human life and health as it participates in energy metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or death. Emerging evidence from preclinical and human studies indicates an age-dependent reduction of cellular NAD, possibly due to reduced synthesis and increased consumption. In preclinical models, NAD repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases. Read More

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September 2021

Common Variants of the gene Are Associated with Osteoporosis Risk: A Meta-Analysis.

Genet Test Mol Biomarkers 2021 Sep 9. Epub 2021 Sep 9.

Department of Orthopedic Trauma, Yuncheng Central Hospital, Shanxi Medical University, Yuncheng, China.

The RANKL/RANK/OPG signaling pathway plays a critical role in osteoclastogenesis and bone remodeling. The associations between sequence variants of the osteoprotegerin () gene and osteoporosis risk have been widely investigated but remain inconclusive. We performed a meta-analysis to evaluate the associations between gene variants and osteoporosis risk. Read More

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September 2021

Was Sleep a Problem for the Elderly During COVID-19?

Sleep Vigil 2021 Sep 6:1-7. Epub 2021 Sep 6.

Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore, Karnataka 575018 India.

Over the past few decades, the population of geriatrics has seen an exponential rise and it is well known that the prevalence of chronic diseases and other associated comorbidities is higher among them which in turn, has an established association with sleep disorders. During these unprecedented circumstances, geriatrics are predisposed to be at an increased risk of sleep disorders due to the social isolation and loneliness imposed on them by the lockdowns. The fact that older adults are at a greater risk of contracting the virus due to the presence of comorbidities and the high virulence adds on to the existing risk of sleep disturbances. Read More

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September 2021

Attributable risks of hospitalizations for urologic diseases due to heat exposure in Queensland, Australia, 1995-2016.

Int J Epidemiol 2021 Sep 11. Epub 2021 Sep 11.

Department of Epidemiology, School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, China.

Background: Heat exposure is a risk factor for urologic diseases. However, there are limited existing studies that have examined the relationship between high temperatures and urologic disease. The aim of this study was to examine the associations between heat exposure and hospitalizations for urologic diseases in Queensland, Australia, during the hot seasons of 1995-2016 and to quantify the attributable risks. Read More

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September 2021

Status of Thyroid Disorder among the Thyroid Function Test Samples Received in a Laboratory among Postmenopausal Women: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Feb 28;59(234):170-175. Epub 2021 Feb 28.

Department of Pathology, Nepalese Army Institute of Health Sciences Bhandarkhal, Kathmandu, Nepal.

Introduction: Thyroid dysfunction prevalence is high in females worldwide which increases with age. Postmenopausal and elderly women are particularly at risk of developing comorbidities and mortality related to thyroid dysfunction. We aimed to study the prevalence of thyroid dysfunction in postmenopausal women in the National Reference Laboratory of Nepal. Read More

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February 2021

The Role of Epigenetic Factors in Psoriasis.

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Centre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 137, Wołoska St., 02-507 Warsaw, Poland.

Psoriasis is a chronic, systemic, immune-mediated disease with an incidence of approximately 2%. The pathogenesis of the disease is complex and not yet fully understood. Genetic factors play a significant role in the pathogenesis of the disease. Read More

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Frequency and predisposing factors for canine otitis externa in the UK - a primary veterinary care epidemiological view.

Canine Med Genet 2021 Sep 7;8(1). Epub 2021 Sep 7.

Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts, AL9 7TA, UK.

Background: Otitis externa is a commonly diagnosed disorder in dogs and can carry a high welfare impact on affected animals. This study aimed to report the prevalence and explore the role of breed and aural conformation as predisposing factors for canine otitis externa in the UK. The study used a cohort design of dogs under UK primary veterinary care at clinics participating in the VetCompass Programme during 2016. Read More

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September 2021

Resting state functional connectivity responses post-mild traumatic brain injury: a systematic review.

Brain Inj 2021 Sep 6:1-12. Epub 2021 Sep 6.

Sports Medicine Research Institute, University of Kentucky, Lexington, Kentucky, USA.

Mild traumatic brain injuries (mTBI) are associated with functional network connectivity alterations throughout recovery. Yet, little is known about the adaptive or maladaptive nature of post-mTBI connectivity and which networks are predisposed to altered function and adaptation. The objective of this review was to determine functional connectivity changes post-mTBI and to determine the adaptive or maladaptive nature of connectivity through direct comparisons of connectivity and behavioral data. Read More

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September 2021

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats.

Clin Sci (Lond) 2021 Sep;135(17):2143-2163

Laboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyzed the effects of CRP overexpression on cardiac susceptibility to ischemia/reperfusion (I/R) injury in adult spontaneously hypertensive rats (SHR) expressing human CRP transgene (SHR-CRP). Using an in vivo model of coronary artery occlusion, we found that transgenic expression of CRP predisposed SHR-CRP to repeated and prolonged ventricular tachyarrhythmias. Read More

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September 2021

Long-Term Effects of Maternal Low-Protein Diet and Post-weaning High-Fat Feeding on Glucose Metabolism and Hypothalamic POMC Promoter Methylation in Offspring Mice.

Front Nutr 2021 16;8:657848. Epub 2021 Aug 16.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Substantial evidence indicated that maternal malnutrition could increase the susceptibility to obesity, insulin resistance, and type 2 diabetes in adulthood. It is increasingly apparent that the brain, especially the hypothalamus, plays a critical role in glucose homeostasis. However, little information is known about the mechanisms linking maternal protein restriction combined with post-weaning high-fat (HF) feeding with altered expression of brain neurotransmitters, and investigations into the epigenetic modifications of hypothalamus in offspring have not been fully elucidated. Read More

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New in vivo model to assess macroscopic, histological, and molecular changes in Peyronie's disease.

Andrology 2021 Aug 31. Epub 2021 Aug 31.

ABC Medical School, Urologic Department, Santo Andre, Brazil.

Background: Peyronie's Disease (PD) is a connective tissue disorder that affects the tunica albuginea (TA) of the penis causing curvature and erectile dysfunction. The pathophysiology is not well understood and, for this reason, treatment options are limited.

Objective: The aim of the present study is to analyze and compare whether single or multiple instillations of plasma in the TA of rats is capable of triggering macroscopic, histopathological, and molecular changes consistent with PD. Read More

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Effect of Alkaline Drinking Water on Bone Density of Postmenopausal Women with Osteoporosis.

J Menopausal Med 2021 Aug;27(2):94-101

Clinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Objectives: Postmenopausal women are predisposed to osteoporosis, and those on acidic diets are at a higher risk, because it has been demonstrated that such diets have adverse effects on bone health. In this study, the effect of alkaline drinking water on bone mineral density was evaluated in postmenopausal women with osteoporosis.

Methods: One hundred postmenopausal women with osteoporosis (T-score ≤ -2. Read More

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Do Positive Emotions Make You More Prosocial? Direct and Indirect Effects of an Intervention Program on Prosociality in Colombian Adolescents During Social Isolation Due to COVID-19.

Front Psychol 2021 12;12:710037. Epub 2021 Aug 12.

Instituto de Filosofía, Universidad Austral, Pilar, Argentina.

The objectives of this study are to analyze the efficacy of the Virtual Hero Program during the social isolation due to COVID-19 to increase the positive emotions (joy, gratitude, serenity, personal satisfaction, and sympathy) and prosocial behavior of Colombian adolescents. Additionally, we will analyze whether the Hero program, by directly promoting positive emotional states in adolescents, can predispose them to take prosocial actions toward other people (via an indirect or mediated effect). The final sample of the study comprised 100 participants from the intervention group ( age = 13. Read More

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The expansion of CD14+ CD163+ subpopulation of monocytes and myeloid cells-associated cytokine imbalance; candidate diagnostic biomarkers for celiac disease (CD).

J Clin Lab Anal 2021 Aug 27:e23984. Epub 2021 Aug 27.

Department of Immunology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Celiac disease (CD) is a chronic autoimmune disorder of small intestine against dietary gluten, among genetically predisposed individuals. Monocytes are versatile innate immune cells involved in the regulation of inflammation, and strongly involved in the intestinal immunity. However, the role of monocytes and their subtypes in CD is not well demonstrated. Read More

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Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.

PLoS One 2021 27;16(8):e0245408. Epub 2021 Aug 27.

Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.

Aim And Objective: The aim of the study was to investigate the relationships between insulin receptor substrate (IRS) 1 (Gly972Arg) and IRS2 (Gly1057Asp) genes with obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) in Asian Indians.

Method: A total of 410 overweight/obese subjects (130 with OSA with NAFLD, 100 with OSA without NAFLD, 95 without OSA and with NAFLD and 85 without OSA and without NAFLD) were recruited. Degree of NAFLD was based on liver ultrasound and of OSA on overnight polysomnography. Read More

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Clinical Spectrum of Cutaneous Malignancies in Central India: A Retrospective Study.

Indian J Dermatol 2021 May-Jun;66(3):284-290

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

Introduction: Cutaneous malignancies account for 1%-2% of all the diagnosed cancers in India. Nonmelanoma skin cancers (NMSCs) include basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). Others include melanoma, cutaneous lymphomas, and sarcomas. Read More

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The Impact of the COVID-19 Pandemic on Pregnant Women with Perinatal Anxiety Symptoms in Pakistan: A Qualitative Study.

Int J Environ Res Public Health 2021 08 4;18(16). Epub 2021 Aug 4.

Human Development Research Foundation, House No 06, Street No 55, F-7/4, Islamabad 44000, Pakistan.

The impact of coronavirus disease 2019 (COVID-19) on people with existing mental health conditions is likely to be high. We explored the consequences of the pandemic on women of lower socioeconomic status with prenatal anxiety symptoms living in urban Rawalpindi, Pakistan. This qualitative study was embedded within an ongoing randomized controlled trial of psychosocial intervention for prenatal anxiety at a public hospital in Rawalpindi. Read More

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Host Age and Denture Wearing Jointly Contribute to Oral Colonization with Intrinsically Azole-Resistant Yeasts in the Elderly.

Microorganisms 2021 Jul 30;9(8). Epub 2021 Jul 30.

Institute for Medical Microbiology and Virology, University Medical Center Göttingen, 37075 Göttingen, Germany.

In elderly patients, several morbidities or medical treatments predisposing for fungal infections occur at a higher frequency, leading to high mortality and morbidity in this vulnerable patient group. Often, this is linked to an innately azole-resistant yeast species such as or . Additionally, host age per se and the wearing of dentures have been determined to influence the mix of colonizing species and, consequently, the species distribution of invasive fungal infections. Read More

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Heavy Metals in the Environment and Thyroid Cancer.

Cancers (Basel) 2021 Aug 12;13(16). Epub 2021 Aug 12.

Endocrinology, Garibaldi-Nesima Medical Center, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, Italy.

In recent decades, the incidence of thyroid cancer has increased more than most other cancers, paralleling the generalized worldwide increase in metal pollution. This review provides an overview of the evidence supporting a possible causative link between the increase in heavy metals in the environment and thyroid cancer. The major novelty is that human thyroid stem/progenitor cells (thyrospheres) chronically exposed to different metals at slightly increased environmentally relevant concentrations show a biphasic increase in proliferation typical of hormesis. Read More

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Depression and Its Effect on the Menstrual Cycle.

Cureus 2021 Jul 21;13(7):e16532. Epub 2021 Jul 21.

Internal Medicine, JC Medical Center, Orlando, USA.

A strong association is noted between depression and early perimenopause as well as menopause. The association was found to be the greatest in women with natural menopause at the age less than 40 years. Excessive corticotropin-releasing hormone (CRH) levels in depression lead to inhibition of the hypothalamic-pituitary-gonadal (HPG) axis and increased cortisol levels which further inhibits the action of gonadotropin-releasing hormone (GnRH) neurons, gonadotrophs, and gonads. Read More

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Reshaping the murine immunoglobulin heavy chain repertoire with bovine DH genes.

Immunology 2021 Aug 24. Epub 2021 Aug 24.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.

Having a limited number of VH segments, cattle rely on uniquely long DH gene segments to generate CDRH3 length variation (3-70 aa) far greater than that in humans or mice. Bovine antibodies with ultralong CDRH3s (>50 aa) possess unusual structures and abilities to bind to special antigens. In this study, we replaced most murine endogenous DH segments with bovine DH genes, generating a mouse line termed B-DH. Read More

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Prospective observational study of young adult ischemic stroke patients.

Brain Behav 2021 Sep 22;11(9):e2283. Epub 2021 Aug 22.

Department of Medicine, Kaplan Medical Center, Rehovot, Israel.

Objective: Ischemic stroke (IS) in young patients may differ in etiology and prognosis from later-life IS, which is much more common. A number of single-center and population-based cohorts of affected individuals have been published, but information on the long-term prognosis of these patients is limited.

Methods: IS patients (≤55 years), discharged over a 10-year period, were evaluated and prospectively followed. Read More

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September 2021

GABA Receptor-Mediated Impairment of Intermediate Progenitor Maturation During Postnatal Hippocampal Neurogenesis of Newborn Rats.

Front Cell Neurosci 2021 6;15:651072. Epub 2021 Aug 6.

Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

The neurotransmitter GABA and its receptors assume essential functions during fetal and postnatal brain development. The last trimester of a human pregnancy and early postnatal life involves a vulnerable period of brain development. In the second half of gestation, there is a developmental shift from depolarizing to hyperpolarizing in the GABAergic system, which might be disturbed by preterm birth. Read More

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Identifying neurocognitive outcomes and cerebral oxygenation in critically ill adults on acute kidney replacement therapy in the intensive care unit: the INCOGNITO-AKI study protocol.

BMJ Open 2021 08 17;11(8):e049250. Epub 2021 Aug 17.

Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada

Introduction: Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and associated with increased morbidity and mortality. KRT has been linked to poor neurocognitive outcomes, leading to reduced quality of life and increased utilisation of healthcare resources. Adults on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisposed to developing cerebrovascular disease and cognitive dysfunction long-term relative to healthy controls. Read More

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Mucormycosis in COVID-19 pandemic: Risk factors and linkages.

Curr Res Microb Sci 2021 Dec 8;2:100057. Epub 2021 Aug 8.

ICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.

Mucormycosis is a serious and potentially fatal fungal infection caused by a type of rare but opportunistic fungal pathogen called mucormycetes. Recently, mucormycosis, also known as black fungus, made severe chaos in India during the second wave (between April and June 2021) of the tragical COVID-19 epidemic by its sudden and devastating surge with up to 50% mortality rate. While the exact cause of its sharp rise suddenly and specifically during the second wave still remains debatable, it has been noted that the people who are diabetic and have recovered from COVID-19 infection are more predisposed to mucormycosis. Read More

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December 2021

Cumulative Social Risk and Child Screen Use: The Role of Child Temperament.

J Pediatr Psychol 2021 Aug 13. Epub 2021 Aug 13.

Psychology Department, University of Calgary, Calgary, AB, Canada.

Objectives: It is critical to understand what children, and in which context, are at risk for high levels of screen use. This study examines whether child temperament interacts with cumulative social risk to predict young children's screen use and if the results are consistent with differential susceptibility or diathesis-stress models.

Methods: Data from 1,992 families in Calgary, Alberta (81% White; 47% female; 94% >$40,000 income) from the All Our Families cohort were included. Read More

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Epidemiology of periodontal disease in dogs in the UK primary-care veterinary setting.

J Small Anim Pract 2021 Aug 9. Epub 2021 Aug 9.

Department of Pathobiology and Population Sciences, The Royal Veterinary College, Herts, AL9 7TA, UK.

Objectives: Periodontal disease is a frequent diagnosis of dogs and can have severe negative impacts on welfare. It was hypothesised that breeds with skull shapes that differ most in conformation from the moderate mesocephalic skull shape have higher odds of periodontal disease.

Materials And Methods: The cohort study included a random sample of dogs under primary veterinary care in 2016 from the VetCompass Programme database. Read More

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Value of quantitative ultrasound and bioelectrical impedance analysis in detecting low bone mineral density in hemodialysis.

Ren Fail 2021 Dec;43(1):1198-1204

Nutrition Department, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Introduction: Patients on maintenance hemodialysis (MHD) are highly predisposed to low bone mineral density (BMD). This study aims to assess the value of quantitative ultrasound (QUS), bioelectrical impedance analysis (BIA), and their combination in detecting high-risk patients for low BMD in MHD.

Methods: Patients' BMD of the total hip, femoral neck, and lumbar spine were measured using dual-energy X-ray absorptiometry (DXA). Read More

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December 2021