56,551 results match your criteria predicted lower


Evidence for efficient non-evaporative leaf-to-air heat dissipation in a pine forest under drought conditions.

New Phytol 2021 Sep 18. Epub 2021 Sep 18.

Earth & Planetary Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.

Drier climates predicted for many regions result in reduced evaporative cooling leading to leaf heat stress and enhanced mortality. The extent to which non-evaporative cooling can contribute to plant resilience to the increasingly stressful conditions is poorly known at present. Using a novel, high accuracy infrared system for continuous measurements of leaf temperature in mature trees under field conditions, we assessed leaf-to-air temperature differences (ΔT ) of pine needles during drought. Read More

View Article and Full-Text PDF
September 2021

Association of sarcopenia and expression of interleukin-23 in colorectal cancer survival.

Clin Nutr 2021 Aug 30;40(10):5322-5326. Epub 2021 Aug 30.

Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Kaohsiung, Taiwan; Department of Pediatric Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background & Aims: The relationship between sarcopenia and interleukin-23 (IL-23) has not been reported. We designed this study to investigate this relationship and the association of sarcopenia and interleukin-23 with poor prognosis of colorectal cancer.

Methods: We used the %FINDCUT SAS macro to determine the cutpoints of the skeletal muscle index (SMI) to define sarcopenia in colorectal cancer patients. Read More

View Article and Full-Text PDF

Injection and Non-Injection Drug Use Among Adults with Diagnosed HIV in the United States, 2015-2018.

AIDS Behav 2021 Sep 18. Epub 2021 Sep 18.

Division of HIV Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, US8-4, Atlanta, GA, 30329-4027, USA.

Understanding behavioral characteristics and health outcomes of people with HIV (PWH) who inject drugs and PWH who use drugs, but do not inject, can help inform public health interventions and improve HIV clinical outcomes. However, recent, nationally representative estimates are lacking. We used 2015-2018 Medical Monitoring Project data to examine health outcome differences among adults with diagnosed HIV who injected drugs or who only used non-injection drugs in the past year. Read More

View Article and Full-Text PDF
September 2021

Regression in melanoma is significantly associated with a lower regional recurrence rate and better recurrence-free survival.

J Surg Oncol 2021 Sep 17. Epub 2021 Sep 17.

Division of Surgical Oncology, Oregon Health & Science University, Portland, Oregon, USA.

Background And Objectives: The prognostic significance of regression in predicting melanoma recurrences is unknown. We present a large multicenter study correlating regression with recurrence.

Methods: The Sentinel Lymph Node Working Group database was queried from 1993 to 2018 for cases with regression data. Read More

View Article and Full-Text PDF
September 2021

The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study.

Eur Arch Psychiatry Clin Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Nussbaumstr. 7, 80336, Munich, Germany.

Background: Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. Read More

View Article and Full-Text PDF
September 2021

A novel variant in DYNC1H1 could contribute to human amyotrophic lateral sclerosis-frontotemporal dementia spectrum.

Cold Spring Harb Mol Case Stud 2021 Sep 17. Epub 2021 Sep 17.

Laboratory of Neurogenetics, Department of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.

Amyotrophic lateral sclerosis (ALS) belongs to the ALS-frontotemporal dementia (FTD) spectrum and is hallmarked by upper and lower motor neuron degeneration. Here, we present a patient with a cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) pathogenic variant who fulfilled the ALS El Escorial criteria, and we review relevant literature. Using whole-exome sequencing, we identified a deleterious point variant in DYNC1H1 [c. Read More

View Article and Full-Text PDF
September 2021

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Crit Care 2021 Sep 17;25(1):341. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Objective: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.

Design: Prospective cohort study with independent replication cohort. Read More

View Article and Full-Text PDF
September 2021

Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Institute of Immunology, Hannover Mecial School, Germany.

Donor lymphocyte infusion (DLI) is a standard of care for relapse of AML after allogeneic hematopoietic stem cell transplantation (aHSCT). Currently it is poorly understood how and when CD8+ αβ T cells exert graft-versus-leukemia (GvL) activity after DLI. Also, there is no reliable biomarker to monitor GvL activity of the infused CD8+ T cells. Read More

View Article and Full-Text PDF
September 2021

Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons.

PLoS Comput Biol 2021 Sep 17;17(9):e1009371. Epub 2021 Sep 17.

Department of Cell Biology and Anatomy, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.

Two subpopulations of midbrain dopamine (DA) neurons are known to have different dynamic firing ranges in vitro that correspond to distinct projection targets: the originally identified conventional DA neurons project to the dorsal striatum and the lateral shell of the nucleus accumbens, whereas an atypical DA population with higher maximum firing frequencies projects to prefrontal regions and other limbic regions including the medial shell of nucleus accumbens. Using a computational model, we show that previously identified differences in biophysical properties do not fully account for the larger dynamic range of the atypical population and predict that the major difference is that originally identified conventional cells have larger occupancy of voltage-gated sodium channels in a long-term inactivated state that recovers slowly; stronger sodium and potassium conductances during action potential firing are also predicted for the conventional compared to the atypical DA population. These differences in sodium channel gating imply that longer intervals between spikes are required in the conventional population for full recovery from long-term inactivation induced by the preceding spike, hence the lower maximum frequency. Read More

View Article and Full-Text PDF
September 2021

Accurate Distinction of Ovarian Clear Cell From Endometrioid Carcinoma Requires Integration of Phenotype, Immunohistochemical Predictions, and Genotype: Implications for Lynch Syndrome Screening.

Am J Surg Pathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pathology, University of Calgary Division of Gynecologic Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB Cancer Control Research, BC Cancer Agency Department of Pathology and Laboratory Medicine, BC Cancer, Vancouver, BC, Canada Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA.

Ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are both associated with endometriosis but differ in histologic phenotype, biomarker profile, and survival. Our objectives were to refine immunohistochemical (IHC) panels that help distinguish the histotypes and reassess the prevalence of mismatch repair deficiency (MMRd) in immunohistochemically confirmed OCCC. We selected 8 candidate IHC markers to develop first-line and second-line panels in a training set of 344 OCCC/OEC cases. Read More

View Article and Full-Text PDF
September 2021

Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an approach.

J Biomol Struct Dyn 2021 Sep 17:1-16. Epub 2021 Sep 17.

Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.

Although Varicella or chickenpox infection which is caused by the varicella-zoster virus (VZV) has significantly been managed through vaccination, it remains an infection that poses threats to the nearest future due to therapeutic drawbacks. The focus of this research was geared towards screening for the identification of novel compounds in plants of ethnopharmacological relevance in the treatment of chicken pox in West Africa. The work evaluated 65 compounds reported to be present in and to identify potential inhibitors of thymidine kinase, the primary drug target of varicella zoster virus. Read More

View Article and Full-Text PDF
September 2021

Expression profiles of tyrosine metabolic pathway genes and functional analysis of DOPA decarboxylase in puparium tanning of Bactrocera dorsalis (Hendel).

Pest Manag Sci 2021 Sep 16. Epub 2021 Sep 16.

Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, 400715, China.

Background: Tanning is an important physiological process that play the critical roles in affecting cuticle pigmentation and sclerotization. Previous studies have showed that insect cuticle tanning was closely associated with tyrosine metabolism pathway that consisted of a series of enzymes.

Results: In this study, a total of 24 tyrosine metabolism pathway genes were identified in the oriental fruit fly Bactrocera dorsalis (Hendel) genome. Read More

View Article and Full-Text PDF
September 2021

Analysis of hand environment factors contributing to the hand surface infection barrier imparted by lactic acid.

Skin Res Technol 2021 Sep 16. Epub 2021 Sep 16.

Personal Health Care Products Research Laboratories, Kao Corporation, Tokyo, Japan.

Background: Organic acids on the surface of human hands contribute to the barrier against transient pathogens. This is the first study to explore the synergistic contribution of lactic acid and other hand environment-related features on the antibacterial properties of the hand surface.

Materials And Methods: We estimated the contribution of fingerprint depth, skin pH, stratum corneum water content, skin temperature, and sweat rate of the hands to the infection barrier using an observational survey of 105 subjects. Read More

View Article and Full-Text PDF
September 2021

Cost Effectiveness of Durvalumab in Unresectable Stage III NSCLC: 4-Year Survival Update and Model Validation from a UK Healthcare Perspective.

Pharmacoecon Open 2021 Sep 16. Epub 2021 Sep 16.

Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Background: In the phase III PACIFIC study, durvalumab improved survival versus placebo in patients with unresectable stage III non-small-cell lung cancer (NSCLC) whose disease had not progressed after platinum-based concurrent chemoradiotherapy. The appraisal by the UK's National Institute for Health and Care Excellence (NICE) included a cost-effectiveness analysis based on an early data readout from PACIFIC [March 2018 data cut-off (DCO); median follow-up duration 25.2 months; range 0. Read More

View Article and Full-Text PDF
September 2021

The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers.

J Bone Miner Metab 2021 Sep 17. Epub 2021 Sep 17.

Departments of Endocrinology, Christian Medical College and Hospital, Vellore, India.

Introduction: There is dearth of data on prevalent vertebral fractures in perimenopausal women in India and limited literature on the utility of FSH, AMH and estradiol in evaluating bone health them. The objective was to study the prevalence of vertebral fractures (VF) and to assess the utility of FSH, estradiol and AMH in predicting them in Indian perimenopausal women MATERIALS AND METHODS: It was a cross-sectional study. Perimenopausal women aged 40-49 years underwent assessment for prevalent vertebral fractures, bone mineral density (BMD) and trabecular bone score (TBS). Read More

View Article and Full-Text PDF
September 2021

Bioinformatics analysis based on immune-autophagy-related lncRNAs combined with immune infiltration in bladder cancer.

Transl Androl Urol 2021 Aug;10(8):3440-3455

Department of Urology, Maoming People's Hospital, Maoming, China.

Background: To construct a prognostic model based on immune-autophagy-related long noncoding RNA (IArlncRNAs), mainly to predict the overall survival rate (OS) of bladder cancer patients and investigate its possible mechanisms.

Methods: Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. We identified the IArlncRNA by co-expression analysis, differential expression analysis, and Venn analysis. Read More

View Article and Full-Text PDF

Low winter precipitation, but not warm autumns and springs, threatens mountain butterflies in middle-high mountains.

PeerJ 2021 27;9:e12021. Epub 2021 Aug 27.

Institute of Entomology, Czech Academy of Sciences, Biology Centre, Ceske Budejovice, Czech Republic.

Low-elevation mountains represent unique model systems to study species endangered by climate warming, such as subalpine and alpine species of butterflies. We aimed to test the effect of climate variables experienced by butterflies during their development on adult abundances and phenology, targeting the key climate factors determining the population dynamics of mountain insects. We analysed data from a long-term monitoring of adults of two subalpine and alpine butterfly species, and (Nymphalidae: Satyrinae) in the Jeseník Mts and Krkonoše Mts (Czech Republic). Read More

View Article and Full-Text PDF

Decreased albumin-to-alkaline phosphatase ratio predicted poor survival of resectable gastric cancer patients.

J Gastrointest Oncol 2021 Aug;12(4):1338-1350

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: The albumin-to-alkaline phosphatase ratio (AAPR) is an innovative prognostic index for various cancer patients, the clinical significance of the AAPR in patients with GC is unknown.

Methods: We retrospectively reviewed 227 resectable GC patients in our center. The Kaplan-Meier method and the Cox proportional hazards model were used to analyze the disease-free survival (DFS) and overall survival (OS). Read More

View Article and Full-Text PDF

Evaluation of organochlorine pesticide residues in , , and in Bloemfontein markets, South Africa.

Food Sci Nutr 2021 Sep 29;9(9):4770-4779. Epub 2021 Jul 29.

Department of Life Sciences Central University of Technology Bloemfontein South Africa.

This study evaluated the level of selected pesticide residues in the staple vegetables;   .  (cabbage), .  (Swiss chard), and   (potato) from fresh produce markets in the city of Bloemfontein, South Africa. Read More

View Article and Full-Text PDF
September 2021

Fibrinogen Level Combined With Platelet Count for Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy.

Front Neurol 2021 31;12:716020. Epub 2021 Aug 31.

Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

A serious complication of acute ischemic stroke (AIS) after mechanical thrombectomy (MT) is hemorrhagic transformation (HT), which is potentially associated with clinical deterioration. This study examined predictors of HT following MT in AIS patients. Patients with AIS due to large artery occlusion in the anterior circulation, treated with MT and successfully recanalized (modified Thrombolysis in Cerebral Infarction score 2b/3), were studied retrospectively. Read More

View Article and Full-Text PDF

Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma.

Int J Gen Med 2021 10;14:5549-5561. Epub 2021 Sep 10.

Department of Thyroid and Breast Surgery, The Union Jiangnan Hospital, Huazhong University of Science and Technology, Wuhan, 430200, Hubei, People's Republic of China.

Objective: Function of calmin (CLMN) was rarely reported in human diseases, especially in tumor. Present study initially assessed the significance of CLMN in breast invasive carcinoma (BRCA).

Methods: Expressions of CLMN containing mRNA and protein in BRCA was firstly assessed, and association of CLMN mRNA expression with clinical phenotypes of BRCA patients was analyzed as well. Read More

View Article and Full-Text PDF
September 2021

A Higher Foci Density of Interstitial Fibrosis and Tubular Atrophy Predicts Progressive CKD after a Radical Nephrectomy for Tumor.

J Am Soc Nephrol 2021 Jun 18. Epub 2021 Jun 18.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota

Background: Chronic tubulointerstitial injury on kidney biopsy is usually quantified by the percentage of cortex with interstitial fibrosis/tubular atrophy (IF/TA). Whether other patterns of IF/TA or inflammation in the tubulointerstitium have prognostic importance beyond percentage IF/TA is unclear.

Methods: We obtained, stained, and digitally scanned full cortical thickness wedge sections of renal parenchyma from patients who underwent a radical nephrectomy for a tumor over 2000-2015, and morphometrically analyzed the tubulointerstitium of the cortex for percentage IF/TA, IF/TA density (foci per mm cortex), percentage subcapsular IF/TA, striped IF/TA, percentage inflammation (both within and outside IF/TA regions), and percentage subcapsular inflammation. Read More

View Article and Full-Text PDF

External Validation of the SYNTAX Score II 2020.

J Am Coll Cardiol 2021 Sep;78(12):1227-1238

Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland; NHLI, Imperial College London, London, United Kingdom. Electronic address:

Background: The SYNTAX score II 2020 (SSII-2020) was derived from cross correlation and externally validated in randomized trials to predict death and major adverse cardiac and cerebrovascular events (MACE) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with 3-vessel disease (3VD) and/or left main coronary artery disease (LMCAD).

Objectives: The authors aimed to investigate the SSII-2020's value in identifying the safest modality of revascularization in a non-randomized setting.

Methods: Five-year mortality and MACE were assessed in 7,362 patients with 3VD and/or LMCAD enrolled in a Japanese PCI/CABG registry. Read More

View Article and Full-Text PDF
September 2021

Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease.

Mol Med 2021 Sep 16;27(1):111. Epub 2021 Sep 16.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Parkinson's disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal stages of PD are essential for the development of new therapeutic strategies. Two categories of patients are ideal to study the early disease stages. Read More

View Article and Full-Text PDF
September 2021

The approach towards the ball, rather than the physical characteristics of the kicker, limits accurate rugby place kicking range.

J Sports Sci 2021 Sep 17:1-12. Epub 2021 Sep 17.

Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK.

The aim of this study was to understand how a place kicker's range is limited by their approach to the ball and their physical characteristics. Thirty-three kickers performed maximal place kicks and vertical jumps in a laboratory. Whole-body motion and ground reaction forces during the approach phase of the kicks, jump performance and anthropometric measurements of those whose predicted was limited by range (n = 17) rather than accuracy were analysed. Read More

View Article and Full-Text PDF
September 2021

Bidirectional relationships between intuitive eating and shape and weight overvaluation, dissatisfaction, preoccupation, and fear of weight gain: A prospective study.

Body Image 2021 Sep 13;39:227-231. Epub 2021 Sep 13.

School of Psychology, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia.

Using a prospective design, we investigated possible bi-directional relationships between intuitive eating and four empirically distinct components of negative body image: overvaluation (judgements of self-worth contingent upon weight/shape), dissatisfaction (general discontent with weight/shape), preoccupation (ruminative thinking about weight/shape), and fear of weight gain. We assessed adult women at baseline (T1) and four-month follow-up (T2), as prior work has demonstrated that this time lag is sufficient to detect change in intuitive eating scores. After adjusting for T1 intuitive eating scores and demographic confounds, higher T1 dissatisfaction was the only body image component to significantly predict lower T2 intuitive eating scores in both univariate and multivariate models. Read More

View Article and Full-Text PDF
September 2021

Negative self-evaluation induced by acute stress indexed using facial EMG.

Psychoneuroendocrinology 2021 Aug 30;133:105402. Epub 2021 Aug 30.

Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Sweden.

Maladaptive stress responses are a key feature of several psychiatric disorders, but findings of stress effects on social behavior are inconsistent. Using a within-subject design, we investigated, in 35 healthy participants, the effects of acute stress on psychophysiological and behavioral responses during a simulated online social interaction task. Participants were exposed to established stress and non-stress exposure procedures in two separate sessions. Read More

View Article and Full-Text PDF

Improving differential diagnosis of pulmonary large cell neuroendocrine carcinoma and small cell lung cancer via a transcriptomic, biological pathway-based machine learning model.

Transl Oncol 2021 Sep 13;14(12):101222. Epub 2021 Sep 13.

Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China. Electronic address:

Background: Accurately differentiating between pulmonary large cell neuroendocrine carcinomas (LCNEC) and small cell lung cancer (SCLC) is crucial to make appropriate therapeutic decisions. Here, a classifier was constructed based on transcriptome data to improve the diagnostic accuracy for LCNEC and SCLC.

Methods: 13,959 genes mapped to 186 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were included. Read More

View Article and Full-Text PDF
September 2021

GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.

Clin Chim Acta 2021 Sep 13. Epub 2021 Sep 13.

Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Background And Aims: Epigenetic changes play a role in the occurrence of asthma. In this study, we evaluated the methylation status of glucocorticoid-induced transcript 1 (GLCCI1) and assessed its associations with asthma and asthma severity.

Materials And Methods: Peripheral blood mononuclear cells were harvested from 33 severe asthma patients, 84 mild-moderate asthma patients and 79 healthy controls of Han nationality. Read More

View Article and Full-Text PDF
September 2021

Unprecedented neptunyl(V) cation-directed structural variations in NpO compounds.

Nanoscale 2021 Sep 16. Epub 2021 Sep 16.

Department of Physics, University of Science and Technology Beijing, Beijing 100083, China.

Studies on transuranic oxides provide a particularly valuable insight into chemical bonding in actinide compounds, in which subtle differences between metal ions and oxygen atoms are of fundamental importance for the stability of these compounds as well as their existence. In the case of neptunium, it is still mainly limited to specific Np oxide compounds without periodicity in the formation of stable structures or different oxidation states. Here, we report a systematic global minimum search of NpO ( = 1-7) clusters and the computational study of their electronic structures and chemical bonding. Read More

View Article and Full-Text PDF
September 2021