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High-Sensitive Cardiac Troponin T for Prediction of Cardiovascular Outcomes in Stable Maintenance Hemodialysis Patients: A 3-Year Prospective Study.

Kidney Blood Press Res 2021 Jun 24:1-11. Epub 2021 Jun 24.

Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Hemodialysis patients, who are often excluded from cardiovascular (CV) clinical trials, are associated with higher CV morbidity and mortality. The risk stratification scheme for these patients is lacking. Therefore, this investigation examined the independent CV prognostic value of high-sensitive cardiac troponin T (hs-cTnT) and added prognostic value over echocardiographic parameters and other clinical risk predictors in asymptomatic stable maintenance hemodialysis (MHD) patients. Read More

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Electronic and Optical Properties of Boron-based Hybrid Monolayers.

Nanotechnology 2021 Jun 24. Epub 2021 Jun 24.

Department of Physics, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan, 49931-1295, UNITED STATES.

Anisotropic 2D Dirac cone materials are important for the fabrication of nanodevices having direction-dependent characteristics since the anisotropic Dirac cones lead to different values of Fermi velocities yielding variable carrier concentrations. In this work, the feasibility of the B-based hybrid monolayers, BX (X = As, Sb, and Bi), as anisotropic Dirac cone materials is investigated. Calculations based on density functional theory and molecular dynamics method find the stability of these monolayers exhibiting unique electronic properties. Read More

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Graph convolutional network approach to investigate potential selective Limk1 inhibitors.

J Mol Graph Model 2021 Jun 16;107:107965. Epub 2021 Jun 16.

Artificial Intelligence Medical Center, School of Intelligent Systems Engineering, Sun Yat-sen University, Shenzhen, Guangdong, 510275, China; Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan. Electronic address:

Since the Limk1 is a promising drug target and few inhibitors with good Limk1/ROCK2 selectivity have been reported, discovering potential and selective Limk1 inhibitors with novel scaffolds is becoming an urgent need to develop new treatments for the related diseases. Here, we utilized molecular docking to screen potential compounds of Limk1 from Traditional Chinese Medicine (TCM) database. Meanwhile, we performed a three-dimensional graph convolutional network (3DGCN), based on 3D molecular graph, to predict the inhibitory activity of Limk1 and ROCK2. Read More

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The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study.

Am J Emerg Med 2021 Jun 19;49:249-252. Epub 2021 Jun 19.

College of Medicine, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar. Electronic address:

Objective: Appendiceal perforation has significant effects on perioperative morbidity and postoperative outcome. The present study aimed to identify possible predictive factors associated with perforated appendicitis (PA) in children at admission in the emergency department (ED).

Methods: In this retrospective observational cohort study, consecutive medical records of children <18 years old with surgically and histopathologically confirmed acute appendicitis (AA) over three years (2013-2015) were analyzed. Read More

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The effects of intensity on a phonological treatment for anomia in post-stroke aphasia.

J Commun Disord 2021 Jun 2;93:106125. Epub 2021 Jun 2.

Department of Speech-Language Pathology, University of Toronto, 160-500 University Avenue, Toronto, ON M5G 1V7, Canada; Rehabilitation Sciences Institute, University of Toronto, 500 University Avenue, Toronto, ON M5G 1V7, Canada; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, 600 Peter Morand Cres., Suite 206, Ottawa, ON K1G 5Z3, Canada; KITE Research Institute, Toronto Rehab, University Health Network, 550 University Avenue, Toronto, ON M5G 2A2, Canada.

Introduction: The evidence regarding optimal treatment intensity is mixed, and differing definitions have further confounded existing findings. The primary objective of this study was to compare the efficacy of Phonological Components Analysis (PCA) treatment for anomia delivered at intense and non-intense schedules, using a well-controlled design. The number of teaching episodes and active ingredients of therapy are important considerations when defining intensity. Read More

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Mycobacterium tuberculosis protein PPE2 binds to DNA region containing promoter activity.

Biochem Biophys Res Commun 2021 Jun 21;567:166-170. Epub 2021 Jun 21.

Laboratory of Molecular Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, 500039, Telangana, India. Electronic address:

ppe2 gene is predicted to be present in operon with non pe/ppe genes, cobq1 and cobu as ppe2-cobq1-cobu. Thus, we were interested to investigate the role of ppe2 in operonic organization. We performed microscale thermophoresis (MST) experiment which revealed that PPE2 protein could bind to upstream DNA segments of ppe2-cobq1-cobu operon. Read More

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Atmospheric deposition of inorganic nutrients to the Western North Pacific Ocean.

Sci Total Environ 2021 Jun 11;793:148401. Epub 2021 Jun 11.

Division of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, Republic of Korea; OJEong Resilience Institute, Korea University, Seoul 02841, Republic of Korea. Electronic address:

We evaluated the potential impacts of atmospheric deposition on marine productivity and inorganic carbon chemistry in the northwestern Pacific Ocean (8-39°N, 125-157°E). The nutrient concentration in atmospheric total suspended particles decreased exponentially with increasing distance from the closest land-mass (Asia), clearly revealing anthropogenic and terrestrial contributions. The predicted mean depositional fluxes of inorganic nitrogen were approximately 34 and 15 μmol m d to the west and east of 140°E, respectively, which were at least two orders of magnitude greater than the inorganic phosphorus flux. Read More

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Physiology, niche characteristics and extreme events: Current and future habitat suitability of a rhodolith-forming species in the Southwestern Atlantic.

Mar Environ Res 2021 Jun 17;169:105394. Epub 2021 Jun 17.

Phycology Laboratory, Botanical Department, Federal University of Santa Catarina, 88040-970, Florianópolis, Santa Catarina, Brazil; Postgraduate Program in Ecology, Federal University of Santa Catarina, 88040-970, Florianópolis, Santa Catarina, Brazil; Postgraduate Program in Oceanography, Federal University of Santa Catarina, 88040-970, Florianópolis, Santa Catarina, Brazil.

Given the ecological and biogeochemical importance of rhodolith beds, it is necessary to investigate how future environmental conditions will affect these organisms. We investigated the impacts of increased nutrient concentrations, acidification, and marine heatwaves on the performance of the rhodolith-forming species Lithothamnion crispatum in a short-term experiment, including the recovery of individuals after stressor removal. Furthermore, we developed an ecological niche model to establish which environmental conditions determine its current distribution along the Brazilian coast and to project responses to future climate scenarios. Read More

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Biomarker Risk Score Algorithm and Preoperative Stratification of Patients with Pancreatic Cystic Lesions.

J Am Coll Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; Walther Oncology Center, Indianapolis, IN; Indiana University Simon Cancer Center, Indianapolis, IN; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN; Department of Biochemistry/Molecular Biology, Indiana University School of Medicine, Indianapolis, IN; Center for Outcomes Research in Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Introduction: Pancreatic cysts are incidentally detected in up to 13% of patients undergoing radiographic imaging. Of the most frequently encountered types, mucin-producing (mucinous) pancreatic cystic lesions may develop into pancreatic cancer, while non-mucinous ones have little or no malignant potential. Accurate preoperative diagnosis is critical for optimal management but has been difficult to achieve, resulting in unnecessary major surgery. Read More

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Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy.

Cancer Lett 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Sorafenib and lenvatinib are approved first-line targeted therapies for advanced liver cancer, but most patients develop acquired resistance. Herein, we found that sorafenib induced extensive acetylation changes towards a more energetic metabolic phenotype. Metabolic adaptation was mediated via acetylation of the Lys-491 (K491) residue of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) (PCK2-K491) and Lys-473 (K473) residue of PCK1 (PCK1-K473) by the lysine acetyltransferase 8 (KAT8), resulting in isoenzyme transition from cytoplasmic PCK1 to mitochondrial PCK2. Read More

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Gender differences in meat consumption and openness to vegetarianism.

Appetite 2021 Jun 21:105475. Epub 2021 Jun 21.

Department of Psychology, University of California, Los Angeles, USA.

Understanding gender differences in meat consumption can help strengthen efforts to improve the sustainability of eating patterns. Compared to women, men eat more meat and are less open to becoming vegetarian. Simply considering between-gender differences, however, may overlook meaningful within-gender heterogeneity in how masculine and feminine identities associate with eating behavior. Read More

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Delivered dose-effect analysis of radiation induced rib fractures after thoracic SBRT.

Radiother Oncol 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background And Purpose: Anatomical changes during the stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC) may cause the delivered dose to deviate from the planned dose. We investigate if normal tissue complication probability (NTCP) models based on the delivered dose predict radiation-induced rib fractures better than models based on the planned dose.

Material And Methods: 437 NSCLC patients treated to a median dose of 3x18 Gy were included. Read More

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Commissioning and clinical implementation of an Autoencoder based Classification-Regression model for VMAT patient-specific QA in a multi-institution scenario.

Radiother Oncol 2021 Jun 21. Epub 2021 Jun 21.

Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. Electronic address:

Background And Purpose: To commission and implement an Autoencoder based Classification-Regression (ACLR) model for VMAT patient-specific quality assurance (PSQA) in a multi-institution scenario.

Materials And Methods: 1835 VMAT plans from seven institutions were collected for the ACLR model commissioning and multi-institutional validation. We established three scenarios to validate the gamma passing rates (GPRs) prediction and classification accuracy with the ACLR model for different delivery equipment, QA devices, and treatment planning systems (TPS). Read More

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Achieving Safe Liberation During Weaning from VV-ECMO in Patients with Severe ARDS: The role of Tidal Volume and Inspiratory Effort.

Chest 2021 Jun 16. Epub 2021 Jun 16.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Canada; Extracorporeal Life Support Program, Toronto General Hospital, Canada. Electronic address:

Background: Weaning from venovenous extracorporeal membrane oxygenation (VV-ECMO) is not well studied. VV-ECMO can be discontinued when patients tolerate non-injurious mechanical ventilation (MV) during a sweep gas off trial (SGOT). However, predictors of safe liberation are unknown. Read More

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Symptomatic and Functional Response and Remission From the Open-Label Treatment-Optimization Phase of a Study With DR/ER-MPH in Children With ADHD.

J Clin Psychiatry 2021 Jun 22;82(4). Epub 2021 Jun 22.

Ironshore Pharmaceuticals & Development, Inc., Camana Bay, Grand Cayman, Cayman Islands.

Delayed-release and extended-release methylphenidate (DR/ER-MPH), the first stimulant predicted to be absorbed primarily in the colon, demonstrated significant improvements in attention-deficit/hyperactivity disorder (ADHD) symptoms and functional impairment from awakening until evening versus placebo in clinical trials. The clinical significance of these improvements was explored post hoc by examining response and remission thresholds as well as safety in the context of dose optimization.

Data from the open-label, treatment-optimization phase of a phase 3 study of DR/ER-MPH in children (aged 6-12 years) with ADHD, as diagnosed by criteria and enrolled between July 2015 and March 2016, were analyzed. Read More

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Breeding responses to environmental variation are age- and trait-dependent in female Nazca boobies.

Ecology 2021 Jun 24:e03457. Epub 2021 Jun 24.

Biology Department, Wake Forest University, Winston-Salem, USA.

Age and environment are important determinants of reproductive parameters in long-lived organisms. These factors may interact to determine breeding responses to environmental change, yet few studies have examined the environmental dependence of aging patterns across the entire lifespan. We do so, using a 20-year longitudinal dataset of reproductive phenotypes in long-lived female Nazca boobies (Sula granti), a monogamous seabird breeding in the eastern tropical Pacific. Read More

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The evolution of coevolution in the study of species interactions.

Evolution 2021 Jun 24. Epub 2021 Jun 24.

Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, 14853.

The study of reciprocal adaptation in interacting species has been an active and inspiring area of evolutionary research for nearly 60 years. Perhaps owing to its great natural history and potential consequences spanning population divergence to species diversification, coevolution continues to capture the imagination of biologists. Here we trace developments following Ehrlich and Raven's classic paper, with a particular focus on the modern influence of two studies by Dr. Read More

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Expression of versican mRNA transcript to predict cardiac remodelling after myocardial infarction.

Kardiol Pol 2021 Jun 24. Epub 2021 Jun 24.

1st Chair and Department of Cardiology, Medical University of Warsaw, Warszawa, Poland.

Background: Adverse left-ventricular remodelling (LVR) is defined as an increase in end-diastolic left-ventricular volume by 20% 6 months after acute myocardial infarction (AMI). LVR is associated with cardiac dysfunction, therefore deteriorating the prognosis.

Aims: We aimed to compare the concentrations of messenger RNA transcripts in the peripheral blood of patients with and without LVR at 6 months. Read More

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Simulating human behavioral changes in livestock production systems during an epidemic: The case of the US beef cattle industry.

PLoS One 2021 24;16(6):e0253498. Epub 2021 Jun 24.

Department of Electrical and Computer Engineering, Kansas State University, Manhattan, Kansas, United States of America.

Human behavioral change around biosecurity in response to increased awareness of disease risks is a critical factor in modeling animal disease dynamics. Here, biosecurity is referred to as implementing control measures to decrease the chance of animal disease spreading. However, social dynamics are largely ignored in traditional livestock disease models. Read More

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A gross margin analysis for Nguni cattle farmers in Limpopo Province, South Africa.

PLoS One 2021 24;16(6):e0253657. Epub 2021 Jun 24.

University of Limpopo, Polokwane, Limpopo Province, South Africa.

Factors such as increases in population, urbanization, growth in per capita income and changes in consumer taste and preferences are causing gradual increases in livestock product consumption and demand. South Africa is addressing this predicted increase in livestock products demand by commercializing smallholder livestock producers. The Limpopo Industrial Development Corporation (IDC) Nguni Cattle Development Project is an example of such effort. Read More

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Mechanisms of parental distress during and after the first COVID-19 lockdown phase: A two-wave longitudinal study.

PLoS One 2021 24;16(6):e0253087. Epub 2021 Jun 24.

Department of Psychology, University of Oslo, Oslo, Norway.

Background: In these unpredictable times of the global coronavirus disease 2019 (COVID-19) pandemic, parents worldwide are affected by the stress and strain caused by the physical distancing protocols that have been put in place.

Objective: In a two-wave longitudinal survey, we investigated the levels of parental stress and symptoms of anxiety and depression in a sample of parents at two time points; during the implementation of the strictest physical distancing protocols following the onset of the COVID-19 pandemic (T1, N = 2,868) and three months after the discontinuation of the protocols (T2, N = 1,489). Further, we investigated the relationships between parental stress and anxiety and depression relative to relationship quality and anger toward their children at the two aforementioned time points, including subgroups based on age, parental role, cultural background, relationship status, education level, number of children, employment status and pre-existing psychiatric diagnosis. Read More

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Lower-Extremity Segment-Length Prediction Accuracy of the Sanders Multiplier, Paley Multiplier, and White-Menelaus Formula.

J Bone Joint Surg Am 2021 Jun 24. Epub 2021 Jun 24.

Texas Scottish Rite Hospital for Children, Dallas, Texas.

Background: Several methods are available to estimate leg lengths at maturity to facilitate the determination of timing of epiphysiodesis. We compared the Paley multiplier, Sanders multiplier, and White-Menelaus methods in an epiphysiodesis-aged cohort. We assessed intra- and interrater reliability for Sanders skeletal stages and Greulich and Pyle atlas skeletal age. Read More

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Association Between an Increase in Serum Sodium and In-Hospital Mortality in Critically Ill Patients.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Department of Intensive Care Medicine, Leiden University Medical Centre, Leiden, The Netherlands. Department of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centre Amsterdam location AMC, Amsterdam, The Netherlands. Department of Intensive Care Medicine, OLVG, Amsterdam, The Netherlands. Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands. Department of Intensive Care Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands. Department of Intensive Care Medicine, University Medical Centre Groningen, Groningen, The Netherlands. Department of Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Department of Intensive Care Medicine, Amsterdam University Medical Centre Amsterdam location VUMC, Amsterdam, The Netherlands. Department of Intensive Care Medicine, Amsterdam University Medical Center Amsterdam location AMC, Amsterdam, The Netherlands. Department of Intensive Care Medicine, Haaglanden Medical Centre, The Hague, The Netherlands. Department of Intensive Care Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands.

Objectives: In critically ill patients, dysnatremia is common, and in these patients, in-hospital mortality is higher. It remains unknown whether changes of serum sodium after ICU admission affect mortality, especially whether normalization of mild hyponatremia improves survival.

Design: Retrospective cohort study. Read More

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A Novel 29-Messenger RNA Host-Response Assay From Whole Blood Accurately Identifies Bacterial and Viral Infections in Patients Presenting to the Emergency Department With Suspected Infections: A Prospective Observational Study.

Crit Care Med 2021 Jun 24. Epub 2021 Jun 24.

Department of Emergency Medicine, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany. Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany. Inflammatix, Burlingame, CA.

Objectives: The rapid diagnosis of acute infections and sepsis remains a serious challenge. As a result of limitations in current diagnostics, guidelines recommend early antimicrobials for suspected sepsis patients to improve outcomes at a cost to antimicrobial stewardship. We aimed to develop and prospectively validate a new, 29-messenger RNA blood-based host-response classifier Inflammatix Bacterial Viral Non-Infected version 2 [IMX-BVN-2] to determine the likelihood of bacterial and viral infections. Read More

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Successful Limb Salvage Using an Orthoplastic Approach of Type IIIB Open Injuries of the Shoulder: A Report of 3 Cases.

JBJS Case Connect 2021 Jun 24;11(2). Epub 2021 Jun 24.

Department of Orthopaedics, Ganga Medical Center and Hospitals Pvt Ltd, Coimbatore, Tamil Nadu, India.

Case: We report 3 adult men (aged 28, 34, and 71 years) with successfully salvaged mangled injuries around the shoulder with high threshold for amputation. Assessment by Mangled Extremity Severity Score, Ganga Hospital Open Injury Severity Score, and Orthopaedic Trauma Association-Open Fracture Classification open injury scores predicted amputation. However, extended salvage was performed by orthoplastic approach. Read More

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Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia.

J Clin Invest 2021 Jun 24. Epub 2021 Jun 24.

St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockfeller University, New York, United States of America.

To the Editor: Povysil G. et al. report that "rare loss-of-function (LOF) variants in type I interferon (IFN) immunity genes are not associated with severe COVID-19" (1). Read More

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Inflammatory cytokines TNFα and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.

J Clin Invest 2021 Jun 24. Epub 2021 Jun 24.

Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, United States of America.

Without CFTR-mediated HCO3- secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an abnormally acidic airway surface liquid (ASL), and the decreased pH impairs respiratory host defenses. However, within a few months of birth, ASL pH increases to match that in non-CF airways. Although the physiological basis for the increase is unknown, this time-course matches the development of inflammation in CF airways. Read More

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Cognition and action: a latent variable approach to study contributions of executive functions to motor control in older adults.

Aging (Albany NY) 2021 Jun 24;13. Epub 2021 Jun 24.

Movement Control and Neuroplasticity Research Group, Department of Movement Sciences, KU Leuven, Flanders, Belgium.

Aging is associated with profound alterations in motor control that may be exacerbated by age-related executive functioning decline. Executive functions span multiple facets including inhibition (suppressing unwanted response tendencies), shifting (switching between cognitive operations), and updating (managing working memory content). However, comprehensive studies regarding the contributions of single facets of executive functioning to movement control in older adults are still lacking. Read More

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A post-hoc interpretable ensemble model to feature effect analysis in warfarin dose prediction for Chinese patients.

IEEE J Biomed Health Inform 2021 Jun 24;PP. Epub 2021 Jun 24.

To interprete the importance of clinical features and genotypes for warfarin daily dose prediction, we developed a post-hoc interpretable framework based on an ensemble predictive model. This framework includes permutation importance for global interpretation and local interpretable model-agnostic explanation (LIME) and shapley additive explanations (SHAP) for local explanation. The permutation importance globally ranks the importance of features on the whole data set. Read More

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