1,962 results match your criteria pre-treatment elevated


Is photosynthetic enhancement sustained through three years of elevated CO2 exposure in 175-year old Quercus robur?

Tree Physiol 2021 Jul 23. Epub 2021 Jul 23.

Birmingham Institute of Forest Research, University of Birmingham, Edgbaston, B15 2TT, England.

Current carbon cycle models attribute rising atmospheric CO2 as the major driver of the increased terrestrial carbon sink, but with substantial uncertainties. The photosynthetic response of trees to elevated atmospheric CO2 is a necessary step, but not the only one, for sustaining the terrestrial carbon uptake, but can vary diurnally, seasonally and with duration of CO2 exposure. Hence we sought to quantify the photosynthetic response of the canopy-dominant species, Quercus robur, in a mature deciduous forest to elevated CO2 (eCO2) (+150 μmol mol-1 CO2) over the first three years of a long-term free air CO2 enrichment facility at the Birmingham Institute of Forest Research in central England (BIFoR FACE). Read More

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Extracellular vesicle miRNA predict FDG-PET status in patients with classical Hodgkin Lymphoma.

J Extracell Vesicles 2021 Jul 15;10(9):e12121. Epub 2021 Jul 15.

Department of Pathology Cancer Center Amsterdam Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam The Netherlands.

Minimally-invasive tools to assess tumour presence and burden may improve clinical management. FDG-PET (metabolic) imaging is the current gold standard for interim response assessment in patients with classical Hodgkin Lymphoma (cHL), but this technique cannot be repeated frequently. Here we show that microRNAs (miRNA) associated with tumour-secreted extracellular vesicles (EVs) in the circulation of cHL patients may improve response assessment. Read More

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d-Pinitol protects against endoplasmic reticulum stress and apoptosis in hepatic ischemia-reperfusion injury via modulation of AFT4-CHOP/GRP78 and caspase-3 signaling pathways.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211032098

Department of Gerontology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, China.

Hepatic ischemia-reperfusion injury (IRI) is a major unavoidable clinical problem often accompanying various liver surgery and transplantation. d-Pinitol, a cyclic polyol, exhibits hepatoprotective efficacy. The objective of this study is to determine the possible mechanism of action of pinitol against endoplasmic reticulum (ER) stress regulation-mediated hepatic IRI and compare its effects with thymoquinone (TQ) in experimental rats. Read More

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Prognostic Value of Peripheral Whole Blood Cell Counts Derived Indexes in Gallbladder Carcinoma: A Systematic Review and Meta-Analysis.

Front Oncol 2021 28;11:707742. Epub 2021 Jun 28.

Department of Hepatobiliary Surgery, General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Gallbladder carcinoma (GBC) is a rare gastrointestinal malignancy with poor prognosis. Adequate pre-treatment prediction of survival is essential for risk stratification and patient selection for aggressive surgery or adjuvant therapeutic strategy. Whole blood cell count (WBCC) derived indexes are broadly used as prognosticative biomarkers in various cancer types, but their utility in GBC needs to be validated. Read More

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Challenges in choosing the appropriate guidelines for use in children and adolescents with hypertension.

Arch Pediatr 2021 Jul 2. Epub 2021 Jul 2.

Bahçeşehir University Faculty of Medicine, Istanbul, Turkey.

Background: This study was designed to observe the effect of antihypertensive treatment on blood pressure (BP) and target organ damage in patients followed up according to the American Academy of Pediatrics Hypertension Guidelines (AAPG). The results were also assessed in comparison with the definitions and target organ damage according to the European Society of Hypertension Guidelines 2016 (ESHG).

Materials And Methods: A total of 44 (34 male) out of 140 patients were enrolled in the study and the mean age was 14±3. Read More

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Role of Oncofetal Protein CR-1 as a Potential Tumor Marker for Oral Squamous Cell Carcinoma.

Indian J Clin Biochem 2021 Jul 12;36(3):288-295. Epub 2020 Jun 12.

Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 India.

Cripto-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancer, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Read More

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Roflumilast improves resolution of sepsis induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments.

Fundam Clin Pharmacol 2021 Jul 1. Epub 2021 Jul 1.

Department of Pharmacology, ISF College of Pharmacy, Moga, (Punjab), India.

Some evidence has demonstrated that both inflammation and immune cell dysregulation are coincident at late phase (post 24 hour) of sepsis. The present study was designed to determine the pathological role of hyperinflammation and renal immune cells mobilization during late phase of sepsis induced acute kidney injury (S-AKI) and tests the pharmacological effects of PDE-4 inhibitor on these events. Sepsis was induced by cecal ligation puncture and renal function, oxidative- inflammatory stress biomarkers were assessed after 24 hours. Read More

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Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment.

J Clin Med 2021 Jun 29;10(13). Epub 2021 Jun 29.

Department of Biochemical Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269 Bialystok, Poland.

Background: Tick-borne encephalitis (TBE) is inflammation of the central nervous system (CNS) caused by a viral infection which may be associated with increased synthesis of immunoglobulins. It can lead to inter alia, breakdown of the blood-brain barrier (BBB), or even death and, unfortunately, treatment is only symptomatic. Therefore, the aim of the present study was assessment of the concentrations of free light chains (FLC) kappa (κ) and lambda (λ in the cerebrospinal fluid (CSF) and serum of patients with TBE. Read More

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RT001 in Progressive Supranuclear Palsy-Clinical and In-Vitro Observations.

Antioxidants (Basel) 2021 Jun 25;10(7). Epub 2021 Jun 25.

Retrotope, Los Altos, CA 94022, USA.

Background: Progressive supranuclear palsy (PSP) is a progressive movement disorder associated with lipid peroxidation and intracerebral accumulation of tau. RT001 is a deuterium reinforced isotopologue of linoleic acid that prevents lipid peroxidation (LPO) through the kinetic isotope effect.

Methods: The effects of RT001 pre-treatment on various oxidative and bioenergetic parameters were evaluated in mesenchymal stem cells (MSC) derived from patients with PSP compared to controls. Read More

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Association of selective serotonin re-uptake inhibitor (SSRI) treatment with acute substance misuse outcomes.

Addiction 2021 Jun 29. Epub 2021 Jun 29.

Institute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.

Background And Aims: Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed medications for patients with anxiety/depression. These patients often have problems with substance use, but it remains unclear whether the risk of substance misuse is influenced by SSRI treatment. We aimed to determine whether SSRI treatment is associated with a decreased risk of acute substance misuse-related outcomes. Read More

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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms.

Leukemia 2021 Jun 25. Epub 2021 Jun 25.

H3 Biomedicine, Cambridge, MA, USA.

We conducted a phase I clinical trial of H3B-8800, an oral small molecule that binds Splicing Factor 3B1 (SF3B1), in patients with MDS, CMML, or AML. Among 84 enrolled patients (42 MDS, 4 CMML and 38 AML), 62 were red blood cell (RBC) transfusion dependent at study entry. Dose escalation cohorts examined two once-daily dosing regimens: schedule I (5 days on/9 days off, range of doses studied 1-40 mg, n = 65) and schedule II (21 days on/7 days off, 7-20 mg, n = 19); 27 patients received treatment for ≥180 days. Read More

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The value of the tumour-stroma ratio for predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer: a case control study.

BMC Cancer 2021 Jun 25;21(1):729. Epub 2021 Jun 25.

Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, China.

Background: The tumour-stroma ratio (TSR) is recognized as a practical prognostic factor in colorectal cancer. However, TSR assessment generally utilizes surgical specimens. This study aims to investigate whether the TSR evaluated from preoperative biopsy specimens by a semi-automatic quantification method can predict the response after neoadjuvant chemoradiotherapy (nCRT) of patients with locally advanced rectal cancer (LARC). Read More

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[Analysis of PARP inhibitors induced anemia in advanced and relapsed epithelial ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2021 Jun;56(6):401-407

Department of Gynecological Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To explore the clinical features of poly ADP-ribose polymerase (PARP) inhibitor-related anemia in advanced and relapsed epithelial ovarian cancer (EOC). Patients diagnosed with advanced or relapsed EOC and treated with PARP inhibitor at National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between January 2015 to October 2020 were accrued. The data included PARP inhibitors, treatment details, and lab tests before treatment and during treatment were collected and the clinical characteristics of PARP inhibitor-related anemia were analyzed. Read More

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Immunomodulatory activity of brown algae Turbinaria ornata derived sulfated polysaccharide on LPS induced systemic inflammation.

Phytomedicine 2021 Aug 29;89:153615. Epub 2021 May 29.

Natural Products Research Laboratory, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, India. Electronic address:

Background: Inflammation and oxidative stress are common pathologies in a wide range of chronic diseases. Polysaccharides are known to exhibit antioxidant and anti-inflammatory potential and are suggested to possess immunomodulatory potential.

Purpose: Herein, the immunomodulatory activity of a sulfated polysaccharide (PS) separated from a brown marine algae Turbinaria ornata is studied in LPS instigated systemic inflammation in experimental rats. Read More

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Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.

PLoS One 2021 21;16(6):e0253534. Epub 2021 Jun 21.

National Institutes of Health-NIRT-International Center for Excellence in Research, Chennai, India.

Background: Neutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation. However, the systemic levels of neutrophil granular proteins were not examined in tuberculous lymphadenitis (TBL) disease. Read More

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D-Dimer: A Potential Solution to Problems of Cancer Screening, Surveillance, and Prognosis Assessment.

Cureus 2021 May 16;13(5):e15064. Epub 2021 May 16.

Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Research has established a direct link between the plasma level of D-dimer and underlying malignancy. D-dimer has a strong association with the detection and prognosis of several cancers. For these reasons, this literature review aimed to evaluate the usefulness of elevated D-dimer levels in the initial screening of cancer, cancer recurrence surveillance, and for use as a cancer prognostic tool. Read More

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Examining depression scores as predictors and moderators of treatment outcomes in patients with binge-eating disorder.

Int J Eat Disord 2021 Jun 17. Epub 2021 Jun 17.

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: A substantial proportion of patients with binge-eating disorder (BED) do not derive sufficient benefits from available evidence-based psychological interventions. We examined depression scores as predictors and moderators of response to cognitive-behavioral therapy (CBT) and behavioral weight-loss (BWL) for BED. We explored associations between changes in depression scores and changes in treatment outcomes. Read More

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Oral pre-treatment with thiocyanate (SCN) protects against myocardial ischaemia-reperfusion injury in rats.

Sci Rep 2021 Jun 16;11(1):12712. Epub 2021 Jun 16.

The Heart Research Institute, Newtown, NSW, 2042, Australia.

Despite improvements in revascularization after a myocardial infarction, coronary disease remains a major contributor to global mortality. Neutrophil infiltration and activation contributes to tissue damage, via the release of myeloperoxidase (MPO) and formation of the damaging oxidant hypochlorous acid. We hypothesized that elevation of thiocyanate ions (SCN), a competitive MPO substrate, would modulate tissue damage. Read More

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Alterations in thymocyte populations under conditions of endotoxin tolerance.

Chin Med J (Engl) 2021 Jun 16. Epub 2021 Jun 16.

Department of Laboratory Medicine, Jiangxi Hospital of Integrated Chinese and Western Medicine, Nanchang, Jiangxi 330009, China Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, China.

Background: Endotoxin tolerance (ET) is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide (LPS) leads to dramatically elevated survival. Accumulating evidence has shown that peripheral T cells contribute to the induction of ET. However, what happens to T cell development in the thymus under ET conditions remains unclear. Read More

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Cardioprotective properties of natural medicine in isoproterenol induced myocardial damage in the male Albino rats.

Saudi J Biol Sci 2021 Jun 20;28(6):3169-3175. Epub 2021 Apr 20.

Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam bin Abdul Aziz University, Al Kharj, Saudi Arabia.

The main aim of this study is to investigate cardioprotective properties of natural medicine inmyocardial damage induced male Albino rats. The aqueous extractof was used for the determination of phenolic compounds and flavonoids. The amount of phenol (1. Read More

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Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling.

Respir Physiol Neurobiol 2021 Oct 1;292:103707. Epub 2021 Jun 1.

Department of Pharmacy, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, 230061, China.

Cerebral ischemia/reperfusion (I/R) injury is a common cerebrovascular disease with high mortality. Bakuchiol (BAK), extracted from the seeds of psoralea corylifolia, exhibits anti-inflammatory effects on lung, kidney and heart injuries. However, the effect of BAK on brain I/R injury remains elusive. Read More

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October 2021

Polyphenolic-Rich Compounds From (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach.

Front Pharmacol 2021 17;12:624706. Epub 2021 May 17.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-Guwahati, Assam, India.

Cardiovascular complications are the foremost concern in patients undergoing anticancer therapy There is an unmet need to address the problems arising from the drug-induced toxicity for the long-term benefit of the patients undergoing chemotherapy. Alternative medicines are gaining their prosperity in addressing the various drug-induced organ toxicity. Roxb (DP) is an ethnomedicinal plant rich in flavonoids and phenolic contents. Read More

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Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 1. Epub 2021 Jun 1.

Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela (Ropar), 140111, India.

Mitochondrial abnormalities and redox imbalance are major pathogenic factors in progression of Huntington's disease (HD), manifested clinically by affective, motor, cognitive, and psychiatric incompetence. Antioxidants behold much promise in mitigation of several pathological facets in HD. Ellagic acid (EA) is a naturally derived polyphenol acknowledged for potent neuroprotective abilities that enabled its significance amongst popular brain tonics. Read More

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Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen.

Clin Toxicol (Phila) 2021 May 28:1-10. Epub 2021 May 28.

Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Drug induced liver injury (DILI) remains a prominent global issue and acetaminophen (APAP) overdose represents a common cause of hepatic injury and DILI. Transient alanine aminotransferase (ALT) elevations have been documented while adhering to recommended daily dosing. However, no metabolites have been identified in pre-treatment samples predicting which patients will develop these transient increases. Read More

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Virological and serological characterization of critically ill patients with COVID-19 in the UK: Interactions of viral load, antibody status and B.1.1.7 variant infection.

J Infect Dis 2021 May 24. Epub 2021 May 24.

Microbiology Services, NHS Blood and Transplant, London, UK.

Background: Convalescent plasma containing neutralising antibody to SARS-CoV-2 is under investigation for COVID-19 treatment. We report diverse virological characteristics of UK intensive care patients enrolled in the Immunoglobulin Domain of the REMAP-CAP randomised controlled trial that potentially influence treatment outcomes.

Methods: SARS-CoV-2 RNA in nasopharyngeal swabs collected pre-treatment was quantified by PCR. Read More

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Change in γ-glutamyl transpeptidase activity as a useful tool in identifying a group of patients with elevated risk of hepatocellular carcinoma development after DAA treatment of chronic hepatitis C.

Clin Exp Hepatol 2021 Mar 15;7(1):93-100. Epub 2021 Mar 15.

Department of Infectious, Tropical Diseases and Hepatology, Medical University of Warsaw, Warsaw, Poland.

Aim Of The Study: Hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) incidence will be diminishing due to use of direct acting antiviral agents (DAA), but there is still constant risk for HCC development. Elevated serum g-glutamyl transpeptidase (GGT) activity is associated with increased risk of liver cancer. In our study we tried to determine whether change in GGT activity may be useful in identifying patients with elevated risk of HCC development after DAA treatment. Read More

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Salicylic acid pre-treatment modulates Pb-induced DNA damage vis-à-vis oxidative stress in Allium cepa roots.

Environ Sci Pollut Res Int 2021 May 17. Epub 2021 May 17.

Department of Botany, Panjab University, Chandigarh, 160 014, India.

The current study investigated the putative role of salicylic acid (SA) in modulating Pb-induced DNA and oxidative damage in Allium cepa roots. Pb exposure enhanced free radical generation and reduced DNA integrity and antioxidant machinery after 24 h; however, SA pre-treatment (for 24 h) ameliorated Pb toxicity. Pb exposure led to an increase in malondialdehyde (MDA) and hydrogen peroxide (HO) accumulation and enhanced superoxide radical and hydroxyl radical levels. Read More

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Prognostic value of pre-treatment systemic immune-inflammation index in patients with endometrial cancer.

PLoS One 2021 14;16(5):e0248871. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.

Background: The systemic immune-inflammation index (SII), which is calculated using absolute platelet, neutrophil, and lymphocyte counts, has recently attracted attentions as a prognostic indicator in patients with solid malignancies. In the current study, we retrospectively investigated the prognostic significance of pre-treatment SII among patients with endometrial cancer.

Method: Endometrial cancer patients treated at Nara medical university hospital between 2008 and 2018 were included in the current study. Read More

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Absolute Neutrophil Count in the Peripheral Blood Predicts Prognosis in Lung Cancer Patients Treated with Anlotinib.

Cancer Manag Res 2021 3;13:3619-3627. Epub 2021 May 3.

Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Purpose: Anlotinib is a multi-targeted tyrosine kinase inhibitor that inhibits tumor angiogenesis and cell proliferation. It is widely used as a third-line therapy for lung cancer. However, reliable prognostic biomarkers for predicting the efficacy of anlotinib are lacking. Read More

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