1,571 results match your criteria pre-existing mood

Disordered eating and self-harm as risk factors for poorer mental health during the COVID-19 pandemic: A population-based cohort study.

medRxiv 2021 May 4. Epub 2021 May 4.

Background: Young adults and especially those with pre-existing mental health conditions, such as disordered eating and self-harm, appear to be at greater risk of developing metal health problems during the COVID-19 pandemic. However, it is unclear whether this increased risk is affected by any changes in lockdown restrictions, and whether any lifestyle changes could moderate this increased risk.

Methods: In a longitudinal UK population-based cohort (The Avon Longitudinal Study of Parents and Children, ALSPAC) we assessed the relationship between pre-pandemic measures of disordered eating and self-harm and mental health during the COVID-19 pandemic in 2,657 young adults. Read More

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The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies.

J Pathol 2021 May 8. Epub 2021 May 8.

Bone Tumor Reference Centre, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Schönbeinstrasse 40, 4056, Basel, Switzerland.

Osteosarcomas are aggressive primary tumors of bone that are typically detected in locally advanced stages, however which genetic mutations drive the cancer before its clinical detection remain unknown. To identify these events, we perform longitudinal genome-sequencing analysis of 12 patients with metastatic or refractory osteosarcoma. Phylogenetic and molecular clock analyses are carried out next to identify actionable mutations, and these are validated by integrating data from additional 153 osteosarcomas and pre-existing functional evidence from mouse PDX models. Read More

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Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals.

Arch Med Res 2021 May 4. Epub 2021 May 4.

Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece. Electronic address:

Post-COVID syndrome also known as long COVID refers to symptoms persisting for more than three weeks after the diagnosis of COVID-19. We reviewed the current evidence on post-COVID syndrome, focusing on its clinical manifestations and addressing the challenges for its management in primary healthcare. The incidence of post-COVID syndrome is estimated at 10-35%, while for hospitalized patients it may reach 85%. Read More

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Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic.

J Affect Disord 2021 Apr 24;289:105-109. Epub 2021 Apr 24.

Centre for Outcomes and Research Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, UK; Camden & Islington NHS Foundation Trust, St Pancras Hospital, 4 St Pancras Way, London, UK.

Background: General population surveys have shown that some groups, particularly young women, experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for current and future lockdowns.

Methods: Mean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services (Improving Access to Psychological Therapies) in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). Read More

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To the Operating Room! Positive Effects of a Healthcare Clown Intervention on Children Undergoing Surgery.

Front Public Health 2021 20;9:653884. Epub 2021 Apr 20.

Department of Clinical Psychology, Motol University Hospital, Prague, Czechia.

In the present study we examined the positive effects of a healthcare clown intervention on children undergoing surgeries, and the role parent-child relationships may play in their effectiveness. Children between 5 and 12 years, who were scheduled to undergo elective surgical procedures in a large university hospital, were randomly assigned to an intervention group (IG; = 35) that was visited by a healthcare clown, and a control group (CG; = 27) that received treatment as usual (i.e. Read More

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Why airborne transmission hasn't been conclusive in case of COVID-19? An atmospheric science perspective.

Sci Total Environ 2021 Jun 1;773:145525. Epub 2021 Feb 1.

Department of Civil Engineering, Centre for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India. Electronic address:

Airborne transmission is one of the routes for the spread of COVID-19 which is caused by inhalation of smaller droplets containing SARS-CoV-2 (i.e., either virus-laden particulate matter: PM and/or droplet nuclei) in an indoor environment. Read More

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Influenza Virus RNA Synthesis and the Innate Immune Response.

Viruses 2021 04 28;13(5). Epub 2021 Apr 28.

Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Infection with influenza A and B viruses results in a mild to severe respiratory tract infection. It is widely accepted that many factors affect the severity of influenza disease, including viral replication, host adaptation, innate immune signalling, pre-existing immunity, and secondary infections. In this review, we will focus on the interplay between influenza virus RNA synthesis and the detection of influenza virus RNA by our innate immune system. Read More

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Emotional Reasoning and Psychopathology.

Brain Sci 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Psychology, Telematic University of Rome "Guglielmo Marconi", Via Plinio 44, 00193 Rome, Italy.

One of the several ways in which affect may influence cognition is when people use affect as a source of information about external events. Emotional reasoning, ex-consequentia reasoning, and affect-as-information are terms referring to the mechanism that can lead people to take their emotions as information about the external world, even when the emotion is not generated by the situation to be evaluated. Pre-existing emotions may thus bias evaluative judgments of unrelated events or topics. Read More

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Different Forms of Tumor Vascularization and Their Clinical Implications Focusing on Vessel Co-option in Colorectal Cancer Liver Metastases.

Front Cell Dev Biol 2021 12;9:612774. Epub 2021 Apr 12.

Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

In modern anti-cancer therapy of metastatic colorectal cancer (mCRC) the anti-angiogenic treatment targeting sprouting angiogenesis is firmly established for more than a decade. However, its clinical benefits still remain limited. As liver metastases (LM) represent the most common metastatic site of colorectal cancer and affect approximately one-quarter of the patients diagnosed with this malignancy, its treatment is an essential aspect for patients' prognosis. Read More

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Association Between Renal Adverse Effects and Mortality in Patients With Hepatocellular Carcinoma Treated With Lenvatinib.

In Vivo 2021 May-Jun;35(3):1647-1653

Department of Nephrology, Teine Keijinkai Medical Center, Sapporo, Japan.

Background/aim: Lenvatinib, a multitargeted tyrosine kinase inhibitor, was recently approved for hepatocellular carcinoma (HCC) treatment in Japan; however, the association between proteinuria following lenvatinib administration in HCC patients and early mortality is unknown. This study aimed to examine the association between nephrotic-range proteinuria (NRP) and mortality and evaluated the risk factors for NRP among Japanese HCC patients treated with lenvatinib.

Patients And Methods: We retrospectively analyzed 45 consecutive patients receiving lenvatinib from 2018-2019. Read More

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January 2021

Elective Resection of Symptomatic Arteriovenous Fistulae and Grafts in Patients with Functioning Renal Allografts at a High Volume Transplant Hospital.

Ann Vasc Surg 2021 Apr 24. Epub 2021 Apr 24.

Division of Nephrology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Objective: Patients with functioning renal allografts may need ligation of pre-existing hemodialysis conduits. Chronic immunosuppression for renal allografts may adversely affect wound healing and perioperative complications following these procedures. We sought to analyze outcomes following elective ligation and resection of symptomatic arteriovenous (AV) access in immunosuppressed patients with renal allografts no longer requiring dialysis at a high-volume renal transplant hospital. Read More

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Effects of a multi-faceted education and support programme on anxiety symptoms among people with systemic sclerosis and anxiety during COVID-19 (SPIN-CHAT): a two-arm parallel, partially nested, randomised, controlled trial.

Lancet Rheumatol 2021 Apr 16. Epub 2021 Apr 16.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.

Background: No trials have tested multifaceted mental health interventions recommended by public health organisations during COVID-19. The objective of this trial was to evaluate the effect of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Program on anxiety symptoms and other mental health outcomes among people vulnerable during COVID-19 owing to a pre-existing medical condition.

Methods: The SPIN-CHAT Trial was a pragmatic, two-arm, parallel, partially nested, randomised, controlled trial (1:1 allocation to intervention or waitlist). Read More

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Relationship Between Procedural Right Bundle Branch Block and 1-Year Outcome After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy - A Retrospective Study.

Circ J 2021 Apr 24. Epub 2021 Apr 24.

Division of Cardiovascular Intensive Care, Nippon Medical School Hospital.

Background: Alcohol septal ablation (ASA) is a treatment option in patients with drug-refractory symptomatic hypertrophic obstructive cardiomyopathy (HOCM). In many patients, right bundle branch block (RBBB) develops during ASA because septal branches supply the right bundle branch. However, the clinical significance of procedural RBBB is uncertain. Read More

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Work-related violence and depressive disorder among 955,573 employees followed for 6.99 million person-years. The Danish Work Life Course Cohort study: Work-related violence and depression.

J Affect Disord 2021 Mar 26;288:136-144. Epub 2021 Mar 26.

National Research Centre for the Working Environment, Copenhagen, Denmark; Section of Epidemiology, Department of Public Health, University of Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Denmark.

Background: We examined the association between probability of work-related violence and first diagnosis of depressive disorder whilst accounting for the potential selection of individuals vulnerable to depression into occupations with high probability of work-related violence.

Methods: Based on a pre-published study protocol, we analysed nationwide register data from the Danish Work Life Course Cohort study, encompassing 955,573 individuals followed from their entry into the workforce, and free from depressive disorder before work-force entry. Depressive disorder was measured from psychiatric in- and outpatient admissions. Read More

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The complex combination of COVID-19 and diabetes: pleiotropic changes in glucose metabolism.

Endocrine 2021 Apr 22. Epub 2021 Apr 22.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Purpose: Angiotensin converting enzyme 2 (ACE2) is the door for SARS-CoV-2, expressed in critical metabolic tissues. So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, resulting in the complication of pre-existing diabetes's pathophysiology or creating new disease mechanisms. However, it seems that less attention has been paid to this issue. Read More

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Three-year study of pre-existing drug resistance substitutions and efficacy of bictegravir/emtricitabine/tenofovir alafenamide in HIV-1 treatment-naive participants.

J Antimicrob Chemother 2021 Apr 21. Epub 2021 Apr 21.

Gilead Sciences, Foster City, CA, USA.

Objectives: Two Phase 3, randomized, double-blind, active-controlled studies of initial HIV-1 treatment demonstrated that bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) was non-inferior to dolutegravir/abacavir/lamivudine (DTG/ABC/3TC; Study 1489) or to DTG+F/TAF (Study 1490) through 144 weeks. In both studies, there was no emergent resistance to study drugs. Here, the 3 year resistance analysis and impact of baseline resistance substitutions on treatment response are described. Read More

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Evolution of epigenetic transmission when selection acts on fecundity versus viability.

Philos Trans R Soc Lond B Biol Sci 2021 Jun 19;376(1826):20200128. Epub 2021 Apr 19.

Behaviour and Evolution Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

Existing theory on the evolution of parental effects and the inheritance of non-genetic factors has mostly focused on the role of environmental change. By contrast, how differences in population demography and life history affect parental effects is poorly understood. To fill this gap, we develop an analytical model to explore how parental effects evolve when selection acts on fecundity versus viability in spatio-temporally fluctuating environments. Read More

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The Coronavirus Health and Impact Survey (CRISIS) reveals reproducible correlates of pandemic-related mood states across the Atlantic.

Sci Rep 2021 04 14;11(1):8139. Epub 2021 Apr 14.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.

The COVID-19 pandemic and its social and economic consequences have had adverse impacts on physical and mental health worldwide and exposed all segments of the population to protracted uncertainty and daily disruptions. The CoRonavIruS health and Impact Survey (CRISIS) was developed for use as an easy to implement and robust questionnaire covering key domains relevant to mental distress and resilience during the pandemic. Ongoing studies using CRISIS include international studies of COVID-related ill health conducted during different phases of the pandemic and follow-up studies of cohorts characterized before the COVID pandemic. Read More

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Factors influencing fertility rates in Australian women receiving kidney replacement therapy: Analysis of linked ANZDATA registry and perinatal data over 22 years.

Nephrol Dial Transplant 2021 Apr 12. Epub 2021 Apr 12.

Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South, Australia.

Background: Pregnancy in women receiving kidney replacement therapy (KRT) is uncommon, and trends and factors influencing fertility rates remain poorly defined.

Methods: The Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) was linked to mandatory perinatal datasets (all births from 1991-2013, ≥20 weeks' gestation) in four Australian jurisdictions. Overall, age and era-specific fertility rates were calculated based on general and KRT population denominators. Read More

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An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.

EClinicalMedicine 2021 Apr 6;34:100806. Epub 2021 Apr 6.

Oxford Brain Health Clinical Trials Unit, Department of Psychiatry, Warneford Hospital,University of Oxford, Oxford OX3 7JX, UK.

Background: The global impact of COVID-19 pandemic continues to affect the lives of billions of people with recurrent waves. Healthcare systems are struggling to manage pre-existing patient care and recurring covid-19 demands. As a result, we evaluated the mental health impact using systematic review and meta-analysis. Read More

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Dermatologist's role in a cancer hospital: An overview of in-hospital consultations.

J Dermatol 2021 Apr 8. Epub 2021 Apr 8.

Division of Dermatology, Niigata Cancer Center Hospital, Niigata, Japan.

As cancer treatment advances, the need for dermatologists in the treatment process is increasing. Cancer patients often experience cutaneous manifestations of internal diseases and dermatological adverse events from chemotherapy, radiation, surgery, and stem cell transplants. These diminish patients' health-related quality of life and negatively affect cancer treatment adherence. Read More

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Optimising cardiovascular care of patients with multiple myeloma.

Heart 2021 Apr 5. Epub 2021 Apr 5.

Department of Cardio-Oncology, St Bartholomew's Hospital, London, UK

Multiple myeloma (MM) is the third most common haematological malignancy, with increasing prevalence over recent years. Advances in therapy have improved survival, changing the clinical course of MM into a chronic condition and meaning that management of comorbidities is fundamental to improve clinical outcomes. Cardiovascular (CV) events affect up to 7. Read More

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What Is the Impact of COVID-19 Pandemic on Patients with Pre-Existing Mood or Anxiety Disorder? An Observational Prospective Study.

Medicina (Kaunas) 2021 Mar 24;57(4). Epub 2021 Mar 24.

Istituto di Psicopatologia, 00196 Rome, Italy.

This observational prospective study aims to examine the psychological and psychopathological impact of the pandemic stress on patients with pre-existing mood, anxiety and obsessive-compulsive disorders. The study includes 386 consecutive patients recruited from 10 March to 30 June 2020 among those being treated at the Institute of Psychopathology in Rome (Italy) with an age ≥18 years and meeting DSM-5 criteria for major depressive disorder (MDD) (35.2%), bipolar I (BD-I) (21. Read More

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Decline of Psychological Health Following the Designation of COVID-19 as a Pandemic: Descriptive Study.

J Med Internet Res 2021 04 22;23(4):e24964. Epub 2021 Apr 22.

Department of Rehabilitation & Sports Medicine, Sir H N Reliance Foundation Hospital, Mumbai, India.

Background: COVID-19 was declared a pandemic by the World Health Organization on March 11, 2020, and as of this writing, Texas, United States, has reported >675,000 cases with over 14,000 deaths. Many of the preventive measures implemented during the pandemic can increase sedentary lifestyles, which can lead to the development of chronic diseases, including obesity, among the general population and cause serious threats to people's physical health and overall quality of life. Individuals with pre-existing comorbidities are at an increased risk of COVID-19 and may hence have higher levels of stress. Read More

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Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution.

medRxiv 2021 Mar 25. Epub 2021 Mar 25.

Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, coronavirus emergence in our species has been associated with zoonotic transmissions from animal reservoirs , underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family - , - human infections reported to date have been limited to alpha- and betacoronaviruses . Read More

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BTK inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Systematic Review.

Res Sq 2021 Mar 22. Epub 2021 Mar 22.

ImportanceThe Bruton tyrosine kinase (BTK) regulates B cell and macrophage signaling, development, survival, and activation. BTK inhibition was shown to protect against lethal influenza-induced acute lung injury in mice. Inhibiting BTK has been hypothesized to ameliorate lung injury in patients with severe coronavirus disease 2019 (COVID-19). Read More

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Machine Learning Approach to Predicting COVID-19 Disease Severity Based on Clinical Blood Test Data: Statistical Analysis and Model Development.

JMIR Med Inform 2021 Apr 13;9(4):e25884. Epub 2021 Apr 13.

School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.

Background: Accurate prediction of the disease severity of patients with COVID-19 would greatly improve care delivery and resource allocation and thereby reduce mortality risks, especially in less developed countries. Many patient-related factors, such as pre-existing comorbidities, affect disease severity and can be used to aid this prediction.

Objective: Because rapid automated profiling of peripheral blood samples is widely available, we aimed to investigate how data from the peripheral blood of patients with COVID-19 can be used to predict clinical outcomes. Read More

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Neurological manifestations of COVID-19 in confirmed and probable cases: A descriptive study from a large tertiary care center.

J Clin Neurosci 2021 Apr 22;86:97-102. Epub 2021 Jan 22.

Department of Infectious Diseases and Clinical Microbiology, Ankara City Hospital, Turkey.

During the early phase of the COVID-19 pandemic, it was thought that virus affects only the respiratory system. However, now it is clear that it can affect other systems too, particularly the nervous system. We aimed to identify the most common neurological symptoms and findings of COVID-19 in hospitalized patients and investigate the relationship between these symptoms and clinical, radiological, and laboratory findings. Read More

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Can a simple fall cause a rotator cuff tear? Literature review and biomechanical considerations.

Int Orthop 2021 Mar 27. Epub 2021 Mar 27.

Orthopädie Sonnenhof, Salvisbergstrasse 4, 3006, Bern, Switzerland.

Purpose: A simple fall on the shoulder is often referred to as minor trauma that cannot cause a tendon tear but at best reveal a pre-existing rotator cuff pathology. We wanted to know whether this statement was true. The purpose of our study was therefore to summarize the causes of acute rotator cuff tears reported in the literature and provide a biomechanical explanation for tendon tears diagnosed after a fall. Read More

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