2,845 results match your criteria pre-diabetic subjects

Awareness of diabetic retinopathy among diabetic patients.

J Pak Med Assoc 2021 Feb;71(2(B)):651-655

Foundation University Medical College, Islamabad, Pakistan.

Objective: To assess the awareness of diabetic patients about diabetic retinopathy.

Methods: The cross-sectional study was conducted at the Ophthalmology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan, from April 2018 to April 2019, and comprised diabetic patients of either gender aged 21-80 years. A pre-tested semi-structured questionnaire was used to collect data on socio-demographic, diabetes and diabetic retinopathy characteristics. Read More

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February 2021

Patterns of Abnormal Glucose Metabolism in Acromegaly and Impact of Treatment Modalities on Glucose Metabolism.

Cureus 2021 Mar 12;13(3):e13852. Epub 2021 Mar 12.

Department of Medicine, Section of Endocrinology, Aga Khan University Hospital, Karachi, PAK.

Background:  Chronic exposure to high levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) leads to metabolic complications, most importantly dysglycemia in the form of diabetes mellitus and pre-diabetes. Dysglycemia if diagnosed early in the course of the disease can decrease complications. Treatment modalities in the form of surgery and medical therapy have varied impacts on glucose metabolism. Read More

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Comparison of "burden of disease" in elderly and non-elderly patients with pre-diabetes: A cross-sectional study.

North Clin Istanb 2021 24;8(2):160-166. Epub 2020 Aug 24.

Department of Rheumatology, Kayseri City Hospital, Kayseri, Turkey.

Objective: There are a lot of studies comparing elderly and adult patients with diabetes but not pre-diabetes systematically. We aimed to compare the discrepancies of clinical status and burden of disease in elderly (≥60 years old) versus non-elderly (18-59 years old) adult pre-diabetics.

Methods: A total of 126 pre-diabetic patients were included in the study and were compared as two groups; the elderly (n=32) and non-elderly (n=94). Read More

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Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers.

Front Med (Lausanne) 2021 23;8:605691. Epub 2021 Mar 23.

Department of Internal Medicine and Therapeutics, Centre of Diabetes and Metabolic Diseases, University of Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

Psoriasis is an immune-mediated dermatosis with cardio-metabolic comorbidities. The aim of this study was to assess insulin-resistance, lipid abnormalities, and cardiovascular risk biomarkers in psoriatic patients with or without type 2 diabetes mellitus (T2DM). We enrolled 425 patients: 86 psoriatics, 69 psoriatics with T2DM, 120 T2DM patients, and 150 healthy subjects. Read More

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Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review article, we focus on metformin which is an insulin sensitizer and is often used as a first-choice drug worldwide. Metformin mainly activates adenosine monophosphate-activated protein kinase (AMPK) in the liver which leads to suppression of fatty acid synthesis and gluconeogenesis. Metformin activates AMPK in skeletal muscle as well, which increases translocation of glucose transporter 4 to the cell membrane and thereby increases glucose uptake. Read More

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Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose.

Nutrients 2021 Mar 18;13(3). Epub 2021 Mar 18.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.

We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35-69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Mediterranean dietary pattern. Read More

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Longitudinal Evolution of Bone Microarchitecture and Bone Strength in Type 2 Diabetic Postmenopausal Women With and Without History of Fragility Fractures-A 5-Year Follow-Up Study Using High Resolution Peripheral Quantitative Computed Tomography.

Front Endocrinol (Lausanne) 2021 16;12:599316. Epub 2021 Mar 16.

Musculoskeletal Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.

Introduction: Diabetic bone disease is characterized by an increased fracture risk which may be partly attributed to deficits in cortical bone quality such as higher cortical porosity. However, the temporal evolution of bone microarchitecture, strength, and particularly of cortical porosity in diabetic bone disease is still unknown. Here, we aimed to prospectively characterize the 5-year changes in bone microarchitecture, strength, and cortical porosity in type 2 diabetic (T2D) postmenopausal women with (DMFx) and without history of fragility fractures (DM) and to compare those to nondiabetic fracture free controls (Co) using high resolution peripheral quantitative computed tomography (HR-pQCT). Read More

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Differences in the characteristics of subjects achieving complete, partial, or no resolution of macular edema in the READ-3 study.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 1. Epub 2021 Apr 1.

Byers Eye Institute, Stanford University, 2370 Watson Court - Suite 200, Palo Alto, CA, 94303, USA.

Purpose: To identify baseline characteristics of subjects enrolled in the READ-3 study that would predict the response of macular edema to ranibizumab (RBZ) therapy at year 1.

Methods: In this post hoc analysis of the READ-3 randomized, multicenter phase 2 clinical trial, subjects with diabetic macular edema (DME) were randomized to receive monthly intravitreal injections of RBZ (0.5 or 2. Read More

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A Comparison of Two Diabetes Self-Management Education Programs for the Reduction of Participant A1c Levels.

Am J Health Promot 2021 Apr 1:8901171211003829. Epub 2021 Apr 1.

Department of Biostatics, 48653School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: Compare the effectiveness of two educational teaching methods for diabetic patients.

Design: Quasi-experimental study comparing two interventions using a pretest/post-test design.

Setting: Three clinics within a western U. Read More

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Analysis of time-dependent alterations of parameters related to erythrocytes after ipragliflozin initiation.

Diabetol Int 2021 Apr 10;12(2):197-206. Epub 2020 Nov 10.

Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017 Japan.

Sodium-glucose cotransporter 2 (SGLT2) inhibitors often increase the hematocrit. It remains unclear whether this increase would be observed in all patients administered SGLT2 inhibitors, however. We therefore used the data from the previous study and investigated time-dependent alterations of various outcomes related to erythrocytes, erythropoiesis, and clinical outcome in type 2 diabetes subjects ( = 89) treated with ipragliflozin for 16 weeks. Read More

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Psychological Outcomes in Children and Early Adolescents With Type 1 Diabetes Following Pediatric Diabetes Summer Camp: A 3-Month Follow-Up Study.

Front Pediatr 2021 10;9:650201. Epub 2021 Mar 10.

Department of the Woman, Child and General and Specialized Surgery, University of Campania "L. Vanvitelli", Naples, Italy.

The aim of this study was to assess general psychosocial adjustment to diabetes and perceived disease management among patients with type 1 diabetes (T1D) and their parents before and after patients' participation in a diabetes summer camp. In this follow-up study, 20 children and adolescents with T1D (eight boys; mean age = 11.01 ± 0. Read More

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A single arm trial using passive simulated jogging for blunting acute hyperglycemia.

Sci Rep 2021 Mar 19;11(1):6437. Epub 2021 Mar 19.

Mount Sinai Medical Center of Greater Miami, Miami Beach, FL, USA.

Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-diabetic subjects. Read More

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Association between Interleukin-1β Polymorphism at Rs16944 and Glucose Metabolism: A Cohort Study.

Immunol Invest 2021 Mar 19:1-11. Epub 2021 Mar 19.

Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

: This study explored the correlation between the interleukin-1β gene rs16944 polymorphism and diabetes through epidemiological and follow-up investigations.: The study was conducted on 600 subjects with normal glucose metabolism recruited from participants of the in Luzhou, China in 2011. All subjects received a unified standardized questionnaire, physical examination, laboratory examination, and follow-up in 2016. Read More

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Short-Term Effects of the Internet-Based Korea Diabetes Prevention Study: 6-Month Results of a Community-Based Randomized Controlled Trial.

Diabetes Metab J 2021 Mar 17. Epub 2021 Mar 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

The aims of this study were to determine the short-term effectiveness of an internet-based lifestyle modification (LSM) program in preventing the onset of type 2 diabetes mellitus (T2DM) in prediabetes patients in community settings. A total of 415 subjects who were diagnosed with prediabetes were randomly assigned to the LSM and standard management (SM) groups. After the 6-month intervention, the LSM group had a statistically significant reduction in body weight, body mass index compared to the SM group participants. Read More

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Immediate effects of hemodialysis on upper extremity and cognitive function.

Am J Surg 2021 Feb 23. Epub 2021 Feb 23.

Division of Vascular Surgery, Oregon Health & Science University, United States. Electronic address:

Background: Subjects undergoing hemodialysis often describe feeling "weak" and "fatigued" after dialysis. This has not previously been quantified. We sought to evaluate upper extremity and cognitive function before and after hemodialysis to see if differences existed and how long recovery takes. Read More

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February 2021

Sex-specific differences in left ventricular mass and myocardial energetic efficiency in non-diabetic, pre-diabetic and newly diagnosed type 2 diabetic subjects.

Cardiovasc Diabetol 2021 Mar 6;20(1):60. Epub 2021 Mar 6.

Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189, Rome, Italy.

Background: Women with type 2 diabetes (T2DM) have a higher excess risk for cardiovascular disease (CVD) than their male counterparts. However, whether the risk for CVD is higher in prediabetic women than men is still debated. We aimed to determine whether sex-related differences exist in left ventricular mass index (LVMI), and myocardial mechano-energetic efficiency (MEEi) in with normal glucose tolerant (NGT), pre-diabetic and newly diagnosed type 2 diabetic subjects. Read More

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Effects of Gastric Bypass Surgery on the Brain; Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity and Cognitive Function during Normo- and Hypoglycemia.

Diabetes 2021 Mar 4. Epub 2021 Mar 4.

Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.

While Roux-en-Y Gastric Bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes hypoglycemia. Previous work showed attenuated counter-regulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. Read More

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Prevalence of Prediabetes and Type 2 Diabetes Mellitus in Football Players: A Novel Multi Football Clubs Cross Sectional Study.

Int J Environ Res Public Health 2021 02 11;18(4). Epub 2021 Feb 11.

Army Medical College, National University of Medical Sciences (NUMS), Rawalpindi 051, Pakistan.

Sports offer great benefits, improving health and reducing the risk of illnesses. This study's aim was to investigate the prevalence of prediabetes and type 2 diabetes mellitus in football players compared to population based non-elite athlete control subjects. Initially 1100 male volunteers, (550) football players, and (550) population based non-elite athlete control subjects were interviewed. Read More

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February 2021

Incidence Hypertension and Fasting Blood Glucose from Real-World Data: Retrospective Cohort for 7-Years Follow-Up.

Int J Environ Res Public Health 2021 02 21;18(4). Epub 2021 Feb 21.

Department of Preventive Medicine, College of Korean Medicine, Dongguk University, Gyeongju-si 38066, Korea.

This retrospective cohort study was done to investigate the incidence of hypertension and its relation to the fasting blood glucose level in Korea. The eligible non-hypertensive subjects ( = 3,396,187) among the National Health Insurance Service-National Health Screening (NHIS-HEALS) examinees ( = 10,644,911) in 2009 were followed up until 2015. A Cox proportional hazards regression was used to estimate the risk of the high blood glucose level for the incident hypertension while controlling for covariates' confounding effect. Read More

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February 2021

Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark.

Genome Med 2021 Mar 3;13(1):36. Epub 2021 Mar 3.

TCS Research, Tata Consultancy Services Limited, 54B Hadapsar Industrial Estate, Pune, 411013, India.

Background: Recent studies have indicated an association of gut microbiota and microbial metabolites with type 2 diabetes mellitus (T2D). However, large-scale investigation of the gut microbiota of "prediabetic" (PD) subjects has not been reported. Identifying robust gut microbiome signatures of prediabetes and characterizing early prediabetic stages is important for the understanding of disease development and could be crucial in early diagnosis and prevention. Read More

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Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort.

Diabetes Metab J 2021 Feb 25. Epub 2021 Feb 25.

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Yonsei University College of Medicine, Seoul, Korea.

Background: Previously developed prediction models for type 2 diabetes mellitus (T2DM) have limited performance. We developed a deep learning (DL) based model using a cohort representative of the Korean population.

Methods: This study was conducted on the basis of the National Health Insurance Service-Health Screening (NHIS-HEALS) cohort of Korea. Read More

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February 2021

Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns.

Exp Clin Endocrinol Diabetes 2021 Feb 22. Epub 2021 Feb 22.

Division of Endocrinology, Metabolism and Diabetes. University of Louisville, Louisville, Kentucky, USA.

Background: Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life.

Aims: To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns. Read More

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February 2021

Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes.

Sci Rep 2021 Feb 18;11(1):4136. Epub 2021 Feb 18.

Department of Medicine and Aging Science, "G. d'Annunzio" University, Chieti, Italy.

Diabetic retinopathy (DR) is a leading cause of vision loss and disability. Effective management of DR depends on prompt treatment and would benefit from biomarkers for screening and pre-symptomatic detection of retinopathy in diabetic patients. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression which are released in the bloodstream and may serve as biomarkers. Read More

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February 2021

High protein diet leads to prediabetes remission and positive changes in incretins and cardiovascular risk factors.

Nutr Metab Cardiovasc Dis 2021 04 8;31(4):1227-1237. Epub 2020 Dec 8.

Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Background And Aims: High Protein diets may be associated with endocrine responses that favor improved metabolic outcomes. We studied the response to High Protein (HP) versus High Carbohydrate (HC) Diets in terms of incretin hormones GLP-1 and GIP, the hunger hormone ghrelin and BNP, which is associated with cardiac function. We hypothesized that HP diets induce more pronounced release of glucose lowering hormones, suppress hunger and improve cardiac function. Read More

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Effect of intensive blood pressure on the progression of non-diabetic chronic kidney disease at varying degrees of proteinuria.

J Investig Med 2021 Feb 4. Epub 2021 Feb 4.

Department of Medicine, Division of Nephrology, Albany Stratton VA Medical Center, Albany, New York, USA.

The ideal blood pressure (BP) target for renoprotection is uncertain in patients with non-diabetic chronic kidney disease (CKD), especially considering the influence exerted by pre-existing proteinuria. In this pooled analysis of landmark trials, we coalesced individual data from 5001 such subjects randomized to intensive versus standard BP targets. We employed multivariable regression to evaluate the relationship between follow-up systolic blood pressure (SBP) and diastolic blood pressure (DBP) on CKD progression (defined as glomerular filtration rate decline by 50% or end-stage renal disease), focusing on the potential for effect modification by baseline proteinuria or albuminuria. Read More

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February 2021

The Impact of Diet and Fibre Fractions on Plasma Adipocytokine Levels in Prediabetic Adults.

Nutrients 2021 Feb 2;13(2). Epub 2021 Feb 2.

Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.

The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)-rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). Read More

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February 2021

Effects of Vitamin D Supplementation on Prevention of Type 2 Diabetes in Patients With Prediabetes: A Systematic Review and Meta-analysis.

Diabetes Care 2020 07;43(7):1650-1658

West China Hospital, Sichuan University, Chengdu, Sichuan, China

Background: While observational studies have shown an association between vitamin D insufficiency and diabetes, it is unclear whether intervention with vitamin D supplements can lower the risk of type 2 diabetes mellitus (T2DM).

Purpose: To assess whether vitamin D supplementation reduces the risk of T2DM in people with prediabetes.

Data Sources: We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 5 July 2019. Read More

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Evaluation of MASP1, CMPF and U.A serum levels in pre-diabetic subjects in comparison to Normal individuals for early diagnosis of subjects with pre-diabetes, a case-control study.

J Diabetes Metab Disord 2020 Dec 21;19(2):1593-1598. Epub 2020 Nov 21.

Department of Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Background: The present study designed to evaluate the Serum levels of CMPF, MASP1 and UA in pre-diabetic subjects was compared to normal subjects

Methods: This research is a case-control study. We studied 44 pre-diabetics with 44 normal subjects and were evaluated serum concentration of CMPF, Masp1 and U.Ain both groups andfurthermore serum concentration FPG, BUN, Cr, Cho, TG, HDLc, LDLc, AST, ALT, ALP, HbA1c was examined and correlation between of CMPF, Masp1 and U. Read More

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December 2020

An increase in inflammation and islet dysfunction is a feature of prediabetes.

Diabetes Metab Res Rev 2020 Sep 10:e3405. Epub 2020 Sep 10.

Institute of Regenerative Medicine, LifeNet Health, Virginia Beach, Virginia, USA.

Aims: Type 2 diabetes (T2D) is a global health problem that will be diagnosed in almost 300 million people by 2025 according to the World Health Organization. Before being diagnosed with T2D, individuals may have glucose levels above normal but below the diabetic range. This condition is known as prediabetes. Read More

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September 2020

Effects of Alpha-2-HS-glycoprotein on cognitive and emotional assessment in prediabetic and diabetic subjects.

J Affect Disord 2021 03 29;282:700-706. Epub 2020 Dec 29.

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Viale Europa, Loc. Germaneto, Catanzaro 88100, Italy.

Background: High concentrations of Alpha-2-HS-glycoprotein, also called Fetuin-A (Fet-A), are associated with insulin resistance, obesity, non-alcoholic fatty liver disease, type 2 diabetes and polycystic ovary syndrome. Moreover, Fet-A is able to cross the bloodbrain barrier into ischemic brain tissue in adult humans. Although the brain is an important target of insulin action, there is little evidence associating serum levels of Fet-A with psychiatric conditions such as depression and cognitive decline, and no reports about the presence and degree of anxiety disorders. Read More

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