74,591 results match your criteria practice characteristics

Investigating the Scientific 'Infodemic' Phenomenon Related to the COVID-19 Pandemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Department of Medical Informatics, Amsterdam University Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Objectives: The study aims at understanding the structural characteristics and content features of COVID-19 literature and public health data from the perspective of the 'Language and Meaning in Biomedicine' Working Group (LaMB WG) of IMIA. The LaMB WG has interest in conceptual characteristics, transparency, comparability, and reusability of medical information, both in science and practice.

Methods: A set of methods were used (i) investigating the overall speed and dynamics of COVID-19 publications; (ii) characterizing the concepts of COVID-19 (text mining, visualizing a semantic map of related concepts); (iii) assessing (re)usability and combinability of data sets and paper collections (as textual data sets), and checking if information is Findable, Accessible, Interoperable, and Reusable (FAIR). Read More

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Drawing Reproducible Conclusions from Observational Clinical Data with OHDSI.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Observational Health Data Sciences and Informatics, New York, New York, USA.

Objective: The current observational research literature shows extensive publication bias and contradiction. The Observational Health Data Sciences and Informatics (OHDSI) initiative seeks to improve research reproducibility through open science.

Methods: OHDSI has created an international federated data source of electronic health records and administrative claims that covers nearly 10% of the world's population. Read More

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Unexpected Term Neonatal Intensive Care Unit Admissions and a Potential Role for Centralized Remote Fetal Monitoring.

Am J Perinatol 2021 Apr 21. Epub 2021 Apr 21.

Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Women's Service Line, Ochsner Health, New Orleans, Louisiana.

Objective:  Centralized remote fetal monitoring (CRFM) has been proposed as a method to improve the performance of intrapartum fetal heart rate (FHR) monitoring and perinatal outcomes. The purpose of this study is to determine whether CRFM was associated with a reduction in unexpected term neonatal intensive care unit (NICU) admissions.

Study Design:  A pre-post design was used to examine the effectiveness of CRFM which was implemented in stages across five hospitals. Read More

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[Concepts for diagnosis, course and fall risk assessment in neurological gait disorders].

Fortschr Neurol Psychiatr 2021 Apr 21. Epub 2021 Apr 21.

Klinikum der Universität München, Deutsches Schwindel- und Gleichgewichtszentrum.

Quantitative gait assessment is increasingly applied in the diagnosis, disease monitoring, and risk stratification of neurological gait disorders. However, it is unclear, which measurement approaches, examination conditions, and gait characteristics are appropriate for answering specific clinical questions. The aim of this review was to provide generally applicable concepts and strategies for the measurement, analysis, and interpretation of gait function in the clinical context and to discuss their implementation in clinical practice. Read More

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Significant Variation in Blood Transfusion Practice Persists following Idiopathic Adolescent Scoliosis Surgery.

Spine (Phila Pa 1976) 2021 Apr 19. Epub 2021 Apr 19.

Department of Trauma and Orthopaedics, Mater Misericordiae University Hospital, Dublin, Ireland Department of Orthopaedics, University of North Carolina, Chapel Hill, North Carolina Department of Orthopedic Surgery, University of Rochester, Rochester, New York The Ohio State University Wexner Medical Center, Department of Surgery, Columbus, OH University of Rochester Medical Center, Surgical Health Outcomes & Research Enterprise (SHORE), Rochester, NY.

Study Design: Retrospective Case Control Study.

Objective: To review current transfusion practise following AIS surgery and assess risks of complication from transfusion in this cohort.

Summary Of Background Data: No study to date has investigated variation in blood transfusion practices across surgeons and hospitals following Adolescent Idiopathic Scoliosis (AIS) surgery. Read More

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Gender differences in physician decisions to adopt new prescription drugs.

Soc Sci Med 2021 Apr 4;277:113886. Epub 2021 Apr 4.

Melbourne Institute: Applied Economic & Social Research, The University of Melbourne, 111 Barry Street, The University of Melbourne, VIC, 3010, Australia. Electronic address:

Physician adoption of new technologies is a key issue for population health and the sustainability of the healthcare system. This paper explores gender differences in general practitioners' (GPs) adoption of new oral anticoagulants. We combine detailed individual data on physician and practice style characteristics from the Medicine in Australia: Balancing Employment and Life (MABEL) panel survey of Australian physicians with administrative prescribing data from the Australian Pharmaceutical Benefits Scheme (PBS) and the Medicare Benefits Schedule (MBS) for the period January 1, 2012 and December 31, 2015. Read More

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Association of Multimorbidity on Healthcare Expenditures Among Older United States Adults With Pain.

J Aging Health 2021 Apr 21:8982643211011841. Epub 2021 Apr 21.

Department of Pharmacy Practice and Science, University of Arizona College of Pharmacy, USA.

This cross-sectional study compared the healthcare expenditures associated with multimorbidity (having ≥2 chronic conditions) versus no multimorbidity among older United States (US) adults (aged ≥ 50 years) with self-reported pain in the past 4 weeks. This research used data from the 2018 Medical Expenditure Panel Survey. Adjusted linear regression models evaluated group differences in various annual healthcare expenditures. Read More

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[Ophthalmic safety profile of antiangiogenic therapy].

Vestn Oftalmol 2021 ;137(2):114-122

Novosibirsk State Region Hospital, Novosibirsk, Russia.

Antiangiogenic therapy with inhibitors of vascular endothelial growth factor (anti-VEGF) has not only fundamentally changed the treatment outcomes of vasoproliferative eye diseases, but also became the most common ophthalmic surgical manipulation. At the same time, in 36-48% of bilateral lesions there is a need to perform injections in both eyes, making relevant the issues of safety and prevention of severe complications that threaten irreversible loss of visual function. The article reviews the results of randomized clinical trials and real clinical practice, analyzes the incidence and causes of its most dangerous complication - endophthalmitis, characterizes the clinical course depending on the type of drug used, and considers the possibility of reducing the risk of this complication occurring. Read More

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January 2021

Placental decidual arteriopathy and vascular endothelial growth factor A (VEGF-A) expression among women with and without HIV.

J Infect Dis 2021 Apr 21. Epub 2021 Apr 21.

Massachusetts General Hospital Department of Pathology, Boston, MA, USA.

Background: Women with HIV (WHIV) are at higher risk of adverse birth outcomes. Proposed mechanisms for the increased risk include placental arteriopathy (vasculopathy) and maternal vascular malperfusion (MVM) due to antiretroviral therapy (ART) and medical comorbidities. However, these features and their underlying pathophysiologic mechanisms have not been well characterized in WHIV. Read More

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Disparities in Guideline-Concordant Initial Systemic Treatment in Women with HER2-Negative Metastatic Breast Cancer: A SEER-Medicare Analysis.

Breast Cancer (Dove Med Press) 2021 13;13:259-269. Epub 2021 Apr 13.

West Virginia University, School of Medicine, Morgantown, WV, USA.

Background: Data on guideline-concordant initial systemic treatment among women with HER2-negative metastatic breast cancer (MBC) are limited. We determined the proportion of women with HER2-negative MBC who received guideline-concordant treatment and the extent to which independent variables explained differences in guideline-concordant treatment by hormone receptor (HR) status.

Methods: We conducted a retrospective cohort study using the SEER-Medicare database. Read More

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Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study.

Open Heart 2021 Apr;8(1)

NIHR School for Primary Care Research, Centre for Primary Care and Health Services Research, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, UK.

Objective: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD) and evaluated the association between severity and adverse outcomes.

Methods: Primary and secondary care data for 213 088 people with CHD in 398 practices in England between 2007 and 2017 were used. Read More

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Feasibility study on elimination of all oral opioids following bariatric surgery.

Surg Obes Relat Dis 2021 Mar 8. Epub 2021 Mar 8.

Department of Bariatric Surgery, Kaiser Permanente, South Sacramento Medical Center, Sacramento, California.

Background: The bariatric population is at increased risk for developing chronic opioid dependence. The practice of prescribing oral opioids for analgesia in postoperative ambulatory settings is a known risk factor for developing chronic opioid dependence. The use of oral opioids following minimally invasive bariatric surgery may not be necessary. Read More

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COVID-19 Management in Clinical Dental Care. Part I: Epidemiology, Public Health Implications, and Risk Assessment.

Int Dent J 2021 Feb 10. Epub 2021 Feb 10.

Faculty of Dental Medicine, University of Lisboa, Lisboa, Portugal.

Coronavirus disease 2019 (COVID-19), a viral disease declared a pandemic by the World Health Organization (WHO) in March 2020, has posed great changes to many sectors of society across the globe. Its virulence and rapid dissemination have forced the adoption of strict public health measures in most countries, which, collaterally, resulted in economic hardship. This article is the first in a series of 3 that aims to contextualise the clinical impact of COVID-19 for the dental profession. Read More

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February 2021

[Evidence-Based Psychological Treatments for Adults: A Selective Review]

Psicothema 2021 05;33(2):188-197

Universidad de La Rioja.

Evidence-Based Psychological Treatments for Adults: A Selective Review.

Background: Psychological treatments have shown their efficacy, effectiveness, and efficiency in dealing with mental disorders. However, considering the scientific knowledge generated in recent years, in the Spanish context, there are no updating studies about empirically supported psychological treatments. Read More

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The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review.

Cancer Imaging 2021 Apr 20;21(1):36. Epub 2021 Apr 20.

Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands.

Background: Diagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several limitations, such as the risk of sampling error. Also, the prognostic impact of BM abnormalities is largely unclear. Read More

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Variation in restraint use between hospitals: a multilevel analysis of multicentre prevalence measurements in Switzerland and Austria.

BMC Health Serv Res 2021 Apr 20;21(1):367. Epub 2021 Apr 20.

Department of Health Services Research, Care and Public Health Research Institute, Maastricht University, PO BOX 616, 6200, MD, Maastricht, The Netherlands.

Background: In restraint use in the somatic acute-care hospital setting, routine and institutional culture seem to play an important role. This implies that similar patient situations would be managed with restraints in one hospital, while in another hospital the situation would be managed without restraints. This practice variation appears to be ethically and legally questionable. Read More

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Type 2 diabetes and COPD: treatment in the right healthcare setting? An observational study.

BMC Fam Pract 2021 Apr 20;22(1):78. Epub 2021 Apr 20.

Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Type 2 diabetes (T2DM) and COPD are chronic medical conditions, for which patients need lifelong healthcare. The aim of this study is to examine in which healthcare setting patients with T2DM and COPD receive their care, and if this is the correct healthcare setting according to guidelines.

Method: T2DM and COPD patients from five primary care practices were included. Read More

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[Immunonutrition in fast-track surgical patients - evidence review and adapted algorithm].

Nutr Hosp 2021 Apr 21. Epub 2021 Apr 21.

Servicio de Anestesia-Reanimación. Hospital Universitario Ramón y Cajal. IRYCIS. Universidad de Alcalá de Henares.

Surgical stress predisposes patients to have immune dysfunction and an increased risk of infection. Malnourished surgical patients have higher postoperative morbidity and mortality rates, higher readmission rates, and higher hospital costs. The use of an immunomodulatory formula is associated in the ESPEN guidelines with a reduction in wound healing problems, suture failure, and infectious and global complications. Read More

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From policy to patient: Using a socio-ecological framework to explore the factors influencing safe practice in UK primary care.

Soc Sci Med 2021 Apr 5;277:113906. Epub 2021 Apr 5.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Background: The recent and rapid changes in the model of primary care delivery have led to an increased focus on patient safety in what is one of the most diverse and complex healthcare settings. However, previous initiatives have failed to deliver the expected improvements, leading to calls for a better understanding of how a range of personal and contextual factors influence the decisions and behaviours of individual care providers.

Methods: The socio-ecological framework, successfully used in public health settings to interpret the complex influences on individual behaviours, enabled a post-hoc deductive analysis of a series of semi-structured interviews conducted with clinical staff and senior managers at a range of practices across five geographically diverse regions in England to explore their perspectives on the factors that influence safe practice. Read More

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Preventing Prostate Biopsy Complications: to Augment or to Swab?

Urology 2021 Apr 17. Epub 2021 Apr 17.

Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Objective: To use data from a large, prospectively- acquired regional collaborative database to compare the risk of infectious complications associated with three American Urologic Association- recommended antibiotic prophylaxis pathways, including culture-directed or augmented antibiotics, following prostate biopsy.

Methods: Data on prostate biopsies and outcomes were collected from the Pennsylvania Urologic Regional Collaborative, a regional quality collaborative working to improve the diagnosis and treatment of prostate cancer. Patients were categorized as receiving one of three prophylaxis pathways: culture-directed, augmented, or provider-discretion. Read More

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Hypothesis Generation during Foodborne Illness Outbreak Investigations.

Am J Epidemiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States.

Hypothesis generation is a critical, but challenging, step in a foodborne outbreak investigation. The pathogens that contaminate food have many diverse reservoirs, resulting in seemingly limitless potential vehicles. Identifying a vehicle is particularly challenging for clusters detected through national pathogen-specific surveillance, as cases can be geographically dispersed and lack an obvious epidemiological link. Read More

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Community knowledge, attitude and practices to SARS-CoV-2 disease 2019 (COVID-19): A cross-sectional study in Woldia town, Northeast Ethiopia.

PLoS One 2021 20;16(4):e0250465. Epub 2021 Apr 20.

Natural and Computational Sciences Faculty, Department of Biology, Woldia University, Woldia, Ethiopia.

SARS-CoV-2 disease 2019 (COVID-19) is pandemic and currently becomes a serious cause of death worldwide. It is caused by a SARS-CoV-2 belonging to a family known as corona virus. The aim of this study is to assess the community knowledge, attitude and practice strategy implementation on SARS-CoV-2 disease 2019 (COVID-19). Read More

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Clinical and economic outcomes of a collaborative cardiology care program.

Am J Manag Care 2021 Apr 1;27(4):e114-e122. Epub 2021 Apr 1.

Institute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Email:

Objectives: We evaluated a collaborative care program aimed at improving cooperation among general practitioners (GPs) and cardiologists in Baden-Wuerttemberg, Germany. The program focused on improving care for patients with chronic cardiac conditions.

Study Design: We conducted a retrospective cohort study. Read More

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Healthcare providers attitudes towards risk stratification of adopted patients with limited family history information: a cross-sectional survey.

J Community Genet 2021 Apr 20. Epub 2021 Apr 20.

Department of Physician Assistant Studies, University of Toledo, Toledo, OH, USA.

Familial medical history (FMH) is crucial for patient risk stratification; however, adopted patients' FMH knowledge may be limited. This can be problematic when determining steps in screening and management of patients. Little is known about providers' opinions and practices regarding adopted patients with limited FMH. Read More

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Farnesol: An approach on biofilms and nanotechnology.

Med Mycol 2021 Apr 20. Epub 2021 Apr 20.

Biotechnology, Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, Goiânia, 74605-050, Brazil.

Biofilms are important virulence factor in infections caused by microorganisms because of its complex structure, which provide resistance to conventional antimicrobials. Strategies involving the use of molecules capable of inhibiting their formation and also act synergistically with conventional drugs have been explored. Farnesol is a molecule present in essential oils and produced by Candida albicans as a quorum sensing component. Read More

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Clinician Burnout Associated With Sex, Clinician Type, Work Culture, and Use of Electronic Health Records.

JAMA Netw Open 2021 Apr 1;4(4):e215686. Epub 2021 Apr 1.

Duke University Health System, Durham, North Carolina.

Importance: Electronic health records (EHRs) are considered a potentially significant contributor to clinician burnout.

Objective: To describe the association of EHR usage, sex, and work culture with burnout for 3 types of clinicians at an academic medical institution.

Design, Setting, And Participants: This cross-sectional study of 1310 clinicians at a large tertiary care academic medical center analyzed EHR usage metrics for the month of April 2019 with results from a well-being survey from May 2019. Read More

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Effectiveness, Core Elements, and Moderators of Response of Cognitive Remediation for Schizophrenia: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

JAMA Psychiatry 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Importance: Cognitive impairment is a core feature of schizophrenia, with negative consequences on functional outcomes. Although cognitive remediation (CR) is effective and mentioned in treatment guidance for schizophrenia, its active ingredients and ideal candidates are still debated.

Objective: To provide a comprehensive update on CR effectiveness for cognition and functioning in schizophrenia and analyze the core ingredients of efficacy and role of patient characteristics. Read More

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Race/Ethnic Differences in Atherosclerotic Cardiovascular Disease Risk Factors Among Patients with Hypertension: Analysis from 143 primary care clinics.

Am J Hypertens 2021 Apr 20. Epub 2021 Apr 20.

Enterprise Population Health, Advocate Aurora Health, Downers Grove, IL, USA.

Background: While it is known that sex and race/ethnic disparities persist for atherosclerotic cardiovascular disease (ASCVD), disparities in risk factor control have not been well-described in primary care where ASCVD can be prevented.

Methods: Adult patients with a hypertension diagnosis without ASCVD were included in this analysis of electronic health records from a large US healthcare system from 2018. Patients were categorized based on risk factor control defined as blood pressure <130/80 mmHg; statin prescription among patients with indications, HbA1c of <7%, and not smoking. Read More

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Implementation of the polycystic ovary syndrome guidelines: A mixed method study to inform the design and delivery of a lifestyle management program for women with polycystic ovary syndrome.

Nutr Diet 2021 Apr 19. Epub 2021 Apr 19.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Aim: The 2018 evidence-based polycystic ovary syndrome (PCOS) guidelines recommend lifestyle management as first-line treatment. This study aims to understand the preferred intervention characteristics of a PCOS lifestyle program from the perspectives of women with PCOS to inform the translation of the guidelines into practice.

Methods: Women with self-reported PCOS residing in Australia took part in semi-structured interviews (n = 20) and an online survey (n = 286). Read More

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Oral Medicine practice in Europe and Australia: identifying practitioner characteristics and their clinical activity.

Oral Dis 2021 Apr 19. Epub 2021 Apr 19.

Australian Centre for Oral Oncology Research & Education, Hollywood Private Hospital, Fiona Stanley Hospital, Australian Clinical Labs, Perth, WA, Australia.

Oral Medicine is a young dental specialty born almost a century ago and deals with orofacial conditions not directly attributable to the most prevalent tooth pathologies such as dental caries or periodontal diseases. Presentations may reflect local disease or orofacial manifestations of more widespread pathology affecting other parts of the body. Due to its recency as a distinct discipline and to heterogeneous global settings, Oral Medicine has not yet achieved a shared scope and definition, as well as a recognized status across the globe. Read More

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