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Practice Patterns and Pain Outcomes for Targeted Muscle Reinnervation: An Informed Approach to Targeted Muscle Reinnervation Use in the Acute Amputation Setting.

J Bone Joint Surg Am 2021 Apr;103(8):681-687

USU-Walter Reed Department of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland.

Background: Targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) procedures have been shown to improve patient-reported outcomes for the treatment of symptomatic neuromas after amputation; however, the specific indications and comparative outcomes of each are unclear. The primary research questions were what complement of nerves most frequently requires secondary pain intervention after conventional amputation, whether this information can guide the focused application of TMR and RPNI to the primary amputation setting, and how the outcomes compare in both settings.

Methods: We performed a retrospective review of records for patients who had undergone lower-extremity TMR and/or RPNI at our institution. Read More

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Mechanical and Ablative Minimally Invasive Techniques for Male LUTS due to Benign Prostatic Obstruction: A Systematic Review according to BPH-6 Evaluation.

Urol Int 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Urology, University of Catania, Catania, Italy.

The treatment of male lower urinary tract symptoms (LUTS) due to benign prostatic obstruction represents one of the major interesting aspects in urological clinical practice. Although transurethral resection of the prostate is still considered the surgical gold standard for treatment of benign prostatic hyperplasia with prostate volume <80 mL, various minimally invasive surgical treatments (MITs) have been developed to overcome the limitations of the "conventional" surgery. To date, there are no validated tools to evaluate the surgical outcomes of MITs; however, in the past, BPH-6 has been used for this purpose. Read More

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Concurrence of 1- and 3-Min Sit-to-Stand Tests with the 6-Min Walk Test in Idiopathic Pulmonary Fibrosis.

Respiration 2021 Apr 13:1-9. Epub 2021 Apr 13.

Department of Respiratory Medicine and Physiology, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France.

Background: In idiopathic pulmonary fibrosis (IPF), some physiological parameters measured during a 6-min walk test (6-MWT) impart reliable prognostic information. Sit-to-stand tests (STSTs) are field exercise tests that are easier to implement than the 6-MWT in daily practice.

Objectives: The aims of the study were to test the reproducibility and compare 2 STSTs (the 1-min STST [1-STST] and the semi-paced 3-min chair rise test [3-CRT]) in IPF, and to determine if selected physiological parameters (speed of displacement and changes in pulse oxygen saturation [SpO2]) are interchangeable between the STSTs and the 6-MWT. Read More

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Current Status and Quality of Machine Learning-Based Radiomics Studies for Glioma Grading: A Systematic Review.

Oncology 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.

Introduction: Radiomics now has significant momentum in the era of precision medicine. Glioma is one of the pathologies that has been extensively evaluated by radiomics. However, this technique has not been incorporated into clinical practice. Read More

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Medical Thoracoscopy Implementation after a European Respiratory Society Course Held from 2003 to 2016: A Survey.

Respiration 2021 Apr 13:1-7. Epub 2021 Apr 13.

Department of Thoracic Oncology, Pleural Diseases and Interventional Pulmonology, Hôpital NORD Aix-Marseille University, Marseille, France.

Background: Medical thoracoscopy (MT) is an important procedure in the management of patients with pleural diseases.

Objectives: We designed a survey to explore whether the participants of our courses implement MT at their hospital after attending the course as no real-life data exist.

Methods: We distributed by e-mail a questionnaire to the participants of the courses. Read More

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Review of litter turning during a grow-out as a litter management practice to achieve dry and friable litter in poultry production.

Poult Sci 2021 Feb 18;100(6):101071. Epub 2021 Feb 18.

Department of Agriculture and Fisheries, Queensland Government, Toowoomba 4350, Queensland, Australia.

Maintaining dry litter that chickens can "work" is a key objective for successful meat chicken production as it reduces the likelihood of health and welfare issues by breaking down and working excreta and contributing to the water evaporation process. Litter turning is a practice that may help reduce moisture content within the litter by accelerating the drying process when it is combined with effective ventilation. However, information and research about the practice and the effects it could have on the health and well-being of meat chickens (broilers) are minimal. Read More

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February 2021

Reporting Quality of Cost-Effectiveness Analyses Conducted in Saudi Arabia: A Systematic Review.

Value Health Reg Issues 2021 Apr 10;25:99-103. Epub 2021 Apr 10.

Clinical Pharmacy Department, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.

Objectives: Pharmacoeconomics and health economics in general is a new field that is still developing and emerging, not only in Saudi Arabia but all over the world. The objective of this study is to collect all published cost-effectiveness analysis (CEA) studies conducted based on Saudi settings and to evaluate their reporting quality.

Methods: We used PRISMA guidelines to search for all English-language CEAs conducted in Saudi Arabia in 3 databases: Medline, Embase, and Scopus. Read More

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Context matters: Examining the factors impacting the implementation of tuberculosis infection prevention and control guidelines in health settings in seven high tuberculosis burden countries.

J Infect Public Health 2021 Feb 8;14(5):588-597. Epub 2021 Feb 8.

School of Public Health and Community Medicine, University of New South Wales, Room 212, Samuels Building, Sydney, Australia.

Background: Healthcare workers (HCWs) in high tuberculosis (TB) burden countries are at increased risk of TB infection due to increased exposures to TB patients and inadequate implementation of TB infection prevention and control (TB IPC) measures in health settings. While various guidelines on TB IPC exist, there is little understanding of the content of these guidelines, whether they are relevant to the context and are being appropriately implemented in low-and middle-income high TB burden countries. This study aimed to critically examine the implementation of TB IPC guidelines, along with factors impacting TB IPC implementation in health settings in seven high TB burden countries. Read More

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February 2021

Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy.

J Infect Public Health 2021 Feb 9;14(5):570-576. Epub 2021 Feb 9.

Department of Infectious Diseases, Hotel Dieu de France, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Objectives: To report available information in the literature regarding frequency, indications, types of antibiotic usage, duration, and their efficacy in Covid-19 infected patients.

Methods: The search was conducted on April 30 and May 7, 2020, using Ovid database and Google search. Patients' characteristics, clinical outcomes, as well as selected characteristics regarding antibiotic use (indication, class used, rates and types of bacterial secondary and co-infection, and duration of treatment) were analyzed. Read More

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February 2021

Decreasing Surgical Management of Secondary Hyperparathyroidism in the United States.

J Surg Res 2021 Apr 10;264:444-453. Epub 2021 Apr 10.

Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Secondary hyperparathyroidism (SHPT) commonly occurs in end-stage renal disease (ESRD), leading to vascular calcification and increased mortality. For SHPT refractory to medical management, parathyroidectomy improves symptoms and decreases mortality. Medical management has changed with the release of new guidelines and advent of novel medications. Read More

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Potential of preventive bioremediation to reduce environmental contamination by pesticides in an agricultural context: A case study with the herbicide 2,4-D.

J Hazard Mater 2021 Mar 27;416:125740. Epub 2021 Mar 27.

Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et Environnement (LMGE), F-63000 Clermont-Ferrand, France.

One of the major problems with pesticides is linked to the non-negligible proportion of the sprayed active ingredient that does not reach its intended target and contaminates environmental compartments. Here, we have implemented and provided new insights to the preventive bioremediation process based on the simultaneous application of the pesticide with pesticide-degrading microorganisms to reduce the risk of leaching into the environment. This study pioneers such a practice, in an actual farming context. Read More

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Correlation study between anatomopathological data and levels of blood morphine concentrations in heroin-related deaths.

Leg Med (Tokyo) 2021 Apr 7;51:101877. Epub 2021 Apr 7.

Department of Law, Institute of Legal Medicine, University of Macerata, Macerata, Italy.

Heroin-related mortality is a complex phenomenon involving several factors that make an individual more susceptible to opioid toxicity. Among these, pre-existing pathological conditions play an important role. The current paper reviewed 51 autopsied cases performed over the last 30 years, each subject ("frequent heroin user") having taken heroin intravenously alone before death. Read More

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Parental decision-making in pediatric intensive care: A concept analysis.

J Pediatr Nurs 2021 Apr 10;59:115-124. Epub 2021 Apr 10.

School of Nursing, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900. Electronic address:

The development of nursing knowledge requires a close relationship between theory, research, and practice. The purpose of the analysis of the concept of "parental decision-making in pediatric critical care" is to facilitate nurses' therapeutic care of critically ill children and their families. To construct, structure, and give meaning to the concept, we use our experience in the field, critical reading of the literature, and careful analysis of data that have emerged about parental decision-making in pediatric intensive care. Read More

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Decreasing Trends in Opioid Prescribing on Discharge to Hospice Care.

J Pain Symptom Manage 2021 Apr 10. Epub 2021 Apr 10.

Division of General Internal Medicine & Geriatrics, Department of Medicine, Oregon Health & Science University, Portland, OR.

Context: There are concerns that policies aimed to prevent opioid misuse may unintentionally reduce access to opioids for patients at end-of-life.

Objective: We assessed trends in opioid prescribing among patients on discharge from the hospital to hospice care.

Methods: This was a retrospective cohort study among adult (age ≥18 years) patients discharged from a 544-576 bed, academic medical center to hospice care between January 1, 2010 to December 31, 2018. Read More

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Current Prescribing Practices and Guideline Concordance for the Treatment of Uncomplicated Urinary Tract Infections in Women.

Am J Obstet Gynecol 2021 Apr 10. Epub 2021 Apr 10.

Stanford University School of Medicine, Department of Medicine. Stanford, CA, USA.

Background: Uncomplicated urinary tract infections are one of the most common bacterial infections in the United States. Clinical practice guidelines from the Infectious Diseases Society of America recommend nitrofurantoin, trimethoprim-sulfamethoxazole and fosfomycin as first-line antibiotic treatments, and discourage the use of fluoroquinolone antibiotics. The United States Food and Drug Administration released several black box warnings about fluoroquinolones over the past decade due to antibiotic resistance and a high burden of adverse events. Read More

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Rapid Antigen Test for Postmortem Evaluation of SARS-CoV-2 Carriage.

Emerg Infect Dis 2021 Apr 13;27(6). Epub 2021 Apr 13.

Detecting severe acute respiratory syndrome coronavirus 2 in deceased patients is key when considering appropriate safety measures to prevent infection during postmortem examinations. A prospective cohort study comparing a rapid antigen test with quantitative reverse transcription PCR showed the rapid test's usability as a tool to guide autopsy practice. Read More

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Venous Leg Ulcers: A Review of Published Assessment and Treatment Algorithms.

Adv Wound Care (New Rochelle) 2021 Apr 13. Epub 2021 Apr 13.

Saratoga Hospital Center for Wound Healing and Hyperbaric Medicine, Saratoga Springs, New York, USA.

Chronic venous disease (CVD) is prevalent in the aging population and leads to venous leg ulcers (VLUs). These wounds can last and recur for years, significantly impacting quality of life. A large body of literature exists on CVD and VLU diagnosis and treatment. Read More

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Simulating Outcomes of Cataract Surgery: Important Advances in Ophthalmology.

Annu Rev Biomed Eng 2021 Apr 13. Epub 2021 Apr 13.

Laboratorio de Óptica, Universidad de Murcia, Murcia 30100, Spain.

As the human eye ages, the crystalline lens stiffens (presbyopia) and opacifies (cataract), requiring its replacement with an artificial lens [intraocular lens (IOL)]. Cataract surgery is the most frequently performed surgical procedure in the world. The increase in IOL designs has not been paralleled in practice by a sophistication in IOL selection methods, which rely on limited anatomical measurements of the eye and the surgeon's interpretation of the patient's needs and expectations. Read More

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What is known about factors improving physiotherapists' adherence to high value interventions in nonspecific low back pain? A scoping review protocol.

Musculoskeletal Care 2021 Apr 13. Epub 2021 Apr 13.

Ashok & Rita Patel Institute of Physiotherapy, Charotar University of Science & Technology (CHARUSAT) CHARUSAT Campus, Changa, Gujarat, India.

Introduction: Despite multiple guidelines providing best practice treatment recommendations for managing low back pain (LBP), current evidence suggests that physiotherapists across the world often provide costly, ineffective, unnecessary, even harmful care. The purpose of this scoping review is to establish the body of evidence regarding factors that improve or hinder physiotherapist's adherence to high-value interventions in the management of non-specific LBP.

Methods: This scoping review will be conducted based on the methodological framework for scoping review recommended by Arksey & O'Malley's and Levac. Read More

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Prenatal chromosome microarray: 'The UK experience'. A survey of reporting practices in UK genetic services (2012-2019).

Prenat Diagn 2021 Apr 2. Epub 2021 Apr 2.

West of Scotland Centre for Genomic Medicine, Laboratory Medicine Building, QEUH, Glasgow, UK.

Background: The value of chromosome microarray (CMA) in the prenatal detection of significant chromosome anomalies is well-established. To guide the introduction of this technique in routine clinical practice, the Joint Committee on Genomics in Medicine developed national UK guidelines for reporting prenatal CMA in 2015.

Objective: To evaluate the UK experience of utilising prenatal CMA. Read More

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Mindfulness Matters: Utilization and Perceptions of Mindfulness Practices Among Athletic Trainers.

J Athl Train 2021 Apr 13. Epub 2021 Apr 13.

Appalachian State University, Boone, NC.

Context: Mindfulness practices are effective for injury/illness recovery, decreasing stress and anxiety, and strengthening emotional resilience. They are also beneficial for healthcare professionals' well-being and improved patient outcomes and safety. However, mindfulness has not been studied in athletic trainers. Read More

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Athletic Administrators' Reporting of Emergency Preparedness Regarding Policies and Procedures in [State] Secondary Schools.


J Athl Train 2021 Apr 13. Epub 2021 Apr 13.

Context: Secondary schools that offer school-sponsored athletic events should follow best-practice guidelines to provide policies that promote student health and safety.

Objective: To assess emergency preparedness from the perspective of athletic administrators (AAs) in [State] secondary schools.

Design: Cross-sectional study. Read More

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Strengthening data collection and use for quality improvement in primary care: the case of Costa Rica.

Health Policy Plan 2021 Apr 13. Epub 2021 Apr 13.

Ariadne Labs, Brigham and Women's Hospital & Harvard T.H. Chan School of Public Health, 401 Park Drive, Boston, MA 02215, USA.

Costa Rica is a bright spot of primary healthcare (PHC) performance, providing first-contact accessibility and continuous, comprehensive, coordinated, and patient-centered care to its citizens. Previous research hypothesized that strong data collection and use for quality improvement are central to Costa Rica's success. Using qualitative data from 40 interviews with stakeholders across the Costa Rican healthcare system, this paper maps the various data streams at the PHC level and delineates how these data are used to make decisions around insuring and improving the quality of PHC delivery. Read More

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Telerehabilitation During the Covid-19 Pandemic in Outpatient Rehabilitation Settings: A Descriptive Study.

Phys Ther 2021 Apr 13. Epub 2021 Apr 13.

Net Health Systems, Inc., Pittsburgh PA, USA.

Objective: COVID-19 has widely affected delivery of health care. In response, telerehabilitation (TR) has emerged as alternative care model. Aims were: (1) describe baseline patient characteristics and available unadjusted outcomes for episodes of care administered during COVID-19 using TR vs. Read More

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Sofosbuvir-based hepatitis C therapies in patients with chronic and end-stage kidney disease.

Nephrol Dial Transplant 2021 Apr 12. Epub 2021 Apr 12.

Miller School of Medicine, University of Miami, Miami, Florida, USA.

Sofosbuvir, a nucleotide inhibitor of the hepatitis C virus (HCV) polymerase, is a component of several all-oral HCV therapies. GS-331007, sofosbuvir's predominant metabolite, is renally eliminated and accumulates 5-fold to 20-fold in patients with advanced chronic kidney disease (CKD) or undergoing hemodialysis, respectively. Pre-clinical data did not determine whether these exposures represented a risk for toxicity. Read More

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Antihypertensive prescribing patterns and hypertension control in females of childbearing age.

Am J Health Syst Pharm 2021 Apr 13. Epub 2021 Apr 13.

University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, USA.

Purpose: The use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to treat hypertension (HTN) during pregnancy presents well-established risks to a developing fetus. A cross-sectional study was conducted to evaluate the current state of antihypertensive prescribing and contraceptive use in females of childbearing age within a large safety-net health system.

Methods: The retrospective cross-sectional study of females aged 18-49 years with a documented diagnosis of HTN. Read More

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US Public's Perceptions of Online Before and After Transformation Photos.

Aesthet Surg J 2021 Apr 13. Epub 2021 Apr 13.

chief of the division of plastic surgery, West Virginia University, Morgantown, WV.

Background: While many plastic surgeons seek to optimize their online presence and reach a broader patient base, no studies have evaluated the general public's perceptions of one of the most valued informational tools: transformation photos.

Objectives: The aim of this study was to evaluate the general public's preferences for viewing transformation photos online.

Methods: Respondents representative of the US public, crowdsourced through Amazon Mechanical Turk, answered a survey assessing perceptions of the posting of before-and-after photos. Read More

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Emergency Airway Management in Patients with COVID-19: A Prospective International Multicenter Cohort Study.

Anesthesiology 2021 Apr 13. Epub 2021 Apr 13.

Background: Tracheal intubation for patients with COVID-19 is required for invasive mechanical ventilation. The authors sought to describe practice for emergency intubation, estimate success rates and complications, and determine variation in practice and outcomes between high-income and low- and middle-income countries. The authors hypothesized that successful emergency airway management in patients with COVID-19 is associated with geographical and procedural factors. Read More

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