2,070 results match your criteria ppv combined

Intraocular perfluorodecalin and silicone oil tamponade (double filling) in the management of complicated retinal detachment: functional and anatomical outcomes using small-gauge surgery.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 22. Epub 2021 Sep 22.

Department of Ophthalmology, Department of Ophthalmology, San Gerardo Hospital, via Gian Battista Pergolesi 33, 20900, Monza, Italy.

Purpose: To describe the functional and anatomical results of complicated retinal detachment (RD) treated with small-gauge pars plana vitrectomy (PPV) and combined perfluorodecalin and polydimethylsiloxane tamponade (double filling, DF).

Methods: Retrospective analysis of consecutive patients with complex RD (severe proliferative vitreoretinopathy, inferior/posterior/giant retinal tears, and traumatic detachments) treated with small-gauge PPV, membrane peeling, and DF at the Department of Ophthalmology at San Gerardo Hospital, Monza, Italy. Main outcome measures included best-corrected visual acuity (BCVA), rates of retinal reattachment, and complications. Read More

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September 2021

Simultaneous pars plana vitrectomy, panretinal photocoagulation, cryotherapy, and Ahmed valve implantation for neovascular glaucoma.

Int J Ophthalmol 2021 18;14(9):1396-1401. Epub 2021 Sep 18.

Institut Clínic d'Oftalmologia (ICOF), Hospital Clínic, Barcelona 08028, Spain.

Aim: To describe and evaluate the efficacy of Ahmed glaucoma valve implantation (AGV) combined with pars plana vitrectomy (PPV) in a single surgical act for the treatment of advanced neovascular glaucoma (NVG).

Methods: Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV, AGV, and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period (2005-2018). Preoperative, intraoperative and postoperative data at day 1 and months 1, 3, 6, 21, and 24 were systematically collected. Read More

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September 2021

Individual localization value of resting-state fMRI in epilepsy presurgical evaluation: A combined study with stereo-EEG.

Clin Neurophysiol 2021 Aug 30. Epub 2021 Aug 30.

Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Objective: To examine the individual-patient-level localization value of resting-state functional MRI (rsfMRI) metrics for the seizure onset zone (SOZ) defined by stereo-electroencephalography (SEEG) in patients with medically intractable focal epilepsies.

Methods: We retrospectively included 19 patients who underwent SEEG implantation for epilepsy presurgical evaluation. Voxel-wise whole-brain analysis was performed on 3. Read More

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Risk Stratification of Breast Fine-Needle Aspiration Biopsy Specimens Performed without Radiologic Guidance by Application of the International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Cytopathology.

Acta Cytol 2021 Sep 14:1-11. Epub 2021 Sep 14.

Department of Radiation Oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.

Background And Objective: The International Academy of Cytology (IAC) Yokohama system for reporting breast fine-needle aspiration biopsy (FNAB) cytopathology has been proposed to standardize breast FNAB reporting. The aim of this study was to categorize breast FNAB cases performed by palpation without radiological guidance according to the IAC system, establish the risk of malignancy (ROM) for the categories and assess the system's utility, pitfalls, and implications in low-resource/financial constraint settings.

Methods: A retrospective analysis of palpation-guided FNAB of breast lesions performed without radiological guidance between January 2016 and December 2019 was carried out and was correlated with follow-up biopsies wherever available. Read More

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September 2021

Diagnostic value of routine pre-operative investigations used in combination in the diagnosis of periprosthetic joint infection.

Acta Orthop Belg 2021 Jun;87(2):374-381

The primary aim of this study was to assess the diagnostic accuracy of joint aspiration culture, serum C-reactive protein (CRP) and serum erythrocyte sedimentation rate (ESR), individually, and in combination for the diagnosis of periprosthetic joint infection (PJI). A consecutive patient series with pre-operative inflammatory marker levels, an aspiration culture of either hip or knee arthroplasty and intra-operative culture samples from subsequent revision surgery was compiled. This retrospective patient cohort analysis included 128 aspiration. Read More

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Role of "Stiff Rim" sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer.

Int J Med Sci 2021 28;18(15):3615-3623. Epub 2021 Aug 28.

Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P.R, China.

Because the halo around the tumor in shear wave elastography (SWE) is defined as the "stiff rim" sign, the diagnosis of breast lesions with the stiff rim sign is popular. However, only a few studies have described the stiff rim sign quantitatively. This study aimed to investigate the usefulness of the stiff rim sign in the diagnosis and tumor, node, metastasis stage of breast cancer. Read More

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Deep Learning Analysis of Echocardiographic Images to Predict Positive Genotype in Patients With Hypertrophic Cardiomyopathy.

Front Cardiovasc Med 2021 27;8:669860. Epub 2021 Aug 27.

Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.

Genetic testing provides valuable insights into family screening strategies, diagnosis, and prognosis in patients with hypertrophic cardiomyopathy (HCM). On the other hand, genetic testing carries socio-economical and psychological burdens. It is therefore important to identify patients with HCM who are more likely to have positive genotype. Read More

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Characteristics of malignant thyroid lesions on [F] fluorodeoxyglucose (FDG)-Positron emission tomography (PET)/Computed tomography (CT).

Eur J Radiol Open 2021 19;8:100373. Epub 2021 Aug 19.

Department of Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Objectives: To determine the imaging variables that can best differentiate malignant from benign thyroid lesions incidentally found on F-18 FDG PET/CT scans.

Methods: All F-18 FDG PET/CT studies starting from 2011 to end of 2016 were reviewed for incidental thyroid lesions or metabolic abnormalities. Only patients who were found to have FNAB or histopathology were included. Read More

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Medicare Claims Data Underestimate Hallucinations in Older Adults With Dementia.

Am J Geriatr Psychiatry 2021 Aug 5. Epub 2021 Aug 5.

Department of Neurology, Perelman School of Medicine, (AGH, DW, AWW) University of Pennsylvania, Philadelphia, PA; Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, (AGH, AWW) University of Pennsylvania, Philadelphia, PA; Department of Psychiatry, Perelman School of Medicine, (AWW) University of Pennsylvania, Philadelphia, PA; Parkinson's Disease Research, Education and Clinical Center, (DW) Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, (AWW) University of Pennsylvania, Philadelphia, PA; Department of Biostatistics, Epidemiology, and Informatics, (AWW) Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Objective: Administrative claims data are used to study the incidence and outcomes of dementia-related hallucinations, but the validity of International Classification of Diseases (ICD) codes for identifying dementia-related hallucinations is unknown.

Methods: We analyzed Medicare-linked survey data from 2 nationally representative studies of U.S. Read More

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First Year of TREC-Based National SCID Screening in Sweden.

Int J Neonatal Screen 2021 Aug 25;7(3). Epub 2021 Aug 25.

Centre for Inherited Metabolic Diseases, Karolinska University Hospital, 17176 Stockholm, Sweden.

Screening for severe combined immunodeficiency (SCID) was introduced into the Swedish newborn screening program in August 2019 and here we report the results of the first year. T cell receptor excision circles (TRECs), kappa-deleting element excision circles (KRECs), and actin beta (ACTB) levels were quantitated by multiplex qPCR from dried blood spots (DBS) of 115,786 newborns and children up to two years of age, as an approximation of the number of recently formed T and B cells and sample quality, respectively. Based on low TREC levels, 73 children were referred for clinical assessment which led to the diagnosis of T cell lymphopenia in 21 children. Read More

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Combined Pars Plana Vitrectomy and Segmental Scleral Buckle for Rhegmatogenous Retinal Detachment with Inferior Retinal Breaks.

Clin Ophthalmol 2021 18;15:3515-3519. Epub 2021 Aug 18.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Purpose: To describe a variation of the traditional segmental scleral buckle (SB) without an encircling band combined with 23-gauge pars plana vitrectomy (PPV) for the management of rhegmatogenous retinal detachment (RRD) with inferior retinal breaks.

Patients And Methods: This is a single-center, retrospective, consecutive review of all RRDs with inferior retinal breaks that were treated with PPV and segmental SB without an encircling band between May 2019 and February 2020.

Results: A total of 12 eyes of 12 patients were included in the study. Read More

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In vitro Validation Assessment of a Fecal Occult Blood Protein Test for Horses.

J Equine Vet Sci 2021 Sep 25;104:103695. Epub 2021 Jun 25.

The Nutraceutical Alliance Inc., Burlington, ON, Canada. Electronic address:

A commercially available equine fecal blood test (FBT) claims to be able to detect the presence of blood proteins (albumin and hemoglobin) in manure. The purpose of this study was to determine the FBT test sensitivity, specificity, positive and negative predictive values (PPV, NPV), lower threshold of detection, time to obtain a visual positive result, effect of temperature and result stability in lab and field conditions. The FBT was assessed for its sensitivity and specificity for detecting pure albumin and hemoglobin at two temperatures over a range of concentrations. Read More

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September 2021

Amplitude Integrated Electroencephalography and Continuous Electroencephalography Monitoring Is Crucial in High-Risk Infants and Their Findings Correlate With Neurodevelopmental Outcomes.

Front Pediatr 2021 3;9:691764. Epub 2021 Aug 3.

Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.

To evaluate seizure diagnosis in sick infants in the neonatal intensive care unit (NICU) based on electroencephalography (EEG) monitoring combined with amplitude integrated electroencephalography (aEEG). We retrospectively reviewed EEG and aEEG findings and determined their correlations with neurodevelopmental outcomes at the age of >1 year in 65 patients with diagnosed seizures, encephalopathy, or both. Seizure identification rate was 43. Read More

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Hypotony Following Intravitreal Silicone Oil Removal in a Patient With a Complex Retinal Detachment With Giant Retinal Tear.

Cureus 2021 Jul 14;13(7):e16387. Epub 2021 Jul 14.

Ophthalmology, Korgialenio-Benakio General Hospital, Athens, GRC.

Postoperative ocular hypotony after silicone oil removal in complex cases of retinal detachment is a complication that can occur in about 20% of cases and can prevent the successful management of retinal detachments. Thus, it is critical to understand the mechanisms of hypotony and the potential interventions that can be done in order to avoid irreversible tissue damage. We present a case of a 35-year-old man who underwent intraocular surgery for removal of silicone oil tamponade following a combined scleral buckling and pars plana vitrectomy (PPV) surgery for a rhegmatogenous retinal detachment associated with a giant retinal tear. Read More

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Does the Addition of Serum PAPP-A and -hCG Improve the Predictive Value of Uterine Artery Pulsatility Index for Preeclampsia at 11-14 Weeks of Gestation? A Prospective Observational Study.

J Obstet Gynaecol India 2021 Jun 21;71(3):226-234. Epub 2021 Jan 21.

Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Purpose Of Study: To study the role of uterine artery Doppler pulsatility index (UtA-PI), serum pregnancy-associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (f-hCG) levels, individually and in combination with each other, at 11-14 weeks of gestation for prediction of preeclampsia (PE).

Methods: In a prospective observational study, a total of 100 low-risk gravid females were recruited at 11-14-weeks of gestation. UtA-PI, PAPP-A and f-hCG levels were estimated. Read More

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Determining the extent of tumor resection at surgical planning with F-fluciclovine PET/CT in patients with suspected glioma: multicenter phase III trials.

Ann Nucl Med 2021 Aug 18. Epub 2021 Aug 18.

Clinical Development Department, Nihon Medi-Physics Co., Ltd, 3-4-10 Shinsuna, Koto-ku, Tokyo, 136-0075, Japan.

Objective: Glioma is the most common type of central nervous system tumor reported worldwide. Current imaging technologies have limitations in the diagnosis and assessment of glioma. The present study aimed to confirm the diagnostic efficacy and safety of anti-1-amino-3-[F]fluorocyclobutane carboxylic acid (F-fluciclovine; anti-[F]FACBC) as a radiotracer for patients undergoing combined positron emission tomography and computed tomography (PET/CT) for suspected glioma. Read More

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F-FDG PET baseline radiomics features improve the prediction of treatment outcome in diffuse large B-cell lymphoma.

Eur J Nucl Med Mol Imaging 2021 Aug 18. Epub 2021 Aug 18.

Cancer Center Amsterdam, Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, Netherlands.

Purpose: Accurate prognostic markers are urgently needed to identify diffuse large B-Cell lymphoma (DLBCL) patients at high risk of progression or relapse. Our purpose was to investigate the potential added value of baseline radiomics features to the international prognostic index (IPI) in predicting outcome after first-line treatment.

Methods: Three hundred seventeen newly diagnosed DLBCL patients were included. Read More

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Scleral Buckling for Primary Retinal Detachment: Outcomes of Scleral Tunnels versus Scleral Sutures.

J Ophthalmic Vis Res 2021 Jul-Sep;16(3):377-383. Epub 2021 Jul 29.

Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: There are primarily two techniques for affixing the scleral buckle (SB) to the sclera in the repair of rhegmatogenous retinal detachment (RRD): scleral tunnels or scleral sutures.

Methods: This retrospective study examined all patients with primary RRD who were treated with primary SB or SB combined with vitrectomy from January 1, 2015 through December 31, 2015 across six sites. Two cohorts were examined: SB affixed using scleral sutures versus scleral tunnels. Read More

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Technical note: On the development of an outcome-driven frequency filter for improving radiomics-based modeling of human papillomavirus (HPV) in patients with oropharyngeal squamous cell carcinoma.

Med Phys 2021 Aug 12. Epub 2021 Aug 12.

Department of Radiation Oncology, Henry Ford Cancer Institute, Detroit, Michigan, USA.

Purpose: To implement an outcome-driven frequency filter for improving radiomics-based modeling of human papillomavirus (HPV) for patients with oropharyngeal squamous cell carcinoma (OPSCC).

Methods And Materials: One hundred twenty-eight OPSCC patients with known HPV status (60-HPV+ and 68-HPV-, confirmed by immunohistochemistry-P16 protein testing) were retrospectively studied. A 3D Discrete Fourier Transform was applied on contrast-enhanced computed tomography (CE-CT) images of patient gross tumor volumes (GTVs) to transform intensity distributions to the frequency domain and estimate frequency power spectrums of HPV- and HPV+ patient cohorts. Read More

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Ultra-Early Differential Diagnosis of Acute Cerebral Ischemia and Hemorrhagic Stroke by Measuring the Prehospital Release Rate of GFAP.

Clin Chem 2021 Aug 11. Epub 2021 Aug 11.

Neurology and Clinical Neurosciences, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Plasma glial fibrillary acidic protein (GFAP) and tau are promising markers for differentiating acute cerebral ischemia (ACI) and hemorrhagic stroke (HS), but their prehospital dynamics and usefulness are unknown.

Methods: We performed ultra-sensitivite single-molecule array (Simoa®) measurements of plasma GFAP and total tau in a stroke code patient cohort with cardinal stroke symptoms [National Institutes of Health Stroke Scale (NIHSS) ≥3]. Sequential sampling included 2 ultra-early samples, and a follow-up sample on the next morning. Read More

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Suprachoroidal hemorrhage associated with pars plana vitrectomy.

BMC Ophthalmol 2021 Aug 11;21(1):295. Epub 2021 Aug 11.

Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, No. 1 Dong Jiao Min Xiang, Eastern District, 100730, Beijing, China.

Purpose: To analyze the characteristics, related risk factors, and prognosis of suprachoroidal hemorrhage (SCH) associated with pars plana vitrectomy (PPV).

Methods: Cases of SCH associated with PPV excluding trauma were retrospectively analyzed in Beijing Tongren Hospital between January 2010 and June 2020. The data collected included general data, myopia status, axial length, state of the crystalline lens, SCH onset time, range, treatment method, visual prognosis, and methods of operation and anesthesia. Read More

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Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study.

Clin Epidemiol 2021 3;13:675-682. Epub 2021 Aug 3.

Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

Purpose: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study.

Patients And Methods: Using the Tromsø Study Cardiovascular Disease Register for 2013-2014 as gold standard, we calculated correctness (defined as positive predictive value (PPV)) and completeness (defined as sensitivity) of MI cases in the Norwegian Myocardial Infarction Register and the Norwegian Patient Register separately and in combination. We calculated the sensitivity and PPV with 95% confidence intervals using the Clopper-Pearson Exact test. Read More

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Integration of symptomatic, demographical and diet-related comorbidities data with SARS-CoV-2 antibody rapid diagnostic tests during epidemiological surveillance: a cross-sectional study in Jakarta, Indonesia.

BMJ Open 2021 08 10;11(8):e047763. Epub 2021 Aug 10.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Objectives: Affordable options for COVID-19 epidemiological surveillance are needed. Virus detection by reverse transcription-PCR (RT-PCR) is sensitive but costly, and antigen-based rapid diagnostic tests (RDTs) are cheap but with reduced sensitivity; both detect current infection but not exposure. RDT-IgM/IgG antibodies to SARS-CoV-2 detect exposure but have poor sensitivity for current infection. Read More

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Establishment and prospective validation of an SUV cutoff value to discriminate clinically significant prostate cancer from benign prostate diseases in patients with suspected prostate cancer by Ga-PSMA PET/CT: a real-world study.

Theranostics 2021 25;11(17):8396-8411. Epub 2021 Jul 25.

Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

The aims of this study were to establish a maximum standardized uptake value (SUV) cutoff to discriminate clinically significant prostate cancer (csPCa) from benign prostate disease (BPD) by Ga-labeled prostate-specific membrane antigen (Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in patients with suspected prostate cancer (PCa), and to perform a prospective real-world validation of this cutoff value. The study included a training cohort to identify an SUV cutoff value and a prospective real-world cohort to validate it. A retrospective analysis assessed 135 patients with suspected PCa in a large tertiary care hospital in China who underwent Ga-PSMA-11 PET/CT. Read More

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Combined serum and synovial C-reactive protein tests: a valuable adjunct to the diagnosis of chronic prosthetic joint infection.

BMC Musculoskelet Disord 2021 Aug 9;22(1):670. Epub 2021 Aug 9.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Diagnosis of periprosthetic joint infection (PJI), especially chronic PJI, is very confusing and challenging. The value of C-reactive protein (CRP) in infectious diseases has been recognized, but the diagnostic value of CRP in chronic PJI is unknown. Our aim was to investigate the diagnostic value of synovial CRP in chronic PJI and to explore the role of combined serum and synovial CRP in distinguishing chronic PJI from aseptic failure after knee and hip arthroplasties. Read More

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Awake extracorporeal membrane oxygenation support for a critically ill COVID-19 patient: A case report.

World J Clin Cases 2021 Jul;9(21):5963-5971

Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.

Background: A critically ill coronavirus disease 2019 (COVID-19) patient complicated by acute respiratory distress syndrome is reported. The patient survived following treatment with awake veno-venous extracorporeal membrane oxygenation (ECMO).

Case Summary: A 53-year-old male patient attended our hospital following a cough for 11 d and fever for 9 d. Read More

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Usefulness of Orientation to the Year as an Aid to Case Finding of Mild Cognitive Impairment or Depression in Community-Dwelling Older Adults.

Int J Environ Res Public Health 2021 07 30;18(15). Epub 2021 Jul 30.

Elderly Frailty Research Center, Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul 02447, Korea.

Mild cognitive impairment (MCI) and depression are common and frequently misdiagnosed in older adults in primary care. In particular, depression combined with cognitive dysfunction is associated with a higher risk of dementia. We tried to find the usefulness of orientation to time as an easy case-finding tool for suspecting MCI or depression. Read More

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The clinical value of platelet parameters combined with sFlt-1/PlGF in predicting preeclampsia.

Ann Palliat Med 2021 Jul;10(7):7619-7626

Clinical Epidemiology Research Office, Beijing Jishuitan Hospital, Beijing, China.

Background: The aim of this study is to evaluate the association between platelet parameters and soluble vascular endothelial growth factor receptor-1 (sFlt-1)/placenta growth factor (PlGF) in preeclampsia (PE) and establish a prediction model by analyzing commonly used biochemical markers.

Methods: A nested case-control study involving 270 pregnant women in their second trimester from the Beijing Jishuitan Hospital was conducted. They were divided into PE group and control group. Read More

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Multi-step structure-activity relationship screening efficiently predicts diverse PPARγ antagonists.

Chemosphere 2021 Jul 21;286(Pt 1):131540. Epub 2021 Jul 21.

Department of Life and Nanopharmaceutical Science, South Korea; Department of Biology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea. Electronic address:

In discovering the potential antagonist of peroxisome proliferator-activated receptor gamma (PPARγ), the structure-activity relationship (SAR) is a useful in silico method. However, it is difficult for conventional SAR approaches to predict the activities of antagonists owing to the large structural diversity of antagonistic compounds. This study provides evidence that multi-step SAR screening is applicable for predicting PPARγ antagonists by combining different complementary methodologies. Read More

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Can the delayed phase of quantitative contrast-enhanced mammography improve the diagnostic performance on breast masses?

Quant Imaging Med Surg 2021 Aug;11(8):3684-3697

Department of Ultrasonic Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Contrast-enhanced mammography (CEM) is an imaging tool for breast cancer detection. Most quantitative analyses of CEM involve two phases, and it is unknown whether an added delayed phase can improve its diagnostic performance compared to dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). This study aimed to evaluate whether the delayed phase improves the diagnostic performance of CEM in distinguishing malignant and benign masses. Read More

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