492,992 results match your criteria potential roles


Electrophoretic deposition of collagen/chitosan films with copper-doped phosphate glasses for orthopaedic implants.

J Colloid Interface Sci 2021 Sep 1;607(Pt 1):869-880. Epub 2021 Sep 1.

Centre for Energy, Materials and Telecommunications, Institut National de la Recherche Scientifique, 1650 Boulevard Lionel-Boulet Varennes, Québec J3X 1S2, Canada. Electronic address:

Coatings with bioactive properties play a key role in the success of orthopaedic implants. Recent studies focused on composite coatings incorporating biocompatible elements that can increase the nucleation of hydroxyapatite (HA), the mineral component of bone, and have promising bioactive and biodegradable properties. Here we report a method of fabricating composite collagen, chitosan and copper-doped phosphate glass (PG) coatings for biomedical applications using electrophoretic deposition (EPD). Read More

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September 2021

Environmental contamination and human exposure of polychlorinated biphenyls (PCBs) in China: A review.

Sci Total Environ 2021 Sep 11;805:150270. Epub 2021 Sep 11.

Key Laboratory of Ministry of Education on Pollution Control and Ecosystem Restoration in Industry Clusters, Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling, School of Environment and Energy, South China University of Technology, Guangzhou 510006, Guangdong, China.

Polychlorinated biphenyls (PCBs), together with 11 other organic compounds, were initially listed as persistent organic pollutants (POPs) by the Stockholm Convention because of their potential threat to ecosystems and humans. In China, many monitoring studies have been undertaken to reveal the level of PCBs in environment since 2005 due to the introduced stricter environmental regulations. However, there are still significant gaps in understanding the overall spatial and temporal distributions of PCBs in China. Read More

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September 2021

Arthroscopic debridement of osteochondral lesions of the talus: A systematic review.

Foot (Edinb) 2021 Jul 12;49:101852. Epub 2021 Jul 12.

Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.

Background: Arthroscopic debridement (AD) for the osteochondral lesions of the talar dome (OLT) was widely documented in the nineties with satisfactory results. However, in modern treatment algorithms, its role is not described. The present systematic review aims to evaluate the current evidence on the clinical outcomes of AD in the management of OLT. Read More

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Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids.

Biomed Pharmacother 2021 Sep 15;143:112142. Epub 2021 Sep 15.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar; Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar; Department of Dermatology and Venereology, Rumailah Hospital, Hamad Medical Corporation, Doha 3050, Qatar; Laboratory Animal Research Center, Qatar University, Doha 2713, Qatar. Electronic address:

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, progression and stemness of cancer cells. Moreover, cancer cells maintain a delicate balance between ROS and antioxidants to promote pathogenesis and clinical challenges via targeting a battery of signaling pathways converging to cancer hallmarks. Read More

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September 2021

Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.

Biomed Pharmacother 2021 Sep 15;143:112171. Epub 2021 Sep 15.

NGN Healthcare - New Generation Nutraceuticals s.r.l., Torrette Via Nazionale 207, 83013 Mercogliano, Avellino, Italy. Electronic address:

Several studies reported an increase in cardiovascular risk (CVR) in women with polycystic ovary syndrome (PCOS), considered primarily as the result of the combination of all the clinical features that characterize the syndrome, including hyperandrogenism, insulin resistance, diabetes, obesity chronic low-grade inflammation. Interestingly, in 2012 it has been proposed the so-called DOGMA theory, suggesting the pivotal role played by microbiota alteration in the development of PCOS. Subsequently, several authors evidenced the existence in PCOS women of a marked dysbiosis, which is related to the development of metabolic diseases and cardiovascular complications, mainly due to the production of bacteria-derived metabolites that interfere with various pathways. Read More

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September 2021

A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).

Int Immunopharmacol 2021 Sep 14;100:108137. Epub 2021 Sep 14.

Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

A growing body of evidence indicates that neutrophil elastase (NE) is involved in the pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patients with COVID-19. We measured the serum concentrations of NE, C-Reactive protein (CRP), interleukin (IL)- 4, IL-6, IL-8, IL-10, and vitamin D levels in 83 ICU and 69 non-ICU patients compared with 82 healthy subjects (HS) in three-time points (T1-T3). Read More

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September 2021

Biochar based photocatalyst for degradation of organic aqueous waste: A review.

Chemosphere 2021 Sep 7;287(Pt 3):132200. Epub 2021 Sep 7.

Department of Biotechnology, Shivaji University, Vidyanagar, Kolhapur, 416004, India; Department of Biochemistry, Shivaji University, Vidyanagar, Kolhapur, 416004, India. Electronic address:

The advancement in the treatment technology for wastewater containing recalcitrant pollutants to lower the overall cost and time of the treatment processes is the prime demand. Biochar (BC) based photocatalyst have proved their potential application in the photo-degradation of a wide range of organic pollutants. The structural and chemical properties of the BC enhance the efficacy of photocatalyst, improving its optical properties with increased stability. Read More

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September 2021

Bacillus siamensis CNE6- a multifaceted plant growth promoting endophyte of Cicer arietinum L. having broad spectrum antifungal activities and host colonizing potential.

Microbiol Res 2021 Sep 11;252:126859. Epub 2021 Sep 11.

Mycology and Plant Pathology Laboratory, Department of Botany, Visva-Bharati, Santiniketan, 731235, India. Electronic address:

Exploration of endophytic bacteria with multiple plant growth promoting (PGP) attributes is considered as an eco-friendly and cost-effective alternative to agricultural chemicals for increasing crop productivity. In the present endeavor, healthy chickpea plants (Cicer arietinum L.) collected from district Birbhum, West Bengal, India were subjected for the isolation of endophytic bacteria having multifarious PGP properties. Read More

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September 2021

Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists.

Eur J Med Chem 2021 Sep 2;226:113805. Epub 2021 Sep 2.

LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK.

A series of Formyl peptide receptor 2 small molecule agonists with a pyrrolidinone scaffold, derived from a combination of pharmacophore modelling and docking studies, were designed and synthesized. The GLASS (GPCR-Ligand Association) database was screened using a pharmacophore model. The most promising novel ligand structures were chosen and then tested in cellular assays (calcium mobilization and β-arrestin assays). Read More

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September 2021

The role of hydrodynamic fluctuations and wind intensity on the distribution of plastic debris on the sandy beaches of Paraná River, Argentina.

Environ Pollut 2021 Sep 14;291:118168. Epub 2021 Sep 14.

UMR 7324 CNRS CITERES and Graduate School of Engineering Polytech Tours, University of Tours, France. Electronic address:

Plastic in the environment is considered an emerging pollutant of global concern. In spite of intensive research, many questions remain open, such as the processes that drive the deposition and remobilization of plastic debris on river beaches. The objectives of this study were: i) to analyze the influence of the natural hydrological fluctuations and wind intensity on the distribution of mesoplastic (0. Read More

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September 2021

C-reactive protein protects against acetaminophen-induced liver injury by preventing complement overactivation.

Cell Mol Gastroenterol Hepatol 2021 Sep 15. Epub 2021 Sep 15.

MOE Key Laboratory of Environment and Genes Related to Diseases, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China; Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province, Xi'an Children's Hospital, Xi'an Jiaotong University, Xi'an, P.R. China. Electronic address:

Background And Aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).

Methods: The effects of CRP in AILI were investigated using CRP knockout mice and rats combined with human CRP rescue. Read More

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September 2021

Mitofusin 2: A Link Between Mitochondrial Function and Substrate Metabolism?

Mitochondrion 2021 Sep 15. Epub 2021 Sep 15.

Department of Molecular and Cellular Biology, School of Natural Sciences, University of California, Merced.

Mitochondria are dynamic, interactive organelles that connect cellular signaling and whole-cell homeostasis. This "mitochatting" allows the cell to receive information about the mitochondria's condition before accommodating energy demands. Mitofusin 2 (Mfn2), an outer mitochondrial membrane fusion protein specializes in mediating mitochondrial homeostasis. Read More

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September 2021

Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.

Cancer Lett 2021 Sep 15. Epub 2021 Sep 15.

Department of Surgery, Faculty of Medicine and HKU-SZH, The University of Hong Kong, Hong Kong, China. Electronic address:

Plasmacytoid dendritic cells (pDCs) play immunosuppressive roles in the tumor microenvironment. However, the molecular mechanisms underlying the recruitment and dysfunction of pDCs in the tumor microenvironment remain largely elusive, especially in hepatocellular carcinoma (HCC). In this study, we observed that pDCs accumulated in the blood, tumor tissue, and ascitic fluid of HCC patients. Read More

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September 2021

The physiologic and physiopathologic roles of perivascular adipose tissue and its interactions with blood vessels and the renin-angiotensin system.

Pharmacol Res 2021 Sep 15:105890. Epub 2021 Sep 15.

Division of Pharmacology & Toxicology, Office of Cardiology, Hematology, Endocrinology, and Nephrology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.

The perivascular adipose tissue (PVAT) refers to an ectopic local deposit of connective tissue that anatomically surrounds most of the blood vessels. While it was initially known only as a structural support for vasculature, the landmark findings of Soltis and Cassis (1991), first demonstrating that PVAT reduces the contractions of norepinephrine in the isolated rat aorta, brought the potential vascular role of PVAT into the limelight. This seminal work implied the potential ability of PVAT to influence vascular responsiveness. Read More

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September 2021

Role of NSD1 as potential therapeutic targets in tumor.

Pharmacol Res 2021 Sep 15:105888. Epub 2021 Sep 15.

Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China. Electronic address:

Nuclear receptor binding SET Domain Protein 1 (NSD1) is a bifunctional transcriptional regulatory protein that encodes histone methyltransferase. Mono- and di-methylation of H3K36 by NSD1 is mainly primarily involved in the regulation of gene expression, DNA repair, alternative splicing, and other important biological processes. Many types of cancers, including acute myelogenous leukemia (AML), liver cancer, lung cancer, endometrial carcinoma, colorectal cancer, and pancreatic cancer, are associated with NSD1 fusion, missense mutation, nonsense mutation, silent mutation, deletion, and insertion of frameshift, and deletion in a frame. Read More

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September 2021

Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved.

Neurochem Int 2021 Sep 15:105188. Epub 2021 Sep 15.

Laboratorio de Dolor en Cáncer, Instituto de Investigaciones en Medicina Traslacional CONICET - Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina; Facultad de Ciencias Biomédicas, Universidad Austral, Av. Pte. Perón 1500, B1629AHJ, Pilar, Buenos Aires, Argentina. Electronic address:

After different types of acute central nervous system insults, including stroke, subarachnoid haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a central role in the induction of cell death, neurodegeneration and functional deficits. Interestingly, secondary cell death presents an attractive target for clinical intervention because the temporal lag between injury and cell loss provides a potential window for effective treatment. While primary injuries are the direct result of the precipitating insult, secondary damage involves the activation of pathological cascades through which endogenous factors can exacerbate initial tissue damage. Read More

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September 2021

Foundations of Osteoarthritis Section 3: Clinical Monitoring in OA Chapter 15: Biomarkers.

Osteoarthritis Cartilage 2021 Sep 15. Epub 2021 Sep 15.

Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.

Objective: The purpose of this overview of osteoarthritis (OA) biomarkers is to provide the non-specialist with a toolbox, based on experience acquired by biomarker researchers over many years, to understand biomarkers in general and their use in the OA field.

Methods: We provide an update on this subject since the OARSI Primer on osteoarthritis (OA) nearly a decade ago.

Results: Since the last update, the importance of molecular biomarkers has been increasingly recognized in the field, but no OA-related biomarkers have been adopted for routine use in clinical practice. Read More

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September 2021

BMSCs-exosomes containing GDF-15 alleviated SH-SY5Y cell injury model of Alzheimer's disease via AKT/GSK-3β/β-catenin.

Brain Res Bull 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, P.R. China. Electronic address:

Background: Mesenchymal stem cells (MSCs) therapy has great potential for Alzheimer's disease (AD) treatment. Here, we investigated the roles of BMSCs-exosomes containing growth differentiation factor-15 (GDF-15) in regulating SH-SY5Y cell injury in AD.

Methods: The SH-SY5Y cell injury model was constructed by treating SH-SY5Y cells with 10μM Aβ. Read More

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September 2021

Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.

Life Sci 2021 Sep 15:119963. Epub 2021 Sep 15.

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China. Electronic address:

Aims: Hepatocyte necroptosis is a critical event in the progression of non-alcoholic fatty liver disease (NAFLD). Obstructive sleep apnea hypopnea syndrome (OSAHS) and chronic intermittent hypoxia (CIH) may be linked with the pathogenesis and the severity of NAFLD. However, the potential role of necroptosis in OSAHS-associated NAFLD has not been evaluated. Read More

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September 2021

Immunomodulatory role of short neuropeptide F in the mud crab Scylla paramamosain.

Dev Comp Immunol 2021 Sep 15:104260. Epub 2021 Sep 15.

College of Fisheries, Jimei University, Xiamen 361021, China. Electronic address:

Short neuropeptide F (sNPF) is bioactive peptide secreted by neurons of invertebrates. It is one of the important pleiotropic neural molecules that is associated with a variety of physiological processes in invertebrates. However, little is known about the role of sNPF in the immune response. Read More

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September 2021

GPR120 inhibits colitis through regulation of CD4T cell IL-10 production.

Gastroenterology 2021 Sep 15. Epub 2021 Sep 15.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA; Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address:

Background & Aims: G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120 regulates CD4T cell function to inhibit colitis development. Read More

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September 2021

Hepatic Stellate Cell Senescence in Liver Fibrosis: Characteristics, Mechanisms and Perspectives.

Mech Ageing Dev 2021 Sep 15:111572. Epub 2021 Sep 15.

Dept. of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which proliferating cells undergo irreversible cell cycle arrest. Read More

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September 2021

Genomic DNA hydroxymethylation reveals potential role in identification of lung injury in coal-burning arsenicosis populations.

Environ Res 2021 Sep 15:112053. Epub 2021 Sep 15.

The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou, Medical University, Guiyang, 550025, Guizhou, PR China. Electronic address:

Arsenic (As) is a toxic metalloid element that causes lung cancer and multiple non-malignant respiratory diseases. The toxicity of arsenic is mediated in part by epigenetic mechanisms, such as alterations in DNA methylation. While increasing studies have highlighted the potential importance of arsenic exposure to DNA methylation patterns and the subsequent risks for arsenic toxicity, there has been little focus on DNA hydroxymethylation-a negative regulation mechanism of DNA methylation. Read More

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September 2021

Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.

Dev Dyn 2021 Sep 18. Epub 2021 Sep 18.

Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY.

Background: Development of paired sensory organs is a highly complex and coordinated process. These organs arise from ectodermal thickenings in the cephalic region known as cranial placodes. We have previously shown that Zic1 is a critical regulator for the formation of the pre-placodal region (PPR), the common territory for the development of all cranial placodes in Xenopus laevis. Read More

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September 2021

Wnt Pathway Modulators in Cancer Therapeutics- An Update on Completed and Ongoing Clinical Trials.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Health Sciences University, Clovis, California.

Wnt signaling plays an essential role in the initiation and progression of various types of cancer. Besides, the Wnt pathway components have been established as reliable biomarkers and potential targets for cancer therapy. Wnt signaling is categorized into canonical and non-canonical pathways. Read More

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September 2021

Sleep Duration and Hypertension: Epidemiological Evidence and Underlying Mechanisms.

Am J Hypertens 2021 Sep 18. Epub 2021 Sep 18.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.

While the contribution of several physiological systems to arterial blood pressure regulation has been studied extensively, the role of normal and disrupted sleep as a modifiable determinant of blood pressure control, and in the pathophysiology of hypertension, has only recently emerged. Several sleep disorders, including sleep apnea and insomnia, are thought to contribute to the development of hypertension, although less attention is paid to the relationship between sleep duration and blood pressure independent of sleep disorders per se. Accordingly, this review focuses principally on the physiology of sleep and the consequences of abnormal sleep duration both experimentally and at the population level. Read More

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September 2021

Secretion of a low-molecular-weight species of endogenous GRP94 devoid of the KDEL motif during endoplasmic reticulum stress in Chinese hamster ovary cells.

Traffic 2021 Sep 18. Epub 2021 Sep 18.

Department of Biotechnology, Graduate School of Engineering.

GRP94 (glucose-regulated protein 94) is a well-studied chaperone with a KDEL (lysine, aspartic acid, glutamic acid, and leucine) motif at its C-terminal, which is responsible for GRP94 localization in the endoplasmic reticulum (ER). GRP94 is upregulated during ER stress to help fold unfolded proteins or direct proteins to ER-associated degradation. In a previous study, engineered GRP94 without the KDEL motif stimulated a powerful immune response in vaccine cells. Read More

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September 2021

Lesser Known Uses of γ-Aminobutyric Acid Analogue Medications in Otolaryngology.

Laryngoscope 2021 Sep 18. Epub 2021 Sep 18.

Department of Otolaryngology-Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland, U.S.A.

Objectives/hypothesis: In otolaryngology, γ-aminobutyric acid (GABA) analogues have been previously analyzed for their roles in neuropathic pain, chronic cough, tinnitus, and perioperative analgesia. The primary aim of this study is to comprehensively summarize and synthesize the existing evidence for lesser known uses of gabapentin and pregabalin in otolaryngology.

Study Design: A scoping review conducted of the available English-language literature was performed by two authors through April 1, 2021. Read More

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September 2021

The mutagenic effect of tobacco smoke on male fertility.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Despite the association between tobacco use and the harmful effects on general health as well as male fertility parameters, smoking remains globally prevalent. The main content of tobacco smoke is nicotine and its metabolite cotinine. These compounds can pass the blood-testis barrier, which subsequently causes harm of diverse degree to the germ cells. Read More

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September 2021

The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!

Clin Rev Allergy Immunol 2021 Sep 18. Epub 2021 Sep 18.

Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.

Immunoglobulin E (IgE) is a well-known key factor in allergic airway disease; however, its central role in non-allergic airway inflammation is often underestimated. In some airway diseases, IgE is produced as a result of allergic sensitization. However, in others, IgE production occurs despite the lack of a specific allergen. Read More

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September 2021