72,327 results match your criteria potential microbial


Multiple fouling dynamics, interactions and synergistic effects in brackish surface water distribution systems.

Chemosphere 2021 Sep 16;287(Pt 3):132268. Epub 2021 Sep 16.

College of Water Resources and Civil Engineering, China Agricultural University, China; Engineering Research Center for Agricultural Water-Saving and Water Resources, Ministry of Education, China. Electronic address:

Dissolved salts, colloidal particles, and active microorganisms in brackish surface water distribution systems (BSWD) cause multiple fouling, poses potential threat to the environmental pollution, and raising technical and economic issues as well. So far, the co-occurrence and interactions of multiple fouling remains largely unknown. Multiple fouling behaviors were assessed in agriculture BSWD under different nitrogen (N) fertilizers. Read More

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September 2021

UPLC-ESI-MS/MS profiling of the underground parts of common Iris species in relation to their anti-virulence activities against Staphylococcusaureus.

J Ethnopharmacol 2021 Sep 20:114658. Epub 2021 Sep 20.

Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr st., Shibin Elkom, 32511, Menoufia, Egypt. Electronic address:

Ethnopharmacological Relevance: The use of plant extracts and their phytochemicals as candidates for targeting the microbial resistance inhibition is increasingly focused in last decades. In Mongolian traditional medicine, Irises were long used for the treatment of bacterial infections. Irises have been used since the Ancient Egyptians. Read More

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September 2021

Metabolic engineering of microbes for monoterpenoid production.

Biotechnol Adv 2021 Sep 20:107837. Epub 2021 Sep 20.

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No. 29 the 13th Street TEDA, Tianjin 300457, PR China. Electronic address:

Monoterpenoids are an important class of natural products that are derived from the condensation of two five‑carbon isoprene subunits. They are widely used for flavouring, fragrances, colourants, cosmetics, fuels, chemicals, and pharmaceuticals in various industries. They can also serve as precursors for the production of many industrially important products. Read More

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September 2021

Point of care testing for infectious disease: ownership and quality.

J Antimicrob Chemother 2021 Sep;76(Supplement_3):iii28-iii32

University of Copenhagen, Hvidovre Hospital, Department of Clinical Microbiology, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark.

Traditionally, diagnosis of acute infections has been organism-growth based, which makes timely and actionable infection diagnosis a major challenge. In addition, traditional microbial detection methods, including direct microscopy, are not suited for outsourcing to clinical, non-laboratory-educated personnel. Optimal management of patients with known or suspected clinical infections, such as targeted (or no) antimicrobial treatment and correct use of single room contact isolation facilities, requires rapid identification of the causative infectious microorganism. Read More

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September 2021

CCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production.

J Agric Food Chem 2021 Sep 23. Epub 2021 Sep 23.

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Crocetin, a high-value apocarotenoid in saffron, is widely applied to the fields of food and medicine. However, the existing method of obtaining crocetin through large-scale cultivation is far from meeting the market demand. Microbial synthesis of crocetin is a potential alternative to traditional resources, and it is found that carotenoid cleavage dioxygenase (CCD) is the critical enzyme to synthesize crocetin. Read More

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September 2021

Testing microbiome association using integrated quantile regression models.

Bioinformatics 2021 Sep 23. Epub 2021 Sep 23.

Department of Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Motivation: Most existing microbiome association analyses focus on the association between microbiome and conditional mean of health or disease-related outcomes, and within this vein, vast computational tools and methods have been devised for standard binary or continuous outcomes. However, these methods tend to be limited either when the underlying microbiome-outcome association occurs somewhere other than the mean level, or when distribution of the outcome variable is irregular (e.g. Read More

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September 2021

A random forest model based on core genome allelic profiles of MRSA for penicillin plus potassium clavulanate susceptibility prediction.

Microb Genom 2021 Sep;7(9)

Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine; Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province; Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China.

Treatment failure of methicillin-resistant (MRSA) infections remains problematic in clinical practice because therapeutic options are limited. Penicillin plus potassium clavulanate combination (PENC) was shown to have potential for treating some MRSA infections. We investigated the susceptibility of MRSA isolates and constructed a drug susceptibility prediction model for the phenotype of the PENC. Read More

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September 2021

Draft Genome Sequence of the Halophilic Strain Citrobacter braakii AN-PRR1, Isolated from Rhizospheric Soil of Rice (Oryza sativa L.) from Pakistan.

Microbiol Resour Announc 2021 Sep 23;10(38):e0078721. Epub 2021 Sep 23.

Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, Tübingen, Germany.

Citrobacter braakii AN-PRR1 is a potential salt-tolerant, plant growth-promoting rice rhizobacterium isolated from Pakistani soil. The 4.9-Mb draft genome sequence contributes to its taxonomic classification and will reveal the genes putatively responsible for its osmoprotectant and plant growth-promoting activity. Read More

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September 2021

Reactor control system in bacterial co-culture based on fluorescent proteins using an Arduino-based home-made device.

Biotechnol J 2021 Sep 23:e2100169. Epub 2021 Sep 23.

Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Co-culture, fermentation with more than two microbial strains, is a potential flexible method for optimizing the metabolic conversion process in bio-production. However, maintaining an ideal population throughout the fermentation process remains a challenge.

Methods And Results: In this study, we developed a proportional control system for controlling the population ratio of Escherichia coli strains to a set value during continuous co-culture. Read More

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September 2021

Whole-plant foods and their macromolecules: untapped approaches to modulate neuroinflammation in Alzheimer's disease.

Crit Rev Food Sci Nutr 2021 Sep 23:1-19. Epub 2021 Sep 23.

Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Guangzhou, P.R. China.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Recently, sustained neuroinflammatory response in microglia and astrocytes has been found to cause the deposition of amyloid beta plaques and the hyperphosphorylation of tau protein, thereby accelerating AD progression. The lipoxin A4-transcription factor nuclear factor-kappa B and mitogen-activated protein kinase pathways have been shown to play important roles in the regulation of inflammatory processes. Read More

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September 2021

A small molecule II-6s inhibits biofilms.

J Oral Microbiol 2021 14;13(1):1978756. Epub 2021 Sep 14.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Limitations of current intracanal irrigants such as sodium hypochlorite (NaOCl) and chlorhexidine (CHX) necessitate the development of novel antimicrobial agents to control endodontic infection.

Aim: This study investigated the antimicrobial activities of a small molecule II-6s against associated with endodontic diseases.

Methods: The susceptibility of to II-6s was evaluated by the microdilution method and time-kill assay. Read More

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September 2021

Therapeutic plasma exchange in liver failure.

World J Hepatol 2021 Aug;13(8):904-915

Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH 44195, United States.

The multi-organ failure syndrome associated with acute and acute-on-chronic liver failure (ACLF) is thought to be mediated by overwhelming systemic inflammation triggered by both microbial and non-microbial factors. Therapeutic plasma exchange (TPE) has been proven to be an efficacious therapy in autoimmune conditions and altered immunity, with more recent data supporting its use in the management of liver failure. Few therapies have been shown to improve survival in critically ill patients with liver failure who are not expected to survive until liver transplantation (LT), who are ineligible for LT or who have no access to LT. Read More

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Depends on Eap Proteins for Preventing Degradation of Its Phenol-Soluble Modulin Toxins by Neutrophil Serine Proteases.

Front Immunol 2021 6;12:701093. Epub 2021 Sep 6.

Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), Infection Biology, University of Tübingen, Tübingen, Germany.

Neutrophil granulocytes act as a first line of defense against pathogenic staphylococci. However, has a remarkable capacity to survive neutrophil killing, which distinguishes it from the less-pathogenic Both species release phenol-soluble modulin (PSM) toxins, which activate the neutrophil formyl-peptide receptor 2 (FPR2) to promote neutrophil influx and phagocytosis, and which disrupt neutrophils or their phagosomal membranes at high concentrations. We show here that the neutrophil serine proteases (NSPs) neutrophil elastase, cathepsin G and proteinase 3, which are released into the extracellular space or the phagosome upon neutrophil FPR2 stimulation, effectively degrade PSMs thereby preventing their capacity to activate and destroy neutrophils. Read More

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September 2021

Parasitoid Causes Cascading Effects on Plant-Induced Defenses Mediated Through the Gut Bacteria of Host Caterpillars.

Front Microbiol 2021 6;12:708990. Epub 2021 Sep 6.

Department of Entomology, Pennsylvania State University, University Park, PA, United States.

Koinobiont endoparasitoid wasps whose larvae develop inside a host insect alter several important facets of host physiology, potentially causing cascading effects across multiple trophic levels. For instance, the hijacking of the host immune responses may have effects on how insects interact with host plants and microbial associates. However, the parasitoid regulation of insect-plant-microbiome interactions is still understudied. Read More

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September 2021

Microbial Composition and Co-occurrence Patterns in the Gut Microbial Community of Normal and Obese Mice in Response to Astaxanthin.

Front Microbiol 2021 6;12:671271. Epub 2021 Sep 6.

Laboratory of Food Science and Human Health, College of Food Science and Engineering, Ocean University of China, Qingdao, China.

The changes and interaction of gut microbiota, which respond to dietary supplements, play critical roles on improving human health. The modulating effect of astaxanthin on gut microbiota has been reported. However, little is known about the co-occurrence patterns among microbial taxa in response to astaxanthin. Read More

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September 2021

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation.

Front Pharmacol 2021 6;12:723233. Epub 2021 Sep 6.

Victor Babes National Institute of Pathology, Biochemistry-Proteomics Department, Bucharest, Romania.

Due to the increasing prevalence of life-threatening bacterial, fungal and viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compunds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable compounds for this task are usually derived from natural sources (animal, plant or even microbial). Read More

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September 2021

Chains of evidence from correlations to causal molecules in microbiome-linked diseases.

Nat Chem Biol 2021 Sep 22. Epub 2021 Sep 22.

Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Human-associated microorganisms play a vital role in human health, and microbial imbalance has been linked to a wide range of disease states. In this Review, we explore recent efforts to progress from correlative studies that identify microorganisms associated with human disease to experiments that establish causal relationships between microbial products and host phenotypes. We propose that successful efforts to uncover phenotypes often follow a chain of evidence that proceeds from (1) association studies; to (2) observations in germ-free animals and antibiotic-treated animals and humans; to (3) fecal microbiota transplants (FMTs); to (4) identification of strains; and then (5) molecules that elicit a phenotype. Read More

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September 2021

Rapid detection of pesticide in milk, cereal and cereal based food and fruit juices using paper strip-based sensor.

Sci Rep 2021 Sep 22;11(1):18855. Epub 2021 Sep 22.

Microbial Biosensors, Food Safety and Quality Assurance Lab, Dairy Microbiology Division, National Dairy Research Institute, Karnal, Haryana, India.

The study was aimed to validate paper strip sensors for the detection of pesticide residues in milk, cereal-based food, and fruit juices in comparison with GC-MS/MS under field conditions. The detection limit of pesticide using rapid paper strip sensor for organophosphate, carbamate, organochlorine, fungicide, and herbicide group ranges from 1 to 10, 1-50, 250-500, 1-50, and 1 ppb, respectively in milk and milk product, cereal-based food and fruit juices. Among 125 samples of milk samples collected from the market 33 milk samples comprising 31 raw milk and 2 pasteurized milk found positive for pesticide using the strip-based sensor. Read More

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September 2021

The influence of the gut microbiome on BCG-induced trained immunity.

Genome Biol 2021 Sep 22;22(1):275. Epub 2021 Sep 22.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Background: The bacillus Calmette-Guérin (BCG) vaccine protects against tuberculosis and heterologous infections but elicits high inter-individual variation in specific and nonspecific, or trained, immune responses. While the gut microbiome is increasingly recognized as an important modulator of vaccine responses and immunity in general, its potential role in BCG-induced protection is largely unknown.

Results: Stool and blood were collected from 321 healthy adults before BCG vaccination, followed by blood sampling after 2 weeks and 3 months. Read More

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September 2021

Skin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus.

BMC Microbiol 2021 Sep 23;21(1):256. Epub 2021 Sep 23.

National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Microbial dysbiosis with increased Staphylococcus aureus (S. aureus) colonization on the skin is a hallmark of atopic dermatitis (AD), however most microbiome studies focus on bacteria in the flexures and the microbial composition at other body sites have not been studied systematically.

Objectives: The aim of the study is to characterize the skin microbiome, including bacteria, fungi and virus, at different body sites in relation to AD, lesional state, and S. Read More

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September 2021

Multiplexed functional metagenomic analysis of the infant microbiome identifies effectors of NF-κB, autophagy, and cellular redox state.

Cell Rep 2021 Sep;36(12):109746

Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY 10065, USA. Electronic address:

The human microbiota plays a critical role in host health. Proper development of the infant microbiome is particularly important. Its dysbiosis leads to both short-term health issues and long-term disorders lasting into adulthood. Read More

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September 2021

Focused Microbiome Shifts in Reconstructed Wetlands Correlated with Elevated Cu Concentrations Originating from Micronized Copper Azole Treated Wood.

Environ Toxicol Chem 2021 Sep 22. Epub 2021 Sep 22.

U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, Pacific Ecological Systems Division, Corvallis, OR, USA.

Micronized copper azole (MCA) wood preservative formulations include Cu in nano form, and relatively little is known about longer-term effects of Cu leached from MCA into wetland ecosystems. Here we tested the hypothesis that changes in soil microbiomes within reconstructed freshwater wetlands will be associated with exposure to elevated Cu concentrations originating from immersed MCA treated wood stakes. Eight replicate communities were assembled with Willamette Valley flood plain soil, and clonally propagated wetland plants within mesocosms. Read More

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September 2021

A natural history museum visitor survey of perception, attitude and knowledge (PAK) of microbes and antibiotics.

PLoS One 2021 22;16(9):e0257085. Epub 2021 Sep 22.

American Museum of Natural History, Sackler Institute for Comparative Genomics, New York, NY, United States of America.

A kiosk-based survey at the American Museum of Natural History in New York City in 2016-2018 allowed us to assess public knowledge of antibiotics and public attitudes toward microbes in museum goers. Over 22,000 visitors from 172 countries and territories answered several carefully designed questions about microbes and antibiotics. These visitors also entered age, gender, and country demographic data that allowed for stratification along these demographic and geographic divisions. Read More

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September 2021

Genomic signatures of Lake Erie bacteria suggest interaction in the Microcystis phycosphere.

PLoS One 2021 22;16(9):e0257017. Epub 2021 Sep 22.

James Madison University, Harrisonburg, VA, United States of America.

Microbial interactions in harmful algal bloom (HAB) communities have been examined in marine systems, but are poorly studied in fresh waters. To investigate HAB-microbe interactions, we isolated bacteria with close associations to bloom-forming cyanobacteria, Microcystis spp., during a 2017 bloom in the western basin of Lake Erie. Read More

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September 2021

Detection of sulfate-reducing bacteria as an indicator for successful mitigation of sulfide production.

Appl Environ Microbiol 2021 Sep 22:AEM0174821. Epub 2021 Sep 22.

Integrative Oceanography Division, Scripps Institution of Oceanography, UC San Diego.

Sulfate-reducing bacteria (SRB) are one of the main sources of biogenic HS generation in oil reservoirs. Excess HS production in these systems leads to oil biosouring, which causes operational risks, health hazards and can increase the cost of refining crude oil. Nitrate salts are often added to the system to suppress sulfidogenesis. Read More

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September 2021

In-vitro and microbiological assay of functionalized nano-hybrids to validate their differential efficacy in nano-theranostics: A combined spectroscopic and computational study.

ChemMedChem 2021 Sep 22. Epub 2021 Sep 22.

SNBNCBS, CBMS, Block JD, Sector III, Salt Lake City, 700098, Kolkata, INDIA.

Functionalized nanoparticles (NPs) reveal new frontiers in simultaneous therapeutics and diagnostics, often termed as theranostics. Functionalization of an inorganic nanoparticle with an organic ligand typically predominates its interaction with various cellular components, which eventually leads to the therapeutic outcome diminishing the adverse side effects. Other physical properties of the organic-inorganic complex (nanohybrid) including fluorescence, x-ray or MRI contrast offer diagnosis of anomalous target cells. Read More

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September 2021

The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression: Protocol for a Phase 2, Double-Blind, Placebo-Controlled Study.

JMIR Res Protoc 2021 Sep 22;10(9):e31439. Epub 2021 Sep 22.

Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

Background: The gut-brain axis is a bidirectional signaling pathway between the gastrointestinal tract and the brain; it is being studied because of its potential influence in mediating mood, anxiety, and other neuropsychiatric symptoms. Previous research examining the effects of gut microbiota on neuropsychiatric disorders suggests that gut repopulation treatments such as probiotics, microbe therapy, and fecal microbiota transplantation show promising results in treating symptoms of anxiety and depression. This study explores the use of an alternative gut repopulation treatment to fecal microbiota transplantation, known as Microbial Ecosystem Therapeutic (MET)-2, as an intervention against symptoms of depression. Read More

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September 2021

The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa.

Microbiol Spectr 2021 Sep 22:e0051921. Epub 2021 Sep 22.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimoregrid.411024.2, Baltimore, Maryland, USA.

To combat infections, the mammalian host limits availability of essential transition metals such as iron (Fe), zinc (Zn), and manganese (Mn) in a strategy termed "nutritional immunity." The innate immune protein calprotectin (CP) contributes to nutritional immunity by sequestering these metals to exert antimicrobial activity against a broad range of microbial pathogens. One such pathogen is Pseudomonas aeruginosa, which causes opportunistic infections in vulnerable populations, including individuals with cystic fibrosis. Read More

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September 2021

Antihyperuricemic Effect of Green Alga Ulvan through Regulating Urate Transporters.

J Agric Food Chem 2021 Sep 22. Epub 2021 Sep 22.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, People's Republic of China.

A novel polysaccharide from (ULP) was purified using a Sepharose CL-4B column. Fourier transform infrared spectroscopy, high-performance liquid chromatography, and nuclear magnetic resonance spectroscopy were employed to analyze the structure of ULP. It consisted of rhamnose (Rha), glucuronic acid (GluA), galactose (Gal), and xylose (Xyl) at a molar ratio of 32. Read More

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September 2021

Microbiological assessment of arterial allografts processed in a tissue bank.

Cell Tissue Bank 2021 Sep 21. Epub 2021 Sep 21.

Service of Microbiology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

The transmission of microbial infection through tissue allografts is one of the main risks that must be controlled in tissue banks. Therefore, microbiological monitoring controls and validated protocols for the decontamination of tissues during processing have been implemented. This study is based on the evaluation of data from microbiological cultures of arteries (mainly long peripheral arteries) processed in the tissue bank of Valencia (Spain). Read More

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September 2021