Search Our Scientific Publications & Authors

J Biomed Mater Res A 2021 Apr 19. Epub 2021 Apr 19.

Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Mesoporous silica nanoparticles coated with Chitosan are exploited here as a potential carrier for oral vaccine delivery. Bovine serum albumin (BSA) was used as a protein antigen model to reveal the carrier property. Chitosan-coated BSA-loaded silica NPs had particle size 345 ± 60 nm with a cationic surface charge of 18. Read More

ACS Omega 2021 Apr 31;6(14):9352-9361. Epub 2021 Mar 31.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4L8, Canada.

SNM1A is a nuclease required to repair DNA interstrand cross-links (ICLs) caused by some anticancer compounds, including cisplatin. Unlike other nucleases involved in ICL repair, SNM1A is not needed to restore other forms of DNA damage. As such, SNM1A is an attractive target for selectively increasing the efficacy of ICL-based chemotherapy. Read More

Regen Ther 2021 Dec 5;18:51-58. Epub 2021 Apr 5.

Hematology and Hemotherapy Center, Hemocentro, University of Campinas (UNICAMP), Campinas, Brazil.

Introduction: Venous ulcers are the most common type of leg wounds (80%) and the main cause is chronic venous insufficiency. Autologous platelet-rich plasma (PRP) is a potential wound healing treatment due to its great variety of growth factors. The aim of this study was to describe in a case series the results of poor-leukocyte PRP (P-PRP) or saline for the treatment of chronic non-healing ulcers of the lower extremity. Read More

Expert Opin Pharmacother 2021 Apr 19. Epub 2021 Apr 19.

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.

: Testosterone deficiency (TD) is defined as low serum testosterone associated with symptoms and signs. There is an increasing prevalence of TD in recent decades, especially in males aged 15-39. Many of these men will require long-term testosterone therapy (TT). Read More

ACS Appl Mater Interfaces 2021 Apr 18. Epub 2021 Apr 18.

Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

Stimuli-responsive materials can enhance the field of three-dimensional (3D) printing by generating objects that change shape in response to external cues. While temperature and pH are common inputs for initiating a response in a 3D-printed object, there are few examples of using a mechanical input to afford a response. Herein, we report a suite of mechanochromic ionic liquid gel inks that can be used to fabricate 3D-printed objects that use a single mechanoactivation event to elicit both a mechanochromic response and an autonomous shape change. Read More

Forensic Sci Int 2021 Apr 10;323:110787. Epub 2021 Apr 10.

University of New Haven, Henry C. Lee College of Criminal Justice and Forensic Science, Forensic Science Department, 300 Boston Post Rd, West Haven, CT 06516, USA. Electronic address:

The main objective of this project was to assess an inkless method to collect reference (exemplar) fingerprints as a low-cost, portable, and hygienic technique; for temporary storage and as an alternative to the conventional black ink method. The tested inkless approach requires alcohol-based hand sanitizer gel as the medium and thermal paper as the substrate. The final quality and clarity of fingerprints were examined and compared between the two methods, especially on the basis of medium/substrate and biological sex effects. Read More

J Pharm Sci 2021 Apr 15. Epub 2021 Apr 15.

Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123, Perugia, Italy. Electronic address:

The urgent need for new green and sustainable models is ground for the current demand of innovative renewable resource based pharmaceutical products. We propose a Rojo Duro skin onion extract loaded poloxamer/chitosan spray mucoadhesive thermogel aimed at solving current limitations in oral mucosits treatment. Being among the main side effects of radio- and chemotherapy, effective treatment of buccal lesions still represents an unmet medical need. Read More

Biochimie 2021 Apr 15. Epub 2021 Apr 15.

INIBIOLP (Instituto de Investigaciones Bioquímicas de La Plata Rodolfo R. Brenner), Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata. 60 y 120 S/N, La Plata, Buenos Aires, Argentina. Electronic address:

Metal ions and metal complexes are important components of nucleic acid biochemistry, participating both in regulation of gene expression and as therapeutic agents. Three new transition metal complexes of copper(II), zinc(II) and oxidovanadium(IV) with a ligand derived from o-vanillin and thiophene were previously synthesized and their antitumor properties were studied in our laboratory. To elucidate some molecular mechanisms tending to explain the cytotoxic effects observed over tumor cells, we investigated the interaction of these complexes with DNA by gel electrophoresis, UV-Vis spectroscopy, docking studies and molecular dynamics simulations. Read More

Planta 2021 Apr 17;253(5):106. Epub 2021 Apr 17.

Department of Comparative Plant and Fungal Biology, Royal Botanic Gardens, Kew, Wakehurst Place, Ardingly, UK.

Main Conclusion: Modulation of the gaseous environment using oxygen absorbers and/or silica gel shows potential for enhancing seed longevity through trapping toxic volatiles emitted by seeds during artificial ageing. Volatile profiling using non-invasive gas chromatography-mass spectrometry provides insight into the specific processes occurring during seed ageing. Production of alcohols, aldehydes and ketones, derived from processes such as alcoholic fermentation, lipid peroxidation and Maillard reactions, are known to be dependent on storage temperature and relative humidity, but little is known about the potential modulating role of the gaseous environment, which also affects seed lifespan, on volatile production. Read More

J Integr Med 2021 Jan 21. Epub 2021 Jan 21.

Department of Otolaryngology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.

Objective: Chinese medicine has the potential to modulate allergic rhinitis (AR). There have been studies investigating the treatment efficacy of Yupingfeng San, alone or in combination with other ingredients, in AR, though few have studied the potential mechanisms of these drugs. In the present study, we measured the effects of Jiawei Yupingfeng (JWYPF), a traditional Chinese medicine formula, on mice with ovalbumin-induced AR and explored its underlying mechanism of action. Read More

Lab Chip 2021 Apr 16. Epub 2021 Apr 16.

Center for Biofilm Engineering, Montana State University, 214 Roberts Hall, Bozeman, MT 59717, USA. and Chemical and Biological Engineering Department, Montana State University, 214 Roberts Hall, Bozeman, MT 59717, USA.

Hydrogels are soft, water-based polymer gels that are increasingly used to fabricate free-standing fluidic devices for tissue and biological engineering applications. For many of these applications, pressurized liquid must be driven through the hydrogel device. To couple pressurized liquid to a hydrogel device, a common approach is to insert tubing into a hole in the gel; however, this usually results in leakage and expulsion of the tubing, and other options for coupling pressurized liquid to hydrogels remain limited. Read More

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Department of Building Materials and Products, Institute of Architecture and Construction, South Ural State University, Chelyabinsk, 454080, Russia.

Environmental threats posed by the cement manufacturing industry and agro-industrial waste discharge have shifted the direction of research towards building sustainable construction without compromising the technical merits of the developed binders. Date palm trees are one of the highest numbers of trees in the world whose generated wastes can be beneficially recycled and reused by the concrete industry. In this study, ordinary Portland cement (OPC) and date palm frond ash (DPFA)-based binders were synthesized by varying ratio of DPFA/(OPC + DPFA) between the range of 0 to 0. Read More

Biomed Res Int 2021 23;2021:6692328. Epub 2021 Mar 23.

School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China.

To investigate the effects of ficin on biofilm formation of conditionally cariogenic (). Biomass and metabolic activity of biofilm were assessed using crystal violet assay, colony-forming unit (CFU) counting, and MTT assay. Extracellular polysaccharide (EPS) synthesis was displayed by SEM imaging, bacteria/EPS staining, and anthrone method while acid production was revealed by lactic acid assay. Read More

Carbohydr Polym 2021 Jul 29;263:118005. Epub 2021 Mar 29.

College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Laboratory of Food Technology and Equipment, Zhejiang University, Hangzhou, 310058, China; Fuli Institute of Food Science, Zhejiang University, Hangzhou, 310058, China; Ningbo Research Institute, Zhejiang University, Hangzhou, 315100, China.

High pressure processing (HPP) has become a promising strategy for extracting bioactive constituents. In this study, the impact of HPP treatment at various pH values (2.0, 8. Read More

J Chem Phys 2021 Apr;154(14):144902

Department of Chemistry, Johannes Gutenberg University Mainz, D-55128 Mainz, Germany.

Charged hydrogels are capable of swelling in aqueous salt solutions, whereby part of the salt ions is repelled due to the presence of fixed charged groups inside the hydrogel. This effect creates a concentration gradient between the absorbed solution and the surrounding fluid known as salt partitioning, offering a potential for these materials to be employed to desalinate saltwater. If the charged hydrogels are thermo-sensitive as well, then the purer, absorbed solution can be recovered by shrinking the hydrogels upon temperature change. Read More

Biomed Mater 2021 Apr 15. Epub 2021 Apr 15.

Chemical Engineering, Indian Institute of Technology Gandhinagar, Chemical Engineering, IIT Gandhinagar, Palaj, Gandhinagar, Gujarat, 382355, INDIA.

We demonstrate a benign and straightforward method to modify the chitosan (CH) by carbamoylation. The free amines on CH are converted into carbamyl functionalities by reacting with potassium cyanate (KCNO). One wt% CH solution, when reacted with KCNO  0. Read More

Int J Biol Macromol 2021 Apr 16;182:689-700. Epub 2021 Apr 16.

College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003 Qingdao, China. Electronic address:

In situ 3D printing technologies is a new frontier for highly personalized medicine, which requires suitable bioink with rheology, biocompatibility, and gelation kinetics to support the right shape and mechanical properties of the printed construct. To this end, a facile design of thermo/photo dual cure composite hydrogel was proposed using MHBC and soluble collagen in this study. M/C composite hydrogel exhibited rapid thermo-induced sol-gel transition and contraction, tunable mechanical properties, proper microstructure and biodegradability for 3D cell culture, as well as improve cyto-compatibility, all of which were dependent upon the methacrylation degree of MHBC and M/C ratios. Read More

J Wound Care 2021 Apr;30(Sup4):S4-S13

Department of Gerontological Nursing/Wound Care Management, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objective: Wound biofilms delay healing of hard-to-heal wounds. Convenient biofilm identification tools for clinical settings are currently not available, hindering biofilm-based wound management. Wound blotting with biofilm staining is a potential tool for biofilm detection, owing to its convenience. Read More

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Department of Emergency and Trauma, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Repair of large bone defects represents a major challenge for orthopedic surgeons. The newly formed microvessels inside grafts play a crucial role in successful bone tissue engineering. Previously, an active role for mesenchymal stem cell (MSC)-derived exosomes in blood vessel development and progression was suggested in the repair of multiple tissues. Read More

ChemMedChem 2021 Apr 15. Epub 2021 Apr 15.

University of East Anglia, School of Chemistry, 3.03 CAP, Norwich Research Park, NR4 7TJ, Norwich, UNITED KINGDOM.

To understand the potential in vitro modes of action of bis(β-diketonato) oxovanadium(IV) complexes, nine compounds of varying functionality have been screened using a range of biological techniques. The antiproliferative activity against a range of cancerous and normal cell lines has been determined, and show these complexes are particularly sensitive against the lung carcinoma, cell line, A549. Annexin V (apoptosis) and Caspase-3/7 assays were studied to confirm these complexes induce programmed cell death. Read More

Angew Chem Int Ed Engl 2021 Apr 14. Epub 2021 Apr 14.

Johns Hopkins University, 400 N. Broadway, Smith Building 6029, 21231, Baltimore, UNITED STATES.

Inhaled gene therapy poses a unique potential of curing chronic lung diseases which are currently managed primarily by symptomatic treatments. However, it has been challenging to achieve therapeutically-relevant gene transfer efficacy in the lung thus far due to the presence of numerous biological delivery barriers. Here, we introduce a simple combinatorial approach that overcomes both extracellular and cellular barriers to enhance gene transfer efficacy in the lung in vivo . Read More

mSphere 2021 Apr 14;6(2). Epub 2021 Apr 14.

Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control College of Animal Science and Technology, Anhui Agricultural University, Hefei, China

Antimicrobial resistance associated with colistin has emerged as a significant concern worldwide, threatening the use of one of the most important antimicrobials for treating human disease. This study aimed to investigate the prevalence of colistin-resistant avian-pathogenic (APEC) and shed light on the possibility of transmission of (mobilized colistin resistance)-positive APEC. A total of 72 APEC isolates from Anhui Province in China were collected between March 2017 and December 2018 and screened for the gene. Read More

J Chromatogr A 2021 Mar 30;1645:462122. Epub 2021 Mar 30.

Department of Earth, Environmental and Planetary Sciences, Brown University, 324 Brook Street, Providence, Rhode Island 02912, USA. Electronic address:

Silver(I)-mercaptopropyl (Ag-MP) functionalized silica gel has demonstrated its effectiveness in separating various unsaturated organic compounds including unsaturated fatty acid ethyl esters (FAEEs), triglycerols (TAGs) and long-chain alkyl ketones (alkenones). While Ag-MP stationary phase displays many advantages over the conventional silver ion-impregnated silica gel (e.g. Read More

J Drugs Dermatol 2021 Apr;20(4):461-465

Background: Skin rejuvenation can be achieved with minimally invasive treatments using energy-based devices that feature reduced side effects and downtime. Post-treatment care is key to minimize any potential side effects and skin reactions such as erythema, dryness, or dyschromia.

Objective: The objective of this study was to evaluate the efficacy and patient satisfaction of a novel carboxytherapy gel mask compared with petroleum-based lanolin-containing ointment to accelerate wound healing facial post-nanofractional radiofrequency treatment. Read More

J Orofac Orthop 2021 Apr 14. Epub 2021 Apr 14.

Institute of Dental, Oral and Maxillary Medicine, Department of Orthodontics, Dentofacial Orthopedics and Pedodontics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Aßmannshauser Str. 4-6, 14197, Berlin, Germany.

Purpose: Main goal of the study was the identification and quantitative analysis of monomer elution from materials commonly used in fixed orthodontic therapy. Studies have shown severe health effects of monomers including cytotoxic, allergenic or mutagenic potential and endocrine changes. This in vitro study focusses primarily on five resins which are usually processed intraorally and remain in the oral cavity long-term. Read More

Biopolymers 2021 Apr 14:e23429. Epub 2021 Apr 14.

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India.

Angiogenin (Ang), is a ribonucleolytic protein that is associated with angiogenesis, the formation of blood vessels. The involvement of Ang in vascularisation makes it a potential target for the identification of compounds that have the potential to inhibit the process. The compounds may be assessed for their ability to inhibit the ribonucleolytic activity of the protein and subsequently blood vessel formation, a crucial requirement for tumor formation. Read More

Appl Sci (Basel) 2020 Aug 28;10(15):5194. Epub 2020 Jul 28.

Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.

Smart nanoparticles for medical applications have gathered considerable attention due to an improved biocompatibility and multifunctional properties useful in several applications, including advanced drug delivery systems, nanotheranostics and in vivo imaging. Among nanomaterials, zinc oxide nanoparticles (ZnO NPs) were deeply investigated due to their peculiar physical and chemical properties. The large surface to volume ratio, coupled with a reduced size, antimicrobial activity, photocatalytic and semiconducting properties, allowed the use of ZnO NPs as anticancer drugs in new generation physical therapies, nanoantibiotics and osteoinductive agents for bone tissue regeneration. Read More

Micron 2021 Apr 1;145:103066. Epub 2021 Apr 1.

Institute of Fundamental Technological Research, Lab. Polymers & Biomaterials, Polish Academy of Sciences, Pawinskiego 5b St., 02-106, Warsaw, Poland. Electronic address:

This research work is aimed at studying the effect of ultrasounds on the effectiveness of fiber fragmentation by taking into account the type of sonication medium, processing time, and various PLLA molecular weights. Fragmentation was followed by an appropriate filtration in order to decrease fibers length distribution. It was evidenced by fiber length determination using SEM that the fibers are shortened after ultrasonic treatment, and the effectiveness of shortening depends on the two out of three investigated parameters, mostly on the sonication medium, and processing time. Read More

Curr Eye Res 2021 Apr 12. Epub 2021 Apr 12.

NDDS Research Laboratory, Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, DPSR-University, Pushp Vihar, Sec 3, New Delhi, India 110017.

Purposes: The present study aimed to develop brimonidine tartrate loaded poly(lactic-co-glycolic acid) acid -vitamin E-tocopheryl polyethylene glycol 1000 succinate(BRT-PLGA-TPGS) nanoparticles in thermosensitive gel to improve mucoadhensive properties and drug holding capacity for the better management of glaucoma.

Methods: Nanoparticles was optimized by means of Box-Behnken Design (BBD). The formulations were prepared using various concentration of PLGA (0. Read More

ACS Nano 2021 Apr 12. Epub 2021 Apr 12.

School of Plant Sciences and Food Security, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Molecular oxygen (O) is a highly reactive oxidizing agent and is harmful to many biological and industrial systems. Although O often interacts metals or reducing agents, a binding mechanism involving an organic supramolecular structure has not been described to date. In this work, the prominent dipeptide hydrogelator fluorenylmethyloxycarbonyl-diphenylalanine is shown to encage O and significantly limit its diffusion and penetration through the hydrogel. Read More