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Potential of antibody-drug conjugates (ADCs) for cancer therapy.

Cancer Cell Int 2022 Aug 13;22(1):255. Epub 2022 Aug 13.

Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar.

The primary purpose of ADCs is to increase the efficacy of anticancer medications by minimizing systemic drug distribution and targeting specific cells. Antibody conjugates (ADCs) have changed the way cancer is treated. However, because only a tiny fraction of patients experienced long-term advantages, current cancer preclinical and clinical research has been focused on combination trials. Read More

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The Ultramarathon of Gene Therapy Development for Rare Diseases: How Can We Cross the Finish Line Together?

Authors:
Erin Ward

Clin Ther 2022 Aug 10. Epub 2022 Aug 10.

MTM-CNM Family Connection Inc, Methuen, Massachusetts. Electronic address:

The promising developments in gene and cell therapy bring an array of hope to the >7000 rare disease patient communities, of which 90% to 95% are still working toward a treatment. However, the pace of gene and cell therapy development pathways often resembles ultramarathon relay races that potentially span decades. It is a pace that is incongruent to the sprint that most individuals with rare diseases and their families are living and working in pursuit of life-saving treatments. Read More

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A proof of concept for targeting the PrP - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer.

Oncogene 2022 Aug 12. Epub 2022 Aug 12.

Centre de Recherche des Cordeliers, Inserm, Sorbonne Université, Université de Paris, F-75006, Paris, France.

The cellular prion protein PrP partners with caveolin-1 (CAV1) in neurodegenerative diseases but whether this interplay occurs in cancer has never been investigated. By leveraging patient and cell line datasets, we uncover a molecular link between PrP and CAV1 across cancer. Using cell-based assays, we show that PrP regulates the expression of and interacts with CAV1. Read More

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Fertility-sparing surgery for diffuse adenomyosis: a narrated, stepwise approach to the Osada procedure.

Fertil Steril 2022 Aug 10. Epub 2022 Aug 10.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Health Sciences Centre, Women's Hospital, Winnipeg, Manitoba, Canada.

Objective: To equip reproductive surgeons with an approach to the Osada procedure and critical prophylactic hemostatic measures that optimize perioperative outcomes.

Design: Stepwise demonstration of the Osada procedure with narrated video footage.

Setting: Definitive management of symptomatic adenomyosis requires hysterectomy. Read More

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Geographic Variations in Growth of Radiologists and Medicare Enrollees From 2012 to 2019.

J Am Coll Radiol 2022 Aug 9. Epub 2022 Aug 9.

Division Chair of Breast Imaging, Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona.

Objective: Analyze changes in the number of Medicare-serving radiologists and Medicare enrollees nationwide and by geographic region and state from 2012 to 2019 to understand variations in allocation of imaging health care services over the past decade.

Methods: The number of radiologists submitting claims to Medicare was extracted from the CMS Physician and Other Supplier Public Use File Database. The number of Medicare enrollees by state was obtained from the Kaiser Family Foundation. Read More

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Digital health transformation in Saudi Arabia: A cross-sectional analysis using Healthcare Information and Management Systems Society' digital health indicators.

Digit Health 2022 Jan-Dec;8:20552076221117742. Epub 2022 Aug 4.

Health Information Management and Technology, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: The digital revolution has had a huge impact on healthcare around the world. Digital technology could dramatically improve the accuracy of diagnosis, treatment, health outcomes, efficiency of care, and workflow of healthcare operations. Using health information technology will bring major improvements in patient outcomes. Read More

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Integrating Health and Social Care Services.

Glob Adv Health Med 2022 5;11:2164957X221117112. Epub 2022 Aug 5.

Lambeth Living Well Network Alliance, Lambeth, London, UK.

Background: A recent UK Government draft Heath White Paper follows the NHS England long term plan when it states that NHS England requires "a new framework that builds on changes already being made as well as building in the flexibility to support the system to tackle challenges of the future". At present the structure of Health and Social Care Services UK reporting to Government seems unhelpfully complex and opaque.

Objective: The purpose of this paper is to contribute to the building of a new framework using a generic approach to identify and use 'systemic processes' to facilitate the integration of Health and Social Care services in NHS England and elsewhere. Read More

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Digital phenotype of mood disorders: A conceptual and critical review.

Front Psychiatry 2022 26;13:895860. Epub 2022 Jul 26.

iCRIN (Infrastructure for Clinical Research in Neurosciences), Paris Brain Institute (ICM), Sorbonne Université, INSERM, CNRS, Paris, France.

Background: Mood disorders are commonly diagnosed and staged using clinical features that rely merely on subjective data. The concept of digital phenotyping is based on the idea that collecting real-time markers of human behavior allows us to determine the digital signature of a pathology. This strategy assumes that behaviors are quantifiable from data extracted and analyzed through digital sensors, wearable devices, or smartphones. Read More

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Enhancing the diversity of self-replicating structures using active self-adapting mechanisms.

Front Genet 2022 26;13:958069. Epub 2022 Jul 26.

Faculty of Science and Engineering, Iwate University, Morioka, Japan.

Numerous varieties of life forms have filled the earth throughout evolution. Evolution consists of two processes: self-replication and interaction with the physical environment and other living things around it. Initiated by von Neumann et al. Read More

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Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.

Expert Rev Endocrinol Metab 2022 Aug 11:1-10. Epub 2022 Aug 11.

Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.

Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and closely interconnected to the metabolic syndrome. Liver-specific and systemic signaling pathways orchestrating glucose and fatty acid metabolism contribute to intrahepatic accumulation of lipids and inflammatory processes eventually causing disease progression to nonalcoholic steatohepatitis (NASH), liver fibrosis, and cirrhosis. Since a high number of key regulatory genes regarding liver homeostasis are directly mediated via thyroid hormone (TH) signaling, targeting TH receptors (TRs) represent a promising therapeutic potential for the treatment of NAFLD. Read More

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To BYOD or not: Are device latencies important for bring-your-own-device (BYOD) smartphone cognitive testing?

Behav Res Methods 2022 Aug 11. Epub 2022 Aug 11.

Charles F. and Joanne Knight Alzheimer Disease Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Studies using remote cognitive testing must make a critical decision: whether to allow participants to use their own devices or to provide participants with a study-specific device. Bring-your-own-device (BYOD) studies have several advantages including increased accessibility, potential for larger sample sizes, and reduced participant burden. However, BYOD studies offer little control over device performance characteristics that could potentially influence results. Read More

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Quantifying the Benefits of Digital Biomarkers and Technology-Based Study Endpoints in Clinical Trials: Project Moneyball.

Digit Biomark 2022 May-Aug;6(2):36-46. Epub 2022 Jun 29.

UCB, Slough, United Kingdom.

Introduction: Digital biomarkers have significant potential to transform drug development, but only a few have contributed meaningfully to bring new treatments to market. There are uncertainties in how they will generate quantifiable benefits in clinical trial performance and ultimately to the chances of phase 3 success. Here we have proposed a statistical framework and ran a proof-of-concept model with hypothetical digital biomarkers and visualized them in a familiar manner to study power calculation. Read More

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Considerations for Conducting Bring Your Own "Device" (BYOD) Clinical Studies.

Digit Biomark 2022 May-Aug;6(2):47-60. Epub 2022 Jul 4.

Novartis Ireland Ltd., Dublin, Ireland.

Background: Digital health technologies are attracting attention as novel tools for data collection in clinical research. They present alternative methods compared to in-clinic data collection, which often yields snapshots of the participants' physiology, behavior, and function that may be prone to biases and artifacts, e.g. Read More

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Costs and benefits of combined sewer overflow management strategies at the European scale.

J Environ Manage 2022 Sep 1;318:115629. Epub 2022 Jul 1.

European Commission Joint Research Centre, Ispra, Italy. Electronic address:

Combined sewer overflows (CSOs) may represent a significant source of pollution, but they are difficult to quantify at a large scale (e.g. regional or national), due to a lack of accessible data. Read More

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September 2022

Effectiveness of oral health promotion interventions for people with type 2 diabetes delivered by non-dental health care professionals: a systematic review.

Glob Health Action 2022 Dec;15(1):2075576

School of Health, Medical and Applied Sciences, College of Science and Sustainability, Central Queensland University, Australia.

Background: Oral health problems among people with diabetes mellitus are an emerging public health problem. Despite the rising concerns of oral health and diabetes mellitus comorbidity, there is a lack of dental health care professionals such as dentists, to address this problem, especially at the primary care level in low- and middle-income countries.

Objective: This review systematically synthesizes the current evidence in terms of the involvement of non-dental health care professionals in promoting oral health among people with type 2 diabetes mellitus and assessed the effectiveness of such programs. Read More

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December 2022

Practical guidance for planning resources required to support publicly-funded adaptive clinical trials.

BMC Med 2022 08 10;20(1):254. Epub 2022 Aug 10.

Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK.

Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to bring benefit. One barrier to their more widespread use is a lack of understanding about how the choice to use an adaptive design, rather than a traditional design, affects resources (staff and non-staff) required to set-up, conduct and report a trial. Read More

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A review of the influence of nanoparticles on the physiological and biochemical attributes of plants with a focus on the absorption and translocation of toxic trace elements.

Environ Pollut 2022 Aug 6;310:119916. Epub 2022 Aug 6.

MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China. Electronic address:

Trace elements (TEs) from various natural and anthropogenic activities contaminate the agricultural water and soil environments. The use of nanoparticles (NPs) as nano-fertilizers or nano-pesticides is gaining popularity worldwide. The NPs-mediated fertilizers encourage the balanced availability of essential nutrients to plants compared to traditional fertilizers, especially in the presence of excessive amounts of TEs. Read More

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Kinetically Consistent Data Assimilation for Plant PET Sparse Time Activity Curve Signals.

Front Plant Sci 2022 22;13:882382. Epub 2022 Jul 22.

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.

Time activity curve (TAC) signal processing in plant positron emission tomography (PET) is a frontier nuclear science technique to bring out the quantitative fluid dynamic (FD) flow parameters of the plant vascular system and generate knowledge on crops and their sustainable management, facing the accelerating global climate change. The sparse space-time sampling of the TAC signal impairs the extraction of the FD variables, which can be determined only as averaged values with existing techniques. A data-driven approach based on a reliable FD model has never been formulated. Read More

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Target cell line characterization reveals changes in expression of a key antigen that impacts T cell dependent cellular cytotoxicity assay performance.

J Immunol Methods 2022 Aug 5:113326. Epub 2022 Aug 5.

Process Development, Amgen Inc., Thousand Oaks, CA, USA.

Cell lines are important tools regularly used for in-vitro potency assays employed in Good Manufacturing Process (GMP) lot release and stability testing of different therapeutic modalities. Characterization of these cell lines is key to understanding their performance. Bispecific T cell engager (BiTE®) molecules are an exciting modality in Amgen's therapeutic product portfolio. Read More

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How Family Members Experienced a Family-Focused Atrial Fibrillation Intervention in an Outpatient Setting-A Qualitative Study.

SAGE Open Nurs 2022 Jan-Dec;8:23779608221114265. Epub 2022 Aug 2.

Nursing and Health Care, Department of Public Health, University of Aarhus, Denmark.

Introduction: Family-focused nursing has gained ground worldwide, and a range of healthcare systems are now practicing family-focused nursing, which has been shown to increase the quality of care. Even so, a lack of research remains into family-focused nursing for various groups of patients in clinical practice.

Objectives: The purpose of this study was to explore how family members (FMs) of patients with atrial fibrillation (AF) experienced a family-focused nursing intervention in a clinical outpatient setting. Read More

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Osteosarcoma immune prognostic index can indicate the nature of indeterminate pulmonary nodules and predict the metachronous metastasis in osteosarcoma patients.

Front Oncol 2022 22;12:952228. Epub 2022 Jul 22.

Department of Orthopedics, Orthopaedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.

Purpose: The relationship between indeterminate pulmonary nodules (IPNs) and metastasis is difficult to determine. We expect to explore a predictive model that can assist in indicating the nature of IPNs, as well as predicting the probability of metachronous metastasis in osteosarcoma patients.

Patients And Methods: We conducted a retrospective study including 184 osteosarcoma patients at West China Hospital from January 2016 to January 2021. Read More

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Tuning brain networks: The emerging role of transcranial direct current stimulation on structural plasticity.

Front Cell Neurosci 2022 21;16:945777. Epub 2022 Jul 21.

Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique (NIBS) that has been proven to promote beneficial effects in a range of neurological and psychiatric disorders. Unfortunately, although has been widely investigated, the mechanism comprehension around tDCS effects presents still some gaps. Therefore, scientists are still trying to uncover the cellular and molecular mechanisms behind its positive effects to permit a more suitable application. Read More

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Innovation capabilities and human development competitiveness in education sector: Evidence from UAE.

Front Psychol 2022 22;13:933432. Epub 2022 Jul 22.

Department of Dakwah and Human Development, University of Malaya, Kuala Lumpur, Malaysia.

Innovation capabilities and human development in education sector is one of the key focused areas in United Nations Sustainable Development Goals. The current research is novel to integrate and address such constructs in single theoretical framework. Grounded in Human Capital Theory, this study aims to investigate the role of innovation capabilities in human development competitiveness in the education sector of UAE. Read More

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Rater severity differences in English language as a second language speaking assessment based on rating experience, training experience, and teaching experience through many-faceted Rasch measurement analysis.

Front Psychol 2022 22;13:941084. Epub 2022 Jul 22.

Research Centre of Education Leadership and Policy, Faculty of Education, Universiti Kebangsaan Malaysia (UKM), Selangor, Malaysia.

Evaluating candidates' answers in speaking skill is difficult and rarely explored. This task is challenging and can bring inconsistency in the rating quality among raters, especially in speaking assessments. Severe raters will bring more harm than good to the results that candidates receive. Read More

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Thankful employees: The manifestation of gratitude at work during a pandemic in South Africa.

Front Psychol 2022 22;13:941787. Epub 2022 Jul 22.

Department of Industrial Psychology and People Management, University of Johannesburg, Johannesburg, South Africa.

Gratitude or the appreciation of being given something of value, is an important element in positive emotions within positive psychology. Gratitude has been linked to wellbeing and gratitude in the workplace is positively associated with constructs such as performance and organizational citizenship behavior. The pandemic brought on many negative experiences but employees could still find things to be grateful for during this time. Read More

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A Case Report of Accelerated Pulmonary Silicosis: Hazardous Exposure in Underrepresented Community Members.

Cureus 2022 Jul 5;14(7):e26587. Epub 2022 Jul 5.

Internal Medicine, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.

A 39-year-old undocumented male immigrant with occupational exposure to quartz, without significant medical history, presented with worsening cough, dyspnea, and weight loss for the past six months, with onset of symptoms starting two years ago. The patient was exposed to silicon dioxide for the past 10 years due to his occupation. Chest x-ray at the time of diagnosis reflected multifocal heterogeneous opacities; CT of the chest demonstrated eggshell calcifications and conglomerate opacities particularly involving the bilateral upper lobes. Read More

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Future Nursing Research of Older Adults: Preserving Independence and Reducing Health Disparities.

Authors:
Ladda Thiamwong

Pac Rim Int J Nurs Res Thail 2022 Jan-Mar;26(1):1-5. Epub 2021 Dec 9.

College of Nursing, University of Central Florida, Orlando, FL, USA.

Nursing professionals are at the forefront of primary care and the largest segment of the health workforce, and nurse researchers can bring vital perspectives to aging research and clinical practice. Although healthcare systems are experiencing more work from the aging of populations, unfortunately there are limited nurse researchers trained in gerontological nursing. Future research in older adults needs to be based on the current needs of and for older adults. Read More

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December 2021

The degradation of gelatin/alginate/fibrin hydrogels is cell type dependent and can be modulated by targeting fibrinolysis.

Front Bioeng Biotechnol 2022 22;10:920929. Epub 2022 Jul 22.

Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.

In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated. Here, we investigated the capacity of primary and immortalized fibroblasts of distinct origins to degrade a gelatin/alginate/fibrin (GAF)-based biomaterial. Read More

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Dementia, Work and Employability: Using the Capability Approach to Understand the Employability Potential for People Living with Dementia.

Work Employ Soc 2022 Aug 2;36(4):591-609. Epub 2020 Dec 2.

University of the West of Scotland, UK.

The importance of remaining in, or re-entering, the labour market is emphasised by governments internationally. While this may bring benefits, progressive disabilities such as dementia affect an individual's employability. Although employers have legal obligations to support employees with disabilities, research suggests that employers are not providing this support to employees living with dementia and are undermining their capabilities. Read More

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Strategies for targeting RNA with small molecule drugs.

Expert Opin Drug Discov 2022 Aug 8. Epub 2022 Aug 8.

Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, FL United States of America, 33458.

Introduction: Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases [1]. Strikingly, less than 15% of disease-associated proteins are predicted or known to be "druggable" [2]. Read More

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