2,444,625 results match your criteria potential


Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines.

Planta Med 2021 Apr 16. Epub 2021 Apr 16.

Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, Uttarakhand, India.

Identification of novel anti-inflammatory strategies are needed to avoid the side effects associated with the currently available therapies. Use of anti-inflammatory herbal remedies is gaining attention. The purpose of the present investigation was to evaluate the pharmacological potential of the withanolide-rich root extracts of the medical plant (L. Read More

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Thromboembolic and Bleeding Events in COVID-19 Patients receiving Extracorporeal Membrane Oxygenation.

Thorac Cardiovasc Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Thoracic and Cardiovascular Surgery, Uniklinik RWTH Aachen, Aachen, Germany.

Background:  Extracorporeal membrane oxygenation (ECMO) is a potential treatment option in critically ill COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) if mechanical ventilation (MV) is insufficient; however, thromboembolic and bleeding events (TEBE) during ECMO treatment still need to be investigated.

Methods:  We conducted a retrospective, single-center study including COVID-19 patients treated with ECMO. Additionally, we performed a univariate analysis of 85 pre-ECMO variables to identify factors influencing incidences of thromboembolic events (TEE) and bleeding events (BE), respectively. Read More

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Reducing Superfluous Opioid Prescribing Practices After Brain Surgery: It Is Time to Talk About Drugs.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.

Background: Opioids are prescribed routinely after cranial surgery despite a paucity of evidence regarding the optimal quantity needed. Overprescribing may adversely contribute to opioid abuse, chronic use, and diversion.

Objective: To evaluate the effectiveness of a system-wide campaign to reduce opioid prescribing excess while maintaining adequate analgesia. Read More

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Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan.

Background: Peripheral nerve injuries result in muscle denervation and apoptosis of the involved muscle, which subsequently reduces mitochondrial content and causes muscle atrophy. The local injection of mitochondria has been suggested as a useful tool for restoring the function of injured nerves or the brain.

Objective: To determine outcomes following the administration of isolated mitochondria into denervated muscle after nerve injury that have not been investigated. Read More

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Highly Conductive and Transparent Electrospun Indium Tin Oxide Nanofibers Calcined by Microwave Plasma.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

Physics, Sichuan University, No. 29 Wangjiang Rd, Wuhou District, Chengdu, Chengdu, Sichuan, 610064, CHINA.

In this work, indium tin oxide (ITO) nanofibers have been prepared by electrospinning of polymers and post-growth microwave plasma calcination (MPC). Interestingly, compared to traditional calcination in furnace, MPC can accelerate the degradation of high polar polymers and improve adhesion of ITO nanofibers to the sapphire substrate. Further characterizations reveal that the ITO nanofibers with diameters of 100-150 nm prepared by MPC at 600℃ can reach a low sheet resistance of 269 Ω/sq and a high transmittance of 90. Read More

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Surface-Confinement Assisted Synthesis of Nitrogen-Rich Single Atom Fe-N/C Electrocatalyst with Dual Nitrogen Sources for Enhanced Oxygen Reduction Reaction.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

Chinese Academy of Sciences - Fujian Institute of Research on the Structure of Matter, Fuzhou, CHINA.

The utilization of earth abundant iron and nitrogen doped carbon as a precious-metal-free electrocatalyst for oxygen reduction reaction (ORR) significantly depends on the rational design and construction of desired Fe-Nx moieties on carbon substrates, which however remains an enormous challenge. Herein a typical nanoporous nitrogen-rich single atom Fe-N/C electrocatalyst on carbon nanotube (NR-CNT@FeN-PC) was successfully prepared by using CNT as carbon substrate, polyaniline (PANI) and dicyandiamine (DCD) as N-containing carbonaceous precursor and silica-confinement-assisted pyrolysis, which not only facilitate rich N-doping for the inhibition of the Fe agglomeration and the formation of single atom Fe-Nx sites in carbon matrix, but also generate abundant micropores for enlarging BET specific surface area (up to 1500 m2•g-1). Benefiting from the advanced composition, nanoporous structure and surface hydrophilicity to guarantee the sufficient accessible active sites for ORR, the NR-CNT@FeN-PC catalyst under optimized conditions delivers prominent ORR performance with a half-wave potential (0. Read More

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The optimisation of paediatric CT examinations in Scotland: phase one; benchmarking current performance.

J Radiol Prot 2021 Apr 16. Epub 2021 Apr 16.

Department of Clinical Physics and Bioengineering, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objectives: To benchmark the dose from paediatric head and chest examinations on CT scanners throughout Scotland, to identify scanners that may require optimisation and to provide optimisation advice based on the protocols from better performing scanners.

Methods: Anthropomorphic phantoms corresponding to 1, 5 and 10-year olds were sent to 50 CT scanners around Scotland. Head and chest examinations were undertaken by local staff using local techniques on each scanner with each phantom, and details of the protocols used were recorded. Read More

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Multi-objective data-driven optimization for improving deep brain stimulation in Parkinson's disease.

J Neural Eng 2021 Apr 16. Epub 2021 Apr 16.

Neurology, Emory University School of Medicine, 12 Executive Park Drive North East, Atlanta, Georgia, 30329, UNITED STATES.

Objective: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD) but its success depends on a time-consuming process of trial-and-error to identify the optimal stimulation settings for each individual patient. Data-driven optimization algorithms have been proposed to efficiently find the stimulation setting that maximizes a quantitative biomarker of symptom relief. However, these algorithms cannot efficiently take into account stimulation settings that may control symptoms but also cause side-effects. Read More

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Nanoscale refractory doped titanium nitride field emitters.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

Department of Electrical and Computer Engineering, Boston University, Boston, UNITED STATES.

Refractory materials exhibit high damage tolerance, which is attractive for the creation of nanoscale field-emission electronics and optoelectronics applications that require operation at high peak current densities and optical intensities. Recent results have demonstrated that the optical properties of titanium nitride, a refractory and CMOS-compatible plasmonic material, can be tuned by adding silicon and oxygen dopants. However, to fully leverage the potential of titanium (silicon oxy)nitride, a reliable and scalable fabrication process with few-nm precision is needed. Read More

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Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.

EBioMedicine 2021 Apr 13;66:103337. Epub 2021 Apr 13.

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Institution of Neuropsychiatry, Southeast University, Nanjing, Jiangsu 210009, China; Department of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu 210096, China; Mental Health Center Zhejiang University School of Medicine, Hangzhou, Zhejiang 310013, China; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China. Electronic address:

Background: circular RNAs (circRNAs) are expressed abundantly in the brain and are implicated in the pathophysiology of neuropsychiatric disease. However, the potential clinical value of circRNAs in major depressive disorder (MDD) remains unclear.

Methods: RNA sequencing was conducted in whole-blood samples in a discovery set (7 highly homogeneous MDD patients and 7 matched healthy controls [HCs]). Read More

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Folate-targeted Pluronic-chitosan nanocapsules loaded with IR780 for near-infrared fluorescence imaging and photothermal-photodynamic therapy of ovarian cancer.

Colloids Surf B Biointerfaces 2021 Apr 8;203:111755. Epub 2021 Apr 8.

Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, T Laurian 42, 400271, Cluj-Napoca, Romania; Department of Biomolecular Physics, Faculty of Physics, Babes-Bolyai University, M Kogalniceanu 1, 400084, Cluj-Napoca, Romania. Electronic address:

Herein, we report the fabrication of a nanotherapeutic platform integrating near-infrared (NIR) imaging with combined therapeutic potential through photodynamic (PDT) and photothermal therapies (PTT) and recognition functionality against ovarian cancer. Owing to its NIR fluorescence, singlet oxygen generation and heating capacity, IR780 iodide is exploited to construct a multifunctional nanosystem for single-wavelength NIR laser imaging-assisted dual-modal phototherapy. We opted for loading IR780 into polymeric Pluronic-F127-chitosan nanoformulation in order to overcome its hydrophobicity and toxicity and to allow functionalization with folic acid. Read More

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Surfactin from Bacillus subtilis displays promising characteristics as O/W-emulsifier for food formulations.

Colloids Surf B Biointerfaces 2021 Apr 7;203:111749. Epub 2021 Apr 7.

Institute of Food Science and Biotechnology (150), Department of Bioprocess Engineering (150k), University of Hohenheim, Fruwirthstr. 12, 70599, Stuttgart, Germany.

Background: Biosurfactants are surface-active molecules produced by different microorganisms and display a promising alternative to synthetically derived food emulsifiers. One of these biosurfactants, synthesized by Bacillus subtilis, is the lipopeptide surfactin, which composes a linear fatty acid and cyclic peptide moiety. This study explores the interfacial and emulsion forming properties of surfactin to further characterize its suitability as an O/W emulsifier in food formulations. Read More

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A pH-sensitive drug delivery system based on hyaluronic acid co-deliver doxorubicin and aminoferrocene for the combined application of chemotherapy and chemodynamic therapy.

Colloids Surf B Biointerfaces 2021 Apr 7;203:111750. Epub 2021 Apr 7.

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, PR China. Electronic address:

Doxorubicin is a broad-spectrum antineoplastic drug used in tumor therapy, its clinical application is limited by side effects on normal tissues. In this article, a pH-responsive drug delivery system (NPs(DOX/AFc)) with co-delivers doxorubicin (DOX) and aminoferrocene (AFc) was prepared by a two-step synthesis method including the oxidation of hyaluronic acid and Schiff base reaction. NPs(DOX/AFc) can be used in combination therapy of chemodynamic therapy (CDT) and chemotherapy (CT), thus the dosage of the chemotherapeutic drug DOX was reduced. Read More

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High-fidelity detection of DNA combining the CRISPR/Cas9 system and hairpin probe.

Biosens Bioelectron 2021 Apr 2;184:113212. Epub 2021 Apr 2.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, PR China. Electronic address:

Methods that enable specific and sensitive detection of DNA are greatly required for high-fidelity sequence measurement and single-nucleotide variations (SNVs) genotyping. The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas systems have provided revolutionary tools for detecting nucleic acids. However, most of the current CRISPR/Cas-based DNA biosensing platforms suffer from inherent off-target effects of Cas proteins and require pre-amplification processes, which compromise the analytical fidelity. Read More

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Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma.

Pathol Res Pract 2021 Apr 5;222:153433. Epub 2021 Apr 5.

Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China. Electronic address:

Increasing literature reported that circRNAs play vital roles in the occurrence and progression of GBM and regulate GBM cell proliferation, metastases, and chemosensitivity. However, the expression pattern and function of circRNAs in GBM still need further studies. In our work, hsa_circ_0072309 was remarkably downregulated in GBM. Read More

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Physician practice variation in head and neck cancer therapy: Results of a national survey.

Oral Oncol 2021 Apr 13;117:105293. Epub 2021 Apr 13.

Service d'otorhinolaryngologie et chirurgie cervico-faciale, Institut Universitaire du Cancer de Toulouse-Oncopole, Institut Claudius Regaud, 1avenue Hubert Curien, 31100 Toulouse, France. Electronic address:

Objectives: Choice between surgical or medical treatments in head and neck cancer depends of many patient-related and disease-related factors. We investigated how patients' socioeconomic status and practitioners' specialty could affect medical decision-making.

Materials And Methods: We conducted a cross-sectional online, nationwide survey, send to surgeons, oncologists and radiotherapists specialized in head and neck oncology. Read More

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Analysis of electrostimulation and electroporation by high repetition rate bursts of nanosecond stimuli.

Bioelectrochemistry 2021 Apr 1;140:107811. Epub 2021 Apr 1.

Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA. Electronic address:

Exposures to short-duration, strong electric field pulses have been utilized for stimulation, ablation, and the delivery of molecules into cells. Ultrashort, nanosecond duration pulses have shown unique benefits, but they require higher field strengths. One way to overcome this requirement is to use trains of nanosecond pulses with high repetition rates, up to the MHz range. Read More

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Evaluation of the association between the introduction of data-driven tools to support calf rearing and reduced calf mortality in dairy herds in the Netherlands.

Prev Vet Med 2021 Apr 8;191:105344. Epub 2021 Apr 8.

Royal GD, PO Box 9, 7400 AA, Deventer, the Netherlands; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, PO Box 80151, 3508 TD, Utrecht, the Netherlands.

Between 2009 and 2017, calf mortality in the Dutch dairy sector showed a slight but steady increase. The Dutch dairy industry decided to act and supported the development of several data-driven tools that were implemented from 2018 on. The tools informed farmers about their calf mortality rates and stimulated them to improve. Read More

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Antivirulence activity and in vivo efficacy of a thiazole derivative against candidiasis.

J Mycol Med 2021 Apr 6;31(2):101134. Epub 2021 Apr 6.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, PO Box 486, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Candida albicans is a pathogen equipped with a variety of commensal and virulence traits that help it colonize the microbiota and invade host tissue during infection. In this study, we investigated the potential anticandidal activity of 3-[2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazino)]butan-1-ol (MT), a thiazolylhydrazone compound synthesized by our group, and identified it as a promising antifungal agent. The activity of MT was evaluated in vitro and in vivo against C. Read More

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Decoding molecular markers and transcriptional circuitry of naive and primed states of human pluripotency.

Stem Cell Res 2021 Apr 8;53:102334. Epub 2021 Apr 8.

Centre of Bioinformatics, Institute of Interdisciplinary Studies, University of Allahabad, Prayagraj 211002, India. Electronic address:

Pluripotent stem cells (PSCs) have been observed to occur in two distinct states - naive and primed. Both naive and primed state PSCs can give rise to tissues of all the three germ layers in vitro but differ in their potential to generate germline chimera in vivo. Understanding the molecular mechanisms that govern these two states of pluripotency in human can open a plethora of opportunities for studying early embryonic development and in biomedical applications. Read More

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Thrombotic microangiopathy in oncology - a review.

Transl Oncol 2021 Apr 12;14(7):101081. Epub 2021 Apr 12.

Nephrology Department, Portuguese Oncology Institute of Porto, Portugal Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.

Thrombotic microangiopathy is a syndrome triggered by a wide spectrum of situations, some of which are specific to the Oncology setting. It is characterized by a Coombs-negative microangiopathic haemolytic anemia, thrombocytopenia and organ injury, with characteristic pathological features, resulting from platelet microvascular occlusion. TMA is rare and its cancer-related subset even more so. Read More

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Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.

Eur J Med Chem 2021 Apr 7;219:113441. Epub 2021 Apr 7.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:

Cumulative evidence suggests that β-amyloid and oxidative stress are closely related with each other and play key roles in the process of Alzheimer's disease (AD). Multitarget regulation of both pathways might represent a promising therapeutic strategy. Here, a series of selenium-containing compounds based on ebselen and verubecestat were designed and synthesized. Read More

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Synthesis and in vivo screening of isosteviol derivatives as new cardioprotective agents.

Eur J Med Chem 2021 Mar 28;219:113396. Epub 2021 Mar 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Isosteviol, an ent-beyerane diterpenoid, has been repeatedly reported to possess potent cardioprotective activity. With the aim of discovering new cardioprotective derivatives from isosteviol, 47 compounds, including 40 new ones, were synthesized and evaluated in vivo using the easy-handling and efficient zebrafish model. The structure-activity relationship of this type of compounds was thus discussed. Read More

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An LCA-based model for assessing prevention versus non-prevention of construction waste in buildings.

Waste Manag 2021 Apr 13;126:608-622. Epub 2021 Apr 13.

Instituto Universitario de Arquitectura y Ciencias de la Construcción, Escuela Técnica Superior de Arquitectura, Universidad de Sevilla, Av. de la Reina Mercedes 2, 41012 Sevilla, Spain.

Waste generated by the Construction Sector represents an environmental problem in many countries. To achieve increasingly eco-efficient waste management, Life Cycle Assessment (LCA) provides an objective method for the quantification of the potential impact that waste management exerts on the environment. Traditionally, LCA has focused on the evaluation of non-prevention scenarios once the waste is generated, mainly by showing the benefits of recycling vs. Read More

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Modeling patient-related workload in the emergency department using electronic health record data.

Int J Med Inform 2021 Apr 9;150:104451. Epub 2021 Apr 9.

University at Buffalo, United States.

Introduction: Understanding and managing clinician workload is important for clinician (nurses, physicians and advanced practice providers) occupational health as well as patient safety. Efforts have been made to develop strategies for managing clinician workload by improving patient assignment. The goal of the current study is to use electronic health record (EHR) data to predict the amount of work that individual patients contribute to clinician workload (patient-related workload). Read More

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Urine proteome changes in a chronic unpredictable mild stress (CUMS) mouse model of major depressive disorder.

J Pharm Biomed Anal 2021 Apr 6;199:114064. Epub 2021 Apr 6.

Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing, 100875, China. Electronic address:

Major depressive disorder (MDD) is a prevalent complex psychiatric disorder, and there are no effective biomarkers for clinical diagnosis. Urine is not subjected to homeostatic control, allowing it to reflect the sensitive changes that occur in various diseases. In this study, we examined the urine proteome changes in a chronic unpredictable mild stress mouse model of MDD. Read More

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Involvement of salicylic acid in the response to potassium deficiency revealed by metabolomics.

Plant Physiol Biochem 2021 Apr 6;163:201-204. Epub 2021 Apr 6.

Research School of Biology, ANU College of Science, Australian National University, 2601, Canberra, ACT, Australia; Institut de Recherche en Horticulture et Semences, Université d'Angers, INRAe, 42 rue Georges Morel, 49070, Beaucouzé, France. Electronic address:

Potassium (K) deficiency has consequences not only on cellular ion balance and transmembrane potential but also on metabolism. In fact, several enzymes are K-dependent including enzymes in catabolism, causing an alteration in glycolysis and respiration. In addition, K deficiency is associated with the induction of specific pathways and accumulation of metabolic biomarkers, such as putrescine. Read More

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Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion.

Biomed Pharmacother 2021 Apr 13;139:111595. Epub 2021 Apr 13.

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Electronic address:

Background: Akkermansia spp. plays important roles in maintenance of host health. Increasing evidence reveals that berberine (BBR) may exert its pharmacological effects via, at least partially, promotion of Akkermansia spp. Read More

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Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats.

Biomed Pharmacother 2021 Apr 13;139:111588. Epub 2021 Apr 13.

Department of Biochemistry, University of Allahabad, Allahabad 211002, India. Electronic address:

Background: Cadmium is one of the most toxic heavy metals. The prolonged exposure of it can lead to severe alterations and damage in different tissues including blood, liver, kidney and brain. Eugenol, a phenolic compound, is present in various aromatic plants. Read More

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