19,615 results match your criteria potassium serum

Patiromer in a Patient with Severe Hyperkalemia on Incremental Hemodialysis with 1 Session per Week: A Case Report and Literature Review.

Case Rep Nephrol Dial 2021 May-Aug;11(2):158-166. Epub 2021 Jun 28.

Department of Nephrology, Central Defense Gomez Ulla Hospital, Madrid, Spain.

Hyperkalemia is common in patients with ESRD, undergoing hemodialysis (HD), and is associated with an increase in hospitalization and mortality. Residual kidney function in long-term dialysis patients is associated with lower morbidity and mortality in HD patients. Although the 2015 National Kidney Foundation-Kidney Disease Outcomes Quality Initiate (NKD-KDOQI) guidelines allow the reduction in the weekly HD dose for patients with a residual kidney urea clearance (Kur) >3 mL/min/1. Read More

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Development of a preoperative index-based nomogram for the prediction of hypokalemia in patients with pituitary adenoma: a retrospective cohort study.

PeerJ 2021 19;9:e11650. Epub 2021 Jul 19.

Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: To develop and validate a preoperative index-based nomogram for the prediction of hypokalemia in patients with pituitary adenoma (PA).

Methods: This retrospective cohort study included 205 patients with PAs between January 2013 and April 2020 in the Sun Yat-sen Memorial Hospital, Guangzhou, China. The patients were randomly classified into either a training set ( = 143 patients) and a validation set ( = 62 patients) at a ratio of 7:3. Read More

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Emergency service results of central venous catheters: Single center, 1042 patients, 10-year experience.

World J Crit Care Med 2021 Jul 9;10(4):120-131. Epub 2021 Jul 9.

Department of Emergency, Gaziantep University Medical Faculty, Gaziantep 27410, Turkey.

Background: Central venous catheterization is currently an important procedure in critical care. Central catheterization has important advantages in many clinical situations. It can also lead to different complications such as infection, hemorrhage, and thrombosis. Read More

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Association between Urinary Potassium Excretion and Acute Kidney Injury in Critically Ill Patients.

Indian J Crit Care Med 2021 Jul;25(7):768-772

Department of Critical Care Medicine, Yashoda Hospital, Hyderabad, Telangana, India.

Introduction: Acute kidney injury (AKI) is defined in terms of serum creatinine (SrCrt) and urine output (UO). AKI occurs in 25% of critically ill patients, which increases the risk of morbidity and mortality. Early diagnosis of AKI is challenging, as utility of biomarkers is limited. Read More

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The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

Shock 2021 Jul 26. Epub 2021 Jul 26.

Institute of Disaster Medicine, Tianjin University, Tianjin, China Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, China Department of Intensive Care Medicine, Taida hospital of Tianjin University, Tianjin, China Department of Intensive Care Medicine, Shijiazhuang Circulating Chemical Industry Park Hospital, Hebei, China Department of Emergency Medicine, General Hospital of Tianjin Medical University, Tianjin, China Department of Nephrology, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin, China Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.

Background: Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient. Read More

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[Incidence of enteral feeding intolerance and its risk factors in patients with oral and maxillofacial malignancies].

J Zeng B Zhang H Su

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1114-1118

Department of Stomatology, Third Xiangya Hospital of Central South University, Changsha 410013, China.

Objective: To explore the incidence of enteral feeding intolerance and its risk factors in patients with malignant oral and maxillofacial tumors.

Methods: We conducted a retrospective analysis of 122 patients with malignant oral and maxillofacial tumor admitted in a general hospital for enteral nutrition between March, 2018 and March, 2021. The incidence of intolerance to enteral nutrition was analyzed, and the two groups of patients with and without intolerance were compared for age, gender, height, weight, pathological staging, types of enteral nutrition preparations, clinical treatment (physical hypothermia and nasal delivery), drug usage (sedatives, vasoactive drugs, acid suppressant, potassium preparation, antibiotics and hormones) and biochemical parameters (serum total protein, serum albumin, blood glucose and serum potassium concentration). Read More

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Effects of Roxadustat on the Anemia and Iron Metabolism of Patients Undergoing Peritoneal Dialysis.

Front Med (Lausanne) 2021 7;8:667117. Epub 2021 Jul 7.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

We investigated the effects of roxadustat on the anemia, iron metabolism, peritoneal membrane function, and residual renal function; and determined the factors associated with the administration of roxadustat in patients who were undergoing peritoneal dialysis. We retrospectively analyzed the changes in hemoglobin, serum ferritin, transferrin saturation (TSAT), 4-h dialysate/plasma creatinine, and renal weekly urea clearance over the 24 weeks following the change from an erythropoiesis-stimulating agent (ESA) to roxadustat in 16 patients who were undergoing peritoneal dialysis and had anemia (Roxadustat group). Twenty-three peritoneal dialysis patients who had anemia and continued ESA served as a control group (ESA group). Read More

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A Clinical-Radiomic Nomogram Based on Unenhanced Computed Tomography for Predicting the Risk of Aldosterone-Producing Adenoma.

Front Oncol 2021 9;11:634879. Epub 2021 Jul 9.

Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Purpose: To develop and validate a clinical-radiomic nomogram for the preoperative prediction of the aldosterone-producing adenoma (APA) risk in patients with unilateral adrenal adenoma.

Patients And Methods: Ninety consecutive primary aldosteronism (PA) patients with unilateral adrenal adenoma who underwent adrenal venous sampling (AVS) were randomly separated into training (n = 62) and validation cohorts (n = 28) (7:3 ratio) by a computer algorithm. Data were collected from October 2017 to June 2020. Read More

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Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients.

Cureus 2021 Jun 14;13(6):e15648. Epub 2021 Jun 14.

Internal Medicine, Jinnah Postgraduate Medical Center, Karachi, PAK.

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020. Read More

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High performance implementation of the hierarchical likelihood for generalized linear mixed models: an application to estimate the potassium reference range in massive electronic health records datasets.

BMC Med Res Methodol 2021 Jul 24;21(1):151. Epub 2021 Jul 24.

Department of Internal Medicine, University of New Mexico School of Medicine, MSC10 5550 1 University of New Mexico Albuquerque, Albuquerque, NM, 87131, USA.

Background: Converting electronic health record (EHR) entries to useful clinical inferences requires one to address the poor scalability of existing implementations of Generalized Linear Mixed Models (GLMM) for repeated measures. The major computational bottleneck concerns the numerical evaluation of multivariable integrals, which even for the simplest EHR analyses may involve millions of dimensions (one for each patient). The hierarchical likelihood (h-lik) approach to GLMMs is a methodologically rigorous framework for the estimation of GLMMs that is based on the Laplace Approximation (LA), which replaces integration with numerical optimization, and thus scales very well with dimensionality. Read More

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Effect of high-dose sulfamethoxazole/trimethoprim and glucocorticoid use on hyperkalemic event: A retrospective observational study.

J Infect Chemother 2021 Jul 20. Epub 2021 Jul 20.

Department of Pharmacy, Tokyo Women's Medical University, Medical Centre East: 2-1-10, Nishiogu, Arakawa-ku, Tokyo, 116-0011, Japan.

Introduction: Sulfamethoxazole/trimethoprim causes hyperkalemia; however, the effect of sulfamethoxazole/trimethoprim dose and co-administered glucocorticoids on hyperkalemia has not been clarified.

Methods: This single-center, retrospective, observational cohort, chart review study involving patients (>20 years) who were treated with sulfamethoxazole/trimethoprim was conducted at Tokyo Women's Medical University, Medical Center East from June 2015 to May 2019. Multivariate Cox proportional hazard model was used to identify risk factors for hyperkalemia (serum potassium level > 5. Read More

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[Analysis of the causes of arrhythmia induced by citrate anticoagulation in continuous renal replacement therapy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):748-751

Department of Critical Care Medicine, Tianjin Third Central Hospital, Tianjin 300170, China. Corresponding author: Feng Quansheng, Email:

Objective: To analyze the possible causes of arrhythmia in patients receiving continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA).

Methods: A retrospective cohort study was conducted. All patients underwent RCA-CRRT treatment from January 1, 2020 to October 31, 2020 in the intensive care unit (ICU) of Tianjin Third Central Hospital were enrolled. Read More

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Bromide toxicosis (bromism) secondary to a decreased chloride intake after dietary transition in a dog with idiopathic epilepsy: a case report.

BMC Vet Res 2021 Jul 22;17(1):253. Epub 2021 Jul 22.

Department of Internal Medicine/ Neurology, University of Toulouse, ENVT, Toulouse, France.

Background: Bromide is a halide ion of the element bromine usually administered in the form of potassium salt as monotherapy or add-on treatment in epileptic dogs. It is excreted unchanged in the urine and undergoes tubular reabsorption in competition with chloride. Thus, dietary chloride content affects serum bromide concentrations. Read More

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Potassium bromate-induced nephrotoxicity and potential curative role of metformin loaded on gold nanoparticles.

Sci Prog 2021 Jul-Sep;104(3):368504211033703

Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.

Potassium bromate (KBrO) is classified by the International Agency for Research on Cancer as a carcinogenic compound, where it causes renal tumors. The present study investigated the potential curative effect of metformin loaded on gold nanoparticles (MET AuNPs) in attenuating KBrO-induced nephrotoxicity. Rats were divided into eight groups (control, MET, AuNPs, MET AuNPs, KBrO, KBrO/MET, KBrO/AuNPS, and KBrO/MET AuNPs). Read More

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Safety, efficacy, and serum concentration monitoring of bedaquiline in Chinese patients with multidrug-resistant tuberculosis.

Int J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. Electronic address:

Objectives: To determine the safety and efficacy of bedaquiline for Chinese multidrug-resistant tuberculosis patients based on serum concentration monitoring and identify factors associated with QTc prolongation occurring during treatment.

Methods: We collected data from 35 patients who received treatment regimens containing bedaquiline for multidrug-resistant tuberculosis (MDR-TB) from May 2018 to December 2020. Blood samples were collected, and serum concentrations of bedaquiline were measured using high-performance liquid chromatography-mass spectrometry. Read More

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Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients.

Rev Endocr Metab Disord 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, School of Medicine, University of California, CA, Irvine, Orange, USA.

Hyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-transplant hyperkalemia in recipients with a well-functioning graft. Read More

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Acute Kidney Injury and Associated Factors in Intensive Care Units at a Tertiary Hospital in Northern Tanzania.

Can J Kidney Health Dis 2021 8;8:20543581211027971. Epub 2021 Jul 8.

Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Background: Acute kidney injury (AKI) is a recognized complication in critically ill patients. The epidemiology of AKI varies worldwide, depending on the diagnostic criteria used and the setting. The International Society of Nephrology has called for a reduction in preventable deaths from AKI to zero by the year 2025. Read More

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Case Report: Three Rare Cases of Ectopic ACTH Syndrome Caused by Adrenal Medullary Hyperplasia.

Front Endocrinol (Lausanne) 2021 1;12:687809. Epub 2021 Jul 1.

Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.

Ectopic ACTH syndrome (EAS) accounts for 10-20% of endogenous Cushing's syndrome (CS). Hardly any cases of adrenal medullary hyperplasia have been reported to ectopically secrete adrenocorticotropic hormone (ACTH). Here we describe a series of three patients with hypercortisolism secondary to ectopic production of ACTH from adrenal medulla. Read More

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Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways.

Environ Toxicol 2021 Jul 16. Epub 2021 Jul 16.

Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, Texas, USA.

Environmental and occupational exposure to chromium compounds has become potential aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis, and inflammatory. These pathophysiologic mechanisms of potassium dichromate (K Cr O ) have been well correlated with nephrotoxicity and cardiotoxicity. The cardioprotective and nephroprotective effects of Luteolin, a known potent antioxidant were evaluated in this study with 40 healthy rats in four experimental groups: Group A (normal saline), Groups B (30 mg/kg K Cr O ), Group C (Luteolin 100 mg/kg and K Cr O 30 mg/kg), and Group D (Luteolin 200 mg/kg and K Cr O 30 mg/kg), respectively. Read More

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Distinct Phenotypes of Hospitalized Patients with Hyperkalemia by Machine Learning Consensus Clustering and Associated Mortality Risks.

QJM 2021 Jul 16. Epub 2021 Jul 16.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Hospitalized patients with hyperkalemia are heterogeneous, and cluster approaches may identify specific homogenous groups. This study aimed to cluster patients with hyperkalemia on admission using unsupervised machine learning consensus clustering approach, and to compare characteristics and outcomes among these distinct clusters.

Methods: Consensus cluster analysis was performed in 5,133 hospitalized adult patients with admission hyperkalemia, based on available clinical and laboratory data. Read More

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Efficacy of apatinib combined with tegafur gimeracil and oteracil potassium in the second-line treatment of advanced gastric cancer.

J BUON 2021 May-Jun;26(3):917-923

Department of Pharmacy, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate the clinical efficacy and safety of apatinib combined with tegafur-gimeracil-oteracil potassium (S-1) in the second-line treatment of advanced gastric cancer.

Methods: A total of 126 patients with advanced gastric cancer admitted to our hospital from January 2017 to September 2018 were enrolled as the research objects, none of whom underwent surgery. For these patients, second-line treatment was recommended due to the failure of first-line treatment. Read More

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[Diet therapy program for weight loss and assessment of its effectiveness in overweight and obese persons].

Vopr Pitan 2021;90(3):84-92. Epub 2021 May 17.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

The basic method of obesity treatment is diet therapy aimed at long-term maintenance of negative energy balance by restricting the caloric intake of the diet. - to evaluate the effectiveness of the diet therapy program for weight loss with the use of a complex of amino acids and glucomannan. . Read More

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Management of hyperkalemia in chronic heart failure using sodium zirconium cyclosilicate.

Clin Cardiol 2021 Jul 15. Epub 2021 Jul 15.

Second Department of Internal Medicine, University of Toyama, Toyama, Japan.

Background: Sodium zirconium cyclosilicate (SZC), a newly-developed selective potassium binder, has been clinically available to treat hyperkalemia. SZC might be a promising option to manage hyperkalemia, particularly in patients with heart failure, who often require potassium-sparing medications. However, the optimal initial dose of SZC therapy at a loading dose (30 g per day for the initial 2 days) versus a maintenance dose (5 g per day) remains unknown. Read More

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Effects of oleanolic acid on inflammation and metabolism in diabetic rats.

Biotech Histochem 2021 Jul 15:1-8. Epub 2021 Jul 15.

Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.

Diabetes mellitus (DM) is a chronic metabolic disease that threatens the health of the world population. We investigated the effects of oleanolic acid (OA) administration on inflammation status and metabolic profile in streptozotocin (STZ) induced diabetic rats. Four experimental groups were established: healthy rats not administered OA, healthy rats administered OA, diabetic rats not administered OA, diabetic rats administered OA. Read More

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Efficacy and safety of apararenone (MT-3995) in patients with nonalcoholic steatohepatitis: A randomized controlled study.

Hepatol Res 2021 Jul 14. Epub 2021 Jul 14.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Aim: To evaluate the efficacy, safety, and tolerability of apararenone 10 mg/day in patients with nonalcoholic steatohepatitis (NASH).

Methods: In this multicenter, randomized, double-blind, placebo-controlled phase 2 study, patients received apararenone 10 mg or placebo once daily for 72 weeks. The primary efficacy endpoint was percent change in serum alanine aminotransferase (ALT) from baseline to 24 weeks after randomization. Read More

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Predictive Factors for Recurrence of Serious Arrhythmias in Patients with Acute Digoxin Poisoning.

Cardiovasc Toxicol 2021 Jul 14. Epub 2021 Jul 14.

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, 6th floor, Medical Collages Complex, El-Gaish Street, Tanta, 31527, Gharbia, Egypt.

Although digoxin poisoning has declined in the past decades, it still has deleterious outcomes. The hallmark of serious life-threatening arrhythmias remains challenging due to its non-specific initial presentation. Therefore, this study aimed to evaluate the initial predictive factors for recurrent serious arrhythmias and the need for temporary pacing in acute digoxin-poisoned patients. Read More

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Is Prevention of Hemolysis Possible in Blood Samples Collected from IV catheters in the Emergency Department?

Clin Lab 2021 Jul;67(7)

Background: The effectiveness of aspiration and vacuum filling method with an adaptor in reducing hemolysis was investigated.

Methods: The study was conducted in the yellow zone of the Emergency department. Two different apparatuses that draw blood with two different techniques from an IV catheter were compared with our routine procedure. Read More

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Response of laying hens to l-arginine, l-citrulline and guanidinoacetic acid supplementation in reduced protein diet.

Anim Nutr 2021 Jun 12;7(2):460-471. Epub 2021 Mar 12.

School of Environmental and Rural Science, Faculty of Science, Agriculture, Business and Law, University of New England, 2351, New South Wales, Australia.

A study was conducted with Hy-Line Brown laying hens to examine the effects of reduced protein diet, deficiency of arginine (Arg), and addition of crystalline Arg, citrulline (Cit) and guanidinoacetic acid (GAA) as substitutes for Arg. Hen performance, egg quality, serum uric acid, liver and reproductive organ weights, and energy and protein digestibility were measured using a completely randomized design with 5 treatments. Treatments were a standard diet (17% protein diet; SP), a reduced diet (13% protein diet deficient in Arg; RP) and RP with added Arg (0. Read More

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Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention.

Clin Exp Nephrol 2021 Jul 13. Epub 2021 Jul 13.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Background: There are few reports on the significance for the combined evaluation of blood humoral factors and urinary biomarkers in terms of worsening renal function (WRF) after coronary angiography (CAG)/percutaneous coronary arterial intervention (PCI).

Method And Results: Urinary liver type-fatty acid-binding protein (L-FABP), neutrophil gelatinase associated lipocalin (NGAL), and adrenomedullin (AM) were measured less than 24 h before and 3 h, 6 h, 1 day, and 2 days after CAG/PCI. WRF was defined as a > 20% decrease in the estimated GFR. Read More

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Impact of universal irradiation on chronic transfusion for sickle cell disease.

Transfusion 2021 Jul 12. Epub 2021 Jul 12.

Children's National Hospital, Washington, District of Columbia, USA.

Background: Irradiation of blood products prevents transfusion-associated graft-versus-host disease, but most patients do not require this modification which could have an adverse impact on transfusion outcomes. We hypothesized that irradiation may increase transfusion requirements for patients with sickle cell disease (SCD) receiving chronic transfusion.

Study Design And Methods: Our pediatric hospital implemented a new policy of universal blood product irradiation in May 2018. Read More

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