34,350 results match your criteria potassium levels

Do carboxyhemoglobin and methemoglobin levels predict the return of spontaneous circulation and prognosis of cardiac arrest patients?

Int J Clin Pract 2021 Jul 31:e14686. Epub 2021 Jul 31.

Department of Anesthesiology and Reanimation, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey, 06010.

Background: Early prediction of return of spontaneous circulation (ROSC) for cardiac arrest (CA) patients is a major challenge. Different biomarkers have been studied as an early predictor for ROSC, but a consensus has not been achieved in this regard. This study's goal was to investigate the value of the carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels as a predictive marker for ROSC and prognostic marker for patients who achieve ROSC. Read More

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Pepper root rot resistance and pepper yield are enhanced through biological agent G15 soil amelioration.

PeerJ 2021 19;9:e11768. Epub 2021 Jul 19.

Institute of Plant Protection and Soil & Fertilizer, Hubei Academy of Agricultural Sciences, Wuhan, Hubei Provience, China.

Pepper root rot is a serious soil-borne disease that hinders pepper production, and efforts are being made to identify biological agents that can prevent and control pepper root rot. Our group recently discovered and produced a biological agent, named G15, which reduces the diversity and richness of fungi and bacteria when applied to pepper fields. In the soil of the G15-treatment condition, the pathogenic fungus was inhibited, while the richness of beneficial bacteria was increased. Read More

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Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K Channels in β Cells.

Front Pharmacol 2021 12;12:683674. Epub 2021 Jul 12.

Department of Pharmacology, Shanxi Medical University, Taiyuan, China.

Recent studies suggest that Sphingosine 1-phosphate (S1P) plays an important role in regulating glucose metabolism in type 2 diabetes. However, its effects and mechanisms of promoting insulin secretion remain largely unknown. Here, we found that S1P treatment decreased blood glucose level and increased insulin secretion in C57BL/6 mice. Read More

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Safety and Efficacy of the Combination of Sacubitril/Valsartan and SGLT2i in HFrEF patients (SECSI Registry).

J Cardiovasc Pharmacol 2021 Jul 19. Epub 2021 Jul 19.

Hospital Universitario Ramón y Cajal, Madrid (Spain) CIBER in Cardiovascular Diseases (CIBERCV), Madrid (Spain) Hospital de Dénia - Marina Salud, Dénia (Spain) Hospital Universitari Arnau de Vilanova, Lleida (Spain) Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida (Spain) Hospital de Navarra, Pamplona (Spain).

Abstract: Recent studies have proven benefit of SGLT2i drugs in patients with heart failure with reduced ejection fraction (HFrEF), but their safety when combined with ARNI has not been established. The SECSI registry was conducted to address this issue. SECSI registry is a consecutive, observational, retrospective, multicentre study carried out in three Heart Failure Units in Spain. Read More

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Effects of tea polyphenols on the activities of antioxidant enzymes and the expression of related gene in the leaves of wheat seedlings under salt stress.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

School of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.

Longchun 30, a new wheat variety, was used to investigate seedling growth, element absorption, and antioxidant response under 150 mM NaCl and tea polyphenols (TP) (25 and 100 mg L) treatments alone or in combination, thus revealing TP-alleviating mechanism on the salt damage to plants. 150 mM NaCl stress alone inhibited the seedling growth, increased sodium content and reactive oxygen species (ROS) accumulation, but reduced potassium (K) and calcium (Ca) levels at different culture times, thus resulting in the oxidative damage to the leaves. Even though 25 or 100 mg L TP treatment alone led to the significant increases of O and HO generation, TP-treated leaves exhibited the reduction of relative electrical conductivity and no change of malondialdehyde content. Read More

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The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

Shock 2021 Jul 26. Epub 2021 Jul 26.

Institute of Disaster Medicine, Tianjin University, Tianjin, China Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, China Department of Intensive Care Medicine, Taida hospital of Tianjin University, Tianjin, China Department of Intensive Care Medicine, Shijiazhuang Circulating Chemical Industry Park Hospital, Hebei, China Department of Emergency Medicine, General Hospital of Tianjin Medical University, Tianjin, China Department of Nephrology, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin, China Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.

Background: Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient. Read More

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N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.

Neuropathol Appl Neurobiol 2021 Jul 27. Epub 2021 Jul 27.

Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Aims: We investigated N471D WASH complex subunit strumpellin (Washc5) knock-in and Washc5 knock-out mice as models for hereditary spastic paraplegia type 8 (SPG8).

Methods: We generated hetero- and homozygous N471D Washc5 knock-in mice and subjected them to a comprehensive clinical, morphological and laboratory parameter screen, and gait analyses. Brain tissue was used for proteomic analysis. Read More

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Transcriptome-level assessment of the impact of deformed wing virus on honey bee larvae.

Sci Rep 2021 Jul 22;11(1):15028. Epub 2021 Jul 22.

Department of Entomology, National Chung Hsing University, Taichung City, 402, Taiwan.

Deformed wing virus (DWV) prevalence is high in honey bee (Apis mellifera) populations. The virus infects honey bees through vertical and horizontal transmission, leading to behavioural changes, wing deformity, and early mortality. To better understand the impacts of viral infection in the larval stage of honey bees, artificially reared honey bee larvae were infected with DWV (1. Read More

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Diverse intracellular signaling pathways mediate the effects of neurotensin on the excitability of type II neurons in the rat dorsolateral bed nucleus of the stria terminalis.

J Pharmacol Sci 2021 Sep 5;147(1):86-94. Epub 2021 Jun 5.

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan. Electronic address:

We examined the effects of neurotensin (NTS) on the excitability of type II neurons in the rat dorsolateral bed nucleus of the stria terminalis (dlBNST) using whole-cell patch-clamp electrophysiology. Bath-application of NTS depolarized type II dlBNST neurons. Analyses of the steady-state I-V relationships implied that the depolarizing effect of NTS is due to potassium conductance blocking. Read More

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September 2021

Safety and efficacy of using cereal food (Frugra®) to improve blood pressure and bowel health in patients undergoing chronic hemodialysis: A pilot study.

J Pharmacol Sci 2021 Sep 18;147(1):132-137. Epub 2021 Jun 18.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

Hypertension and constipation are major hemodialysis complications. Salt restriction is one of the most important nonpharmacological interventions in managing hypertension. In patients undergoing hemodialysis, nonpharmacological strategies to manage constipation are extremely difficult to develop owing to the presence of excess dietary potassium and fluids. Read More

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September 2021

Bromide toxicosis (bromism) secondary to a decreased chloride intake after dietary transition in a dog with idiopathic epilepsy: a case report.

BMC Vet Res 2021 Jul 22;17(1):253. Epub 2021 Jul 22.

Department of Internal Medicine/ Neurology, University of Toulouse, ENVT, Toulouse, France.

Background: Bromide is a halide ion of the element bromine usually administered in the form of potassium salt as monotherapy or add-on treatment in epileptic dogs. It is excreted unchanged in the urine and undergoes tubular reabsorption in competition with chloride. Thus, dietary chloride content affects serum bromide concentrations. Read More

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Potassium bromate-induced nephrotoxicity and potential curative role of metformin loaded on gold nanoparticles.

Sci Prog 2021 Jul-Sep;104(3):368504211033703

Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.

Potassium bromate (KBrO) is classified by the International Agency for Research on Cancer as a carcinogenic compound, where it causes renal tumors. The present study investigated the potential curative effect of metformin loaded on gold nanoparticles (MET AuNPs) in attenuating KBrO-induced nephrotoxicity. Rats were divided into eight groups (control, MET, AuNPs, MET AuNPs, KBrO, KBrO/MET, KBrO/AuNPS, and KBrO/MET AuNPs). Read More

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The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters.

J Biochem Mol Toxicol 2021 Jul 26:e22847. Epub 2021 Jul 26.

Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Avcilar-Istanbul, Turkey.

In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control (n = 8) rats; rats given EDA (30 mg kg  day ; n = 10); rats given only (VPA, 500 mg kg  day ; n = 10); rats given VPA + EDA (in the same dose and time) for 7 days. Read More

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Association Between Long-Term Use of Non-steroidal Anti-inflammatory Drugs and Hyperkalemia in Diabetic Patients.

Cureus 2021 Jun 14;13(6):e15648. Epub 2021 Jun 14.

Internal Medicine, Jinnah Postgraduate Medical Center, Karachi, PAK.

Introduction The association between continuous use of nonsteroidal anti-inflammatory drugs (NSAIDs) and hyperkalemia is not consistent in the literature and creates grounds for further large-scale trials, particularly in patients with a chronic disease that affects renal function, such as diabetes mellitus (DM). In this study, we will compare mean serum potassium level and the prevalence of hyperkalemia in diabetic and non-diabetic patients based on their use of NSAIDs. Methods This case-control study was conducted in the internal medicine unit of a tertiary care hospital from May 2019 to December 2020. Read More

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Efficiency of biochar, nitrogen addition, and microbial agent amendments in remediation of soil properties and microbial community in Qilian Mountains mine soils.

Ecol Evol 2021 Jul 19;11(14):9318-9331. Epub 2021 Jun 19.

Linze Inland River Basin Research Station Chinese Ecosystem Research Network Key Laboratory of Eco-hydrology of Inland River Basin Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou China.

Lacking systematic evaluations in soil quality and microbial community recovery after different amendments addition limits optimization of amendments combination in coal mine soils. We performed a short-term incubation experiment with a varying temperature over 12 weeks to assess the effects of three amendments (biochar: C; nitrogen fertilizer at three levels: N-N1~N3; microbial agent at two levels: M-M1~M2) based on C/N ratio (regulated by biochar and N level: 35:1, 25:1, 12.5:1) on mine soil properties and microbial community in the Qilian Mountains, China. Read More

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Nano-selenium alleviating the lipid metabolism disorder of LMH cells induced by potassium dichromate via down-regulating ACACA and FASN.

Environ Sci Pollut Res Int 2021 Jul 23. Epub 2021 Jul 23.

Veterinary Clinical Medicine Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Shizishan Street, Wuhan, 430070, People's Republic of China.

Chromium (Cr) VI is a common environmental contaminant highly toxic to livers. To explore the protective effect of nano-selenium (NANO-Se) on broiler liver damage caused by Cr (VI), this experiment was conducted with chicken hepatocellular carcinoma cell line (LMH) as the research object, using potassium dichromate (PDC) and NANO-Se gel for culturing cells. The results indicated that: (1) in the PDC-exposure group, LMH cells being treated with 20 μmol/L PDC for 24 h, IC50 (median inhibition concentration) = 23. Read More

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Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

J Clin Med 2021 Jul 14;10(14). Epub 2021 Jul 14.

National Advisory Unit for CFS/ME, Rikshospitalet, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway.

There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. Read More

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[Analysis of the causes of arrhythmia induced by citrate anticoagulation in continuous renal replacement therapy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):748-751

Department of Critical Care Medicine, Tianjin Third Central Hospital, Tianjin 300170, China. Corresponding author: Feng Quansheng, Email:

Objective: To analyze the possible causes of arrhythmia in patients receiving continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA).

Methods: A retrospective cohort study was conducted. All patients underwent RCA-CRRT treatment from January 1, 2020 to October 31, 2020 in the intensive care unit (ICU) of Tianjin Third Central Hospital were enrolled. Read More

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Safety, efficacy, and serum concentration monitoring of bedaquiline in Chinese patients with multidrug-resistant tuberculosis.

Int J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. Electronic address:

Objectives: To determine the safety and efficacy of bedaquiline for Chinese multidrug-resistant tuberculosis patients based on serum concentration monitoring and identify factors associated with QTc prolongation occurring during treatment.

Methods: We collected data from 35 patients who received treatment regimens containing bedaquiline for multidrug-resistant tuberculosis (MDR-TB) from May 2018 to December 2020. Blood samples were collected, and serum concentrations of bedaquiline were measured using high-performance liquid chromatography-mass spectrometry. Read More

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Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients.

Rev Endocr Metab Disord 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Division of Nephrology, Hypertension and Kidney Transplantation, School of Medicine, University of California, CA, Irvine, Orange, USA.

Hyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-transplant hyperkalemia in recipients with a well-functioning graft. Read More

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Novel lncRNA lncRNA001074 participates in the low salinity-induced response in the sea cucumber Apostichopus japonicus by targeting the let-7/NKAα axis.

Cell Stress Chaperones 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture, Dalian Ocean University, Heishijiao Street, No. 52, Dalian, 116023, China.

Salinity fluctuations have severe impacts on sea cucumbers and therefore important consequences in sea cucumber farming. The responses of sea cucumbers to salinity changes are reflected in the expression profiles of multiple genes and non-coding RNAs (ncRNAs). The microRNA (let-7) which is a developmental regulator, the ion transporter gene sodium potassium ATPase gene (NKAα), and the long ncRNA lncRNA001074 were previously shown to be involved in responses to salinity changes in various marine species. Read More

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Acute Kidney Injury and Associated Factors in Intensive Care Units at a Tertiary Hospital in Northern Tanzania.

Can J Kidney Health Dis 2021 8;8:20543581211027971. Epub 2021 Jul 8.

Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Background: Acute kidney injury (AKI) is a recognized complication in critically ill patients. The epidemiology of AKI varies worldwide, depending on the diagnostic criteria used and the setting. The International Society of Nephrology has called for a reduction in preventable deaths from AKI to zero by the year 2025. Read More

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Association of Dyskalemias with Ischemic Stroke in Advanced Chronic Kidney Disease Patients Transitioning to Dialysis.

Am J Nephrol 2021 Jul 21:1-9. Epub 2021 Jul 21.

Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Introduction: Hypo- and hyperkalemia are associated with a higher risk of ischemic stroke. However, this association has not been examined in an advanced chronic kidney disease (CKD) population.

Methods: From among 102,477 US veterans transitioning to dialysis between 2007 and 2015, 21,357 patients with 2 pre-dialysis outpatient estimated glomerular filtration rates <30 mL/min/1. Read More

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Shoot potassium content provides a physiological marker to screen cotton genotypes for osmotic and salt tolerance.

Int J Phytoremediation 2021 Jul 20:1-7. Epub 2021 Jul 20.

Department of Biology, University of York, York, United Kingdom.

Drought and salinity are considered two major abiotic stresses that diminish cotton production worldwide. Studying common morphological and physiological responses in cotton cultivars may help plant biologists to develop and apply standard screening criteria for either of these stresses and for their combination. Therefore, this research aimed to assess the suitability of several physiological parameters as diagnostic to report on osmotic and salinity tolerance in six elite cotton genotypes. Read More

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Nutrient uptake and pharmaceutical compounds of as influenced by integration of inorganic fertilizer and poultry manure in soil.

Heliyon 2021 Jul 2;7(7):e07464. Epub 2021 Jul 2.

Department of Agricultural Chemistry, Sher-e-Bangla Agricultural University, Dhaka 1207, Bangladesh.

had been used for numerous medical and cosmetic applications since ancient times. The study aimed to investigate the integrated effects of inorganic fertilizer (IF) and poultry manure (PM) on the nutritional and pharmaceutical constituents of . Eighteen month old seedlings were used following completely randomized design with three replications. Read More

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Effects of Soil Type on Trace Element Absorption and Fruit Quality of Pepper.

Front Plant Sci 2021 30;12:698796. Epub 2021 Jun 30.

College of Horticulture, Hunan Agricultural University, Changsha, China.

The inbred "SJ11-3" pepper was cultured in yellow brown soil, paddy soil, fluvo-aquic soil, and pastoral soil, and the factors affecting the absorption of trace elements and fruit quality were analyzed. The results showed that the physicochemical properties of the soils were significantly different, which led to differences in the nutritional quality of pepper fruits. The pH value had a significant effect on the absorption of trace elements in pepper. Read More

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Case Report: Three Rare Cases of Ectopic ACTH Syndrome Caused by Adrenal Medullary Hyperplasia.

Front Endocrinol (Lausanne) 2021 1;12:687809. Epub 2021 Jul 1.

Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.

Ectopic ACTH syndrome (EAS) accounts for 10-20% of endogenous Cushing's syndrome (CS). Hardly any cases of adrenal medullary hyperplasia have been reported to ectopically secrete adrenocorticotropic hormone (ACTH). Here we describe a series of three patients with hypercortisolism secondary to ectopic production of ACTH from adrenal medulla. Read More

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Social impairments in mice lacking the voltage-gated potassium channel Kv3.1.

Behav Brain Res 2021 Jul 15;413:113468. Epub 2021 Jul 15.

Department of Psychology, The Ohio State University, Columbus, OH, 43210, United States; Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, United States. Electronic address:

Parvalbumin (PV)-expressing neurons have been implicated in the pathology of autism spectrum disorders (ASD). Loss of PV expression and/or reduced number of PV-expressing neurons have been reported not only in genetic and environmental rodent models of ASD, but also in post-mortem analyses of brain tissues from ASD vs. healthy control human subjects. Read More

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Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia/reoxygenation.

J Thorac Cardiovasc Surg 2021 Jun 26. Epub 2021 Jun 26.

Division of Cardiothoracic Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI. Electronic address:

Objective: Cardioplegic ischemia-reperfusion and diabetes mellitus are correlated with coronary endothelial dysfunction and inactivation of small conductance calcium-activated potassium channels. Increased reactive oxidative species, such as mitochondrial reactive oxidative species, may contribute to oxidative injury. Thus, we hypothesized that inhibition of mitochondrial reactive oxidative species may protect coronary small conductance calcium-activated potassium channels and endothelial function against cardioplegic ischemia-reperfusion-induced injury. Read More

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KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology.

Sci Rep 2021 Jul 16;11(1):14632. Epub 2021 Jul 16.

Molecular Physiology Laboratory, Departament de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.

The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis. The regulatory subunit KCNE4 acts as an ancillary peptide of Kv1. Read More

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