12,202 results match your criteria postsurgical treatment

From the Immune Profile to the Immunoscore: Signatures for Improving Postsurgical Prognostic Prediction of Pancreatic Neuroendocrine Tumors.

Front Immunol 2021 23;12:654660. Epub 2021 Apr 23.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Objective: Immune infiltration plays an important role in tumor development and progression and shows promising prognostic value in numerous tumors. In this study, we aimed to identify the role of immune infiltration in pancreatic neuroendocrine tumors (Pan-NETs) and to establish an Immunoscore system to improve the prediction of postsurgical recurrence-free survival.

Methods: To derive transcriptional signatures and deconvolute specific immune populations, two GEO datasets containing 158 Pan-NET patients were reanalyzed to summarize the immune infiltration landscape and identify immune-related signatures. Read More

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The predictive value of tumor infiltrating leukocytes in Hepatocellular Carcinoma: A systematic review and meta-analysis.

Eur J Surg Oncol 2021 May 4. Epub 2021 May 4.

Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. Electronic address:

Background: For Hepatocellular carcinoma (HCC) surgery either through resection or transplantation often provides the only chance for cure. Since hepatocarcinogenesis and postsurgical prognosis is not only dependent on cirrhosis but also on immune activation and exhaustion, many studies have investigated tumor infiltrating leukocyte (TIL) subsets. This systematic review and meta-analysis aims at describing the cell groups and their predictive power regarding overall (OS), disease free (DFS) and recurrence free survival (RFS). Read More

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Portable Chest Radiography Immediately after Post-Cardiac Surgery; an Essential Tool for the Early Diagnosis and Treatment of Atelectasis: a Case Report.

Tanaffos 2020 Dec;19(4):418-421

Department of Surgery, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Atelectasis after endobronchial intubation (ETT) is a known complication of general anesthesia. In-bed auscultation of lungs and use of the 21/23 rule are the two suggestive, but not reliable, methods for the early detection of this event; however, none of them guarantees its prevention. The portable chest radiograph (CXR) is a simple, quick method to detect atelectasis and proper placement of the endotracheal tube in the intensive care unit (ICU). Read More

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December 2020

[Surgical removal of an intraperitoneal foreign body in a Swiss Simmental cow with a magnet].

C Binici

Schweiz Arch Tierheilkd 2021 May;163(5):351-355

Tierarztpraxis Beo-Vet, 3800 Matten bei Interlaken.

Introduction: This case report describes the surgical removal of a foreign body from the abdominal cavity in a Swiss Simmental cow with a disinfected magnet. The procedure was performed from the right flank a few days after a ruminotomy. An inflamed connective tissue mass was found and prepared. Read More

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Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study.

PLoS Med 2021 May 3;18(5):e1003620. Epub 2021 May 3.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

Background: In patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies have shown that circulating tumor DNA (ctDNA) analysis, as a marker of minimal residual disease, is a powerful prognostic factor in patients with nonmetastatic colorectal cancer (CRC). Serial analysis of ctDNA in patients with resectable CRLM could inform the optimal use of perioperative chemotherapy. Read More

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Therapy with PTH 1-34 or calcitriol and calcium in diverse etiologies of hypoparathyroidism over 27 years at a single tertiary care center.

Bone 2021 Apr 28;149:115977. Epub 2021 Apr 28.

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.

Objective: Hypoparathyroidism has heterogeneous genetic and acquired etiologies with a broad spectrum of severity. Herein we describe the clinical outcomes of the largest cohort of hypoparathyroid patients reported to date, who were followed over 27-years.

Design: Pooled analysis of current and past studies describing the differential responses to PTH 1-34 injections vs conventional therapy among the varied hypoPT etiologies. Read More

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Dilemmas in the management of rhinophyma in pigmented individuals.

Ann R Coll Surg Engl 2021 May;103(5):e165-e168

Queen Victoria Hospital NHS Trust, East Grinstead, UK.

Rhinophyma affects predominantly the Caucasian population and is rare in those with Fitzpatrick skin type IV-VI. Diagnosis is based on clinical evaluation. Prominent features include abnormal coloration and texture of skin, impaired vascularity, irregular nodular exophytic growth and telangiectasia. Read More

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Joint-Preserving Surgery for Forefoot Deformities in Patients with Rheumatoid Arthritis: A Literature Review.

Int J Environ Res Public Health 2021 Apr 13;18(8). Epub 2021 Apr 13.

Department of Orthopedic Surgery, Tokyo Women's Medical University, Tokyo 162-8666, Japan.

The combination of first metatarsophalangeal joint arthrodesis and resection arthroplasty of all lesser metatarsal heads has been historically considered the golden standard treatment for rheumatoid forefoot deformities. However, as recent improved management of rheumatoid arthritis have reduced progression of joint destruction, the surgical treatments for rheumatoid forefoot deformities have gradually changed from joint-sacrificing surgery, such as arthrodesis and resection arthroplasty, to joint-preserving surgery. The aim of this literature review was to provide current evidence for joint-preserving surgery for rheumatoid forefoot deformities. Read More

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Unicompartmental Knee Arthroplasty: Minimal Important Difference and Patient Acceptable Symptom State for the Forgotten Joint Score.

Medicina (Kaunas) 2021 Apr 1;57(4). Epub 2021 Apr 1.

Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, Trigoria, 00128 Rome, Italy.

: Unicompartmental knee arthroplasty (UKA) is a valid alternative to total knee arthroplasties (TKAs) in selected cases. After surgery, patients' experience and satisfaction were traditionally evaluated by pre- and postsurgical scores and Patient-Reported Outcome Measures (PROMs). Otherwise, a statistically significant change does not necessarily correlate to a clinically meaningful improvement when measured using PROMs. Read More

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Minimally invasive laparoscopic technique for lymph node dissection in penile cancer: the Pelvic and Inguinal Single-site Approach: PISA technique.

Urology 2021 Apr 26. Epub 2021 Apr 26.

Servicio de Urología. Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address:

Background: Lymph node dissection(LND) remains the gold standard in the staging and treatment of locally advanced penile cancer(PC).

Objective: To describe our initial experience with a new minimally invasive inguinal and pelvic single-access laparoscopic approach,for performing LND in PC, first described in Urology by our group in 2015: the Pelvic and Inguinal Single Access(PISA) technique (Figure 1).

Material: Between 2015-2018, 10 consecutive patients with different PC stages and indication of inguinal LND (cN0 and ≥pT1G3 or cN1/cN2) were operated by means of the PISA technique (Table 1). Read More

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Postsurgical oral symptoms after insertion of one or two implants for mandibular overdentures: short-term results of a randomized clinical trial.

Int J Implant Dent 2021 Apr 28;7(1):38. Epub 2021 Apr 28.

Department of Oral Rehabilitation, School of Dentistry, Federal University of Goias, Praça Universitária, s/n, Setor Universitário, Goiania, Goias, 74605-220, Brazil.

Objective: This randomized clinical trial aimed to compare the short-term postsurgical symptoms after insertion of one or two implants for retention of a mandibular overdenture. This study investigated whether the less invasive single-implant approach results in lower postoperative symptoms compared to the conventional two-implant overdenture.

Materials And Methods: Patients received new complete dentures and were randomly assigned to groups receiving one or two single-stage, early-loaded hydrophilic implants, inserted in the midline (n = 23), or the lateral incisor-canine area bilaterally (n = 24). Read More

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Efficacy and Safety of Ultrasound Cycloplasty for Refractory Glaucoma: A 3-Year Study.

J Glaucoma 2021 May;30(5):428-435

Department of Ophthalmology, Grenoble Alpes University Hospital, Grenoble, France.

Precis: Ultrasound cycloplasty (UCP) treatment using high-intensity focused ultrasound is an effective and safe therapy to reduce intraocular pressure (IOP) in patients with refractory glaucoma over a 3-year period.

Purpose: The purpose of this study was to evaluate the 3-year efficacy and safety of UCP in patients with refractory glaucoma.

Patients And Methods: In all, 104 patients with refractory glaucoma recruited from 2 university hospitals underwent UCP. Read More

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Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling.

J Neurosci 2021 Apr 20. Epub 2021 Apr 20.

Department of Anesthesia

A number of cellular systems work in concert to modulate nociceptive processing in the periphery, but the mechanisms that regulate neonatal nociception may be distinct compared with adults. Our previous work indicated a relationship between neonatal hypersensitivity and growth hormone (GH) signaling. Here, we explored the peripheral mechanisms by which GH modulated neonatal nociception under normal and injury conditions (incision) in male and female mice. Read More

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Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation: A Systematic Review and Network Meta-analysis.

Anesth Analg 2021 Apr 22. Epub 2021 Apr 22.

From the Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Background: Topical pharmacological agents typically used to treat postoperative sore throat (POST) after tracheal intubation include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, lidocaine, Glycyrrhiza (licorice), and N-methyl-d-aspartate (NMDA) receptor antagonists (including ketamine and magnesium). However, the optimal prophylactic drug remains elusive.

Methods: The literature published before September 8, 2019 was searched on the PubMed, the Embase, the Web of Science, and the Cochrane Library. Read More

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Changes in the facial soft tissue profile after maxillary orthognathic surgery.

J Orofac Orthop 2021 Apr 21. Epub 2021 Apr 21.

Department of Orthodontics, Ludwig-Maximilians University of Munich, Munich, Germany.

Objectives: To compare the changes of the soft tissue profile in relation to the displacement of the underlying hard structures in maxillary orthognathic surgery and to contribute to the esthetic prediction of the facial profile after surgical procedures.

Materials And Methods: We analyzed the sagittal changes in the facial soft tissue profile related to surgical changes in skeletal structures after maxillary osteotomy in a retrospective study. The study sample comprised 115 adult patients between the ages of 18-50 years who had undergone maxillary orthognathic surgery and interdisciplinary orthodontic treatment at the Department of Orthodontics, Ludwig-Maximilians University of Munich, Germany. Read More

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Clinical and Economic Outcomes Associated With Use of Liposomal Bupivacaine Versus Standard of Care for Management of Postsurgical Pain in Pediatric Patients Undergoing Spine Surgery.

J Health Econ Outcomes Res 2021 Apr 14;8(1):29-35. Epub 2021 Apr 14.

Pacira BioSciences, Inc., Parsippany, NJ.

Approximately 60% of hospitalized children undergoing surgery experience at least 1 day of moderate-to-severe pain after surgery. Pain following spine surgery may affect opioid exposure, length of stay (LOS), and costs in hospitalized pediatric patients. This is a retrospective cohort analysis of pediatric patients undergoing inpatient primary spine surgery. Read More

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A virtual reality-based intervention for surgical patients: study protocol of a randomized controlled trial.

Trials 2021 Apr 19;22(1):289. Epub 2021 Apr 19.

Department of Surgery, V-th Surgical Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.

Background: Pain after surgery is normal, and treatments, including both pharmacological and psychological components, are fundamental for proper postoperative care. While several trials have investigated the analgesic effect of traditional non-pharmacological treatments, such as cognitive behavior therapies, the newer ways of delivering psychological interventions for pain after surgery are scarcely investigated. The aim of this randomized controlled trial (RCT) is to determine if delivering the psychological content through virtual reality (VR) along with the standard pharmacological treatment return better pain relief outcomes than standard care in adult patients following surgery. Read More

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Utility of 18F-AlF-NOTA-octreotide PET/CT in the localization of Tumor-Induced Osteomalacia.

J Clin Endocrinol Metab 2021 Apr 17. Epub 2021 Apr 17.

Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Purpose: Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of the hormone fibroblast-growth-factor 23 (FGF23). The only curative therapy of the disease is resection of the causative tumors. This research was conducted to evaluate the efficacy of 18F-AlF-NOTA-octreotide ( 18F-OC) PET/CT in detecting TIO and its impact on patient management. Read More

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Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice.

Sci Rep 2021 Apr 16;11(1):8376. Epub 2021 Apr 16.

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Postoperative delirium is a common neuropsychiatric syndrome resulting a high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human and animal delirium-like models due to their clinical significance, focusing on systematic inflammation and consequent neuroinflammation playing a key role in the pathogenesis of postoperative cognitive dysfunctions. Since animal models are widely utilized for pathophysiological study of neuropsychiatric disorders, this study aimed at examining the validity of the scopolamine-induced delirium-like mice model with respect to the neuroinflammatory hypothesis of delirium. Read More

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Postsurgical Prosthetic Rehabilitation after Mandibular Ameloblastoma Resection: A 7-Year Follow-Up Case Report.

Case Rep Dent 2021 28;2021:5593973. Epub 2021 Mar 28.

Department of Odontostomatology, Faculty of Medicine and Health Sciences (Dentistry), University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

Ameloblastomas are benign but locally invasive odontogenic tumors most frequently located in the mandible. The gold standard of treatment is the surgical resection of the tumor with safety margins. Postsurgical defects generate a significant morbidity that needs reconstruction and oral rehabilitation to restore the oral functions. Read More

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A Novel Immunotype-based Risk Stratification Model Predicts Postoperative Prognosis and Adjuvant TACE Benefit in Chinese Patients with Hepatocellular Carcinoma.

J Cancer 2021 15;12(10):2866-2876. Epub 2021 Mar 15.

Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

: The tumor microenvironment can be divided into inflamed, immune-excluded and immunedesert phenotypes according to CD8 T cell categories with differential programmed cell death protein 1 (PD-L1) expression. The study aims to construct a novel immunotype-based risk stratification model to predict postsurgical survival and adjuvant trans-arterial chemoembolization (TACE) response in patients with hepatocellular carcinoma (HCC). A total of 220 eligible HCC patients participated in this study. Read More

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Chinese Association for the Study of Pain: Expert consensus on chronic postsurgical pain.

World J Clin Cases 2021 Mar;9(9):2090-2099

Department of Algology, The Affiliated T.C.M Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

Chronic postsurgical pain is a common surgical complication that severely reduces a patient's quality of life. Many perioperative interventions and management strategies have been developed for reducing and managing chronic postsurgical pain. Under the leadership of the Chinese Association for the Study of Pain, an editorial committee was formed for chronic postsurgical pain diagnosis and treatment by experts in relevant fields. Read More

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Association between postsurgical pain and heart rate variability: protocol for a scoping review.

BMJ Open 2021 Apr 13;11(4):e044949. Epub 2021 Apr 13.

Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada

Introduction: Surgical interventions can elicit neuroendocrine responses and sympathovagal imbalance, ultimately affecting cardiac autonomic function. Cardiac complications account for 30% of postoperative complications and are the leading cause of morbidity and mortality following non-cardiac surgery. One cardiovascular parameter, heart rate variability (HRV), has been found to be predictive of postoperative morbidity and mortality. Read More

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Focal cortical dysplasia: an update on diagnosis and treatment.

Expert Rev Neurother 2021 Apr 25:1-12. Epub 2021 Apr 25.

Neuroscience Department, Children's Hospital Meyer-University of Florence, Florence, Italy.

Introduction: Focal cortical dysplasias (FCDs) represent the most common etiology in pediatric drug-resistant focal epilepsies undergoing surgical treatment. The localization, extent and histopathological features of FCDs are considerably variable. Somatic mosaic mutations of genes that encode proteins in the PI3K-AKTmTOR pathway, which also includes the tuberous sclerosis associated genes and , have been implicated in FCD type II in a substantial subset of patients. Read More

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Clinical experience of poly-L-lactic acid injections for body contouring treatment.

J Cosmet Dermatol 2021 Apr 8. Epub 2021 Apr 8.

Galderma Aesthetics, Global Medical Affairs, Uppsala, Sweden.

Introduction: Clinical data on body contouring with injectable poly-L-lactic acid are sparsely reported in published literature. This study describes the lead author's clinical experience using injectable poly-L-lactic acid for body contouring in various anatomic locations.

Methods: Twenty consecutive patients undergoing body contouring treatments with poly-L-lactic acid were prospectively followed. Read More

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Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.

Mol Pain 2021 Jan-Dec;17:1744806921997206

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In the current study, we examined the therapeutic efficacy of the β2-AR agonist clenbuterol in a rat model of persistent postsurgical hypersensitivity induced by disruption of descending noradrenergic signaling in rats with plantar incision. We used growth curve modeling of ipsilateral mechanical paw withdrawal thresholds following incision to examine effects of treatment on postoperative trajectories. Read More

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

J Gynecol Oncol 2021 May;32(3):e44

Department of Obstetrics and Gynecology, Tokai University School of Medicine, Isehara, Japan.

Objective: The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.

Methods: This analysis included 9,756 patients who were diagnosed based on the pathological Tumor-Node-Metastasis (pTNM) classification (i. Read More

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Determining the relation between total knee arthroplasty surgery site drainage in two weeks after surgery with periprosthetic joint infection (PJI) in two years.

Int J Burns Trauma 2021 15;11(1):62-68. Epub 2021 Feb 15.

Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.

Background: Prosthetic joint infection (PJI) is a devastating complication in total knee arthroplasty (TKA) surgeries and prompt diagnosis and treatment are vital; however, no study has been conducted to determine the relationship between characteristics and duration of surgical site discharge and PJI.

Methods: This is a longitudinal observational study that was performed at Al-Zahra and Kashani and Sadi university hospitals from 2017 until 2019. A total of 961 elective TKA were performed on 850 consecutive patients. Read More

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February 2021

Outcomes of Conductive Keratoplasty Combined with Corneal Crosslinking in Advanced Ectatic Corneal Disease.

Clin Ophthalmol 2021 29;15:1317-1329. Epub 2021 Mar 29.

Department of Ophthalmology, University of Arizona, Tucson, AZ, USA.

Purpose: To assess the effectiveness of a novel treatment for patients with advanced corneal ectasia and loss of visual acuity (VA). Conductive keratoplasty (CK) is performed to improve VA followed by epithelium-on (epi-on) corneal crosslinking (CXL) to stabilize the cornea after CK.

Methods: Retrospective, exploratory cohort study. Read More

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Imbalanced flow changes of distal arteries: An important factor in process of delayed ipsilateral parenchymal hemorrhage after flow diversion in patients with cerebral aneurysms.

Interv Neuroradiol 2021 Apr 7:15910199211009120. Epub 2021 Apr 7.

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background And Objective: Hemodynamic forces may play a role in symptomatic delayed ipsilateral parenchymal hemorrhage (DIPH) of intracranial aneurysm (IA) after flow diverter placement. We aimed to investigate the hemodynamic risk factors in the postsurgical DIPH process.

Methods: Six patients with internal carotid artery (ICA) aneurysm developed to DIPH and 12 patients without DIPH (1:2 matched controls) after flow diverter were included between January 2015 to January 2019. Read More

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