32,085 results match your criteria postoperative radiotherapy

The Italian Association of Radiotherapy and Oncology Recommendation for Breast Tumor Recurrence: Grades of Recommendation, Assessment, Development and Evaluation Criteria.

J Breast Cancer 2021 May 13. Epub 2021 May 13.

Radioterapia, Dipartimento di Biomedicina e prevenzione, Università degli Studi di Roma Tor Vergata, Roma, Italy.

Salvage mastectomy is currently considered the standard of care for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) and postoperative radiotherapy (RT). Alternative treatment options for these patients, such as a second BCS followed by repeated RT, have been suggested. The panel of the Italian Association of Radiotherapy and Clinical Oncology developed clinical recommendations for second BCS followed by re-irradiation over mastectomy alone for women with IBTR using the Grades of Recommendation, Assessment, Development, and Evaluation methodology and the evidence to decision framework. Read More

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A comparative study on using superior thyroid artery perforator flaps versus traditional sternocleidomastoid myocutaneous flaps for reconstructions after oral cancer ablation: "New tricks for old dogs"?

Oral Oncol 2021 Jun 11:105374. Epub 2021 Jun 11.

Department of Oral Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

Objectives: To introduce new superior thyroid artery perforator flaps (STAPF), and to compare the clinical outcomes with sternocleidomastoid myocutaneous flaps (SCMMF) for their intraoral applications.

Materials And Methods: Between January 2013 and December 2020, forty-three oral cancer patients who received post-oncologic reconstructions with one of these two regional flaps were retrospectively collected. Their techniques and outcomes were compared. Read More

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Helical tomotherapy for prostate cancer radiation therapy: An audit of early toxicity and quality of life.

J Cancer Res Ther 2021 Apr-Jun;17(2):366-371

Department of Amrita School of Medicine, AIMS, Amrita Vishwa Vidyapeetham, Kochi, India.

Background: Radiation plays a major role in the management of localized prostate cancer (CaP). There are limited studies reporting the quality of life (QOL) and toxicity with CaP tomotherapy.

Materials And Methods: This is a single-institutional prospective observational study evaluating the acute toxicity and QOL of patients with CaP receiving tomotherapy from May 2018 to October 2019. Read More

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Effectiveness of rectal displacement devices during prostate external-beam radiation therapy: A review.

J Cancer Res Ther 2021 Apr-Jun;17(2):303-310

Department of Medical Physics, School of Medicine, Iran University of Medical Sciences; Department of Medical Physics, Roshana Cancer Institute, Tehran, Iran.

Dose-escalated prostate radiotherapy (RT) can improve treatment outcomes, but rectal toxicity is the main limiting factor for introducing dose-escalated RT. Pushing rectal wall away from the prostate reduces the volume of the rectum in high-dose region, which can decrease both short- and long-term rectal toxicities after RT. This review focuses on the literature using different rectal displacement devices such as endorectal balloons, tissue spacers, rectal retractor, and ProSpare during prostate External beam radiotherapy, with regard to dosimetric effects, clinical benefits, prostate motion, and postoperative RT setting. Read More

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Neoadjuvant chemotherapy combined with immunotherapy for pulmonary large-cell neuroendocrine carcinoma: a case report.

Ann Palliat Med 2021 May 26. Epub 2021 May 26.

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer. Nonsmall cell lung cancer can be further divided into squamous cell carcinoma, adenocarcinoma, and large-cell neuroendocrine carcinoma (LCNEC). At present, our understanding of LCNEC is limited. Read More

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Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.

Dermatol Ther (Heidelb) 2021 Jun 11. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

Previous approaches to acne management have focused on the four main factors implicated in acne, namely, androgen-mediated sebogenesis (considered integral to acne), hyperkeratinization, colonization with Cutibacterium acnes, and inflammation related to both innate and adaptive mechanisms. Recent advances have facilitated potential novel approaches to acne management, as the pathophysiology and the immunological aspects related to acne and wound healing have evolved. Particular targets that have been shown to be closely involved in acne pathophysiology and wound healing include interleukin (IL)-1β, IL-17, IL-23, and tumor necrosis factor alpha (TNFα). Read More

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Identifying Patterns of Failure and Risk Factors for Recurrence in Patients of Paratesticular Sarcomas: Protocol of a Systematic Review and Meta-Analysis.

Int J Surg Protoc 2021 May 28;25(1):84-91. Epub 2021 May 28.

Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi, IN.

Introduction: Para testicular sarcomas are rare mesenchymal tumors that affect patients of all ages. Unlike other sites of sarcoma, they tend to be of lower grade and have a higher propensity for lymphatic spread. Management is hampered by the small number of patients who differ in terms of tumor grade and histology. Read More

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The Preliminary Study for Postoperative Radiotherapy Survival Associated with and Expression in Lung Cancer.

Cancer Manag Res 2021 4;13:4497-4507. Epub 2021 Jun 4.

Jinshan Hospital Center for Tumor Diagnosis & Therapy, Shanghai, 201508, People's Republic of China.

Background: Many studies have reported that the inflammatory immune response related to signaling activation participates in tumor development and affects the treatment outcome. functions as a tumor suppressor by regulating DNA methylation. protein plays an important role in TGF-β signaling pathway that is involved in tumor growth inhibition and apoptosis. Read More

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Tumor-to-Gland Volume Ratio versus Tumor-to-Breast Ratio as Measured on CBBCT: Possible Predictors of Breast-Conserving Surgery.

Cancer Manag Res 2021 3;13:4463-4471. Epub 2021 Jun 3.

Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.

Background: Breast-conserving surgery plus postoperative radiotherapy is the standard surgical treatment mode for early breast cancer. Currently, there are no clear predictive indicators to determine whether a patient can choose breast-conserving surgery, which mainly depends on the surgeon's clinical experience and subjective judgment. Cone-beam breast computed tomography (CBBCT) reconstructs the breast 3D image from three mutually perpendicular angles, helping surgeons to locate and accurately measure the volume of the tumor, mammary gland, and breast. Read More

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Predictive value of the new ESGO-ESTRO-ESP endometrial cancer risk classification on survival and recurrence in the Danish population.

Int J Gynecol Cancer 2021 Jun 10. Epub 2021 Jun 10.

Department of Gynecology and Obstetrics, Aarhus Universitetshospital, Aarhus, Denmark.

Objective: To compare the performance of the new ESGO-ESTRO-ESP (European Society of Gynecological Oncology-European Society for Radiotherapy & Oncology-European Society for Pathology) 2020 risk classification system with the previous 2016 risk classification in predicting survival and patterns of recurrence in the Danish endometrial cancer population.

Methods: This Danish national cohort study included 4516 patients with endometrial cancer treated between 2005 and 2012. Five-year Kaplan-Meier adjusted and unadjusted survival estimates and actuarial recurrence rates were calculated for the previous and the new classification systems. Read More

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Post-operative volumes following endoscopic surgery for non-functioning pituitary macroadenomas are predictive of further intervention, but not endocrine outcomes.

BMC Endocr Disord 2021 Jun 10;21(1):116. Epub 2021 Jun 10.

Leeds Centre for Diabetes & Endocrinology, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: Transsphenoidal surgery (TSS) remains the treatment of choice for non-functioning pituitary macroadenomas (NFPMA). The value of measuring tumour volumes before and after surgery, and its influence on endocrine outcomes and further treatment of the residual or recurrent tumour are unknown.

Methods: Data from patients who underwent endoscopic TSS for a NFPMA (2009-2018) in a UK tertiary centre were analysed for pre- and post-operative endocrine and surgical outcomes. Read More

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Frailty and restrictions in geriatric domains are associated with surgical complications but not with radiation-induced acute toxicity in head and neck cancer patients: A prospective study.

Oral Oncol 2021 Jul 7;118:105329. Epub 2021 Jun 7.

Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, PO box 30.001, 9700 RB, Groningen, the Netherlands.

Objectives: We aimed to evaluate the association between frailty screening and geriatric assessment (GA) on short term adverse events in patients treated for head and neck cancer (HNC) for the first time in a prospective study.

Materials And Methods: Newly diagnosed HNC patients undergoing curative treatment were prospectively included in OncoLifeS, a data biobank. Prior to the start of treatment, frailty was assessed with a GA, Groningen Frailty Indicator (GFI) and Geriatric-8 (G8). Read More

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CT findings of acute radiation-induced pneumonitis in breast cancer.

Br J Radiol 2021 Jun 16:20200997. Epub 2021 Jun 16.

Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, South Korea.

Objectives: To evaluate the CT findings of acute radiation pneumonitis (RP) in breast cancer patients undergoing post-operative radiotherapy, and to analyze clinicodosimetric factors associated with acute RP.

Methods: Between 2015 and 2017, 61 patients with breast cancer who underwent follow-up chest CT at 3 months after radiotherapy were analyzed. The degree of acute RP on CT was evaluated by the change of extent and scoring system (grade 0, no RP; Grade 1, ground-glass opacities (GGOs); Grade 2, GGOs and/or consolidations; Grade 3, clear focal consolidation; Grade 4, dense consolidation). Read More

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Effect of anthracycline-based postoperative chemotherapy on blood glucose and lipid profiles in patients with invasive breast cancer.

Ann Palliat Med 2021 May;10(5):5502-5508

Department of General Surgery, the First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

Background: Recent studies have shown that chemotherapy can cause abnormal glucose and lipid metabolism in breast cancer patients; however, the effects of different chemotherapy regimens on the glucose and lipid profiles in this population remain unclear.

Methods: The clinical data of 141 invasive breast cancer patients who were treated in our center from January 2019 to December 2020 were retrospectively collected. All patients received surgical treatment and postoperative chemotherapy in our center. Read More

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Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes.

J Neurooncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, 2015 North Jefferson Street, Jacksonville, FL, 32206, USA.

Purpose: We report disease control, survival outcomes, and treatment-related toxicity among adult medulloblastoma patients who received proton craniospinal irradiation (CSI) as part of multimodality therapy.

Methods: We reviewed 20 adults with medulloblastoma (≥ 22 years old) who received postoperative proton CSI ± chemotherapy between 2008 and 2020. Patient, disease, and treatment details and prospectively obtained patient-reported acute CSI toxicities were collected. Read More

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Georgian Med News 2021 Apr(313):139-146

Higher State Educational Institution of Ukraine Bukovinian State Medical University, Chernivtsi, Ukraine.

The aim of the research was to study experimentally the morphologic peculiarities of the granular tissue around the elements of the reticular allotransplant of the muscular aponeurotic layer of the anterior abdominal wall when using postoperative distant gamma therapy. The experiment has been done on 168 laboratory rats which were implanted with a prolenic mesh allograft into the tissues of muscular aponeurotic layer of the anterior abdominal wall. From the 13th to 19th day after the implantation of the reticular allograft, animals from the main group (96 rats) received irradiation of the site of the last one. Read More

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Salvage surgery after definitive chemoradiotherapy through VATS for an initial unresectable locally advanced lung cancer: an alternative consolidative modality to radiotherapy?

Surg Case Rep 2021 Jun 8;7(1):138. Epub 2021 Jun 8.

Division of Thoracic Oncology, Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Definitive chemoradiotherapy (dCRT) is the first choice treatment for patients with locally advanced non-small cell lung cancer (NSCLC), but up to 35% of dCRT-treated tumors may have persistent or recurrent disease. Since the last decades, multimodality therapy showing potential for cure has become the mainstream for treatment of locally advanced NSCLCs, even some that were initially inoperable. Although salvage lung resection after dCRT has been reported with acceptable survivals, experiences in this respect are still limited. Read More

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Volumetry and Surgical Grading Systems for Vestibular Schwannoma Size Assessment and their Relationship to Postoperative Facial Nerve Function.

J Neurol Surg A Cent Eur Neurosurg 2021 Jun 7. Epub 2021 Jun 7.

Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany.

Background And Study Aims:  Treatment modalities in vestibular schwannoma (VS) are difficult to compare since different techniques for size measurements are used. The purpose of this study was to evaluate the relation between different tumor size grading systems regarding their compatibility as well as the relationship to facial nerve outcome facilitating comparisons of different studies.

Material And Methods:  In this retrospective study, preoperative magnetic resonance imaging of 100 patients with surgically treated VS was evaluated regarding total tumor volume and anatomical extension based on the Koos and Samii classification, as well as volumetric and maximal diameter measures. Read More

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Phase II study of adjuvant radiotherapy following narrow-margin hepatectomy in patients with hepatocellular carcinoma.

Hepatology 2021 Jun 7. Epub 2021 Jun 7.

Key Laboratory of Carcinogenesis and Translational Research, Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, P. R. China.

Background & Aims: Surgical resection is the primary treatment for hepatocellular carcinoma (HCC); however, it is associated with a high rate of recurrence and death. We conducted this phase II study to investigate the efficacy and safety of postoperative intensity-modulated radiotherapy (IMRT) for HCC after narrow-margin hepatectomy.

Approach & Results: We designed a single-arm, prospective phase II trial to evaluate overall survival (OS), disease-free survival (DFS), recurrence patterns, and toxicity in patients receiving adjuvant radiotherapy. Read More

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Outcome after treatment of pediatric supratentorial ependymoma: long-term follow-up of a single consecutive institutional series of 26 patients.

Br J Neurosurg 2021 Jun 7:1-9. Epub 2021 Jun 7.

Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.

Background: Long-term outcome after surgical treatment of supratentorial ependymoma (STE) in children has not been extensively reported.

Findings: We identified 26 children who underwent primary tumor resection of STE between 1953 and 2011, with at least 8 years follow-up. Ten patients (38%) had anaplastic and 16 had low grade ependymoma. Read More

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Primary Intracranial Leiomyosarcoma Secondary to Glioblastoma: Case Report and Literature Review.

Front Oncol 2021 20;11:642683. Epub 2021 May 20.

Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.

Background: Leiomyosarcoma is a highly malignant soft-tissue sarcoma with a poor prognosis. In recent years, treatment for leiomyosarcoma has not shown much progress. Primary intracranial leiomyosarcoma (PILMS) is a much rarer type of neoplasm, which occurs more frequently in immunocompromised patients. Read More

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The Efficacy of Radiofrequency Ablation for Bone Tumors Unsuitable for Radical Excision.

Clin Orthop Surg 2021 Jun 18;13(2):278-285. Epub 2021 May 18.

Department of Orthopaedic Surgery, Kosin University College of Medicine, Busan, Korea.

Background: Bone tumors can cause severe pain and poor quality of life due to recurrence and non-achievement of complete remission after surgery, chemotherapy, or radiotherapy. Radiofrequency ablation (RFA) can be considered for minimally invasive treatment of bone tumors that are difficult to radically excise. In this study, RFA was performed for bone tumors that were difficult to radically excise and did not respond to surgery, chemotherapy, or radiotherapy due to their large sizes and/or locations. Read More

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The relative importance of predictive factors for single first-generation EGFR-TKI use for more than 5 years in patients with advanced non-small cell lung cancer: Taiwan multicenter TIPS-5 study.

Ther Adv Med Oncol 2021 22;13:17588359211018022. Epub 2021 May 22.

Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, No.110, Sec. 1, Jianguo N. Road, Taichung, 402.

Background: The relative importance of predictive factors for advanced non-small cell lung cancer (NSCLC) patients on epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment remains unclear.

Materials And Methods: We retrospectively enrolled advanced NSCLC patients with single first-generation EGFR-TKI treatment for ⩾5 years (Y) in Taiwan. Clinical data was collected and compared with those of another cohort with single first-line EGFR-TKI treatment for <5 Y. Read More

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A retrospective review of phyllodes tumors of the breast from a single institution.

Breast Dis 2021 May 28. Epub 2021 May 28.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior.

Objective: This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors.

Methods: Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Read More

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[Radiotherapy for Glioma].

Hiroshi Igaki

No Shinkei Geka 2021 May;49(3):575-587

Department of Radiation Oncology, National Cancer Center Hospital.

Gliomas are infiltrative tumors that are difficult to cure by surgery alone. Postoperative radiotherapy or chemoradiotherapy is the treatment option for patients with high-grade gliomas. However, most pathological types of glioma other than glioblastoma do not have enough evidence, especially concerning the dose-fractionation scheme and clinical target volume definition for radiotherapy. Read More

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Preoperative stereotactic ablative body radiotherapy with postoperative conventional irradiation of soft tissue sarcomas: protocol overview with a preliminary safety report.

Radiother Oncol 2021 Jun 2. Epub 2021 Jun 2.

Department of Radiation Oncology & Nuclear Medicine, N.N. Petrov National Medical Research Center of Oncology, St. Petersburg 197758, Russia. Electronic address:

Preoperative radiotherapy in patients with soft tissue sarcomas is characterized by important advantages: high precision of dose delivery, reduction of tumour volume and implantation potential, induction of immunologic response. Postoperative irradiation is associated with a reduced risk of complication, and a comprehensive radiotherapy planning in accordance with the pathologic report. Combination of pre- and postoperative irradiation gives the opportunity to use the best of both methods. Read More

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Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II).


BJS Open 2021 May;5(3)

Background: A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate whether the addition of induction chemotherapy to neoadjuvant chemo(re)irradiation improves the R0 resection rate in LRRC. Read More

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Mucosa plication reinforced colorectal anastomosis and trans-anal vacuum drainage: a pilot study with preliminary results.

Updates Surg 2021 Jun 5. Epub 2021 Jun 5.

Laboratory of Bioinformatics and Biostatistics, Jessenius Medical Faculty in Martin, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovak Republic.

Dehiscence of colorectal anastomosis is a serious complication that is associated with increased mortality, impaired functional and oncological outcomes. The hypothesis was that anastomosis reinforcement and vacuum trans-anal drainage could eliminate some risk factors, such as mechanically stapled anastomosis instability and local infection. Patients with rectal cancer within 10 cm of the anal verge and low anterior resection with double-stapled technique were included consecutively. Read More

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Solitary vulvar metastasis from early-stage endometrial cancer: Case report and literature review.

Medicine (Baltimore) 2021 Jun;100(22):e25863

Unit of Surgical Gynecol Oncology.

Rationale: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. It is usually diagnosed at early-stage and presents a favorable prognosis. Conversely, advanced or recurrent disease shows poor outcome. Read More

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Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S18-S21. Epub 2021 Mar 19.

Department of Oral and Maxillofacial Surgery, General Hospital George Papanikolaou, Thessaloniki, Greece.

Solitary extramedullary plasmacytomas of the head and neck region are rare entities. Very few have been described in the parotid gland. They can clinically and radiologically mimic the rather common benign tumors of the parotid gland (pleomorphic adenoma and Wharthin's tumor), and subsequently the need careful consideration by the involving surgeon and pathologist is needed for a proper diagnosis. Read More

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