Ann Surg 2021 Jul 29. Epub 2021 Jul 29.
Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany Department of HPB Surgery and Liver Transplantation, Royal Free Hospital, London, UK University College London, London, UK Department of Hepatology, Maastricht University Medical Center (MUMC), Maastricht, The Netherlands Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany Institute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, Aachen, Germany Institute for Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany Department of Hepatology and Gastroenterology, Campus Charité Mitte | Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany Department of General Surgery and Liver transplantation, Fundeni Clinical Institute, Bucharest, Romania Department for General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Objective: To evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold storage (SCS) in extended criteria donation (ECD) liver transplantation (LT) from donation after brain death (DBD).
Background: HOPE might improve outcomes in LT, particularly in high-risk settings such as ECD organs after DBD, but this hypothesis has not yet been tested in a randomized controlled clinical trial (RCT).
Methods: Between 09/2017-09/2020 46 patients undergoing ECD-DBD LT from four centers were randomly assigned to HOPE (n=23) or SCS (n=23). Read More