8,738 results match your criteria postnatal outcome


Effects of skin-to-skin care on electrical activity of the diaphragm in preterm infants during neurally adjusted ventilatory assist.

Early Hum Dev 2021 Apr 29;157:105379. Epub 2021 Apr 29.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Electronic address:

Background: Skin-to-skin care (SSC) reduces neonatal mortality and morbidity and is widely implemented in the neonatal intensive care unit. However, changes in respiratory effort during SSC in ventilated preterm infants remain unclear.

Aims: To evaluate the effect of SSC on electrical activity of the diaphragm (Edi) and vital signs in premature infants who are intubated and under neurally adjusted ventilatory assist ventilation. Read More

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The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

AJNR Am J Neuroradiol 2021 May 6. Epub 2021 May 6.

Department of Pediatric Radiology and Neuroradiology (A.R.), Vittore Buzzi Children's Hospital, Milan, Italy.

Background And Purpose: Ganglionic eminence abnormalities on fetal MR imaging are associated with cerebral malformations. Their presumed genetic basis and associated postnatal outcomes remain largely unknown. We aimed to elucidate these through a multicenter study. Read More

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Relative effectiveness and safety of pharmacotherapeutic agents for patent ductus arteriosus (PDA) in preterm infants: a protocol for a multicentre comparative effectiveness study (CANRxPDA).

BMJ Open 2021 May 5;11(5):e050682. Epub 2021 May 5.

Mount Sinai Hospital, Toronto, Ontario, Canada.

Introduction: Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding the best treatment approach is lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exists in PDA treatment practices across Canada. Read More

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Association of Adherence to Surfactant Best Practice Uses With Clinical Outcomes Among Neonates in Sweden.

JAMA Netw Open 2021 May 3;4(5):e217269. Epub 2021 May 3.

Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Importance: While surfactant therapy for respiratory distress syndrome (RDS) in preterm infants has been evaluated in clinical trials, less is known about how surfactant is used outside such a framework.

Objective: To evaluate registered use, off-label use, and omissions of surfactant treatment by gestational age (GA) and associations with outcomes, mainly among very preterm infants (GA <32 weeks).

Design, Setting, And Participants: This population-based cohort study used registry data for 97 377 infants born in Sweden between 2009 and 2018. Read More

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Mother Matters: Pilot randomized wait-list controlled trial of an online therapist-facilitated discussion board and support group for postpartum depression symptoms.

Depress Anxiety 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Women's College Hospital and Women's College Research Institute, Toronto, Ontario, Canada.

Methods: In a pilot randomized waitlist-controlled trial (Ontario, Canada), individuals aged ≥18 years with Edinburgh Postnatal Depression Scale (EPDS) scores greater than 9 and who self-identified as a mother to a child aged 0-12 months were randomized 1:1 to Mother Matters (intervention) or usual care (control), with an opportunity to receive the intervention after the study was complete. The primary outcome was protocol feasibility, evaluated through recruitment feasibility, intervention acceptability, and adherence to study follow-up measures. Secondarily, postintervention EPDS scores and remission rates (EPDS < 10) were compared between groups. Read More

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Education can modify the long term impact of early childhood famine exposure on adulthood economic achievement: a historical cohort study among the survivors of the great Ethiopian famine 1983-85.

Arch Public Health 2021 May 4;79(1):67. Epub 2021 May 4.

Department of Nutrition and Dietetics, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Previous famine studies reported the inverse link between early life nutritional deprivation and adulthood optimal health outcomes. However, there remain sparse data on the impact of early life famine exposure in later life economic achievement. Hence, we set out to examine the association of early life famine exposure on economic achievement among survivors of the 1983-85 great Ethiopian famine. Read More

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Risk of asthma in children diagnosed with bronchiolitis during infancy: protocol of a longitudinal cohort study linking emergency department-based clinical data to provincial health administrative databases.

BMJ Open 2021 May 3;11(5):e048823. Epub 2021 May 3.

Research Institute, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Introduction: The Canadian Bronchiolitis Epinephrine Steroid Trial (CanBEST) and the Bronchiolitis Severity Cohort (BSC) study enrolled infants with bronchiolitis during the first year of life. The CanBEST trial suggested that treatment of infants with a combined therapy of high-dose corticosteroids and nebulised epinephrine reduced the risk of admission to hospital. Our study aims to-(1) quantify the risk of developing asthma by age 5 and 10 years in children treated with high-dose corticosteroid and epinephrine for bronchiolitis during infancy, (2) identify risk factors associated with development of asthma in children with bronchiolitis during infancy, (3) develop asthma prediction models for children diagnosed with bronchiolitis during infancy. Read More

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Preventing postnatal depression: a causal mediation analysis of a 20-year preconception cohort.

Philos Trans R Soc Lond B Biol Sci 2021 Jun 3;376(1827):20200028. Epub 2021 May 3.

Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.

Postnatal depression (PND) is common and predicts a range of adverse maternal and offspring outcomes. PND rates are highest among women with persistent mental health problems before pregnancy, and antenatal healthcare provides ideal opportunity to intervene. We examined antenatal perceived social support as a potential intervention target in preventing PND symptoms among women with prior mental health problems. Read More

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Poorer mental health and sleep quality are associated with greater self-reported reward-related eating during pregnancy and postpartum: an observational cohort study.

Int J Behav Nutr Phys Act 2021 May 1;18(1):58. Epub 2021 May 1.

Social and Behavioral Sciences Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Dr., MSC 7004, Bethesda, MD, 20892, USA.

Background: Depression, stress, and poor-quality sleep are common during pregnancy and postpartum, but the relationship of these factors with reward-related eating is not well understood. This observational cohort study examines associations of depression, stress, and sleep quality with self-reported reward-related eating in pregnancy and postpartum.

Methods: Participants were enrolled at < 12 weeks gestation and followed through 1 year postpartum. Read More

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Safety and Efficacy of Sodium and Potassium Arachidonic Acid Salts in the Young Pig.

Nutrients 2021 Apr 27;13(5). Epub 2021 Apr 27.

Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.

Arachidonic acid (ARA; 20:4n6) and docosahexaenoic acid (DHA; 22:6n3) are polyunsaturated fatty acids (FA) naturally present in breast milk and added to most North American infant formulas (IF). We investigated the safety and efficacy of novel sodium and potassium salts of arachidonic acid as bioequivalent to support tissue levels of ARA comparable to the parent oil; oil (Na-ARA and K-ARA) and including a Na-DHA group. Pigs of both sexes were randomized to one of five dietary treatments ( = 16 per treatment; 8 male and 8 female) from postnatal day 2 to 23. Read More

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Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period.

Biomolecules 2021 Apr 28;11(5). Epub 2021 Apr 28.

Department of Pharmacology and Pharmacodynamics, Medical University, Chodzki 4A, 20-093 Lublin, Poland.

Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR) signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mTOR Complex 1 (mTORC1) inhibitor, on deficits in spatial memory and reversal learning in the Barnes maze task, as well as the ethanol-induced rewarding effects (1.0 or 1. Read More

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Morphometric Analysis of Brain in Newborn with Congenital Diaphragmatic Hernia.

Brain Sci 2021 Apr 2;11(4). Epub 2021 Apr 2.

Medical Physics Department, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Congenital diaphragmatic hernia (CDH) is a severe pediatric disorder with herniation of abdominal viscera into the thoracic cavity. Since neurodevelopmental impairment constitutes a common outcome, we performed morphometric magnetic resonance imaging (MRI) analysis on CDH infants to investigate cortical parameters such as cortical thickness (CT) and local gyrification index (LGI). By assessing CT and LGI distributions and their correlations with variables which might have an impact on oxygen delivery (total lung volume, TLV), we aimed to detect how altered perfusion affects cortical development in CDH. Read More

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Obstetric early warning system to predict maternal morbidity of pre-eclampsia, postpartum hemorrhage and infection after birth in high-risk women: a prospective cohort study.

Midwifery 2021 Apr 15;99:103015. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere Finland. Electronic address:

Objective: The purpose of early warning systems is to detect deterioration of the patient and to enable timely intervention to prevent possible severe illness. The most common causes of maternal morbidity and mortality after birth are worsening pre-eclampsia, postpartum haemorrhage and puerperal infection. Our aim was to validate the accuracy of the obstetric early warning system and different physiological triggers to predict morbidity on the postnatal ward in high-risk women. Read More

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Characteristics and outcome in prenatally diagnosed vascular aorta-umbilical vein malformation.

J Matern Fetal Neonatal Med 2021 Apr 28:1-4. Epub 2021 Apr 28.

Obstetrics and Gynecology department, American University of Beirut, Beirut, Lebanon.

Congenital arteriovenous fistulas involving the abdominal aorta are very rare. We report an unusual presentation involving the umbilical vein and characterized by the occurrence of a postnatal thrombosis and a favorable outcome. Fetal abdominal arteriovenous fistulas are rare involve branches from the aorta and can lead to umbilical vein thrombosis. Read More

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Feeding Practice During a Diarrheal Episode and Associated Factors Among Mothers/Caregivers with 6-59-Month-Old Children Visiting Health Centers in Shanan Dhuggo District, West Hararge Zone, Oromia Region, Ethiopia.

Pediatric Health Med Ther 2021 21;12:197-204. Epub 2021 Apr 21.

Department of Nursing, College of Health Sciences, Salale University, Fiche, Ethiopia.

Background: Continued feeding and increasing fluids is the cornerstone treatment package for a child with acute diarrhea. However, there is a deficiency of evidence on child feeding practice during a diarrheal episode globally and particularly in low-income countries. This study aimed at assessing feeding practice during diarrheal episodes and associated factors among mothers/caregivers with 6-59-month-old children visiting health centers in Shanan Dhuggo district, West Hararge zone, Oromia region, Ethiopia. Read More

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Antibiotic Safety and Effectiveness in Premature Infants With Complicated Intraabdominal Infections.

Pediatr Infect Dis J 2021 Jun;40(6):550-555

From the Division of Pediatric Infectious Diseases, Duke University, Durham, NC.

Background: In premature infants, complicated intraabdominal infections (cIAIs) are a leading cause of morbidity and mortality. Although universally prescribed, the safety and effectiveness of commonly used antibiotic regimens have not been established in this population.

Methods: Infants ≤33 weeks gestational age and <121 days postnatal age with cIAI were randomized to ≤10 days of ampicillin, gentamicin, and metronidazole (group 1); ampicillin, gentamicin, and clindamycin (group 2); or piperacillin-tazobactam and gentamicin (group 3) at doses stratified by postmenstrual age. Read More

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Comparison of Two Techniques of Superior Vena Cava Flow Measurement in Preterm Infants With Birth Weight <1,250 g in the Transitional Period-Prospective Observational Cohort Study.

Front Pediatr 2021 7;9:661698. Epub 2021 Apr 7.

Coombe Women and Infants University Hospital, Dublin, Ireland.

Superior Vena Cava (SVC) flow in neonates measured by the standard approach has been validated by different groups around the world. The modified SVC flow measurement technique was recently suggested. The aim of our study was to evaluate standard and modified technique of echocardiography SVC flow measurement in a cohort of extremely preterm neonates in the immediate postnatal period. Read More

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Renal outcome among children with posterior urethral valve: When to worry?

Urol Ann 2021 Jan-Mar;13(1):30-35. Epub 2020 Nov 4.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Introduction: Posterior urethral valve (PUV) is a congenital obstructive defect of male urethra that is diagnosed early during antenatal period with a presence of hydroureteronephrosis and associated with several morbidities including chronic kidney disease (CKD) that requires management, therefore, this study aim to evaluate the renal outcome of endoscopic valve ablation and urinary tract diversion in children with PUV, "when to worry, and what to do."

Methodology: This is a retrospective cohort study reviewing medical records of all patients diagnosed with PUV that has been managed in Pediatric Urology Unit at King Abdul-Aziz Medical City, Jeddah in the period of 1998-2008 with proven diagnosis at age younger than 16 accounted for 39 patients, and with different multiple demographics such as antenatal and postnatal ultrasound findings, serum levels of preoperative creatinine, mode of surgical treatment (i.e. Read More

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November 2020

Prenatal findings and postnatal follow-up of a midline dural sinus malformation.

Acta Radiol Open 2021 Apr 7;10(4):20584601211006315. Epub 2021 Apr 7.

Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.

Dural sinus malformation is a rare condition. We describe a prenatally detected case followed by repeated ultrasound scans and a prenatal magnetic resonance imaging examination. A substantial spontaneous regression was observed, which is associated with a favorable outcome. Read More

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Prenatal diagnosis of exomphalos and prediction of outcome.

Sci Rep 2021 Apr 22;11(1):8752. Epub 2021 Apr 22.

Department of Obstetrics and Gynecology, University Clinic of Carl Gustav Carus Dresden, Technische Universität Dresden, 01307, Dresden, Germany.

The aim of this study was to detect a parameter for predicting prenatal complications or postnatal surgical options after detecting a fetal exomphalos. This was a retrospective analysis of prenatal diagnosis and outcome of fetuses with 41 cases of exomphalos in between 2007 and 2017, considering the measurement of ratios. The 41 fetuses with exomphalos were examined, 34 cases (82. Read More

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Validation of the postnatal growth and retinopathy of prematurity screening criteria: A retrospective Italian analysis.

Eur J Ophthalmol 2021 Apr 22:11206721211011362. Epub 2021 Apr 22.

Department of Neurosceince, Ophthalmology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Purpose: Retinopathy of prematurity (ROP) is the leading cause of childhood blindness. The aim of our study is to validate the new screening criteria elaborated by the Postnatal Growth and Retinopathy of Prematurity (G-ROP) study group in a monocentric cohort of Italian preterm infants.

Methods: We retrospectively applied the G-ROP screening criteria to a cohort of preterm infants born between May 2015 and July 2020 with known birth weight, gestational age, serial weight measurement, and known ROP outcome. Read More

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Percutaneous fetoscopic spina bifida repair: effect on need for postnatal cerebrospinal fluid diversion, ambulation and bladder catheterization.

Ultrasound Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Fetal Medicine Research Institute, King's College Hospital, London, UK.

Background: A trial comparing prenatal with postnatal open spina bifida (OSB) repair established that prenatal surgery was associated with better postnatal outcome. However, in the trial the fetal surgery was carried out through hysterotomy. Minimally invasive approaches are being developed to mitigate the risks of open maternal fetal surgery. Read More

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Sequencing cell-free fetal DNA in pregnant women with GCK-MODY: a proof-of-concept study.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Context: Persons with monogenic diabetes due to inactivating glucokinase (GCK) variants typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal GCK genotype determines whether treatment is indicated, but non-invasive methods are not clinically available.

Objective: To develop a method to determine fetal GCK genotype non-invasively using maternal cell-free fetal DNA. Read More

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Single-center thorough evaluation and targeted treatment of globozoospermic men.

J Assist Reprod Genet 2021 Apr 20. Epub 2021 Apr 20.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, Y720, New York, NY, 10021, USA.

Purpose: To characterize, by specific biomarkers and nucleic acid sequencing, the structural and genomic sperm characteristics of partial (PG) and complete globozoospermic (CG) men in order to identify the best reproductive treatment.

Methods: We assessed spermatozoa from 14 consenting men ultrastructurally, as well as for histone content, sperm chromatin integrity, and sperm aneuploidy. Additional genomic, transcriptomic, and proteomic evaluations were carried out to further characterize the CG cohort. Read More

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Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial.

Stem Cells Transl Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, South Korea.

We previously demonstrated the safety and feasibility of mesenchymal stem cell (MSC) transplantation for bronchopulmonary dysplasia (BPD) in preterm infants in a phase I clinical trial. We thus investigated the therapeutic efficacy of MSCs for BPD in premature infants. A phase II double-blind, randomized, placebo-controlled clinical trial was conducted on preterm infants at 23 to 28 gestational weeks (GW) receiving mechanical ventilator support with respiratory deterioration between postnatal days 5 and 14. Read More

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Can EEG accurately predict 2-year neurodevelopmental outcome for preterm infants?

Arch Dis Child Fetal Neonatal Ed 2021 Apr 19. Epub 2021 Apr 19.

INFANT Research Centre, University College Cork, Ireland

Objective: Establish if serial, multichannel video electroencephalography (EEG) in preterm infants can accurately predict 2-year neurodevelopmental outcome.

Design And Patients: EEGs were recorded at three time points over the neonatal course for infants <32 weeks' gestational age (GA). Monitoring commenced soon after birth and continued over the first 3 days. Read More

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Parent engagement with the New South Wales child health home-based record: A cross-sectional survey and a retrospective chart review.

Child Care Health Dev 2021 Apr 19. Epub 2021 Apr 19.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

Background: In 2018, World Health Organization endorsed universal use of home-based records to improve care for mothers, pregnant women, newborns and children. New South Wales (NSW), Australia has had universal use of a child health home-based record since 1988, with the first major update in 2013. Since the update, limitedbelief is sufficient for constituting evidence has been collected about factors influencing parent use of the record. Read More

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The first 1000 days of life: traffic-related air pollution and development of wheezing and asthma in childhood. A systematic review of birth cohort studies.

Environ Health 2021 Apr 17;20(1):46. Epub 2021 Apr 17.

Unit of Epidemiology, Meyer Children's University Hospital, Viale Pieraccini 24, 50139, Florence, Italy.

Background: The first 1000 days of life -including pregnancy and the first 2 years after birth- represent a critical window for health interventions. This systematic review aimed to summarize the evidence on the relationship between traffic-related air pollutants exposure in the first 1000 days of life and the development of wheezing and asthma, with a particular focus on windows of exposure.

Methods: Medline and Embase were searched from January 2000 to May 2020 to retrieve population-based birth-cohort studies, including registries, providing quantitative information on the association between exposure to traffic-related air pollutants during pregnancy or early life, and the risk of developing wheezing and asthma in childhood. Read More

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Thyroid function and dysfunction in preterm infants-Challenges in evaluation, diagnosis and therapy.

Clin Endocrinol (Oxf) 2021 Apr 16. Epub 2021 Apr 16.

Medical Faculty, University Ss. Cyril and Methodius Skopje, University Children's Hospital, Skopje, Macedonia.

Thyroid hormone levels have a crucial role for optimal brain development from gestation through the first 2 postnatal years. However, thyroid hormones vary with gestational age, and their levels vary between term and preterm infants. Preterm newborns are prone to thyroid dysfunction which is now more frequently observed with the advances of neonatal care and improved survival of extremely premature infants. Read More

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Health-related quality of life and quality of care in pregnant and postnatal women during the coronavirus disease 2019 pandemic: A cohort study.

Int J Gynaecol Obstet 2021 Apr 16. Epub 2021 Apr 16.

Rotunda Hospital, Dublin, Ireland.

Objective: Health-related quality of life (HRQoL) and the delivery of high-quality care are ongoing concerns when caring for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. We compared self-reported HRQoL and hospital quality of care among perinatal women with and without COVID-19.

Methods: This is a prospective cohort study of perinatal women attending a tertiary maternity unit during the pandemic. Read More

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