114,370 results match your criteria postnatal


Neonatal FeNO, risk factors, and respiratory morbidity in infants: A cohort study.

Pediatr Pulmonol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pediatrics and Adolescence Medicine, Nordsjaellands Hospital, Capital Region of Denmark, Denmark.

Background: Respiratory symptoms in infancy are more common in premature infants. Nitric oxide (NO) is involved in prenatal and neonatal lung development. Measurement of exhaled NO is easy and well-tolerated by neonates. Read More

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Severity of Maternal SARS-CoV-2 Infection in Pregnancy Predicts Neonatal Outcomes.

Am J Perinatol 2021 Jul 28. Epub 2021 Jul 28.

Neonatology Department, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Objective:  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak had an enormous global impact. Pregnant women with SARS-CoV-2 appear to have higher morbidity and mortality. This study aimed to evaluate the effect of the severity of maternal SARS-CoV-2 infection on neonatal outcomes. Read More

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Growth Hormone Receptor (Ghr) 6ω Pseudoexon Activation: A Novel Cause Of Severe Growth Hormone Insensitivity (Ghi).

J Clin Endocrinol Metab 2021 Jul 28. Epub 2021 Jul 28.

Centre for Endocrinology, William Harvey Research Institute: Barts and The London School of Medicine and Dentistry William Harvey Research Institute.

Context: Severe forms of Growth Hormone Insensitivity (GHI) are characterized by extreme short stature, dysmorphism and metabolic anomalies.

Objective: Identification of the genetic cause of growth failure in 3 'classical' GHI subjects.

Design: A novel intronic GHR variant was identified, and in vitro splicing assays confirmed aberrant splicing. Read More

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Postnatal development alters functional compartmentalization of myosin light chain kinase in ovine carotid arteries.

Am J Physiol Regul Integr Comp Physiol 2021 07 28. Epub 2021 Jul 28.

Division of Physiology, Center for Perinatal Biology, Loma Linda University, Loma Linda, CA, United States.

The rate-limiting enzyme for vascular contraction, Myosin Light Chain Kinase (MLCK), phosphorylates regulatory myosin light chain (MLC) at rates that appear faster despite lower MLCK abundance in fetal compared to adult arteries. This study explores the hypothesis that greater apparent tissue activity of MLCK in fetal arteries is due to age-dependent differences in intracellular distribution of MLCK in relation to MLC. Under optimal conditions, common carotid artery homogenates from non-pregnant adult female sheep and near-term fetuses exhibited similar values of Vmax and Km for MLCK. Read More

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Developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate, disrupts the mesocortical serotonin pathway and alters impulsive decision-making in rats.

Dev Neurobiol 2021 Jul 28. Epub 2021 Jul 28.

Department of Psychology & Center for Neuroscience Research, University at Albany, Albany, NY, USA.

The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to women at risk for preterm birth during a critical period of fetal development for mesocortical pathways. Yet, little information is available regarding the potential effects of 17-OHPC on the developing fetal brain. In rat models, the mesocortical serotonin pathway is sensitive to progestins. Read More

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Prenatal Diagnosis of Aberrant Right Subclavian Artery: Association with Genetic Abnormalities.

Rev Bras Ginecol Obstet 2021 Jun 27;43(6):452-456. Epub 2021 Jul 27.

Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Objective:  The objective of the present study was to determine the frequency of malformations and chromosomal abnormalities in a population of fetuses with an aberrant right subclavian artery (ARSA).

Methods:  This is a 6-year retrospective study of fetuses with a prenatal diagnosis of ARSA conducted during the period between September 2013 and June 2019 at a fetal medicine unit. Data were collected from ultrasound, fetal echocardiograms, genetic studies, and neonatal records. Read More

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Foramen Ovale Restriction in a Late Gestation Fetus Resembling Hypoplastic Left Heart Syndrome.

JACC Case Rep 2021 May 14;3(5):721-723. Epub 2021 Apr 14.

Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

A pregnant woman presented at term with a fetus with foramen ovale restriction. We illustrate the contrast between fetal and postnatal echocardiography of this rare entity. (). Read More

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Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.

Advers Resil Sci 2020 Dec 27;1(4):223-234. Epub 2020 Oct 27.

Psychiatry and Behavioral Sciences and Pediatrics, Emory University, Atlanta, GA, USA.

Current efforts to design research on developmental effects of prenatal opioid exposure can benefit from knowledge gained from 50 years of studies of fetal alcohol and prenatal drug exposures such as cocaine. Scientific advances in neurobiology, developmental psychopathology, infant assessments, genetics, and imaging support the principles of developmental neurotoxicology that guide research in prenatal exposures. Important to research design is accurate assessment of amount, frequency, and timing of exposure which benefits from accurate self-report and biomarkers of exposure. Read More

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December 2020

Effect of drying and/or warming piglets at birth under warm farrowing room temperatures on piglet rectal temperature over the first 24 h after birth.

Transl Anim Sci 2021 Jul 5;5(3):txab060. Epub 2021 Apr 5.

Department of Animal Sciences, University of Illinois, Urbana-Champaign, IL 61801, USA.

Piglets experience a decline in body temperature immediately after birth, and both drying and warming piglets at birth reduce this. However, these interventions may be less effective at higher farrowing room temperatures. This study was carried out at a commercial facility to compare the effect of drying and/or warming piglets at birth on postnatal rectal temperature () under relatively warm farrowing room temperatures (26. Read More

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Maternal depressed mood and child development over the first five years of life in South Africa.

J Affect Disord 2021 Jul 16;294:346-356. Epub 2021 Jul 16.

Institute for Life Course Health Research, Department of Global Health, Stellenbosch University, Cape Town, South Africa; Arizona State University, Tempe, AZ, United States; School of Nursing and Midwifery, Queens University, Belfast, United Kingdom. Electronic address:

Background: While the negative impact of peri-natal depression is well-documented in high-income countries, the long-term effects across the life course in low and middle-income countries is less clear. Children's adjustment over the first five years is examined as a function of patterns of maternal depressed mood.

Methods: Pregnant women in 24 peri-urban townships (N = 1,238) were randomized to a home-visiting intervention or standard care and reassessed five times, with high retention. Read More

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Resting-state EEG theta activity reflects degree of genetic determination of the major epilepsy syndromes.

Clin Neurophysiol 2021 Jul 3;132(9):2232-2239. Epub 2021 Jul 3.

University of Debrecen, Faculty of Medicine, Department of Neurology, Hungary.

Objective: To explore relationship between EEG theta activity and clinical data that imply the degree of genetic determination of epilepsy.

Methods: Clinical data of interest were epilepsy diagnosis and positive / negative family history of epilepsy. Study groups were: idiopathic generalized epilepsy (IGE), focal epilepsy (FE); FE of unknown etiology (FEUNK), FE of postnatal-acquired etiology (FEPA); all patients with positive / negative family history of epilepsy (FAPALL, FANALL, respectively), disregarding of the syndrome; FAP patients with 1st degree affected relative (FAP1) and those with 2nd degree epileptic relative only (FAP2). Read More

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Sensitivity to interaural time differences in the inferior colliculus of cochlear implanted rats with or without hearing experience.

Hear Res 2021 Jul 9;408:108305. Epub 2021 Jul 9.

Department of Neouroscience, City University of Hong Kong, 31 To Yuen Street, Kowloon, Hong Kong SAR, China; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address:

For deaf patients cochlear implants (CIs) can restore substantial amounts of functional hearing. However, binaural hearing, and in particular, the perception of interaural time differences (ITDs) with current CIs has been found to be notoriously poor, especially in the event of early hearing loss. One popular hypothesis for these deficits posits that a lack of early binaural experience may be a principal cause of poor ITD perception in pre-lingually deaf CI patients. Read More

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Endothelial neuropilin-2 influences angiogenesis by regulating actin pattern development and α5-integrin-p-FAK complex recruitment to assembling adhesion sites.

FASEB J 2021 08;35(8):e21679

Gut Microbes and Health, Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.

The ability to form a variety of cell-matrix connections is crucial for angiogenesis to take place. Without stable anchorage to the extracellular matrix (ECM), endothelial cells (ECs) are unable to sense, integrate and disseminate growth factor stimulated responses that drive growth of a vascular bed. Neuropilin-2 (NRP2) is a widely expressed membrane-bound multifunctional non-tyrosine kinase receptor, which has previously been implicated in influencing cell adhesion and migration by interacting with α5-integrin and regulating adhesion turnover. Read More

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Intrinsic and growth-mediated cell and matrix specialization during murine meniscus tissue assembly.

FASEB J 2021 08;35(8):e21779

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The incredible mechanical strength and durability of mature fibrous tissues and their extremely limited turnover and regenerative capacity underscores the importance of proper matrix assembly during early postnatal growth. In tissues with composite extracellular matrix (ECM) structures, such as the adult knee meniscus, fibrous (Collagen-I rich), and cartilaginous (Collagen-II, proteoglycan-rich) matrix components are regionally segregated to the outer and inner portions of the tissue, respectively. While this spatial variation in composition is appreciated to be functionally important for resisting complex mechanical loads associated with gait, the establishment of these specialized zones is poorly understood. Read More

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Impact of parental perinatal depressive and anxiety symptoms trajectories on early parent-infant impaired bonding: a cohort study in east and west coasts of Malaysia.

Arch Womens Ment Health 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 141 83 Huddinge, Stockholm, Sweden.

The association between maternal depressive and anxiety symptoms and impaired bonding with infants were widely studied, but not in fathers and none in Malaysia. We investigated the impact of different trajectories of perinatal depressive and anxiety symptoms on parent-infant impaired bonding during 2-3 months postpartum in both mothers and fathers in two areas of Malaysia. This study originated from a psychiatric morbidity cohort study carried out in health clinics in east and west Malaysia. Read More

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Posthatching ultrastructural development of the oropharyngeal cavity roof in five age-stages of Coturnix coturnix (Linnaeus, 1758).

Microsc Res Tech 2021 Jul 27. Epub 2021 Jul 27.

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

Recent literature has demonstrated only adult avian palate, albeit there has been only limited focus on the postnatal development of the avian oropharyngeal cavity roof. Hence, the current investigation was designed to obtain the full ultrastructure postnatal description of the oropharyngeal roof during the five developmental age-stages of Coturnix coturnix by employing assessments using gross morphometric analysis and stero and scanning electron microscopy. The elongated triangular oropharyngeal roof has a spoonful rounded beak tip. Read More

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Are you my mummy? Long-term olfactory memory of mother's body odour by offspring in the domestic cat.

Anim Cogn 2021 Jul 26. Epub 2021 Jul 26.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Longevity of odour memories, particularly those acquired during early development, has been documented in a wide range of taxa. Here, we report that kittens of the domestic cat retained a memory into adult life of their mother´s body odour experienced before weaning. Kittens from 15 litters were tested when permanently separated from their mother at weaning on postnatal week 8, and tested again when 4 and 6 months and over 1 year of age. Read More

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Knockout of Ca1.3 L-type calcium channels in a mouse model of retinitis pigmentosa.

Sci Rep 2021 Jul 26;11(1):15146. Epub 2021 Jul 26.

Institute of Pharmacy, Pharmacology and Toxicology, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Retinitis Pigmentosa is a genetically heterogeneous, degenerative retinal disorder characterized by gradual dysfunction and death of photoreceptors, first rods and later cones, and progressive blindness. Studies suggested that application of L-type calcium channel blockers rescues photoreceptors in paradigms related to Ca overflow. To investigate whether Cav1. Read More

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Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development.

Cell Death Discov 2021 Jul 26;7(1):194. Epub 2021 Jul 26.

Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea.

Testis development, including early embryonic gonad formation and late postnatal spermatogenesis, is essential for the reproduction of higher metazoans to generate fertile gametes, called sperm. We have previously reported that the polyubiquitin gene Ubb is required for fertility in both male and female mice. In particular, the Ubb-null male mice showed an azoospermia phenotype due to arrest of spermatogenesis at the pachytene stage. Read More

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Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development.

Dev Psychopathol 2021 Jul 27:1-10. Epub 2021 Jul 27.

Department of Psychology, University of Denver, Denver, CO, USA.

Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Read More

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Bone turnover in pregnancy, measured by urinary C-terminal telopeptide of type I collagen (CTX), is influenced by vitamin D supplementation and is associated with maternal bone health: Findings from the MAVIDOS trial.

Am J Clin Nutr 2021 Jul 23. Epub 2021 Jul 23.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.

Background: The pattern of change in maternal bone turnover throughout pregnancy is poorly characterized.

Objective: We investigated changes across pregnancy in a marker of maternal bone resorption, urinary C-terminal telopeptide of type I collagen (CTX), the influence of gestational vitamin D supplementation, and associations between CTX and maternal postnatal bone indices.

Design: The Maternal Vitamin D Osteoporosis Study (MAVIDOS) is a randomized, double-blind, placebo-controlled trial of 1000 IU/day cholecalciferol vs placebo from 14 weeks' gestation to birth. Read More

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A transient postnatal quiescent period precedes emergence of mature cortical dynamics.

Elife 2021 Jul 23;10. Epub 2021 Jul 23.

Neurology, Columbia University, New York, United States.

Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neural networks to perform complex computations remains unknown. We investigate the progression of large-scale synaptic and cellular activity patterns across development using high spatiotemporal resolution electrophysiology in immature mice. Read More

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Spontaneous and induced labor: association with maternal well-being three months after childbirth.

Psychol Health Med 2021 Jul 23:1-6. Epub 2021 Jul 23.

Department of Health Sciences, University of Florence, Florence, Italy.

A woman's first childbirth represents a moment of elevated maternal emotional vulnerability. Indeed, there is a prevalence of anxiety and depression symptomatology in primiparas during the postpartum period that negatively influences the well-being of the woman, of her newborn, and of the quality of their attachment bond. Much attention has been paid to the possible risk factors involved in the onset of mood disturbance in the postpartum. Read More

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Postnatal inflammation in ApoE-/- mice is associated with immune training and atherosclerosis.

Clin Sci (Lond) 2021 Jul 23. Epub 2021 Jul 23.

The University of Queensland School of Chemistry and Molecular Biosciences, Brisbane, Australia.

Background And Aims: Preterm birth is associated with increased risk of cardiovascular disease (CVD). This may reflect a legacy of inflammatory exposures such as chorioamnionitis, that complicate pregnancies delivering preterm, or recurrent early-life infections, common in preterm infants. We previously reported that experimental chorioamnionitis followed by postnatal inflammation has additive and deleterious effects on atherosclerosis in ApoE-/- mice. Read More

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Olfactory shifts linked to postpartum depression.

Sci Rep 2021 Jul 22;11(1):14947. Epub 2021 Jul 22.

Department of Psychological Medicine, School of Medicine, University of Otago, Dunedin, New Zealand.

Postpartum Depression (PPD) is the most common non-obstetric complications associated with childbearing, but currently has poor diagnostic regimes. Sensory symptoms of PPD are understudied, particularly with regard to the sense of olfaction. The present study addresses this research gap by assessing differences in olfactory abilities between 39 depressed mothers, who were within the perinatal period (i. Read More

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Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain.

Transl Psychiatry 2021 Jul 22;11(1):405. Epub 2021 Jul 22.

Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.

Although antipsychotics, such as olanzapine, are effective in the management of psychiatric conditions, some patients experience excessive antipsychotic-induced weight gain (AIWG). To illuminate pathways underlying AIWG, we compared baseline blood gene expression profiles in two cohorts of mice that were either prone (AIWG-P) or resistant (AIWG-R) to weight gain in response to olanzapine treatment for two weeks. We found that transcripts elevated in AIWG-P mice relative to AIWG-R are enriched for high-confidence transcriptional targets of numerous inflammatory and immunomodulatory signaling nodes. Read More

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Women's decision-making power in a context of free reproductive healthcare and family planning in rural Burkina Faso.

BMC Womens Health 2021 Jul 22;21(1):272. Epub 2021 Jul 22.

School of Public Health, University of Montreal, Montreal, QC, Canada.

Background: In 2016, the national user fee exemption policy for women and children under five was introduced in Burkina Faso. It covers most reproductive healthcare services for women including prenatal care, delivery, and postnatal care. In subsequent years, the policy was gradually extended to include family planning. Read More

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LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification.

Hear Res 2021 Jul 15;409:108311. Epub 2021 Jul 15.

GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, C.H.U. B36, B-4000 Liège, Belgium. Electronic address:

There is now growing evidence that hypercholesterolemia and high serum levels of low-density lipoproteins (LDL) predispose to sensorineural hearing loss. Circulating LDL-cholesterol is delivered to peripheral tissues via LDL receptor (LDLR) -mediated endocytosis. Recently, it has been shown that LDLR gene polymorphisms are associated with higher susceptibility to sudden deafness. Read More

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The influence of developmental noise exposure on the temporal processing of acoustical signals in the auditory cortex of rats.

Hear Res 2021 Jul 9;409:108306. Epub 2021 Jul 9.

Department of Auditory Neuroscience, Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14220 Prague 4, Czech Republic.

Previous experiments have acknowledged that inappropriate or missing auditory inputs during the critical period of development cause permanent changes of the structure and function of the auditory system (Bures et al., 2017). We explore in this study how developmental noise exposure influences the coding of temporally structured stimuli in the neurons of the primary auditory cortex (AC) in Long Evans rats. Read More

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Risk factor analysis and outcomes of airway management in antenatally diagnosed cervical masses.

Int J Pediatr Otorhinolaryngol 2021 Jul 21;149:110851. Epub 2021 Jul 21.

Division of Otolaryngology, Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. Electronic address:

Purpose: To investigate antenatally-determined imaging characteristics associated with invasive airway management at birth in patients with cervical masses, as well as to describe postnatal management and outcomes.

Study Design: A retrospective analysis of 52 patients with antenatally diagnosed neck masses was performed using single-center data from January 2008 to January 2019. Antenatal imaging, method of delivery, management, and outcomes data were abstracted from the medical record and analyzed. Read More

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