48,425 results match your criteria postmenopausal women


Association of lifestyle factors with osteoporosis and fracture in postmenopausal women: a Japanese cohort study.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka-shi, Fukuoka, Japan Department of Psychosomatic Medicine, International University of Health and Welfare Narita Hospital, Narita City, Chiba, Japan Department of General Internal Medicine, Kyushu University Hospital, Fukuoka-shi, Fukuoka, Japan Taihaku Avenue Clinic, Hakata-ku, Fukuoka, Japan.

Objective: Osteoporosis is a major risk factor for fracture later in life; however, few studies have examined the association of lifestyle factors with osteoporosis and fracture. This study aimed to identify factors associated with osteoporosis and fracture in postmenopausal women.

Methods: We evaluated the association between baseline characteristics and outcomes (diagnosis of osteoporosis or incidence of fracture) in 4,427 postmenopausal women who participated in the Kyushu University Fukuoka Cohort Study on lifestyle-related diseases (baseline: February 2004 to August 2007; follow-up: February 2010 to December 2012). Read More

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Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA Department of Epidemiology, University of Washington, Seattle, WA Department of Medicine, University of Washington, Seattle, WA Kaiser Permanente Washington Health Research Institute, Seattle, WA Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Objective: Hormone therapy (HT) is used by menopausal women to treat vasomotor symptoms. Venous thromboembolism (VTE) is an important risk of HT use, and more knowledge on the comparative safety of different estrogenic compounds is useful for women who use HT for these symptoms. The objective was to compare the risk of VTE among users of oral conjugated equine estrogen (CEE), oral estradiol (E2), and transdermal E2, in a cohort of women veterans. Read More

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Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis.

Public Health Nutr 2021 Jul 27:1-13. Epub 2021 Jul 27.

Department of Clinical Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang110016, People's Republic of China.

Objective: We aimed to evaluate the association between coffee and/or tea consumption and breast cancer (BC) risk among premenopausal and postmenopausal women and to conduct a network meta-analysis.

Design: Systematic review and network meta-analysis.

Setting: We conducted a systematic review of electronic publications in the last 30 years to identify case-control studies or prospective cohort studies that evaluated the effects of coffee and tea intake. Read More

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Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial.

J Sex Marital Ther 2021 Jul 27:1-10. Epub 2021 Jul 27.

Department of Biostatistics and Epidemiology, School of Public Health, Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to investigate the effect of zinc supplementation on testosterone levels and sexual function in postmenopausal women. This randomized clinical trial was performed on 116 postmenopausal women with serum zinc levels below 62, and low sexual function who were randomly divided into two groups: intervention and control. Serum zinc levels, testosterone, hemoglobin and hematocrit, as well as their Female Sexual Function Index (FSFI) were evaluated before and after the intervention. Read More

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8-Hydroxy-2'-Deoxyguanosine as an Oxidative Stress Marker in Insomnia.

Bull Exp Biol Med 2021 Jul 23. Epub 2021 Jul 23.

Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.

We performed comparative analysis of 8-hydroxy-2'-deoxyguanosine in women in different climax stages with and without insomnia. The study involved 90 women aged 45 to 60 years divided into perimenopausal (n=30) and postmenopausal (n=60) groups. After questioning using special sleep questionnaires (Insomnia Severity Index, Epworth Sleepiness Scale, Munich Chronotype Questionnaire), the groups were divided into subgroups with insomnia and without it (control). Read More

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VDR polymorphisms effect on bone mineral density in Polish postmenopausal women.

Homo 2021 Jul 23. Epub 2021 Jul 23.

Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, 12/16 Banacha St., 90-237 Łódź, Poland.

Osteoporosis is the most widespread systemic disease of the skeleton. According to estimated data for Poland, it affects ca. 3 million people. Read More

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Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation.

Eur J Pharmacol 2021 Jul 23:174381. Epub 2021 Jul 23.

The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China. Electronic address:

Epidemiological data suggest that the incidence of rheumatoid arthritis (RA) increases in postmenopausal women, which may be related to estrogen deficiency. Tissue acidosis is a common symptom of RA. Acid-sensitive ion channel 1a (ASIC1a), a member of the extracellular H-activated cation channel family, could be activated by changes in extracellular pH and plays a crucial role in the pathogenesis of RA. Read More

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Risks vs. benefits of switching therapy in patients with postmenopausal osteoporosis.

Expert Rev Endocrinol Metab 2021 Jul 26:1-12. Epub 2021 Jul 26.

Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.

: Osteoporosis is characterized by the fragility of bones, leading to fractures and, consequently, the deterioration of functional capacity and quality of life. Postmenopausal women, in particular, are prone to osteoporosis and often require anti-osteoporosis treatment. In the last few decades, various anti-osteoporosis drugs have been approved for clinical use. Read More

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A pas de deux of osteoporosis and sarcopenia: osteosarcopenia.

Climacteric 2021 Jul 26:1-8. Epub 2021 Jul 26.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.

The musculoskeletal conditions osteoporosis and sarcopenia are highly prevalent in older adults. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone, whereas sarcopenia is identified by the loss of muscle strength, function and mass. Osteoporosis represents a major health problem contributing to millions of fractures worldwide on an annual basis, whereas sarcopenia is associated with a range of adverse physical and metabolic outcomes. Read More

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Religion, spirituality and diurnal rhythms of salivary cortisol and dehydroepiandrosterone in postmenopausal women.

Compr Psychoneuroendocrinol 2021 Aug 6;7. Epub 2021 Jun 6.

MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.

Background: Religion and spirituality (R/S) are important resources for coping with stress and are hypothesized to influence health outcomes via modulation of the hypothalamic-pituitary-adrenal (HPA) axis, though this has not been evaluated extensively. In this study, we examined associations between several measures of religiosity or spirituality (R/S) and three HPA axis biomarkers: cortisol, dehydroepiandrosterone (DHEA), and cortisol: DHEA ratio.

Methods: Sample included 216 female postmenopausal Nurses' Health Study II participants who provided up to five timed saliva samples: immediately upon awakening, 45 min, 4 h, and 10 h after waking, and prior to going to sleep during a single day in 2013. Read More

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Pasta meal intake in relation to risks of type 2 diabetes and atherosclerotic cardiovascular disease in postmenopausal women : findings from the Women's Health Initiative.

BMJ Nutr Prev Health 2021 30;4(1):195-205. Epub 2021 Apr 30.

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.

Objective: To evaluate the association between pasta meal intake and long-term risk of developing diabetes or atherosclerotic cardiovascular disease (ASCVD, including coronary heart disease (CHD) and stroke) in postmenopausal women.

Design: Prospective cohort study.

Setting: Women's Health Initiative (WHI) in the USA. Read More

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A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer.

J Endocr Soc 2021 Sep 19;5(9):bvab116. Epub 2021 Jun 19.

Department of Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.

Objective: Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone treatment (LTTT) entails oral delivery of a small dose of testosterone that does not raise peripheral blood testosterone levels. Read More

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September 2021

The Effects of L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study.

Front Pharmacol 2021 7;12:654459. Epub 2021 Jul 7.

School of Biology, Damghan University, Damghan, Iran.

Menopause is the last menstrual period associated with a decline in ovarian steroid secretion and follicular loss. Hormone profile changes during menopause include a decrease in the production of estrogen, dehydroepiandrosterone (DHEA), and prolactin (PRL), and an increase in thyroid-stimulating hormone (TSH) and cortisol. Herbal medicines are considered as alternatives to hormone therapy. Read More

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Effect of TSH Suppression Therapy on Bone Mineral Density in Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis.

J Clin Endocrinol Metab 2021 Jul 24. Epub 2021 Jul 24.

Department of Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

Context: As subclinical hyperthyroidism increases the risk of osteoporosis and fractures, concerns are growing about the long-term skeletal safety of thyrotropin (TSH) suppression therapy after total thyroidectomy in patients with differentiated thyroid cancer (DTC).

Objective: We aimed to determine the effect of TSH suppression therapy on bone mineral density (BMD) in DTC patients.

Methods: We searched PubMed, Embase, the Cochrane library, and other sources. Read More

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Diagnostic, treatment, and follow-up of osteoporosis-position statement of the Latin American Federation of Endocrinology.

Arch Osteoporos 2021 Jul 24;16(1):114. Epub 2021 Jul 24.

Presidente de la Federación Latinoamericana de Endocrinología (FELAEN), Universidad Nacional de Colombia, Asociación Colombiana de Endocrinología, Diabetes y Metabolismo (ACE), Bogotá, Colombia.

The Latin American Federation of Endocrinology position statement on osteoporosis was developed by endocrinologists from 9 countries. It encompasses the definition, diagnosis, treatment, and follow-up of the disease, the identification of barriers to healthcare, and proposals to improve the disease care in the region.

Introduction: There is a gap in the understanding of osteoporosis in Latin America. Read More

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Metabolomics and physiological analysis of the effect of calcium supplements on reducing bone loss in ovariectomized rats by increasing estradiol levels.

Nutr Metab (Lond) 2021 Jul 23;18(1):76. Epub 2021 Jul 23.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing, 100050, China.

Background: Data from the 2010-2012 Chinese National Nutrition and Health Survey showed that the vast majority of postmenopausal women in China had dual deficiencies in calcium and estrogen.

Objective: This study aimed to clarify whether calcium supplementation alleviated bone loss caused by calcium restriction combined with estrogen deficiency in rats.

Methods: Forty-eight female rats aged 9 weeks were assigned to 4 groups and fed a low-calcium diet: sham-operated (SHAM-LC), ovariectomized (OVX-LC), and ovariectomized rats treated with 750 mg/kg (OVX-LC-M) or 2800 mg/kg CaCO (OVX-LC-H). Read More

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The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease.

Int J Environ Res Public Health 2021 Jul 16;18(14). Epub 2021 Jul 16.

Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China.

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, = 33), or maintained their daily lifestyle (Con, = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Read More

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Evaluation of frozen section biopsy for fast track diagnosis of endometrial pathology in high-risk women with abnormal uterine bleeding.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 8;264:97-102. Epub 2021 Jul 8.

Department of Obstetrics and Gynecology, UCMS and GTB Hospital, New Delhi, India.

Objective: To study the accuracy of frozen section biopsy for endometrial pathology in high-risk women with abnormal uterine bleeding (AUB).

Study Design: A case-control study was conducted between November 2017 to April 2019, a total of 150 women with postmenopausal bleeding, perimenopausal AUB, and high-risk women of age < 40 years with AUB were recruited. All women underwent transvaginal sonography and Doppler, based on age-appropriate endometrial thickness cut-offs 80 women then underwent hysteroscopy. Read More

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The Vaginal Microbiome: A Long Urogenital Colonization Throughout Woman Life.

Front Cell Infect Microbiol 2021 6;11:686167. Epub 2021 Jul 6.

Dipartimento di Medicina Clinica e Chirurgia, Università Federico II di Napoli, Naples, Italy.

Vaginal microbial niche is a dynamic ecosystem, composed by more than 200 bacterial species which are influenced by genes, ethnic background and environmental-behavioral factors. Several lines of evidence have well documented that vaginal microbiome constantly changes over the course of woman's life, so to exert an important impact on woman quality of life, from newborn to post-menopausal ages. This review aims at analyzing the role of vaginal microbiome in the maintenance of woman's homeostasis and at tracking critical changes that commonly occur across woman's lifetime. Read More

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Vaginal collagen I and III changes after carbon dioxide laser application in postmenopausal women with the genitourinary syndrome: a pilot study.

Climacteric 2021 Jul 22:1-9. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Zaragoza, Spain.

Objective: The aim of the study was to evaluate the clinical response and collagen remodeling in the vaginal wall after three sessions of carbon dioxide (CO) laser application.

Methods: Fourteen postmenopausal women with vulvovaginal atrophy, aged 45-65 years and sexually active, were evaluated with clinical questionnaires, gynecological examinations and histological techniques before and after 20 weeks of treatment (ClinicalTrials.gov NCT03939078). Read More

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A systematic review of clinical trials on Ginkgo () effectiveness on sexual function and its safety.

Avicenna J Phytomed 2021 Jul-Aug;11(4):324-331

Clinical Instructor Mpilo School of Midwifery Zimbabwe. Zimbabwe Confederation of Midwives, Bulawayo, Zimbabwe.

Objective: During recent years, evidence-based practice as a way to support higher standards of care was emphasized by health care policymakers. Sexual dysfunction (SD) is a common problem that affects the quality of life in individuals. Today, the use of extract (GBE) for treating SD has been considered, so this study was performed to evaluate the current evidence for the efficacy and safety of ginkgo in treating SD. Read More

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November 2020

MicroRNA-151a-3p Functions in the Regulation of Osteoclast Differentiation: Significance to Postmenopausal Osteoporosis.

Clin Interv Aging 2021 14;16:1357-1366. Epub 2021 Jul 14.

Community Medicine Department, Beijing Jishuitan Hospital, Beijing City, 100096, People's Republic of China.

Background: Studies have found the pivotal role of miRNAs in the progression of postmenopausal osteoporosis (OP). However, the function of miRNAs in OP is unclear. This study aimed to explore the biological functions of microRNA-151a-3p in OP. Read More

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Yoga versus massage in the treatment of aromatase inhibitor-associated knee joint pain in breast cancer survivors: a randomized controlled trial.

Sci Rep 2021 Jul 21;11(1):14843. Epub 2021 Jul 21.

Graduate Institute of Acupuncture Science, China Medical University, No.91, Hsueh-Shih Road, Taichung, 40402, Taiwan.

Aromatase inhibitors (AIs) are standard adjuvant therapy for postmenopausal women with oestrogen receptor-positive, early-stage, and metastatic breast cancer. Although effective, the risk of falls due to AI-associated knee joint pain significantly increased. The aim of this study was to evaluate the therapeutic effects of yoga and massage on AI-associated knee joint pain. Read More

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Hiding unhealthy heart outcomes in a low-fat diet trial: the Women's Health Initiative Randomized Controlled Dietary Modification Trial finds that postmenopausal women with established coronary heart disease were at increased risk of an adverse outcome if they consumed a low-fat 'heart-healthy' diet.

Open Heart 2021 Jul;8(2)

Applied Design, Cape Peninsula University of Technology, Bellville, South Africa

The Women's Health Initiative Randomized Controlled Dietary Modification Trial (WHIRCDMT) was designed to test whether the US Department of Agriculture's 1977 Dietary Guidelines for Americans protects against coronary heart disease (CHD) and other chronic diseases. The only significant finding in the original 2006 WHIRCDMT publication was that postmenopausal women with CHD randomised to a low-fat 'heart-healthy' diet in 1993 were at 26% greater risk of developing additional CHD events compared with women with CHD eating the control diet. A 2017 WHIRCDMT publication includes data for an additional 5 years of follow-up. Read More

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Knowledge, attitudes and practices towards menopause among Congolese middle-aged and postmenopausal women.

Pan Afr Med J 2021 30;38:315. Epub 2021 Mar 30.

Department of Obstetrics and Gynaecology, Medical Faculty, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.

Introduction: with the increase in life expectancy, women will live longer during their postmenopausal period. To improve their quality of life, they should be aware of what challenges they will be facing. This study aimed to evaluate the knowledge, attitudes and practices of middle-aged women towards menopause. Read More

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Sleep Quality and Associated Factors in Premenopausal, Perimenopausal, and Postmenopausal Women in Korea: Findings from the K-Stori 2016.

Nat Sci Sleep 2021 14;13:1137-1145. Epub 2021 Jul 14.

Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea.

Purpose: Poor sleep quality is a common problem among middle-aged women. Few studies, however, have assessed differences in sleep quality among premenopausal, perimenopausal, and postmenopausal women and related risk factors in Korea women. The aim of this study was to assess sleep quality and factors associated therewith according to menopausal status in Korean women. Read More

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Gene Variants and Response to Zoledronic Acid Treatment in Chinese Women with Postmenopausal Osteoporosis.

Pharmgenomics Pers Med 2021 13;14:859-866. Epub 2021 Jul 13.

Department of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213003, People's Republic of China.

Purpose: Alpha-L-iduronidase (IDUA) rs3755955 and rs6831280 polymorphisms have been demonstrated to be associated with bone mineral density (BMD). However, no study has investigated the association of these two polymorphisms with osteoporosis (OP) susceptibility in Chinese postmenopausal women.

Patients And Methods: gene polymorphisms were genotyped in 278 women with OP and 303 healthy controls via polymerase chain reaction and Sanger sequencing. Read More

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Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass.

Sci Rep 2021 Jul 20;11(1):14750. Epub 2021 Jul 20.

The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Menopause is associated with a redistribution of adipose tissue towards central adiposity, known to cause insulin resistance. In this cross-sectional study of 33 women between 45 and 60 years, we assessed adipose tissue inflammation and morphology in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) across menopause and related this to menopausal differences in adipose tissue distribution and insulin resistance. We collected paired SAT and VAT biopsies from all women and combined this with anthropometric measurements and estimated whole-body insulin sensitivity. Read More

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Different cutoff points to diagnose low muscle mass and prediction of osteoporosis in postmenopausal women.

Menopause 2021 Jul 19. Epub 2021 Jul 19.

Applied Physiology, Aging, Nutrition and Exercise Research Group (PHYANER), Health Science Institute, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil Department of Sport Sciences, Health Science Institute, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil Department Health Science, Oeste Paulista University (UNOESTE), Jau, Sao Paulo, Brazil Physiotherapy Course, Department of Health Sciences, Rehabilitation and Functional Performance Program, Ribeirao Preto Medical School, University of São Paulo, São Paulo, Brazil Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil.

Objective: This study aimed to verify which of the different cutoff points of low muscle mass (LMM) based on appendicular lean mass (ALM) is associated with osteoporosis in postmenopausal women (PMW).

Methods: Cross-sectional study. PMW (n = 355) were classified for the presence of osteoporosis (score <-2. Read More

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